Processing of polycaprolactone and polycaprolactone-based copolymers into 3D scaffolds, and their cellular responses

Tissue Engineering - Part A

Volumn 15, Issue 10, 2009, Pages 3013-3024

  Hoque, Md Enamul ^a   San, Wong Yoke ^b   Wei, Feng ^b   Li, Suming ^c   Huang, Ming Hsi ^c,d   Vert, Michel ^c   Hutmacher, Dietmar W ^e,f  

^a UNIVERSITY OF NOTTINGHAM MALAYSIA CAMPUS   (Malaysia)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c UNIV MONTPELLIER   (France)

^d NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^e QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^f GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; BIOMECHANICS; CELL ADHESION; CELL CULTURE; CELL MEMBRANES; COMPUTERIZED TOMOGRAPHY; CONCURRENT ENGINEERING; COPOLYMERIZATION; COPOLYMERS; DYNAMIC ANALYSIS; ETHYLENE; ETHYLENE GLYCOL; HYDROPHILICITY; JOB ANALYSIS; MECHANICAL PROPERTIES; MORPHOLOGY; POLYCAPROLACTONE; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYMERS; RAPID PROTOTYPING; SCANNING ELECTRON MICROSCOPY; THERMOANALYSIS; THREE DIMENSIONAL; TISSUE; TISSUE ENGINEERING; TOMOGRAPHY;

3D SCAFFOLDS; BIOMECHANICAL PROPERTIES; CAPROLACTONE; CELLULAR RESPONSE; CONFOCAL LASER MICROSCOPY; DESKTOP ROBOT; DIBLOCKS; DYNAMIC THERMAL ANALYSIS; EXTRACELLULAR MATRICES; EXTRACELLULAR MATRIX FORMATION; HIGH UNIFORMITY; HOMOPOLYMERS; IN-VITRO; INTERCONNECTIVITY; MECHANICAL CHARACTERISTICS; MICROCOMPUTED TOMOGRAPHY; PORE MORPHOLOGY; PORE NETWORKS; PROCESS PARAMETERS; SCANNING ELECTRONS; SMOOTH MUSCLE CELLS; SYNTHETIC POLYMERS; THREE-DIMENSIONAL POROUS SCAFFOLDS; THREE-DIMENSIONAL STRUCTURE; TIME POINTS; TRIBLOCK COPOLYMERS;

SCAFFOLDS;

COPOLYMER; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U; POLYCAPROLACTONE;

ARTICLE; BIOMECHANICS; CELL ADHESION; CELL CULTURE; CELL PROLIFERATION; CELL STRUCTURE; COMPUTER ASSISTED TOMOGRAPHY; CONFOCAL LASER MICROSCOPY; EXTRACELLULAR MATRIX; HYDROPHILICITY; IN VITRO STUDY; NONHUMAN; POROSITY; PRIORITY JOURNAL; RABBIT; SCANNING ELECTRON MICROSCOPY; THERMAL ANALYSIS; TISSUE ENGINEERING;

ORYCTOLAGUS CUNICULUS;

EID: 70349906286     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2008.0355     Document Type: Article

References (32)

1. Li, S., and Vert, M. Biodegradable polymers: polyesters. In: Mathiowitz, E., ed. Encyclopedia of Controlled Drug Delivery. New York: Wiley & Sons, 1999, pp. 71-93.
2. Jalil, R., and Nixon, J.R. Biodegradable poly(lactic acid) and poly(lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties. J Microencapsul 7, 297, 1990.
3. Tice, T.R., and Tabibi, E.S. Parenteral drug delivery: inject-ables. In: Kydonieus, A., ed. Treatise on Controlled Drug Delivery: Fundamentals Optimization and Applications. New York: Marcel Dekker, 1991, pp. 315-339.
4. Wu, X.S. Preparation, characterization, and drug delivery applications of microspheres based on biodegradable lactic= glycolic acid polymers. In: Donald L. Wise ed. Encyclopedic Handbook of Biomaterials and Bioengineering. New York: Marcel Dekker, 1995, pp. 1151-1200.
5. Hutmacher, D.W. Polymeric scaffolds in tissue engineering bone and cartilage. Biomaterials 21, 2529, 2000.
6. Hutmacher, D.W., Schantz, J.T., Zein, I., Ng, K.W., Teoh, S.H., and Tan, K.C. Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. J Biomed Mater Res 55, 203, 2001.
7. Huang, M.H., Li, S., Coudane, J., and Vert, M. Synthesis and characterization of block copolymers of e-caprolactone and DL-lactide initiated by ethylene glycol or poly(ethylene glycol). Macromol Chem Phys 204, 1994, 2003.
8. Huang, M.H., Li, S., Hutmacher, D.W., Schantz, J.T., Vacanti, C.A., Braud, C., and Vert, M. Degradation and cell culture studies on block copolymers prepared by ring opening polymerization of e-caprolactone in the presence of poly (ethylene glycol). J Biomed Mater Res A 69, 417, 2004.
9. Sachlos, E., and Czernuszka, J.T. Making tissue engineering scaffolds work-review on the application of solid freeform fabrication technology to the production of tissue engineering scaffolds. Eur Cells and Mater 5, 29, 2003.
10. Hollister, S.J., Levy, R.A., Chu, T.M., Halloran, J.W., and Feinberg, S.E. An image based approach to design and manufacture craniofacial scaffolds. Int J Oral Maxillofac Surg 29, 67, 2000.
11. Giordano, R.A., Wu, B.M., Borland, S.W., Cima, L.G., Sachs, E.M., and Cima, M.J. Mechanical properties of dense poly-lactic acid structures fabricated by three dimensional printing. J Biomater Sci Polym Ed 8, 63, 1996.
12. Sherwood, J.K., Riley, S.L., Palazzolo, R., Brown, S.C., Monkhouse, D.C., Griffith, L.G., Landeen, L.K., and Ratcliffe, A.A. Three-dimensional osteochondral composite scaffold for articular cartilage repair. Biomaterials 23, 4739, 2002.
13. Zein, I., Hutmacher, D.W., Tan, K.C., and Teoh, S.H. Fused deposition modeling of novel scaffold architectures for tissue engineering applications. Biomaterials l23, 1169, 2002.
14. Woodfield, T.B.F., Bezemer, J.M., Pieper, J.S., van Blitterswijk, C.A., and Riesle, J. Scaffolds for tissue engineering of cartilage. Crit Rev Eukaryot Gene Expr 12, 209, 2002.
15. Woodfield, T.B.F., Malda, J., de Wijn, J., Péters, F., Riesle, J., and van Blitterswijk, C.A. Design of porous scaffolds for cartilage tissue engineering using a three-dimensional fiber-deposition technique. Biomaterials 25, 4149, 2004.
16. Wang, F., Shor, L., Darling, A., Khalil, S., Sun, W., Güçeri, S., and Lau, A. Precision extruding deposition and characterization of cellular poly-e-caprolactone tissue scaffolds. Rapid Prot J 10, 42, 2004.
17. Hoque, M.E., Hutmacher, D.W., Feng, W., Li, S., Huang, M.H., Vert, M., and Wong, Y.S. Fabrication using a RP system and in vitro characterization of PEG-PCL-PLA scaffolds for tissue engineering. J Biomater Sci Polym Ed 16, 1595, 2005.
18. Li, S., Garreau, H., Vert, M., Petrova, T.S., Manolova, N., and Rashkov, I. Hydrolytic degradation of poly(oxyethylene)-poly(e-caprolactone) multiblock copolymers. J Appl Polym Sci 68, 989, 1998.
19. Pitt, C.G., Chasalow, F.I., Hibionada, Y.M., Klimas, D.M., and Schindler, A. Aliphatic polyesters. I. The degradation of poly(e-caprolactone) in vivo. J Appl Polym Sci 26, 3779, 1981.
20. Peter, S.J., Miller, S.T., Zhu, G., Yasko, A.W., and Mikos, A.G. In vivo degradation of a poly(propylene fumarate)= b-tricalcium phosphate injectable composite scaffold. J Biomed Mater Res 41, 1, 1998.
21. Thomson, R.C., Yaszemski, M.J., Powers, J.M., and Mikos, A.G. Hydroxyapatite fiber reinforced poly(a-hydroxy ester) foams for bone regeneration. Biomaterials 19, 1935, 1998.
22. Hollister, S.J., and Lin, C.Y. Computational design of tissue engineering scaffolds. Comput Methods Appl Mech Eng 196, 2991, 2007.
23. Moroni, L., de Wijn, J.R., and van Blitterswijk, C.A. 3D fiber-deposited scaffolds for tissue engineering: influence of pores geometry and architecture on dynamic mechanical properties. Biomaterials 27, 974, 2006.
24. Byrne, D.P., Lacroix, D., Plannel, J.A., Kelly, D.J., and Prendergast, P.J. Simulation of tissue differentiation in a scaffold as a function of porosity, Young's modulus and dissolution rate: application of mechanobiological models in tissue engineering. Biomaterials 28, 5544, 2007.
25. Saltzman, W.M. Delivering tissue regeneration. Nat Bio-technol 17, 534, 1999.
26. Ng, K.W., Leong, D.T., and Hutmacher, D.W. The challenge to measure cell proliferation in two and three dimensions. Tissue Eng 11, 182, 2005.
27. Corden, T.J., Jones, I.A., Rudd, C.D., Christian, P., Downes, S., and McDougall, K.E. Physical and biocompatibility properties of poly(e-caprolactone) produced using in situ polymerisation: a novel manufacturing technique for long-fibre composite materials. Biomaterials 21, 713, 2000.
28. Sun, H., Mei, L., Song, C., Cui, X., and Wang, P. The in vivo degradation, absorption and excretion of PCL-based implant. Biomaterials 27, 1735, 2006.
29. Marra, K.G., Szem, J.W., Kumta, P.N., DiMilla, P.A., and Weiss, L.E. In vitro analysis of biodegradable polymer blend=hydroxyapatite composites for bone tissue engineering. J Biomed Mater Res 47, 324, 1999.
30. Hattori, K., Tomita, N., Tamai, S., and Ikada, Y. Bioresorb-able thread for tight tying of bones. J Orthop Sci 5, 57, 2000.
31. Gough, J.E., Christian, P., Unsworth, J., Evans, M.P., Scotchford, C.A., and Jones, I.A. Controlled degradation and macrophage responses of a fluoride-treated polycapro-lactone. J Biomed Mater Res A 69, 17, 2004.
32. Silva-Cunha, A., Fialho, S.L., Naud, M.C., and Behar-Cohen, F. Poly-epsilon-caprolactone intravitreous devices: an in vivo study. Invest Ophthalmol Vis Sci 50, 2312, 2008