Immune modulation by lactoferrin and curcumin in children with recurrent respiratory infections

Journal of Biological Regulators and Homeostatic Agents

Volumn 23, Issue 2, 2009, Pages 119-123

  Zuccotti, G V ^a   Trabattoni, D ^b   Morelli, M ^a   Borgonovo, S ^a   Schneider, L ^a   Clerici, Mario ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Curcumin; Immunology; Lactoferrin; Recurrent respiratory tract infections (RRTIs)

Indexed keywords

CURCUMIN; INTERLEUKIN 10; LACTOFERRIN; TOLL LIKE RECEPTOR 2; CD14 ANTIGEN; CYTOKINE; IMMUNOLOGIC FACTOR; TLR2 PROTEIN, HUMAN;

ARTICLE; CD8+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; HUMAN; IMMUNOMODULATION; PRESCHOOL CHILD; RECURRENT DISEASE; RESPIRATORY TRACT INFECTION; SCHOOL CHILD; BIOSYNTHESIS; IMMUNOLOGY; METABOLISM; ORAL DRUG ADMINISTRATION; T LYMPHOCYTE SUBPOPULATION;

ADMINISTRATION, ORAL; ANTIGENS, CD14; CHILD; CHILD, PRESCHOOL; CURCUMIN; CYTOKINES; HUMANS; IMMUNOLOGIC FACTORS; LACTOFERRIN; RECURRENCE; RESPIRATORY TRACT INFECTIONS; T-LYMPHOCYTE SUBSETS; TOLL-LIKE RECEPTOR 2;

EID: 70349895662     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Bellanti JA. Recurrent respiratory tract infections in paediatric patients. Drugs 1997; 54(S)1:1-4 (Pubitemid 27417390)
2. De Vries E. Immunological investigations in children with recurrent respiratory infections. Paediatric Respiratory Reviews 2001; 2:32-36 (Pubitemid 32454717)
3. Berber A, Del-Rio Navarro B. Compilation and meta-analysis of randomized placebocontrolled clinical trial on the prevention of respiratory tract infections in children using immunostimulants. J Invest Allergol Clin Immunol 2001; 11:235-246 (Pubitemid 34230130)
4. Ranjan D, Johnston TD, Wu G, Elliott L, Bondada S, Nagabhushan M. Curcumin blocks cyclosporine A-resistant CD28 costimulatory pathway of human T-cell proliferation. J Surg Res 1998; 77:174-178 (Pubitemid 28413509)
5. Yadav VS, Mishra KP, Singh DP, Mehrotra S, Singh VK. Immunomodulatory effects of curcumin. Immunopharmacol Immunotoxicol 2005; 27:485-497
6. Kim GY, Kim KH, Lee SH, et al. Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. J Immunol 2005; 174:8116-8124
7. Gaddipati JP, Sundar SV, Calemine J, Seth P, Sidhu GS, Maheshwari RK. Differential regulation of cytokines and transcription factors in liver by curcumin following hemorrhage/resuscitation. Shock 2003; 19:150-156
8. Renard P, Delaive E, Van Steenbrugge M, Remacle J, Raes M. Is the effect of interleukin-1 on glutathione oxidation in cultured human fibroblasts involved in nuclear factor-kappaB activation? Antioxid Redox Signal 2001; 3:329-340
9. Kato S, Yuzawa Y, Tsuboi N, Maruyama S, Morita Y, Matsuguchi T, Matsuo S. Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4. J Am Soc Nephrol 2004; 15:1289-1299 (Pubitemid 38526010)
10. Marchetti M, Superti F. Antiviral activity of lactoferrin. In: Pandalai SG editor. Recent developments in antiviral research. 1. Trivandrum, India: Transworld Research Network; 2001. p. 193-203.
11. Miyauchi H, Hashimoto S, Nakajima M, Shinoda I, Fukuwatari Y, Hayasawa H. Bovine lactoferrin stimulates the phagocytic activity of human neutrophils: identification of its active domain. Cell Immunol 1998; 187:34-37 (Pubitemid 28359692)
12. Zuccotti GV, Viganò A, Borelli M, Saresella M, Giacomet V, Clerici M. Modulation of innate and adaptive immunity by lactoferrin in human immunodeficiency virus (HIV)-infected. Antiretroviral therapy-naïve children. Int J Antimicrobial Agents 2007; 29:353-355 (Pubitemid 46240757)
13. Trabattoni D, Saresella M, Biasin M, et al. B7-H1 is upregulated in HIV infection and is a novel surrogate marker of disease progression. Blood 2003; 101: 2514-2520 (Pubitemid 36857606)
14. Adkins B, Leclerc C, Marshall-Clarke S. Neonatal adaptive immunity comes of age. Nat Rev Immunol 2004; 4:553-564 (Pubitemid 38931770)
15. Levy O. Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat Rev Immunol 2007; 7:379-390 (Pubitemid 46674489)
16. Siegrist CA. The challenges of vaccine responses in early life: selected examples. J Comp Pathol 2007; 137:4-9.
17. Basic concepts in immunology. In: Janeway CA, Travers P Walport M, et al. (eds). Immunobiology. The immune system in health and disease. New York: Churchill Livingstone 1999; 1-31.
18. Akira S. Mammalian toll-like receptors. Curr Opin Immunol 2003; 15:5-11.