The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or InCHIANTI studies

International Journal of Epidemiology

Volumn 38, Issue 5, 2009, Pages 1374-1379

  Rice, Neil E ^a   Bandinelli, Stefania ^b   Corsi, Anna Maria ^c   Ferrucci, Luigi ^d   Guralnik, Jack M ^e   Miller, Michelle A ^f   Kumari, Meena ^g   Murray, Anna ^a   Frayling, Tim M ^a   Melzer, David ^a  

^a PENINSULA MEDICAL SCHOOL   (United Kingdom)

^b Azienda Sanitaria di Firenze   (Italy)

^c Tuscany Regional Health Agency   (Italy)

^d NATIONAL INSTITUTE ON AGING   (United States)

^e NATIONAL INSTITUTE ON AGING   (United States)

^f UNIVERSITY OF WARWICK   (United Kingdom)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Depression; Detoxification; Mendelian randomization; Organo phosphates; Paraoxonase activity; PON1 Q192R polymorphism; Rs662

Indexed keywords

ARGININE; ARYLDIALKYLPHOSPHATASE 1; GLUTAMINE;

AGE STRUCTURE; DETOXIFICATION; DOSE-RESPONSE RELATIONSHIP; HEALTH STATUS; LOGISTICS; MENTAL HEALTH; ORGANOPHOSPHATE; POLYMORPHISM; PROTEIN; REGRESSION ANALYSIS; THEORETICAL STUDY; TOXIN;

ADULT; AGED; ARTICLE; CENTER FOR EPIDEMIOLOGICAL STUDIES DEPRESSION SCALE; DEPRESSION; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEALTH STATUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; POPULATION RESEARCH; PRIORITY JOURNAL; SELF CONCEPT; SELF REPORT; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ARYLDIALKYLPHOSPHATASE; DEPRESSIVE DISORDER; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GREAT BRITAIN; HEALTH STATUS; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PHOSPHORIC ACID ESTERS; POLYMORPHISM, GENETIC;

OVIS ARIES;

EID: 70349876873     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyp265     Document Type: Article

References (25)

1. Davies HG, Richter RJ, Keifer M, Broomfield CA, Sowalla J, Furlong CE. The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin. Nat Genet 1996;14:334-36.
2. Buchanan D, Pilkington A, Sewell C et al. Estimation of cumulative exposure to organophosphate sheep dips in a study of chronic neurological health effects among United Kingdom sheep dippers. Occup Environ Med 2001; 58:694-701.
3. Mackness B, Durrington P, Povey A et al. Paraoxonase and susceptibility to organophosphorus poisoning in farmers dipping sheep. Pharmacogenetics 2003;13:81-88.
4. Bhattacharyya T, Nicholls SJ, Topol EJ et al. Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. JAMA 2008; 299:1265-76.
5. Costa LG, Richter RJ, Li WF, Cole T, Guizzetti M, Furlong CE. Paraoxonas (PON1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 2003; 8:1-12.
6. Humbert R, Adler DA, Disteche CM, Hassett C, Omiecinski CJ, Furlong CE. The molecular basis of the human serum paraoxonase activity polymorphism. Nat Genet 1993;3:73-76.
7. Cherry N, Mackness M, Durrington P et al. Paraoxonase (PON1) polymorphisms in farmers attributing ill health to sheep dip. Lancet 2002;359:763-34.
8. Li WF, Costa LG, Richter RJ et al. Catalytic efficiency determines the in vivo efficacy of PON1 for detoxifying organo-phosphorus compounds. Pharmacogenetics 2000;10:767-79.
9. Richter RJ, Jarvik GP, Furlong CE. Paraoxonase 1 (PON1) status and substrate hydrolysis. Toxicol Appl Pharmacol 2009;235:1-9.
10. O'Leary KA, Edwards RJ, Town MM, Boobis AR. Genetic and other sources of variation in the activity of serum paraoxonase/diazoxonase in humans: consequences for risk from exposure to diazinon. Pharmacogenet Genomics 2005;15:51-60.
11. Davey Smith G, Ebrahim S. 'Mendelian randomization': Can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1-22.
12. Ebrahim S, Davey Smith G. Mendelian randomization: Can genetic epidemiology help redress the failures of observational epidemiology? Hum Genet 2008;123:15-33.
13. Haley RW, Billecke S, La Du BN. Association of low PON1 type Q (type A) arylesterase activity with neurologic symptom complexes in Gulf War veterans. Toxicol Appl Pharmacol 1999;157:227-33.
14. Lawlor DA, Day IN, Gaunt TR et al. The association of the paraoxonase (PON1) Q192R polymorphism with depression in older women: findings from the British Women's Heart and Health Study. J Epidemiol Community Health 2007;61:85-87.
15. Marmot M, Banks J, Blundell R, Lessof C, Nazroo J. Health, Wealth and Lifestyles of the Older Population in England: The 2002 English Longitudinal Study of Ageing. London: Institute for Fiscal Studies, 2003.
16. Ferrucci L, Bandinelli S, Benvenuti E et al. Subsystems contributing to the decline in ability to walk: Bridging the gap between epidemiology and geriatric practice in the InCHIANTI study. J Am Geriatr Soc 2000;48:1618.
17. Melzer D, Perry JR, Hernandez D et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet 2008;4:e1000072.
18. Radloff LS. The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Meas 1977;1:385.
19. Beekman AT, Deeg DJ, Van Limbeek J, Braam AW, De Vries MZ, Van Tilburg W. Criterion validity of the Center for Epidemiologic Studies Depression scale (CES-D): Results from a community-based sample of older subjects in The Netherlands. Psychol Med 1997; 27:231-35.
20. Steffick DE. Documentation of affective functioning measures in the Health and Retirement Study. HRS/AHEAD Documentation Report, Ann Arbor, MI: Survey Research Center, University of Michigan, 2000.
21. Kondo I, Yamamoto M. Genetic polymorphism of paraoxonase 1 (PON1) and susceptibility to Parkinson's disease. Brain Res 1998;806 271-73.
22. Pankratz N, Wilk JB, Latourelle JC et al. Genomewide association study for susceptibility genes contributing to familial Parkinson disease. Hum Genet 2009;124: 593-605.
23. Sullivan PF, de Geus EJ, Willemsen G et al. Genome-wide association for major depressive disorder: A possible role for the presynaptic protein piccolo. Mol Psychiatry 2009;14: 359-75.
24. van den Oord EJ, Kuo PH, Hartmann AM, Webb BT et al. Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism. Arch Gen Psychiatry 2008;65 1062-71.
25. Ferreira MA, O'Donovan MC, Meng YA et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 2008;40:1056-58.