Insulin-mediated cortical activity in the slow frequency range is diminished in obese mice and promotes physical inactivity

Diabetologia

Volumn 52, Issue 11, 2009, Pages 2416-2424

  Hennige, A M ^a   Sartorius, T ^a   Lutz, S Z ^a   Tschritter, O ^a   Preissl, H ^a,b   Hopp, S ^a   Fritsche, A ^a   Rammensee, H G ^a   Ruth, P ^a   Haring H U ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Brain; Electrocorticogram; Insulin resistance; Locomotor activity; Obesity; Toll like receptor

Indexed keywords

HUMAN INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 2; MARGATOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; POTASSIUM CHANNEL KV1.3; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN CORTEX; BRAIN FUNCTION; CIRCADIAN RHYTHM; CONTROLLED STUDY; DRUG EFFECT; ELECTRIC ACTIVITY; ELECTROCORTICOGRAPHY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HORMONE ACTION; IMMOBILIZATION; INSULIN RESISTANCE; LEAN BODY WEIGHT; LIPID DIET; MALE; MOUSE; NEUROMODULATION; NONHUMAN; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CEREBRAL CORTEX; CEREBRAL VENTRICLES; INSULIN; INSULIN RESISTANCE; LETHARGY; LOCOMOTION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; OBESITY; PHOSPHORYLATION; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TELEMETRY; TOLL-LIKE RECEPTOR 2;

EID: 70349852826     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1522-5     Document Type: Article

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