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Volumn 9, Issue 8, 2009, Pages 1125-1134

Osteonecrosis of the jaw and bisphosphonate use in breast cancer patients

Author keywords

Bisphosphonate; Breast cancer; Dental extraction; Denture; Ibandronate; Jaw; Osteonecrosis; Pamidronate; Prevention; Zoledronate

Indexed keywords

ALENDRONIC ACID; ANGIOGENESIS INHIBITOR; ANTIBIOTIC AGENT; AROMATASE INHIBITOR; BISPHOSPHONIC ACID DERIVATIVE; CORTICOSTEROID; FIBROBLAST GROWTH FACTOR 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; INTERLEUKIN 1ALPHA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PAMIDRONIC ACID; PARATHYROID HORMONE RELATED PROTEIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; RISEDRONIC ACID; TUMOR NECROSIS FACTOR; VASCULOTROPIN; ZOLEDRONIC ACID;

EID: 70349850428     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/ERA.09.74     Document Type: Review
Times cited : (24)

References (104)
  • 2
    • 44349185434 scopus 로고    scopus 로고
    • Risks and benefits of bisphosphonates
    • Well written review from Professor Coleman who first introduced bisphosphonates (BPs) into the oncology practice
    • Coleman RE. Risks and benefits of bisphosphonates. Br. J. Cancer 98(11), 1736-1740 (2008). • Well written review from Professor Coleman who first introduced bisphosphonates (BPs) into the oncology practice.
    • (2008) Br. J. Cancer , vol.98 , Issue.11 , pp. 1736-1740
    • Coleman, R.E.1
  • 3
    • 0035010803 scopus 로고    scopus 로고
    • Metastatic bone disease: Clinical features, pathophysiology and treatment strategies
    • Coleman RE. Metastatic bone disease: clinical features, pathophysiology and treatment strategies. Cancer Treat. Rev. 27(3), 165-176 (2001).
    • (2001) Cancer Treat. Rev. , vol.27 , Issue.3 , pp. 165-176
    • Coleman, R.E.1
  • 4
    • 33750726077 scopus 로고    scopus 로고
    • Clinical features of metastatic bone disease and risk of skeletal morbidity
    • Coleman RE. Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin. Cancer Res. 12(20 Pt 2), 6243s-6249s (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.20 PART 2
    • Coleman, R.E.1
  • 6
    • 10644231736 scopus 로고    scopus 로고
    • The role of bisphosphonates in breast cancer
    • Coleman RE. The role of bisphosphonates in breast cancer. Breast 13(Suppl. 1), S19-S28 (2004).
    • (2004) Breast , vol.13 , Issue.SUPPL. 1
    • Coleman, R.E.1
  • 7
    • 58149179539 scopus 로고    scopus 로고
    • Advancing treatment for metastatic bone cancer: Consensus recommendations from the Second Cambridge Conference
    • Coleman RE, Guise TA, Lipton A et al. Advancing treatment for metastatic bone cancer: consensus recommendations from the Second Cambridge Conference. Clin. Cancer Res. 14(20), 6387-6395 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.20 , pp. 6387-6395
    • Coleman, R.E.1    Guise, T.A.2    Lipton, A.3
  • 8
    • 0037392630 scopus 로고    scopus 로고
    • Treatment of tumor-induced hypercalcemia: A solved problem?
    • DOI 10.1586/14787210.3.2.241
    • Body J-J, Mancini I. Treatment of tumor-induced hypercalcemia: a solved problem? Expert Rev. Anticancer Ther. 3(2), 241-246 (2003). (Pubitemid 36503401)
    • (2003) Expert Review of Anticancer Therapy , vol.3 , Issue.2 , pp. 241-246
    • Body, J.-J.1    Mancini, I.2
  • 9
    • 22744455581 scopus 로고    scopus 로고
    • Breast cancer metastasis to bone: Mechanisms of osteolysis and implications for therapy
    • DOI 10.1007/s10911-005-5399-8
    • Kozlow W, Guise TA. Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy. J. Mammary Gland Biol. Neoplasia 10(2), 169-180 (2005). (Pubitemid 41031006)
    • (2005) Journal of Mammary Gland Biology and Neoplasia , vol.10 , Issue.2 , pp. 169-180
    • Kozlow, W.1    Guise, T.A.2
  • 10
    • 34948818179 scopus 로고    scopus 로고
    • Insights on adjuvant endocrine therpay for premenopausal and postmenopausal breast cancer
    • DOI 10.1586/14737140.7.9.1243
    • Briest S, Wolff AC. Insights on adjuvant endocrine therapy for premenopausal and postmenopausal breast cancer. Expert Rev. Anticancer Ther. 7(9), 1243-1253 (2007). (Pubitemid 47521020)
    • (2007) Expert Review of Anticancer Therapy , vol.7 , Issue.9 , pp. 1243-1253
    • Briest, S.1    Wolff, A.C.2
  • 11
    • 33847153983 scopus 로고    scopus 로고
    • Key roles of the OPG-RANK-RANKL system in bone oncology
    • Summarizes the actions of BPs in the osteoprotegerin (RANK-RANKL-OPG) triad, useful in the understanding of the pathophysiology of the drugs
    • Baud'huin M, Duplomb L, Velasco CR, Fortun Y, Heymann D, Padrines M. Key roles of the OPG-RANK-RANKL system in bone oncology. Expert Rev. Anticancer Ther. 7(2), 221-232 (2007). • Summarizes the actions of BPs in the osteoprotegerin (RANK-RANKL-OPG) triad, useful in the understanding of the pathophysiology of the drugs.
    • (2007) Expert Rev. Anticancer Ther. , vol.7 , Issue.2 , pp. 221-232
    • Baud'huin, M.1    Duplomb, L.2    Velasco, C.R.3    Fortun, Y.4    Heymann, D.5    Padrines, M.6
  • 15
    • 33645783039 scopus 로고    scopus 로고
    • Changes in the RANK ligand/osteoprotegerin system are correlated to changes in bone mineral density in bisphosphonate-treated osteoporotic patients
    • Dobnig H, Hofbauer LC, Viereck V, Obermayer-Pietsch B, Fahrleitner-Pammer A. Changes in the RANK ligand/osteoprotegerin system are correlated to changes in bone mineral density in bisphosphonate-treated osteoporotic patients. Osteoporos. Int. 17(5), 693-703 (2006).
    • (2006) Osteoporos. Int. , vol.17 , Issue.5 , pp. 693-703
    • Dobnig, H.1    Hofbauer, L.C.2    Viereck, V.3    Obermayer-Pietsch, B.4    Fahrleitner-Pammer, A.5
  • 16
    • 46849110780 scopus 로고    scopus 로고
    • Practical guidance for the management of aromatase inhibitor-associated bone loss
    • Hadji P, Body JJ, Aapro MS et al. Practical guidance for the management of aromatase inhibitor-associated bone loss. Ann. Oncol. 19(8), 1407-1416 (2008).
    • (2008) Ann. Oncol. , vol.19 , Issue.8 , pp. 1407-1416
    • Hadji, P.1    Body, J.J.2    Aapro, M.S.3
  • 17
    • 17544363336 scopus 로고    scopus 로고
    • Bisphosphonates and bone metastases: Current status and future directions
    • DOI 10.1586/14787210.5.2.295
    • Krempien R, Niethammer A, Harms W, Debus J. Bisphosphonates and bone metastases: current status and future directions. Expert Rev. Anticancer Ther. 5(2), 295-305 (2005). (Pubitemid 40553094)
    • (2005) Expert Review of Anticancer Therapy , vol.5 , Issue.2 , pp. 295-305
    • Krempien, R.1    Niethammer, A.2    Harms, W.3    Debus, J.4
  • 18
    • 56749102816 scopus 로고    scopus 로고
    • Cancer treatment-induced bone loss in breast and prostate cancer
    • Saad F, Adachi JD, Brown JP et al. Cancer treatment-induced bone loss in breast and prostate cancer. J. Clin. Oncol. 26(33), 5465-5476 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.33 , pp. 5465-5476
    • Saad, F.1    Adachi, J.D.2    Brown, J.P.3
  • 19
    • 55249120962 scopus 로고    scopus 로고
    • IBIS II: A breast cancer prevention trial in postmenopausal women using the aromatase inhibitor anastrozole
    • Cuzick J. IBIS II: a breast cancer prevention trial in postmenopausal women using the aromatase inhibitor anastrozole. Expert Rev. Anticancer Ther. 8(9), 1377-1385 (2008).
    • (2008) Expert Rev. Anticancer Ther. , vol.8 , Issue.9 , pp. 1377-1385
    • Cuzick, J.1
  • 20
    • 56449103037 scopus 로고    scopus 로고
    • Pharmacovigilance and reporting oversight in US FDA fast-track process: Bisphosphonates and osteonecrosis of the jaw
    • Edwards BJ, Gounder M, McKoy JM et al. Pharmacovigilance and reporting oversight in US FDA fast-track process: bisphosphonates and osteonecrosis of the jaw. Lancet Oncol. 9(12), 1166-1172 (2008).
    • (2008) Lancet Oncol. , vol.9 , Issue.12 , pp. 1166-1172
    • Edwards, B.J.1    Gounder, M.2    McKoy, J.M.3
  • 21
    • 34447252128 scopus 로고    scopus 로고
    • Intravenous bisphosphonate therapy and inflammatory conditions or surgery of the jaw: A population-based analysis
    • Wilkinson GS, Kuo YF, Freeman JL, Goodwin JS. Intravenous bisphosphonate therapy and inflammatory conditions or surgery of the jaw: a population-based analysis. J. Natl Cancer Inst. 99(13), 1016-1024 (2007).
    • (2007) J. Natl Cancer Inst. , vol.99 , Issue.13 , pp. 1016-1024
    • Wilkinson, G.S.1    Kuo, Y.F.2    Freeman, J.L.3    Goodwin, J.S.4
  • 22
    • 0042861578 scopus 로고    scopus 로고
    • Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic
    • Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J. Oral Maxillofac. Surg. 61(9), 1115-1117 (2003).
    • (2003) J. Oral Maxillofac. Surg. , vol.61 , Issue.9 , pp. 1115-1117
    • Marx, R.E.1
  • 24
    • 33748751877 scopus 로고    scopus 로고
    • Bisphosphonate-related osteonecrosis of the jaw: Background and guidelines for diagnosis, staging and management
    • DOI 10.1016/j.tripleo.2006.06.004, PII S1079210406004185
    • Ruggiero SL, Fantasia J, Carlson E. Bisphosphonate-related osteonecrosis of the jaw: background and guidelines for diagnosis, staging and management. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 102(4), 433-441 (2006). (Pubitemid 44403162)
    • (2006) Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology , vol.102 , Issue.4 , pp. 433-441
    • Ruggiero, S.L.1    Fantasia, J.2    Carlson, E.3
  • 25
    • 67449105031 scopus 로고    scopus 로고
    • Osteonecrosis of the jaws in intravenous bisphosphonate use: Proposal for a modification of the clinical classification
    • Proposal of a new classification of Osteonecrosis of the jaws (ONJ), which if implemented could allow for earlier diagnosis
    • Bagan JV, Jimenez Y, Diaz JM et al. Osteonecrosis of the jaws in intravenous bisphosphonate use: proposal for a modification of the clinical classification. Oral Oncol. 45(7), 645-656 (2009) • Proposal of a new classification of Osteonecrosis of the jaws (ONJ), which if implemented could allow for earlier diagnosis.
    • (2009) Oral Oncol. , vol.45 , Issue.7 , pp. 645-656
    • Bagan, J.V.1    Jimenez, Y.2    Diaz, J.M.3
  • 26
    • 53749083356 scopus 로고    scopus 로고
    • Biphosphonate related osteonecrosis of the jaws: Risk factors in breast cancer patients. A case control study
    • Clinical study setting the current level of evidence linking dental extractions and use of dentures with ONJ
    • Kyrgidis A, Vahtsevanos K, Koloutsos G et al. Biphosphonate related osteonecrosis of the jaws: risk factors in breast cancer patients. A case control study. J. Clin. Oncol. 26(28), 4634-4638 (2008). • Clinical study setting the current level of evidence linking dental extractions and use of dentures with ONJ.
    • (2008) J. Clin. Oncol. , vol.26 , Issue.28 , pp. 4634-4638
    • Kyrgidis, A.1    Vahtsevanos, K.2    Koloutsos, G.3
  • 27
    • 59449088606 scopus 로고    scopus 로고
    • Incidence and risk factors of bisphosphonate-associated osteonecrosis of the jaws
    • Stumpe MR, Chandra RK, Yunus F, Samant S. Incidence and risk factors of bisphosphonate-associated osteonecrosis of the jaws. Head Neck 31(2), 202-206 (2008).
    • (2008) Head Neck , vol.31 , Issue.2 , pp. 202-206
    • Stumpe, M.R.1    Chandra, R.K.2    Yunus, F.3    Samant, S.4
  • 28
    • 55649090798 scopus 로고    scopus 로고
    • Prevalence and risk factors of bisphosphonate-associated osteonecrosis of the jaw in prostate cancer patients with advanced disease treated with zoledronate
    • Walter C, Al-Nawas B, Grotz KA et al. Prevalence and risk factors of bisphosphonate-associated osteonecrosis of the jaw in prostate cancer patients with advanced disease treated with zoledronate. Eur. Urol. 54(5), 1066-1072 (2008).
    • (2008) Eur. Urol. , vol.54 , Issue.5 , pp. 1066-1072
    • Walter, C.1    Al-Nawas, B.2    Grotz, K.A.3
  • 30
    • 34250159241 scopus 로고    scopus 로고
    • Incidence of Osteonecrosis of the Jaw in Patients with Multiple Myeloma and Breast or Prostate Cancer on Intravenous Bisphosphonate Therapy
    • DOI 10.1016/j.joms.2007.03.006, PII S027823910700328X
    • Wang EP, Kaban LB, Strewler GJ, Raje N, Troulis MJ. Incidence of osteonecrosis of the jaw in patients with multiple myeloma and breast or prostate cancer on intravenous bisphosphonate therapy. J. Oral Maxillofac. Surg. 65(7), 1328-1331 (2007). (Pubitemid 46915477)
    • (2007) Journal of Oral and Maxillofacial Surgery , vol.65 , Issue.7 , pp. 1328-1331
    • Wang, E.P.1    Kaban, L.B.2    Strewler, G.J.3    Raje, N.4    Troulis, M.J.5
  • 31
    • 33747426633 scopus 로고    scopus 로고
    • Incidence, risk factors and management of osteonecrosis of the jaw in patients with multiple myeloma: A single-centre experience in 303 patients
    • DOI 10.1111/j.1365-2141.2006.06230.x
    • Zervas K, Verrou E, Teleioudis Z et al. Incidence, risk factors and management of osteonecrosis of the jaw in patients with multiple myeloma: a single-centre experience in 303 patients. Br. J. Haematol. 134(6), 620-623 (2006). (Pubitemid 44253605)
    • (2006) British Journal of Haematology , vol.134 , Issue.6 , pp. 620-623
    • Zervas, K.1    Verrou, E.2    Teleioudis, Z.3    Vahtsevanos, K.4    Banti, A.5    Mihou, D.6    Krikelis, D.7    Terpos, E.8
  • 32
    • 65249098369 scopus 로고    scopus 로고
    • Incidence of bisphosphonate-associated osteonecrosis of the jaws in breast cancer patients
    • Another recent, well-designed clinical study to characterize the complication
    • Walter C, Al-Nawas B, du Bois A, Buch L, Harter P, Grotz KA. Incidence of bisphosphonate-associated osteonecrosis of the jaws in breast cancer patients. Cancer 115(8), 1631-1637 (2009). • Another recent, well-designed clinical study to characterize the complication.
    • (2009) Cancer , vol.115 , Issue.8 , pp. 1631-1637
    • Walter, C.1    Al-Nawas, B.2    Du Bois, A.3    Buch, L.4    Harter, P.5    Grotz, K.A.6
  • 33
    • 73849148160 scopus 로고    scopus 로고
    • Bisphosphonate related osteonecrosis of the jaws: A longitudinal cohort study of risk factors in cancer patients
    • DOI: 10.1200/JCO.2009.21.9584 (Epub ahead of print). • Very recent study, comparing the most common BPs in a clinical oncology setting in regard to their potencies to induce ONJ
    • Vahtsevanos K, Kyrgidis A, Verrou E et al. Bisphosphonate related osteonecrosis of the jaws: a longitudinal cohort study of risk factors in cancer patients. J. Clin. Oncol. DOI: 10.1200/JCO.2009.21.9584 (2009) (Epub ahead of print). • Very recent study, comparing the most common BPs in a clinical oncology setting in regard to their potencies to induce ONJ.
    • (2009) J. Clin. Oncol.
    • Vahtsevanos, K.1    Kyrgidis, A.2    Verrou, E.3
  • 35
    • 58149340535 scopus 로고    scopus 로고
    • Clinical characterization might help in preventing osteonecrosis of the jaw
    • Kyrgidis A, Andreadis C. Clinical characterization might help in preventing osteonecrosis of the jaw. Clin. Cancer Res. 14(24), 8321 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.24 , pp. 8321
    • Kyrgidis, A.1    Andreadis, C.2
  • 36
    • 58149194578 scopus 로고    scopus 로고
    • Bisphosphonates promote jaw osteonecrosis through facilitating bacterial colonisation
    • Kos M, Luczak K. Bisphosphonates promote jaw osteonecrosis through facilitating bacterial colonisation. Bioscience Hypotheses 2, 34-36 (2009).
    • (2009) Bioscience Hypotheses , vol.2 , pp. 34-36
    • Kos, M.1    Luczak, K.2
  • 37
    • 42149184112 scopus 로고    scopus 로고
    • Inhibition of oral mucosal cell wound healing by bisphosphonates
    • Landesberg R, Cozin M, Cremers S et al. Inhibition of oral mucosal cell wound healing by bisphosphonates. J. Oral Maxillofac. Surg. 66(5), 839-847 (2008).
    • (2008) J. Oral Maxillofac. Surg. , vol.66 , Issue.5 , pp. 839-847
    • Landesberg, R.1    Cozin, M.2    Cremers, S.3
  • 38
    • 58849116790 scopus 로고    scopus 로고
    • Effect of zoledronic acid on oral fibroblasts and epithelial cells: A potential mechanism of bisphosphonate-associated osteonecrosis
    • Scheper MA, Badros A, Chaisuparat R, Cullen KJ, Meiller TF. Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. Br. J. Haematol. 144(5), 667-676 (2009).
    • (2009) Br. J. Haematol. , vol.144 , Issue.5 , pp. 667-676
    • Scheper, M.A.1    Badros, A.2    Chaisuparat, R.3    Cullen, K.J.4    Meiller, T.F.5
  • 39
    • 34547612321 scopus 로고    scopus 로고
    • Is bisphosphonate-associated osteonecrosis of the jaw caused by soft tissue toxicity?
    • Reid IR, Bolland MJ, Grey AB. Is bisphosphonate-associated osteonecrosis of the jaw caused by soft tissue toxicity? Bone 41(3), 318-320 (2007).
    • (2007) Bone , vol.41 , Issue.3 , pp. 318-320
    • Reid, I.R.1    Bolland, M.J.2    Grey, A.B.3
  • 40
    • 57549103742 scopus 로고    scopus 로고
    • Osteonecrosis of the jaw - who gets it, and why?
    • Reid IR. Osteonecrosis of the jaw - who gets it, and why? Bone 44(1), 4-10. (2009).
    • (2009) Bone , vol.44 , Issue.1 , pp. 4-10
    • Reid, I.R.1
  • 41
    • 65549142106 scopus 로고    scopus 로고
    • Increased risk for biphosphonate related osteonecrosis of the jaws in patients wearing overdentures could be attributable to impaired mucosal cell wound healing
    • Kyrgidis A, Vahtsevanos K. Increased risk for biphosphonate related osteonecrosis of the jaws in patients wearing overdentures could be attributable to impaired mucosal cell wound healing. J. Oral Maxillofac. Surg. 67(6), 1355-1356 (2008).
    • (2008) J. Oral Maxillofac. Surg. , vol.67 , Issue.6 , pp. 1355-1356
    • Kyrgidis, A.1    Vahtsevanos, K.2
  • 42
    • 0037329610 scopus 로고    scopus 로고
    • Role of gastric mucosal and gastric juice cytokine concentrations in development of bisphosphonate damage to gastric mucosa
    • DOI 10.1023/A:1021979510860
    • Thomson AB, Appleman S, Keelan M, Wallace JL. Role of gastric mucosal and gastric juice cytokine concentrations in development of bisphosphonate damage to gastric mucosa. Dig. Dis. Sci. 48(2), 308-314 (2003). (Pubitemid 36232997)
    • (2003) Digestive Diseases and Sciences , vol.48 , Issue.2 , pp. 308-314
    • Thomson, A.B.R.1    Appleman, S.2    Keelan, M.3    Wallace, J.L.4
  • 43
    • 34347369542 scopus 로고    scopus 로고
    • Impairment of gastric ulcer healing by alendronate, a nitrogen-containing bisphosphonate, in rats
    • Amagase K, Hayashi S, Nishikawa K, Aihara E, Takeuchi K. Impairment of gastric ulcer healing by alendronate, a nitrogen-containing bisphosphonate, in rats. Dig. Dis. Sci. 52(8), 1879-1889 (2007).
    • (2007) Dig. Dis. Sci. , vol.52 , Issue.8 , pp. 1879-1889
    • Amagase, K.1    Hayashi, S.2    Nishikawa, K.3    Aihara, E.4    Takeuchi, K.5
  • 44
    • 0010496839 scopus 로고    scopus 로고
    • Esophagitis associated with the use of alendronate
    • de Groen PC, Lubbe DF, Hirsch LJ et al. Esophagitis associated with the use of alendronate. N. Engl. J. Med. 335(14), 1016-1021 (1996).
    • (1996) N. Engl. J. Med. , vol.335 , Issue.14 , pp. 1016-1021
    • De Groen, P.C.1    Lubbe, D.F.2    Hirsch, L.J.3
  • 45
    • 58249090943 scopus 로고    scopus 로고
    • Reports of esophageal cancer with oral bisphosphonate use
    • A US FDA researcher notes a novel complication of BP
    • Wysowski DK. Reports of esophageal cancer with oral bisphosphonate use. N. Engl. J. Med. 360(1), 89-90 (2009). • A US FDA researcher notes a novel complication of BP.
    • (2009) N. Engl. J. Med. , vol.360 , Issue.1 , pp. 89-90
    • Wysowski, D.K.1
  • 46
    • 18044392589 scopus 로고    scopus 로고
    • New molecular concepts of Barrett's esophagus: Clinical implications and biomarkers
    • DOI 10.1016/j.jss.2004.12.022
    • Kyrgidis A, Kountouras J, Zavos C, Chatzopoulos D. New molecular concepts of Barrett's esophagus: clinical implications and biomarkers. J. Surg. Res. 125(2), 189-212 (2005). (Pubitemid 40602392)
    • (2005) Journal of Surgical Research , vol.125 , Issue.2 , pp. 189-212
    • Kyrgidis, A.1    Kountouras, J.2    Zavos, C.3    Chatzopoulos, D.4
  • 47
    • 67349168286 scopus 로고    scopus 로고
    • Effects of bisphosphonates on keratinocytes and fibroblasts may have a role in the development of osteonecrosis of the jaw
    • Novel hypothesis on the pathogenesis of ONJ, supported by evidence from a critical review of the literature
    • Kyrgidis A, Triaridis S, Antoniades K. Effects of bisphosphonates on keratinocytes and fibroblasts may have a role in the development of osteonecrosis of the jaw. Bioscience Hypotheses 2(3), 153-159 (2009). • Novel hypothesis on the pathogenesis of ONJ, supported by evidence from a critical review of the literature.
    • (2009) Bioscience Hypotheses , vol.2 , Issue.3 , pp. 153-159
    • Kyrgidis, A.1    Triaridis, S.2    Antoniades, K.3
  • 48
    • 41049084067 scopus 로고    scopus 로고
    • Aminobisphosphonates cause osteoblast apoptosis and inhibit bone nodule formation in vitro
    • Idris AI, Rojas J, Greig IR, Van't Hof RJ, Ralston SH. Aminobisphosphonates cause osteoblast apoptosis and inhibit bone nodule formation in vitro. Calcif. Tissue Int. 82(3), 191-201 (2008).
    • (2008) Calcif. Tissue Int. , vol.82 , Issue.3 , pp. 191-201
    • Idris, A.I.1    Rojas, J.2    Greig, I.R.3    Van't Hof, R.J.4    Ralston, S.H.5
  • 52
    • 10644257502 scopus 로고    scopus 로고
    • Ibandronate: Its pharmacology and clinical efficacy in the management of tumor-induced hypercalcemia and metastatic bone disease
    • Heidenreich A, Ohlmann CH. Ibandronate: its pharmacology and clinical efficacy in the management of tumor-induced hypercalcemia and metastatic bone disease. Expert Rev. Anticancer Ther. 4(6), 991-1005 (2004). (Pubitemid 39646556)
    • (2004) Expert Review of Anticancer Therapy , vol.4 , Issue.6 , pp. 991-1005
    • Heidenreich, A.1    Ohlmann, C.H.2
  • 53
    • 23244462780 scopus 로고    scopus 로고
    • Effects of bisphosphonates on proliferation and osteoblast differentiation of human bone marrow stromal cells
    • DOI 10.1016/j.biomaterials.2005.04.059, PII S014296120500373X
    • von Knoch F, Jaquiery C, Kowalsky M et al. Effects of bisphosphonates on proliferation and osteoblast differentiation of human bone marrow stromal cells. Biomaterials 26(34), 6941-6949 (2005). (Pubitemid 41095518)
    • (2005) Biomaterials , vol.26 , Issue.34 , pp. 6941-6949
    • Von Knoch, F.1    Jaquiery, C.2    Kowalsky, M.3    Schaeren, S.4    Alabre, C.5    Martin, I.6    Rubash, H.E.7    Shanbhag, A.S.8
  • 55
    • 27644568995 scopus 로고    scopus 로고
    • The inhibitory effect of alendronate, a nitrogen-containing bisphosphonate on the PI3K-Akt-NFκB pathway in osteosarcoma cells
    • DOI 10.1038/sj.bjp.0706373, PII 0706373
    • Inoue R, Matsuki NA, Jing G, Kanematsu T, Abe K, Hirata M. The inhibitory effect of alendronate, a nitrogen-containing bisphosphonate on the PI3K-Akt-NFκB pathway in osteosarcoma cells. Br. J. Pharmacol. 146(5), 633-641 (2005). (Pubitemid 41573614)
    • (2005) British Journal of Pharmacology , vol.146 , Issue.5 , pp. 633-641
    • Inoue, R.1    Matsuki, N.-A.2    Jing, G.3    Kanematsu, T.4    Abe, K.5    Hirata, M.6
  • 56
    • 20544473523 scopus 로고    scopus 로고
    • Zoledronic acid down-regulates adhesion molecules of bone marrow stromal cells in multiple myeloma: A possible mechanism for its antitumor effect
    • DOI 10.1002/cncr.21104
    • Corso A, Ferretti E, Lunghi M et al. Zoledronic acid down-regulates adhesion molecules of bone marrow stromal cells in multiple myeloma: a possible mechanism for its antitumor effect. Cancer 104(1), 118-125 (2005). (Pubitemid 40847759)
    • (2005) Cancer , vol.104 , Issue.1 , pp. 118-125
    • Corso, A.1    Ferretti, E.2    Lunghi, M.3    Zappasodi, P.4    Mangiacavalli, S.5    De Amici, M.6    Rusconi, C.7    Varettoni, M.8    Lazzarino, M.9
  • 58
    • 27344453813 scopus 로고    scopus 로고
    • Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: Risk factors, recognition, prevention, and treatment
    • DOI 10.1016/j.joms.2005.07.010, PII S0278239105011870
    • Marx RE, Sawatari Y, Fortin M, Broumand V. Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J. Oral Maxillofac. Surg. 63(11), 1567-1575 (2005). (Pubitemid 41525412)
    • (2005) Journal of Oral and Maxillofacial Surgery , vol.63 , Issue.11 , pp. 1567-1575
    • Marx, R.E.1    Sawatari, Y.2    Fortin, M.3    Broumand, V.4
  • 59
    • 40749119721 scopus 로고    scopus 로고
    • Updates on bisphosphonates and potential pathobiology of bisphosphonate-induced jaw osteonecrosis
    • Sarin J, DeRossi SS, Akintoye SO. Updates on bisphosphonates and potential pathobiology of bisphosphonate-induced jaw osteonecrosis. Oral Dis. 14(3), 277-285 (2008).
    • (2008) Oral Dis. , vol.14 , Issue.3 , pp. 277-285
    • Sarin, J.1    DeRossi, S.S.2    Akintoye, S.O.3
  • 61
    • 33749385468 scopus 로고    scopus 로고
    • Skeletal site-specific characterization of orofacial and iliac crest human bone marrow stromal cells in same individuals
    • DOI 10.1016/j.bone.2005.10.027, PII S8756328205004424
    • Akintoye SO, Lam T, Shi S, Brahim J, Collins MT, Robey PG. Skeletal site-specific characterization of orofacial and iliac crest human bone marrow stromal cells in same individuals. Bone 38(6), 758-768 (2006). (Pubitemid 44500651)
    • (2006) Bone , vol.38 , Issue.6 , pp. 758-768
    • Akintoye, S.O.1    Lam, T.2    Shi, S.3    Brahim, J.4    Collins, M.T.5    Robey, P.G.6
  • 62
    • 44449085517 scopus 로고    scopus 로고
    • Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation
    • Meran S, Thomas DW, Stephens P et al. Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation. J. Biol. Chem. 283(10), 6530-6545 (2008).
    • (2008) J. Biol. Chem. , vol.283 , Issue.10 , pp. 6530-6545
    • Meran, S.1    Thomas, D.W.2    Stephens, P.3
  • 64
    • 2142817155 scopus 로고    scopus 로고
    • Osteonecrosis of the Jaws Associated with the Use of Bisphosphonates: A Review of 63 Cases
    • DOI 10.1016/j.joms.2004.02.004
    • Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL. Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J. Oral Maxillofac. Surg. 62(5), 527-534 (2004). (Pubitemid 38542516)
    • (2004) Journal of Oral and Maxillofacial Surgery , vol.62 , Issue.5 , pp. 527-534
    • Ruggiero, S.L.1    Mehrotra, B.2    Rosenberg, T.J.3    Engroff, S.L.4
  • 67
    • 50649114676 scopus 로고    scopus 로고
    • Osteonecrosis of the maxilla and mandible in patients with advanced cancer treated with bisphosphonate therapy
    • A clinical study from Memorial Sloan-Kettering Cancer Center, shedding light on many aspects of ONJ
    • Estilo CL, Van Poznak CH, Wiliams T et al. Osteonecrosis of the maxilla and mandible in patients with advanced cancer treated with bisphosphonate therapy. Oncologist 13(8), 911-920 (2008). • A clinical study from Memorial Sloan-Kettering Cancer Center, shedding light on many aspects of ONJ.
    • (2008) Oncologist , vol.13 , Issue.8 , pp. 911-920
    • Estilo, C.L.1    Van Poznak, C.H.2    Wiliams, T.3
  • 68
    • 59049083106 scopus 로고    scopus 로고
    • Dental extractions and bisphosphonates: The assessment, consent and management, a proposed algorithm
    • Malden N, Beltes C, Lopes V. Dental extractions and bisphosphonates: the assessment, consent and management, a proposed algorithm. Br. Dent. J. 206(2), 93-98 (2009).
    • (2009) Br. Dent. J. , vol.206 , Issue.2 , pp. 93-98
    • Malden, N.1    Beltes, C.2    Lopes, V.3
  • 70
    • 58549091291 scopus 로고    scopus 로고
    • Bony changes in the jaws of rats treated with zoledronic acid and dexamethasone before dental extractions mimic bisphosphonate-related osteonecrosis in cancer patients
    • Sonis ST, Watkins BA, Lyng GD, Lerman MA, Anderson KC. Bony changes in the jaws of rats treated with zoledronic acid and dexamethasone before dental extractions mimic bisphosphonate-related osteonecrosis in cancer patients. Oral Oncol. 45(6), e38 (2009).
    • (2009) Oral Oncol. , vol.45 , Issue.6
    • Sonis, S.T.1    Watkins, B.A.2    Lyng, G.D.3    Lerman, M.A.4    Anderson, K.C.5
  • 71
    • 43749089576 scopus 로고    scopus 로고
    • Factors Associated with Osteonecrosis of the Jaw among Bisphosphonate Users
    • DOI 10.1016/j.amjmed.2008.01.047, PII S0002934308002349
    • Hess LM, Jeter JM, Benham-Hutchins M, Alberts DS. Factors associated with osteonecrosis of the jaw among bisphosphonate users. Am. J. Med. 121(6), 475-483 e473 (2008). • A NIH-founded systematic review of patients who developed ONJ under BP treatment for non-malignant indications. (Pubitemid 351694348)
    • (2008) American Journal of Medicine , vol.121 , Issue.6
    • Hess, L.M.1    Jeter, J.M.2    Benham-Hutchins, M.3    Alberts, D.S.4
  • 72
    • 60849105693 scopus 로고    scopus 로고
    • Higher incidence of osteonecrosis of the jaw (ONJ) in patients with metastatic castration resistant prostate cancer treated with anti-angiogenic agents
    • Clinical study conducted in a randomized controlled trial setting, reporting an increased incidence of ONJ among patients who received BP and anti-VEGF treatment
    • Aragon-Ching JB, Ning YM, Chen CC et al. Higher incidence of osteonecrosis of the jaw (ONJ) in patients with metastatic castration resistant prostate cancer treated with anti-angiogenic agents. Cancer Invest. 27(2), 221-226 (2009). • Clinical study conducted in a randomized controlled trial setting, reporting an increased incidence of ONJ among patients who received BP and anti-VEGF treatment.
    • (2009) Cancer Invest. , vol.27 , Issue.2 , pp. 221-226
    • Aragon-Ching, J.B.1    Ning, Y.M.2    Chen, C.C.3
  • 73
    • 59749100961 scopus 로고    scopus 로고
    • Combination of bisphosphonates and antiangiogenic factors induces osteonecrosis of the jaw more frequently than bisphosphonates alone
    • Christodoulou C, Pervena A, Klouvas G et al. Combination of bisphosphonates and antiangiogenic factors induces osteonecrosis of the jaw more frequently than bisphosphonates alone. Oncology 76(3), 209-211 (2009).
    • (2009) Oncology , vol.76 , Issue.3 , pp. 209-211
    • Christodoulou, C.1    Pervena, A.2    Klouvas, G.3
  • 74
  • 76
    • 58949104001 scopus 로고    scopus 로고
    • Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid
    • Dimopoulos MA, Kastritis E, Bamia C et al. Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid. Ann. Oncol. 20(1), 117-120 (2009).
    • (2009) Ann. Oncol. , vol.20 , Issue.1 , pp. 117-120
    • Dimopoulos, M.A.1    Kastritis, E.2    Bamia, C.3
  • 77
    • 58949093771 scopus 로고    scopus 로고
    • Decreased occurrence of osteonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates. the experience of the National Cancer Institute of Milan
    • Ripamonti CI, Maniezzo M, Campa T et al. Decreased occurrence of osteonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates. the experience of the National Cancer Institute of Milan. Ann. Oncol. 20(1), 137-145 (2009).
    • (2009) Ann. Oncol. , vol.20 , Issue.1 , pp. 137-145
    • Ripamonti, C.I.1    Maniezzo, M.2    Campa, T.3
  • 78
    • 33646836925 scopus 로고    scopus 로고
    • Narrative [corrected] review: Bisphosphonates and osteonecrosis of the jaws
    • Woo SB, Hellstein JW, Kalmar JR. Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. Ann. Intern. Med. 144(10), 753-761 (2006).
    • (2006) Ann. Intern. Med. , vol.144 , Issue.10 , pp. 753-761
    • Woo, S.B.1    Hellstein, J.W.2    Kalmar, J.R.3
  • 79
    • 51949083037 scopus 로고    scopus 로고
    • Treatment results of bisphosphonate-related osteonecrosis of the jaws
    • Wutzl A, Biedermann E, Wanschitz F et al. Treatment results of bisphosphonate-related osteonecrosis of the jaws. Head Neck 30(9), 1224-1230 (2008).
    • (2008) Head Neck , vol.30 , Issue.9 , pp. 1224-1230
    • Wutzl, A.1    Biedermann, E.2    Wanschitz, F.3
  • 81
    • 20544464439 scopus 로고    scopus 로고
    • Bisphosphonateassociated osteonecrosis of mandibular and maxillary bone: An emerging oral complication of supportive cancer therapy
    • Migliorati CA, Schubert MM, Peterson DE, Seneda LM. Bisphosphonateassociated osteonecrosis of mandibular and maxillary bone: an emerging oral complication of supportive cancer therapy. Cancer 104(1), 83-93 (2005).
    • (2005) Cancer , vol.104 , Issue.1 , pp. 83-93
    • Migliorati, C.A.1    Schubert, M.M.2    Peterson, D.E.3    Seneda, L.M.4
  • 82
    • 33747879839 scopus 로고    scopus 로고
    • Bisphosphonates and osteonecrosis of the jaw: Cause and effect or a post hoc fallacy?
    • DOI 10.1093/annonc/mdl294
    • Van den Wyngaert T, Huizing MT, Vermorken JB. Bisphosphonates and osteonecrosis of the jaw: cause and effect or a post hoc fallacy? Ann. Oncol. 17(8), 1197-1204 (2006). (Pubitemid 44288209)
    • (2006) Annals of Oncology , vol.17 , Issue.8 , pp. 1197-1204
    • Van Den Wyngaert, T.1    Huizing, M.T.2    Vermorken, J.B.3
  • 83
    • 33646235165 scopus 로고    scopus 로고
    • The role of bone markers in metastatic bone disease
    • Coleman RE. The role of bone markers in metastatic bone disease. Cancer Treat. Rev. 32(Suppl. 1), 1-2 (2006).
    • (2006) Cancer Treat. Rev. , vol.32 , Issue.SUPPL. 1 , pp. 1-2
    • Coleman, R.E.1
  • 84
    • 64649105333 scopus 로고    scopus 로고
    • American Association of Oral and Maxillofacial Surgeons Position Paper on bisphosphonate-related osteonecrosis of the jaws - 2009 update
    • The task-force position of the American Association of Oral and Maxillofacial Surgeons (AAOMS)
    • Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B. American Association of Oral and Maxillofacial Surgeons Position Paper on bisphosphonate-related osteonecrosis of the jaws - 2009 update. Br. J. Oral Maxillofac. Surg. 67(5 Suppl. 1), 2-12 (2009). • The task-force position of the American Association of Oral and Maxillofacial Surgeons (AAOMS).
    • (2009) Br. J. Oral Maxillofac. Surg. , vol.67 , Issue.5 SUPPL. 1 , pp. 2-12
    • Ruggiero, S.L.1    Dodson, T.B.2    Assael, L.A.3    Landesberg, R.4    Marx, R.E.5    Mehrotra, B.6
  • 85
    • 45849140564 scopus 로고    scopus 로고
    • Osteoclast targeted therapy for prostate cancer: Bisphosphonates and beyond
    • Smith MR. Osteoclast targeted therapy for prostate cancer: bisphosphonates and beyond. Urol. Oncol. 26(4), 420-425 (2008).
    • (2008) Urol. Oncol. , vol.26 , Issue.4 , pp. 420-425
    • Smith, M.R.1
  • 86
    • 58049204438 scopus 로고    scopus 로고
    • Potential new drug targets for osteoporosis
    • Deal C. Potential new drug targets for osteoporosis. Nat. Clin. Pract. Rheumatol. 5(1), 20-27 (2009).
    • (2009) Nat. Clin. Pract. Rheumatol. , vol.5 , Issue.1 , pp. 20-27
    • Deal, C.1
  • 87
    • 54049091219 scopus 로고    scopus 로고
    • RANKL inhibition in the treatment of bone metastases
    • Lipton A, Jun S. RANKL inhibition in the treatment of bone metastases. Curr. Opin. Support Palliat. Care 2(3), 197-203 (2008).
    • (2008) Curr. Opin. Support Palliat. Care , vol.2 , Issue.3 , pp. 197-203
    • Lipton, A.1    Jun, S.2
  • 88
    • 67349162952 scopus 로고    scopus 로고
    • Comment on: Bony changes in the jaws of rats treated with zoledronic acid and dexamethasone before dental extractions mimic bisphosphonate-related osteonecrosis in cancer patients
    • Kyrgidis A, Triaridis S. Comment on: bony changes in the jaws of rats treated with zoledronic acid and dexamethasone before dental extractions mimic bisphosphonate-related osteonecrosis in cancer patients. Oral Oncol. 45(6), e38 (2009)
    • (2009) Oral Oncol. , vol.45 , Issue.6
    • Kyrgidis, A.1    Triaridis, S.2
  • 89
    • 61449214304 scopus 로고    scopus 로고
    • Epidemiologic studies are needed to clarify whether dental modalities could be predictors of bisphosphonates osteonecrosis of the jaw in breast cancer patient
    • Kyrgidis A, Andreadis C. Epidemiologic studies are needed to clarify whether dental modalities could be predictors of bisphosphonates osteonecrosis of the jaw in breast cancer patient. Oncologist 14, 101-102 (2009).
    • (2009) Oncologist , vol.14 , pp. 101-102
    • Kyrgidis, A.1    Andreadis, C.2
  • 90
    • 47549117752 scopus 로고    scopus 로고
    • More on atypical fractures of the femoral diaphysis
    • author reply 317-318
    • Kwek EB, Koh JS, Howe TS. More on atypical fractures of the femoral diaphysis. N. Engl. J. Med. 359(3), 316-317; author reply 317-318 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , Issue.3 , pp. 316-317
    • Kwek, E.B.1    Koh, J.S.2    Howe, T.S.3
  • 91
    • 40949099444 scopus 로고    scopus 로고
    • Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate
    • Lenart BA, Lorich DG, Lane JM. Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate. N. Engl. J. Med. 358(12), 1304-1306 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , Issue.12 , pp. 1304-1306
    • Lenart, B.A.1    Lorich, D.G.2    Lane, J.M.3
  • 92
    • 67650468390 scopus 로고    scopus 로고
    • Association of low-energy femoral fractures with prolonged bisphosphonate use: A case control study
    • DOI 10.1007/s00198-008-0805-x Epub ahead of print
    • Lenart BA, Neviaser AS, Lyman S et al. Association of low-energy femoral fractures with prolonged bisphosphonate use: a case control study. Osteoporos. Int. DOI 10.1007/s00198-008-0805-x (2008) (Epub ahead of print).
    • (2008) Osteoporos. Int.
    • Lenart, B.A.1    Neviaser, A.S.2    Lyman, S.3
  • 93
    • 0004173507 scopus 로고    scopus 로고
    • (Second edition). John Wiley & Sons, Inc, New York, NY, USA
    • Stephens R. Metal Fatigue in Engineering (Second edition). John Wiley & Sons, Inc, New York, NY, USA (2001).
    • (2001) Metal Fatigue in Engineering
    • Stephens, R.1
  • 95
    • 60349109817 scopus 로고    scopus 로고
    • Regular dental check-ups could be of benefit for patients receiving intravenous bisphosphonates. Regarding 'risks and benefits of bisphosphonates'
    • Kyrgidis A, Triaridis S. Regular dental check-ups could be of benefit for patients receiving intravenous bisphosphonates. Regarding 'risks and benefits of bisphosphonates'. Br. J. Cancer 100(4), 670 (2009).
    • (2009) Br. J. Cancer , vol.100 , Issue.4 , pp. 670
    • Kyrgidis, A.1    Triaridis, S.2
  • 96
    • 34247192531 scopus 로고    scopus 로고
    • Keratinocyte-fibroblast interactions in wound healing
    • Werner S, Krieg T, Smola H. Keratinocyte-fibroblast interactions in wound healing. J. Invest. Dermatol. 127(5), 998-1008 (2007).
    • (2007) J. Invest. Dermatol. , vol.127 , Issue.5 , pp. 998-1008
    • Werner, S.1    Krieg, T.2    Smola, H.3
  • 97
    • 0035088024 scopus 로고    scopus 로고
    • Overexpression of BMP-2/4, -5 and BMPR-IA associated with malignancy of oral epithelium
    • DOI 10.1016/S1368-8375(00)00087-7, PII S1368837500000877
    • Jin Y, Tipoe GL, Liong EC, Lau TY, Fung PC, Leung KM. Overexpression of BMP-2/4, -5 and BMPR-IA associated with malignancy of oral epithelium. Oral Oncol. 37(3), 225-233 (2001). (Pubitemid 32245846)
    • (2001) Oral Oncology , vol.37 , Issue.3 , pp. 225-233
    • Jin, Y.1    Tipoe, G.L.2    Liong, E.C.3    Lau, T.Y.H.4    Fung, P.C.W.5    Leung, K.M.6
  • 98
    • 33645220545 scopus 로고    scopus 로고
    • Apoptosis of oral epithelial cells in oral lichen planus caused by upregulation of BMP-4
    • Kim SG, Chae CH, Cho BO et al. Apoptosis of oral epithelial cells in oral lichen planus caused by upregulation of BMP-4. J. Oral Pathol. Med. 35(1), 37-45 (2006).
    • (2006) J. Oral Pathol. Med. , vol.35 , Issue.1 , pp. 37-45
    • Kim, S.G.1    Chae, C.H.2    Cho, B.O.3
  • 99
    • 38049069892 scopus 로고    scopus 로고
    • Long chain polyunsaturated fatty acids alter membrane-bound RANK-L expression and osteoprotegerin secretion by MC3T3-E1 osteoblast-like cells
    • Poulsen RC, Wolber FM, Moughan PJ, Kruger MC. Long chain polyunsaturated fatty acids alter membrane-bound RANK-L expression and osteoprotegerin secretion by MC3T3-E1 osteoblast-like cells. Prostaglandins Other Lipid Mediat. 85(1-2), 42-48 (2008).
    • (2008) Prostaglandins Other Lipid Mediat. , vol.85 , Issue.1-2 , pp. 42-48
    • Poulsen, R.C.1    Wolber, F.M.2    Moughan, P.J.3    Kruger, M.C.4
  • 100
    • 48749088193 scopus 로고    scopus 로고
    • Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells
    • Boswell BA, Lein PJ, Musil LS. Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells. Mol. Biol. Cell 19(6), 2631-2641 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , Issue.6 , pp. 2631-2641
    • Boswell, B.A.1    Lein, P.J.2    Musil, L.S.3
  • 101
    • 33645657652 scopus 로고    scopus 로고
    • RANK ligand expression in heat shock factor-2 deficient mouse bone marrow stromal/ preosteoblast cells
    • Kajiya H, Ito M, Ohshima H et al. RANK ligand expression in heat shock factor-2 deficient mouse bone marrow stromal/ preosteoblast cells. J. Cell Biochem. 97(6), 1362-1369 (2006).
    • (2006) J. Cell Biochem. , vol.97 , Issue.6 , pp. 1362-1369
    • Kajiya, H.1    Ito, M.2    Ohshima, H.3
  • 102
    • 19444385578 scopus 로고    scopus 로고
    • Distribution of EGF and its receptor in growing red deer antler
    • Barling PM, Lai AK, Nicholson LF. Distribution of EGF and its receptor in growing red deer antler. Cell Biol. Int. 29(3), 229-236 (2005).
    • (2005) Cell Biol. Int. , vol.29 , Issue.3 , pp. 229-236
    • Barling, P.M.1    Lai, A.K.2    Nicholson, L.F.3
  • 104
    • 65949105078 scopus 로고    scopus 로고
    • New evidence on bisphosphonate related osteonecrosis of the jaws suggests dental referral prior to commencement of treatment
    • Kyrgidis A, Triaridis S, Vahtsevanos K. New evidence on bisphosphonate related osteonecrosis of the jaws suggests dental referral prior to commencement of treatment. Hippokratia 13(1), 64 (2009).
    • (2009) Hippokratia , vol.13 , Issue.1 , pp. 64
    • Kyrgidis, A.1    Triaridis, S.2    Vahtsevanos, K.3


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