Treadmill training enhances axon regeneration in injured mouse peripheral nerves without increased loss of topographic specificity

Journal of Comparative Neurology

Volumn 517, Issue 2, 2009, Pages 245-255

  English, Arthur W ^a   Cucoranu, Delia ^a   Mulligan, Amanda ^a   Sabatier, Manning ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Exercise; Motoneurons; Retrograde tracing; Spinal cord

Indexed keywords

N ACETYLGALACTOSAMINE 4 SULFATASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COUNT; CELL LABELING; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ELECTROSTIMULATION; FLUORESCENCE; MOTONEURON; MOUSE; NERVE FIBER REGENERATION; NONHUMAN; PERIPHERAL NERVE INJURY; PERONEUS NERVE; PRIORITY JOURNAL; TIBIAL NERVE; TREADMILL EXERCISE;

ANIMALS; AXONS; CHONDROITIN ABC LYASE; DEXTRANS; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; EXERCISE TEST; EXERCISE THERAPY; MICE; MICE, INBRED C57BL; MOTOR NEURONS; NERVE REGENERATION; SCIATIC NEUROPATHY; SPINAL CORD; TIME FACTORS;

EID: 70349845459     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.22149     Document Type: Article

References (28)

1. Abercrombie M. 1946. Estimation of nuclear population from microtome sections. Anat Rec 94:239-247.
2. Al-Majed AA, Neumann CM, Brushart TM, Gordon T. 2000. Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration. J Neurosci 20:2602-2608.
3. Brushart TM. 1993. Motor axons preferentially reinnervate motor pathways. J Neurosci 13:2730-2738.
4. Brushart TM. 1998. Nerve repair and grafting. In: Green D, Hotchkiss R, Pederson W, editors. Green's operative hand surgery. New York: Churchill Livingstone. p 1381-1403.
5. Brushart TM, Jari R, Verge V, Rohde C, Gordon T. 2005. Electrical stimulation restores the specificity of sensory axon regeneration. Exp Neurol 194:221-229.
6. Brushart TM, Mesulam MM. 1980. Alteration in connections between muscle and anterior horn motoneurons after peripheral nerve repair. Science 208:603-605.
7. Brushart TM, Tarlov EC, Mesulam MM. 1983. Specificity of muscle reinnervation after epineurial and individual fascicular suture of the rat sciatic nerve. J Hand Surg [Am] 8:248-253.
8. de Ruiter GC, Malessy MJ, Alaid AO, Spinner RJ, Engelstad JK, Sorenson EJ, Kaufman KR, Dyck PJ, Windebank AJ. 2008. Misdirection of regenerating motor axons after nerve injury and repair in the rat sciatic nerve model. Exp Neurol 211:339-350.
9. English AW. 2005. Enhancing axon regeneration in peripheral nerves also increases functionally inappropriate reinnervation of targets. J Comp Neurol 490:427-441.
10. English AW, Mulligan A, Meador W, Sabatier MJ, Schwartz G. 2007. Electrical stimulation promotes peripheral axon regeneration by enhanced neuronal neurotrophin signaling. Dev Neurobiol 67:158-172.
11. English AW, Mulligan A, Cucoranu D. 2008. Treadmill training enhances axon regeneration in cut peripheral nerves without effecting topographic specificity of reinnervating motoneurons. Abstr Soc Neurosci 76.7.
12. Franz CK, Rutishauser U, Rafuse VF. 2005. Polysialylated neural cell adhesion molecule is necessary for selective targeting of regenerating motor neurons. J Neurosci 25:2081-2091.
13. Frostick SP, Yin Q, Kemp GJ. 1998. Schwann cells, neurotrophic factors, and peripheral nerve regeneration. Microsurgery 18:397-405.
14. Geremia NM, Gordon T, Al-Majed AA, Brushart TM, Verge VMK. 2005. Brief electrical stimulation promotes sensory neuron regeneration and intrinsic growth-associated gene expression. Soc Neurosci Program No. 28.26.
15. Gilbert RJ, McKeon RJ, Darr A, Calabro A, Hascall VC, Bellamkonda RV. 2005. CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension. Mol Cell Neurosci 29:545-558.
16. Gordon T, Sulaiman O, Boyd JG. 2003. Experimental strategies to promote functional recovery after peripheral nerve injuries. J Peripher Nerv Syst 8:236-250.
17. Groves ML, McKeon R, Werner E, Nagarsheth M, Meador W, English AW. 2005. Axon regeneration in peripheral nerves is enhanced by proteoglycan degradation. Exp Neurol 195:278-292.
18. Kobbert C, Thanos S. 2000. Topographic representation of the sciatic nerve motor neurons in the spinal cord of the adult rat correlates to region-specific activation patterns of microglia. J Neurocytol 29:271-283.
19. MacGillivray TE. 2003. Fibrin sealants and glues. J Card Surg 18:480-485.
20. McHanwell S, Biscoe TJ. 1981. The localization of motoneurons supplying the hindlimb muscles of the mouse. Philos Trans R Soc Lond B Biol Sci 293:477-508.
21. McLean IW, Nakane PK. 1974. Periodate-lysate-paraformaldehyde fixative. A new fixative for immunoelectron microscopy. J Histochem Cytochem 22:1077-1083.
22. Menovsky T, Beek JF. 2001. Laser, fibrin glue, or suture repair of peripheral nerves: a comparative, functional, and morphometric study in the rat sciatic nerve. J Neurosurg 95:694-699.
23. Neubauer D, Graham JB, Muir D. 2007. Chondroitinase treatment increases the effective length of acellular nerve grafts. Exp Neurol 207: 163-170.
24. Sabatier M, Redmon N, Schwartz G, English A. 2008. Treadmill training promotes axon regeneration in injured peripheral nerves. Exp Neurol 211:489-493.
25. Swett JE, P. WR, Blanks RH, Swett AL, Conley LC. 1986. Motoneurons of the rat sciatic nerve. Exp Neurol 93:227-252.
26. Witzel C, Rohde C, Brushart TM. 2005. Pathway sampling by regenerating peripheral axons. J Comp Neurol 485:183-190.
27. Zuo J, Hernandez YJ, Muir D. 1998. Chondroitin sulfate proteoglycan with neurite-inhibiting activity is up-regulated following peripheral nerve injury. J Neurobiol 34:41-54.
28. Zuo J, Neubauer D, Graham J, Krekoski CA, Ferguson TA, Muir D. 2002. Regeneration of axons after nerve transection repair is enhanced by degradation of chondroitin sulfate proteoglycan. Exp Neurol 176:221-228.