Pilot clinical study to evaluate the anticoagulant activity of fucoidan

Blood Coagulation and Fibrinolysis

Volumn 20, Issue 7, 2009, Pages 607-610

  Irhimeh, Mohammad R ^a,b   Fitton, J Helen ^c   Lowenthal, Ray M ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

^b HASHEMITE UNIVERSITY   (Jordan)

^c Marinova Pty Ltd   (Australia)

Author keywords

Activated partial thromboplastin time; Anticoagulant; Fucoidan; Hemostasis; Polyanions; Seaweed; Sulfated polysaccharides; Undaria pinnatifida

Indexed keywords

ANTITHROMBIN III; BLOOD CLOTTING FACTOR 10A INHIBITOR; FUCOIDIN; PLACEBO; ANTICOAGULANT AGENT; POLYSACCHARIDE;

ADULT; ANTICOAGULATION; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG SAFETY; FEMALE; HEMOSTASIS; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; MALE; PARTIAL THROMBOPLASTIN TIME; PILOT STUDY; PRIORITY JOURNAL; PROTHROMBIN TIME; THROMBIN TIME; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; BLOOD CLOTTING; BLOOD CLOTTING TEST; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECTS; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; SINGLE BLIND PROCEDURE; TOXICITY; TREATMENT OUTCOME; YOUNG ADULT;

ADMINISTRATION, ORAL; ADULT; ANTICOAGULANTS; ANTITHROMBIN III; BLOOD COAGULATION; BLOOD COAGULATION TESTS; FEMALE; HEMOSTASIS; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; POLYSACCHARIDES; SINGLE-BLIND METHOD; TREATMENT OUTCOME; YOUNG ADULT;

EID: 70349826651     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/MBC.0b013e32833135fe     Document Type: Article

References (18)

1. Shanmugam M, Mody KH. Heparinoid-active sulphated polysaccharides from marine algae as potential blood anticoagulant agents. Curr Sci 2000; 79:1672-1683.
2. McLellan DS, Jurd KM. Anticoagulants from marine algae. Blood Coagul Fibrinolysis 1992; 3:69-77.
3. Springer GF, Wurzel HA, McNeal GM, Ansell NJ, Doughty MF. Isolation of anticoagulant fractions from crude fucoidin. Proc Soc Exp Biol Med 1957; 94:404-409.
4. Colliec S, Fischer AM, Tapon-Bretaudiere J, Boisson C, Durand P, Jozefonvicz J. Anticoagulant properties of a fucoidan fraction. Thromb Res 1991; 64:143-154.
5. Mauray S, Sternberg C, Theveniaux J, Millet J, Sinquin C, Tapon- Bretaudiere J, et al. Venous antithrombotic and anticoagulant activities of a fucoidan fraction. Thromb Haemost 1995; 74:1280-1285.
6. Warkentin TE. Heparin-induced thrombocytopenia: a clinicopathologic genesis. Thromb Haemost 1999; 82:439-447.
7. Visentin GP. Heparin-induced thrombocytopenia: molecular pathogenesis. Thromb Haemost 1999; 82:448-456.
8. Kelton JG, Hirsh J. Bleeding associated with antithrombotic therapy. Semin Hematol 1980; 17:259-379.
9. Kakkar VV, Kakkar S, Sanderson RM, Peers CE. Efficacy and safety of two regimens of low molecular weight heparin fragment (Fragmin) in preventing postoperative venous thromboembolism. Haemostasis 1986; 16:19-24.
10. Weitz JI. Low-molecular-weight heparins. N Engl J Med 1992; 337:688-698.
11. Liaw PCY, Becker DJ, Stafford AR, Fredenburgh JC, Weitz JI. Molecular basis for the susceptibility of fibrin-bound thrombin to inactivation by heparin cofactor II in the presence of dermatan sulfate but not heparin. J Biol Chem 2001; 276:20959-20965.
12. Irhimeh MR, Fitton JH, Lowenthal RM, Kongtawelert P. A quantitative method to detect fucoidan in human plasma using a novel antibody. Methods Find Exp Clin Pharmacol 2005; 27:1-7.
13. Engelberg H. Orally ingested heparin is absorbed in, humans. Clin Appl Thromb Hemost 1995; 1:283-285.
14. Hiebert LM, Wice SM, Jaques LB, Williams KE, Conly JM. Orally administered dextran sulphate is absorbed in HIV-positive individuals. J Lab Clin Med 1999; 133:161-170.
15. Hiebert LM. Oral heparins. Clin Lab 2002; 48:111-116; Review.
16. Berteau O, Mulloy B. Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide. Glycobiology 2003; 13:29R-40R.
17. Durig J, Bruhn T, Zurborn KH, Gutensohn K, Bruhn HD, Beress L. Anticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitro. Thromb Res 1997; 85:479-491.
18. Alwayn IP, Appel JZ, Goepfert C, Buhler L, Cooper DK, Robson SC. Inhibition of platelet aggregation in baboons: therapeutic implications for xenotransplantation. Xenotransplantation 2000; 7:247-257.