Can quetiapine-induced hypothyroidism be reversible without quetiapine discontinuation?

Clinical Neuropharmacology

Volumn 32, Issue 5, 2009, Pages 295-296

  Kontaxakis, Vassilis P ^a   Karaiskos, Dimitris ^a   Havaki Kontaxaki, Beata J ^a   Ferentinos, Panagiotis ^a   Papadimitriou, George N ^a  

^a NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

Author keywords

Discontinuation; Hypothyroidism; Quetiapine; Thyroid function tests; Thyroid replacement

Indexed keywords

CHLORPROMAZINE; FLUOXETINE; QUETIAPINE; RISPERIDONE; THYROTROPIN; THYROXINE; VALPROIC ACID;

ADULT; ARTICLE; BIPOLAR DISORDER; BIPOLAR I DISORDER; CASE REPORT; CLINICAL FEATURE; DRUG DOSE TITRATION; FEMALE; FREE THYROXINE INDEX; HUMAN; HYPOTHYROIDISM; LOW DRUG DOSE; MALE; PARANOID SCHIZOPHRENIA; PRIORITY JOURNAL; REMISSION; SYMPTOM; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

DIBENZOTHIAZEPINES; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; HYPOTHYROIDISM; MALE; MIDDLE AGED;

EID: 70349811304     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNF.0b013e3181a8cbcc     Document Type: Article

References (11)

1. Seroquel (Quetiapine Fumarate) Product Monograph. Rev 01/04. Wilmington, DE:Astra Zeneca Pharmaceuticals; 2004.
2. Arvanitis LA, Miller BG. Multiple fixed doses of WSeroquelW (quetiapine) in patients with acute exacerbation of schizophrenia:A comparison with haloperidol and placebo. The Seroquel Trial 13 Study Group. Biol Psychiatry 1997;42:233-246.
3. Tariot PN, Salzman C, Yeung PP, et al. Long-term use of quetiapine in elderly patients with psychotic disorders. Clin Ther 2000;22:1068-1084.
4. Shaw JA, Lewis JE, Pascal S, et al. A study of quetiapine: efficacy and tolerability in psychotic adolescents. J Child Adolesc Psychopharmacol 2001;11:415-424.
5. Kelly DL, Conley RR. Thyroid function in treatment-resistant schizophrenia patients treated with quetiapine, risperidone, or fluphenazine. J Clin Psychiatry 2005;66:80-84.
6. Potkin SG, Gharabawi GM, Greemspan AJ, et al. A double-blind comparison of risperidone, quetiapine and placebo in patients with schizophrenia experiencing an acute exacerbation requiring hospitalization. Schizophr Res 2006;85:254-265.
7. Feret BM, Caley CF. Possible hypothyroidism associated with quetiapine. Ann Pharmacother 2000;34:483-486.
8. Ramaswamy S, Siddiqui Z, Saharan S, et al. Quetiapine-induced hypothyroidism. J Psychiatry Neurosci 2005;30:57.
9. Liappas J, Paparrigopoulos T, Mourikis I, et al. Hypothyroidism induced by quetiapine:A case report. J Clin Psychopharmacol 2006;26:208-209.
10. Haggerty JJ Jr, Stern RA, Mason GA, et al. Subclinical hypothyroidism:A modifiable risk factor for depression? Am J Psychiatry 1993;150:508-510.
11. Berlin I, Payan C, Corruble E, et al. Serum thyroid-stimulating-hormone concentration as an index of severity of major depression. Int J Neuropsychopharmacol 1999;2:105-110.