Radiobiological modeling of interplay between accelerated repopulation and altered fractionation schedules in head and neck cancer

Journal of Medical Physics

Volumn 34, Issue 4, 2009, Pages 206-211

  Marcu, Loredana G ^a,b   Bezak, Eva ^a,c  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF ORADEA   (Romania)

^c ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

Altered fractionation; Monte Carlo; Tumor repopulation

Indexed keywords

ARTICLE; CANCER CONTROL; CANCER RADIOTHERAPY; CELL INTERACTION; CELL KINETICS; CELL POPULATION; DYNAMICS; HEAD AND NECK CANCER; IONIZING RADIATION; MONTE CARLO METHOD; OUTCOME ASSESSMENT; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIOBIOLOGY; TREATMENT DURATION; TREATMENT OUTCOME; TUMOR CELL; TUMOR GROWTH;

EID: 70349795805     PISSN: 09716203     EISSN: 19983913     Source Type: Journal    
DOI: 10.4103/0971-6203.56081     Document Type: Article

References (14)

1. Withers HR. Treatment-induced accelerated human tumour growth. Semin Radiat Oncol 1993;3:135-143
2. Peters LJ, Withers HR. Applying radiobiological principles to combined modality treatment of head and neck cancer-the time factor. Int J Radit Oncol Biol Phys 1997;39:831-836
3. Marcu L, van Doorn T, Zavgorodni S, Olver I. Growth of a virtual tumour using probabilistic methods of cell generation. Aust Phys Eng Sci Med 2002;25:155-161
4. Begg AC. Cell proliferation in tumours. In: Steel GG, editor. Basic clinical radiobiology, 2nd ed. New York: Oxford University Press; 1997. p. 14-23.
5. Malaise E P, Fertil B, Chavaudra N, Guichard M. Distribution of radiation sensitivities for human tumor cells of specific histological types: Comparison of in vitro to in vivo data. Int J Radiat Oncol 1986;12:617-624
6. Withers HR, Elkind MM. Radiosensitivity and fractionation response of crypt cells of mouse jejunum. Radiat Res 1969;38:598-613.
7. Trott K, Kummermehr J. Accelerated repopulation in tumours and normal tissues. Radiother Oncol 1991;22:159-160
8. Hansen O, Grau C, Bentzen S, Overgaard J. Repopulation in the SCCVII squamous cell carcinoma assessed by an in vivo-in vitro excision assay. Radiother Oncol 1996;39:137-144
9. Dörr W. Three A's of repopulation during fractionated irradiation of squamous epithelia: Asymmetry loss, Acceleration of stem-cell divisions and Abortive divisions. Int J Radiat Biol 1997;72:635-643
10. Marcu L, van Doorn T, Olver I. Modelling of post irradiation accelerated repopulation in squamous cell carcinomas. Phys Med Biol 2004;49:3676-3679
11. Fu K, Pajak T, Trotti A, Jones CU, Spencer SA, Phillips T, et al. Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: First report of RTOG 9003. Int J Radiat Oncol Biol Phys 2000;48:7-16.
12. Munro TR, Gilbert C W. The relation between tumor lethal dose and the radiosensitivity of tumor cells. Br J Radiol 1961;34:246-251
13. Fu K, Pajak T F, Marcial V, Ortiz HG, Rotman M, Asbell S, et al. Late effects of hyperfractionated radiotherapy for advanced head and neck cancer: Long-term follow-up results of RTOG 83-13. Int J Radiat Oncol Biol Phys 1995;32:577-588
14. Bourhis J, Overgaard J, Audry H, Ang K, Saunders M, Bernier J, et al. Hyperfractionated or accelerated radiotherapy for head and neck cancer: A meta-analysis. Lancet 2006;368:843-854 (Pubitemid 44292807)