Retinoid ameliorates experimental autoimmune myositis, with modulation of th cell differentiation and antibody production in vivo

Arthritis and Rheumatism

Volumn 60, Issue 10, 2009, Pages 3118-3127

  Ohyanagi, Naho ^a   Ishido, Miwako ^b   Suzuki, Fumihito ^a   Kaneko, Kayoko ^a   Kubota, Tetsuo ^a   Miyasaka, Nobuyuki ^a   Nanki, Toshihiro ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b R and R Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G2B ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 4; MONOCYTE CHEMOTACTIC PROTEIN 1; MYOSIN; MYOSIN ANTIBODY; RANTES; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR GAMMA; TAMIBAROTENE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CELL INFILTRATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; EXPERIMENTAL AUTOIMMUNE MYOSITIS; HELPER CELL; IMMUNOREGULATION; IN VIVO STUDY; INFLAMMATION; INFLAMMATORY CELL; LYMPHOCYTE DIFFERENTIATION; MACROPHAGE; MALE; MONONUCLEAR CELL; MOUSE; MUSCLE TISSUE; MYOBLAST; MYOSITIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL; TH1 CELL; TH17 CELL; TH2 CELL;

ANIMALS; ANTIBODIES; BENZOATES; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; IMMUNOGLOBULIN G; INTERLEUKIN-1BETA; MALE; MICE; MICE, MUTANT STRAINS; MYOSINS; NERVOUS SYSTEM AUTOIMMUNE DISEASE, EXPERIMENTAL; RETINOIDS; T-LYMPHOCYTES, HELPER-INDUCER; TETRAHYDRONAPHTHALENES; TH1 CELLS; TH2 CELLS; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70349780617     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24930     Document Type: Article

References (43)

1. Arahata K, Engel AG. Monoclonal antibody analysis of mononuclear cells in myopathies. I. Quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells. Ann Neurol 1984;16:193-208.
2. Engel AG, Arahata K. Monoclonal antibody analysis of mononuclear cells in myopathies. II. Phenotypes of autoinvasive cells in polymyositis and inclusion body myositis. Ann Neurol 1984;16: 209-215
3. Dalakas MC. Polymyositis, dermatomyositis and inclusion-body myositis. N Engl J Med 1991;325:1487-1498
4. Nagaraju K, Lundberg IE. Inflammatory diseases of muscle and other myopathies. In: Firestein GS, Budd RC, Harris ED Jr, McInnes IB, Ruddy S, Sergent JS, editors. Kelley's textbook of rheumatology. 8th ed. Philadelphia: Saunders Elsevier; 2009. p. 1353-1380
5. Greenberg SA, Pinkus JL, Pinkus GS, Burleson T, Sanoudou D, Tawil R, et al. Interferon-α/β-mediated innate immune mechanisms in dermatomyositis. Ann Neurol 2005;57:664-678 (Pubitemid 40628855)
6. Goebels N, Michaelis D, Engelhardt M, Huber S, Bender A, Pongratz D, et al. Differential expression of perforin in muscle-infiltrating T cells in polymyositis and dermatomyositis. J Clin Invest 1996;97:2905-2910 (Pubitemid 26197106)
7. Cherin P, Herson S, Crevon MC, Hauw JJ, Cervera P, Galanaud P, et al. Mechanisms of lysis by activated cytotoxic cells expressing perforin and granzyme-B genes and the protein TIA-1 in muscle biopsies of myositis. J Rheumatol 1996;23:1135-1142 (Pubitemid 26240576)
8. Tews DS, Goebel HH. Cytokine expression profile in idiopathic inflammatory myopathies. J Neuropathol Exp Neurol 1996;55: 342-347 (Pubitemid 26085583)
9. Lepidi H, Frances V, Figarella-Branger D, Bartoli C, Machado-Baeta A, Pellissier JF. Local expression of cytokines in idiopathic inflammatory myopathies. Neuropathol Appl Neurobiol 1998;24: 73-79 (Pubitemid 28105417)
10. Sugiura T, Kawaguchi Y, Harigai M, Takagi K, Ohta S, Fukasawa C, et al. Increased CD40 expression on muscle cells of polymyositis and dermatomyositis: role of CD40-CD40 ligand interaction in IL-6, IL-8, IL-15, and monocyte chemoattractant protein-1 production. J Immunol 2000;164:6593-6600 (Pubitemid 30408846)
11. Walsh RJ, Kong SW, Yao Y, Jallal B, Kiener PA, Pinkus JL, et al. Type I interferon-inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis. Arthritis Rheum 2007;56:3784-3792 (Pubitemid 350100711)
12. Suzuki F, Nanki T, Imai T, Kikuchi H, Hirohata S, Kohsaka H, et al. Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice. J Immunol 2005;175:6987-6996 (Pubitemid 41598945)
13. Nemoto H, Nemoto K, Sugimoto H, Kinoshita M. FK506 suppressed the inflammatory change of EAM in SJL/J mice. J Neurol Sci 2001;193:7-11. (Pubitemid 33062389)
14. Noy N. Physical-chemical properties and action of retinoids. In: Nau H, Blaner WS, editors. Retinoids: the biochemical and molecular basis of vitamin A and retinoid action. New York: Springer; 1999. p. 3-30.
15. Gudas LJ. Retinoids and vertebrate development. J Biol Chem 1994;269:15399-15402
16. Fisher GJ, Voorhees JJ. Molecular mechanisms of retinoid actions in skin. FASEB J 1996;10:1002-1013
17. Hayes CE, Nashold FE, Gomez FE, Hoag KA. Retinoids and immunity. In: Nau H, Blaner WS, editors. Retinoids: the biochemical and molecular basis of vitamin A and retinoid action. New York: Springer; 1999. p. 589-610.
18. Iwata M, Eshima Y, Kagechika H. Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors. Int Immunol 2003;15: 1017-1025 (Pubitemid 36987299)
19. Hoag KA, Nashold FE, Goverman J, Hayes CE. Retinoic acid enhances the T helper 2 cell development that is essential for robust antibody responses through its action on antigen-presenting cells. J Nutr 2002;132:3736-3739 (Pubitemid 35435055)
20. + T cells. Br J Pharmacol 2000;130:581-586
21. Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007;317:256-260 (Pubitemid 47076203)
22. Elias KM, Laurence A, Davidson TS, Stephens G, Kanno Y, Shevach EM, et al. Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood 2008;111:1013-1020 (Pubitemid 351213378)
23. Massacesi L, Castigli E, Vergelli M, Olivotto J, Abbamondi AL, Sarlo F, et al. Immunosuppressive activity of 13-cis-retinoic acid and prevention of experimental autoimmune encephalomyelitis in rats. J Clin Invest 1991;88:1331-1337
24. Racke MK, Burnett D, Pak SH, Albert PS, Cannella B, Raine CS, et al. Retinoid treatment of experimental allergic encephalomyelitis: IL-4 production correlates with improved disease course. J Immunol 1995;154:450-458
25. Wang T, Niwa S, Bouda K, Matsuura S, Homma T, Shudo K, et al. The effect of Am-80, one of retinoids derivatives on experimental allergic encephalomyelitis in rats. Life Sci 2000;67:1869-1879
26. Aranami T, Yamamura T. Th17 cells and autoimmune encephalomyelitis (EAE/MS). Allergol Int 2008;57:115-120 (Pubitemid 351897665)
27. Notley CA, Inglis JJ, Alzabin S, McCann FE, McNamee KE, Williams RO. Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells. J Exp Med 2008;205:2491-2497
28. Serada S, Fujimoto M, Mihara M, Koike N, Ohsugi Y, Nomura S, et al. IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 2008;105:9041-9046
29. Miwako I, Kagechika H. Tamibarotene. Drugs Today (Barc) 2007;43:563-568
30. Dedieu S, Lefebvre P. Retinoids interfere with the AP1 signalling pathway in human breast cancer cells. Cell Signal 2006;18:889-898 (Pubitemid 43208942)
31. Nanki T, Nagasaka K, Hayashida K, Saita Y, Miyasaka N. Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Immunol 2001;167:5381-5385 (Pubitemid 33009778)
32. Confalonieri P, Bernasconi P, Megna P, Galbiati S, Cornelio F, Mantegazza R. Increased expression of β-chemokines in muscle of patients with inflammatory myopathies. J Neuropathol Exp Neurol 2000;59:164-169 (Pubitemid 30106472)
33. Liprandi A, Bartoli C, Figarella-Branger D, Pellissier JF, Lepidi H. Local expression of monocyte chemoattractant protein-1 (MCP-1) in idiopathic inflammatory myopathies. Acta Neuropathol 1999;97:642-648 (Pubitemid 29231683)
34. Adams EM, Kirkley J, Eidelman G, Dohlman J, Plotz PH. The predominance of β (CC) chemokine transcripts in idiopathic inflammatory muscle diseases. Proc Assoc Am Physicians 1997; 109:275-285
35. Martin T, Cardarelli PM, Parry GC, Felts KA, Cobb RR. Cytokine induction of monocyte chemoattractant protein-1 gene expression in human endothelial cells depends on the cooperative action of NF-κB and AP-1. Eur J Immunol 1997;27:1091-1097 (Pubitemid 27197210)
36. Lundberg I, Ulfgren AK, Nyberg P, Andersson U, Klareskog L. Cytokine production in muscle tissue of patients with idiopathic inflammatory myopathies. Arthritis Rheum 1997;40:865-874 (Pubitemid 27200003)
37. Figarella-Branger D, Civatte M, Bartoli C, Pellissier JF. Cytokines, chemokines, and cell adhesion molecules in inflammatory myopathies. Muscle Nerve 2003;28:659-682 (Pubitemid 37484828)
38. Wang X, Allen C, Ballow M. Retinoic acid enhances the production of IL-10 while reducing the synthesis of IL-12 and TNF-α from LPS-stimulated monocytes/macrophages. J Clin Immunol 2007;27:193-200. (Pubitemid 46348724)
39. Liu PT, Krutzik SR, Kim J, Modlin RL. Cutting edge: all-trans retinoic acid down-regulates TLR2 expression and function. J Immunol 2005;174:2467-2470 (Pubitemid 40279655)
40. Abbas AK, Lichtman AH. Cytokine. In: Abbas AK, Lichtman AH, editors. Cellular and molecular immunology. 5th ed. Philadelphia: Elsevier Saunders; 2005. p. 243-274
41. Mohty M, Morbelli S, Isnardon D, Sainty D, Arnoulet C, Gaugler B, et al. All-trans retinoic acid skews monocyte differentiation into interleukin-12- secreting dendritic-like cells. Br J Haematol 2003; 122:829-836 (Pubitemid 37100312)
42. Tokuyama H, Tokuyama Y. The regulatory effects of all-transretinoic acid on isotype switching: retinoic acid induces IgA switch rearrangement in cooperation with IL-5 and inhibits IgG1 switching. Cell Immunol 1999;192:41-47 (Pubitemid 29133837)
43. Chen Q, Ross AC. Vitamin A and immune function: retinoic acid modulates population dynamics in antigen receptor and CD38-stimulated splenic B cells. Proc Natl Acad Sci U S A 2005;102: 14142-14149 (Pubitemid 41429666)