Renal plasma flow: glomerular filtration rate relationships in man during direct renin inhibition with aliskiren

Journal of the American Society of Hypertension

Volumn 3, Issue 5, 2009, Pages 315-320

  Splenser, Andres E ^a   Fisher, Naomi D L ^a   Danser, A H Jan ^b   Hollenberg, Norman K ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

blood pressure; body mass index; para aminohippurate; Renin angiotensin system

Indexed keywords

4 AMINOHIPPURIC ACID; ALISKIREN; INULIN; RENIN INHIBITOR;

ADULT; ARTICLE; BODY MASS; DRUG MECHANISM; FEMALE; GLOMERULUS CAPILLARY; GLOMERULUS FILTRATION; GLOMERULUS FILTRATION RATE; HORMONE RESPONSE; HUMAN; HUMAN EXPERIMENT; INULIN CLEARANCE; KIDNEY BLOOD FLOW; KIDNEY CLEARANCE; KIDNEY PLASMA FLOW; MALE; NORMAL HUMAN; ONCOTIC PRESSURE; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SODIUM RESTRICTION;

EID: 70349776042     PISSN: 19331711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jash.2009.06.004     Document Type: Article

References (28)

1. Carey R.M., and Padia S.H. Physiology and regulation of the renin-angiotensin-aldosterone system. In: Singh A.K., and Williams G.H. (Eds). Textbook of nephro-endocrinology (2009), Elsevier, San Diego, California 147-165
2. Navar L.G., Bell P.D., Evan A.P., Andreoli T.E., Hoffman J.F., Fanestil D.D., et al. The regulation of glomerular filtration rate in mammalian kidneys. Physiology of membrane disorders (1986), Plenum Publishing, New York, New York 637-667
3. Hollenberg N.K., Williams G.H., Taub K.J., Ishikawa I., Brown C., and Adams D.F. Renal vascular response to interruption of the renin-angiotensin system in normal man. Kidney Int 12 (1977) 285-293
4. Fisher N.D.L., Danser J.A.H., Nussberger J., Dole W.P., and Hollenberg N.K. Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans. Circulation 117 (2008) 3199-3205
5. Shoback D.M., Williams G.H., Moore T.J., Dluhy R.G., Podolsky S., and Hollenberg N.K. Defect in the sodium-modulated tissue responsiveness to angiotensin II in essential hypertension. J Clin Invest 72 (1983) 2115-2124
6. Fisher N.D., Allan D., Kifor I., Gaboury C.L., Williams G.H., Moore T.J., et al. Responses to converting enzyme and renin inhibition. Role of angiotensin II in humans. Hypertension 23 (1994) 44-51
7. Menard J., Guyene T.T., Peyrard S., and Azizi M. Conformational changes in prorenin during renin inhibition in vitro and in vivo. J Hypertension 24 (2006) 529-534
8. Derkx F.H., Deinum J., Lipovski M., Verhaar M., Fischli W., and Schalekamp M.A. Nonproteolytic "activation" of prorenin by active site-directed renin inhibitors as demonstrated by renin-specific monoclonal antibody. J Biol Chem 267 (1992) 22837-22842
9. Danser A.H., and Deinum J. Renin, prorenin, and the putative (pro)renin receptor. Hypertension 46 (2005) 1069-1076
10. Nussberger J., Fasanella D.T., Porchet M., Waeber B., Brunner D.B., Brunner H.R., et al. Repeated administration of the converting enzyme inhibitor cilazapril to normal volunteers. J Cardiovasc Pharmacol 9 (1987) 39-44
11. Nussberger J., Brunner D.B., Waeber B., and Brunner H.R. Specific measurement of angiotensin metabolites and in vitro generated angiotensin II in plasma. Hypertension 8 (1986) 476-482
12. Nussberger J., Brunner D.B., Waeber B., and Brunner H.R. In vitro renin inhibition to prevent generation of angiotensins during determination of angiotensin I and II. Life Sci 42 (1988) 1683-1688
13. Hollenberg N.K., Price D.A., Fisher N.D.L., Lansang M.C., Perkins B., Gordon M.S., et al. Glomerular hemodynamics and the renin-angiotensin system in patients with type 1 diabetes mellitus. Kidney Int 63 (2003) 172-178
14. Chagnac A., Weinstein T., Korzets A., Ramadan E., Hirsch J., and Gafter U. Glomerular hemodynamics in severe obesity. Am J Physiol Renal Physiol 278 (2000) F817-F822
15. Hladunewich M.A., Lafayette R.A., Derby G.C., Blouch K.L., Bialek J.W., Druzin M.L., et al. The dynamics of glomerular filtration in the puerperium. Am J Physiol Renal Physiol 286 (2004) F496-F503
16. Milne J.E., Lindheimer M.D., and Davison J.M. Glomerular heterosporous membrane modeling in third trimester and postpartum before and during amino acid infusion. Am J Physiol Renal Physiol 282 (2002) F170-F175
17. Oken D.E. An analysis of glomerular dynamics in rat, dog, and man. Kidney Int 22 (1982) 136-145
18. Durvasula R.V., Petermann A.T., Hiromura K., Blonski M., Pippin J., Mundel P., et al. Activation of a local tissue angiotensin system in podocytes by mechanical strain. Kidney Int 65 (2004) 30-39
19. Wang L., Flannery P.J., and Spurney R.F. Characterization of angiotensin II-receptor subtypes in podocytes. J Lab Clin Med 142 (2003) 313-321
20. Ritt M., Ott C., Raff U., Schneider M.P., Schuster I., Hilgers K.F., et al. Renal vascular endothelial function in hypertensive patients with type 2 diabetes mellitus. Am J Kidney Dis 53 (2009) 281-289
21. Thachil J. Nitric oxide depletion is responsible for the adverse effects of vascular endothelial growth factor inhibitors. Nat Clin Pract Nephrol 4 (2008) 536-537
22. Guan Z., Osmond D.A., and Inscho E.W. P2X receptors as regulators of the renal microvasculature. Trends Pharmacol Sci 28 (2007) 646-652
23. Faulhaber-Walter R., Chen L., Oppermann M., Kim S.M., Huang Y., Hiramats N., et al. Lack of A1 adenosine receptors augments diabetic hyperfiltration and glomerular injury. J Am Soc Nephrol 19 (2008) 722-730
24. Phipps J.A., and Feener E.P. The kallikrein-kinin system in diabetic retinopathy: lessons for the kidney. Kidney Int 73 (2008) 1114-1119
25. Vieitez P., Gomez O., Uceda E.R., Vera M.E., and Molina-Holgado E. Systemic and local effects of Angiotensin II blockade in experimental diabetic nephropathy. J Renin Angiotensin Aldosterone Syst 9 (2008) 96-102
26. Chen S., Ge Y., Si J., Rifai A., Dworkin L.D., and Gong R. Candesartan suppresses chronic renal inflammation by a novel antioxidant action independent of AT1R blockade. Kidney Int 74 (2008) 1128-1138
27. Dubey R.K., and Jackson E.K. Estrogen-induced cardiorenal protection: potential cellular, biochemical, and molecular mechanisms. Am J Physiol Renal Physiol 280 (2001) F365-F388
28. Busse R., and Fleming I. Regulation of endothelium-derived vasoactive autacoid production by hemodynamic forces. Trends Pharmacol Sci 24 (2003) 24-29