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Volumn 4, Issue 4, 2009, Pages 579-592

Engineering tissue alternatives to animals: Applying tissue engineering to basic research and safety testing

Author keywords

3Rs; Alternative; Animal model; In vitro; NC3Rs; Regenerative medicine; Replacement; Safety testing; Stem cells; Tissue engineering

Indexed keywords

ALLERGIC ASTHMA; BASIC RESEARCH; BIOREACTOR; BIOTECHNOLOGY; CHRONIC OBSTRUCTIVE LUNG DISEASE; DIABETES MELLITUS; DISEASE MODEL; ENDOCRINE CELL; HUMAN; IMMUNOTOXICITY; IN VITRO STUDY; INSULIN RELEASE; LYMPH NODE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REVIEW; SAFETY; TISSUE ENGINEERING; ANIMAL TESTING ALTERNATIVE; ASTHMA; BIOLOGICAL THERAPY; IMMUNOLOGY; METHODOLOGY; RESEARCH;

EID: 70349764058     PISSN: 17460751     EISSN: None     Source Type: Journal    
DOI: 10.2217/rme.09.26     Document Type: Review
Times cited : (27)

References (107)
  • 1
    • 0027595948 scopus 로고
    • Tissue engineering
    • Langer R, Vacanti JP: Tissue engineering. Science 260, 920-926 (1993).
    • (1993) Science , vol.260 , pp. 920-926
    • Langer, R.1    Vacanti, J.P.2
  • 2
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola I, Landis J: Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3, 711-715 (2004).
    • (2004) Nat. Rev. Drug Discov , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 3
    • 2442482962 scopus 로고    scopus 로고
    • Key factors in the rising cost of new drug discovery and development
    • Dickson M, Gagnon JP: Key factors in the rising cost of new drug discovery and development. Nat. Rev. Drug Discov. 3, 417-429 (2004).
    • (2004) Nat. Rev. Drug Discov , vol.3 , pp. 417-429
    • Dickson, M.1    Gagnon, J.P.2
  • 4
    • 0036656818 scopus 로고    scopus 로고
    • An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991)
    • Combes R, Balls M, Bansil L et al.: An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991). Altern. Lab. Anim. 30, 365-406 (2002).
    • (2002) Altern. Lab. Anim , vol.30 , pp. 365-406
    • Combes, R.1    Balls, M.2    Bansil, L.3
  • 5
    • 14644426625 scopus 로고    scopus 로고
    • The feasibility of replacing animal testing for assessing consumer safety: A suggested future direction
    • Fentem J, Chamberlain M, Sangster B: The feasibility of replacing animal testing for assessing consumer safety: a suggested future direction. Altern. Lab. Anim. 32, 617-623 (2004).
    • (2004) Altern. Lab. Anim , vol.32 , pp. 617-623
    • Fentem, J.1    Chamberlain, M.2    Sangster, B.3
  • 6
    • 85054115149 scopus 로고    scopus 로고
    • EU: Directive 2003/15/EC of the European parliament and of the council of 27 February 2003 amending council directive 76/768/EEC on the approximation of the laws of the member states relating to cosmetic products. Official J. EU L66, 26-35 (2003).
    • EU: Directive 2003/15/EC of the European parliament and of the council of 27 February 2003 amending council directive 76/768/EEC on the approximation of the laws of the member states relating to cosmetic products. Official J. EU L66, 26-35 (2003).
  • 7
    • 0037186867 scopus 로고    scopus 로고
    • Currently available in vitro methods used in the regulatory toxicology
    • Liebsch M, Spielmann H: Currently available in vitro methods used in the regulatory toxicology. Toxicol. Lett. 127, 127-134 (2002).
    • (2002) Toxicol. Lett , vol.127 , pp. 127-134
    • Liebsch, M.1    Spielmann, H.2
  • 9
    • 70350100054 scopus 로고    scopus 로고
    • Expanded utilization of the EpiOcular™ human corneal tissue model for ocular irritation testing
    • S
    • Kaluzhny Y, Thornton-d'Argembeau L, Kandarova H, Hayden P, Klausner M: Expanded utilization of the EpiOcular™ human corneal tissue model for ocular irritation testing. Toxicol. Lett. 180, S107 (2008).
    • (2008) Toxicol. Lett , vol.180 , pp. 107
    • Kaluzhny, Y.1    Thornton-d'Argembeau, L.2    Kandarova, H.3    Hayden, P.4    Klausner, M.5
  • 10
    • 33947501678 scopus 로고    scopus 로고
    • Comparative studies on the ocular and dermal irritation potential of surfactants
    • Mehling A, Kleber M, Hensen H: Comparative studies on the ocular and dermal irritation potential of surfactants. Food Chem. Toxicol. 45, 747-758 (2007).
    • (2007) Food Chem. Toxicol , vol.45 , pp. 747-758
    • Mehling, A.1    Kleber, M.2    Hensen, H.3
  • 11
    • 33749237882 scopus 로고    scopus 로고
    • Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis
    • Valore EV, Wiley DJ, Ganz T: Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. Infect. Immun. 74, 5693-5702 (2006).
    • (2006) Infect. Immun , vol.74 , pp. 5693-5702
    • Valore, E.V.1    Wiley, D.J.2    Ganz, T.3
  • 12
    • 4844220914 scopus 로고    scopus 로고
    • Usefulness of a novel Caco-2 cell perfusion system. I. In vitro prediction of the absorption potential of passively diffused compounds
    • Masungi C, Borremans C, Willems B et al.: Usefulness of a novel Caco-2 cell perfusion system. I. In vitro prediction of the absorption potential of passively diffused compounds. Pharm. J. Sci. 93, 2507-2521 (2004).
    • (2004) Pharm. J. Sci , vol.93 , pp. 2507-2521
    • Masungi, C.1    Borremans, C.2    Willems, B.3
  • 13
    • 33947577597 scopus 로고    scopus 로고
    • In vitro formulation optimization of intranasal galantamine leading to enhanced bioavailability and reduced emetic response in vivo
    • Leonard AK, Sileno AP, Brandt GC, Foerder CA, Quay SC, Costantino HR: In vitro formulation optimization of intranasal galantamine leading to enhanced bioavailability and reduced emetic response in vivo. Int. Pharm. J. 335, 138-146 (2007).
    • (2007) Int. Pharm. J , vol.335 , pp. 138-146
    • Leonard, A.K.1    Sileno, A.P.2    Brandt, G.C.3    Foerder, C.A.4    Quay, S.C.5    Costantino, H.R.6
  • 14
    • 64849086385 scopus 로고    scopus 로고
    • In vitro models of inhalation toxicity and disease. The report of a FRAME workshop
    • Berube K, Aufderheide M, Breheny D et al.: In vitro models of inhalation toxicity and disease. The report of a FRAME workshop. Altern. Lab. Anim. 37, 89-141 (2009).
    • (2009) Altern. Lab. Anim , vol.37 , pp. 89-141
    • Berube, K.1    Aufderheide, M.2    Breheny, D.3
  • 16
  • 17
    • 57349145721 scopus 로고    scopus 로고
    • Assuring consumer safety without animal testing: A feasibility case study for skin sensitisation
    • Maxwell G, Aleksic M, Aptula A et al.: Assuring consumer safety without animal testing: a feasibility case study for skin sensitisation. Altern. Lab. Anim. 36, 557-568 (2008).
    • (2008) Altern. Lab. Anim , vol.36 , pp. 557-568
    • Maxwell, G.1    Aleksic, M.2    Aptula, A.3
  • 20
    • 21044455622 scopus 로고    scopus 로고
    • Adjuvants and antibody production: Dispelling the myths associated with Freund's complete and other adjuvants
    • Stills HF Jr: Adjuvants and antibody production: dispelling the myths associated with Freund's complete and other adjuvants. ILAR J. 46, 280-293 (2005).
    • (2005) ILAR J , vol.46 , pp. 280-293
    • Stills Jr, H.F.1
  • 21
    • 17744396114 scopus 로고    scopus 로고
    • Skin sensitization testing in potency and risk assessment
    • Kimber I, Basketter DA, Berthold K et al.: Skin sensitization testing in potency and risk assessment. Toxicol. Sci. 59, 198-208 (2001).
    • (2001) Toxicol. Sci , vol.59 , pp. 198-208
    • Kimber, I.1    Basketter, D.A.2    Berthold, K.3
  • 22
    • 0035070023 scopus 로고    scopus 로고
    • Skin sensitisation testing - new perspectives and recommendations
    • Steiling W, Basketter D, Berthold K et al.: Skin sensitisation testing - new perspectives and recommendations. Food Chem. Toxicol. 39, 293-301 (2001).
    • (2001) Food Chem. Toxicol , vol.39 , pp. 293-301
    • Steiling, W.1    Basketter, D.2    Berthold, K.3
  • 24
    • 44149104083 scopus 로고    scopus 로고
    • The reduced local lymph node assay: The impact of group size
    • Ryan CA, Chaney JG, Kern PS et al.: The reduced local lymph node assay: the impact of group size. Appl. J. Toxicol. 28, 518-523 (2008).
    • (2008) Appl. J. Toxicol , vol.28 , pp. 518-523
    • Ryan, C.A.1    Chaney, J.G.2    Kern, P.S.3
  • 25
    • 33645720142 scopus 로고    scopus 로고
    • The local lymph node assay and skin sensitization: A cut-down screen to reduce animal requirements?
    • Kimber I, Dearman RJ, Betts CJ et al.: The local lymph node assay and skin sensitization: a cut-down screen to reduce animal requirements? Contact Derm. 54, 181-185 (2006).
    • (2006) Contact Derm , vol.54 , pp. 181-185
    • Kimber, I.1    Dearman, R.J.2    Betts, C.J.3
  • 26
    • 0035697810 scopus 로고    scopus 로고
    • ICCVAM evaluation of the murine local lymph node assay. Conclusions and recommendations of an independent scientific peer review panel
    • Dean JH, Twerdok LE, Tice RR, Sailstad DM, Hattan DG, Stokes WS: ICCVAM evaluation of the murine local lymph node assay. Conclusions and recommendations of an independent scientific peer review panel. Regul. Toxicol. Pharmacol. 34, 258-273 (2001).
    • (2001) Regul. Toxicol. Pharmacol , vol.34 , pp. 258-273
    • Dean, J.H.1    Twerdok, L.E.2    Tice, R.R.3    Sailstad, D.M.4    Hattan, D.G.5    Stokes, W.S.6
  • 27
    • 0032847626 scopus 로고    scopus 로고
    • Local lymph node assay: Use in hazard and risk assessment
    • Dearman RJ, Basketter DA, Kimber I: Local lymph node assay: use in hazard and risk assessment. Appl. J. Toxicol. 19, 299-306 (1999).
    • (1999) Appl. J. Toxicol , vol.19 , pp. 299-306
    • Dearman, R.J.1    Basketter, D.A.2    Kimber, I.3
  • 29
    • 36749077563 scopus 로고    scopus 로고
    • The local lymph node assay: Current position in the regulatory classification of skin sensitizing chemicals
    • Basketter DA, Gerberick GF, Kimber I: The local lymph node assay: current position in the regulatory classification of skin sensitizing chemicals. Cutan. Ocul. Toxicol. 26, 293-301 (2007).
    • (2007) Cutan. Ocul. Toxicol , vol.26 , pp. 293-301
    • Basketter, D.A.1    Gerberick, G.F.2    Kimber, I.3
  • 30
    • 33845347862 scopus 로고    scopus 로고
    • In vitro tests to evaluate immunotoxicity: A preliminary study
    • Carfi M, Gennari A, Malerba I et al.: In vitro tests to evaluate immunotoxicity: a preliminary study. Toxicology 229, 11-22 (2007).
    • (2007) Toxicology , vol.229 , pp. 11-22
    • Carfi, M.1    Gennari, A.2    Malerba, I.3
  • 32
    • 40449124687 scopus 로고    scopus 로고
    • Microarray-based in vitro test system for the discrimination of contact allergens and irritants: Identification of potential marker genes
    • Szameit S, Vierlinger K, Farmer L, Tuschl H, Noehammer C: Microarray-based in vitro test system for the discrimination of contact allergens and irritants: identification of potential marker genes. Clin. Chem. 54, 525-533 (2008).
    • (2008) Clin. Chem , vol.54 , pp. 525-533
    • Szameit, S.1    Vierlinger, K.2    Farmer, L.3    Tuschl, H.4    Noehammer, C.5
  • 33
    • 57349145721 scopus 로고    scopus 로고
    • Assuring consumer safety without animal testing: A feasibility case study for skin sensitisation
    • Maxwell G, Aleksic M, Aputla A et al.: Assuring consumer safety without animal testing: a feasibility case study for skin sensitisation. Altern. Lab. Anim. 36, 557-568 (2008).
    • (2008) Altern. Lab. Anim , vol.36 , pp. 557-568
    • Maxwell, G.1    Aleksic, M.2    Aputla, A.3
  • 34
    • 0036178498 scopus 로고    scopus 로고
    • The hexamethonium asthma study and the death of a normal volunteer in research
    • Savulescu J, Spriggs M: The hexamethonium asthma study and the death of a normal volunteer in research. Med. J. Ethics 28, 3-4 (2002).
    • (2002) Med. J. Ethics , vol.28 , pp. 3-4
    • Savulescu, J.1    Spriggs, M.2
  • 35
    • 33645846620 scopus 로고    scopus 로고
    • Can super-antibody drugs be tamed
    • Hopkin, M: Can super-antibody drugs be tamed. Nature 440, 855-856 (2006).
    • (2006) Nature , vol.440 , pp. 855-856
    • Hopkin, M.1
  • 36
    • 33645504676 scopus 로고    scopus 로고
    • Learning from the TGN1412 trial
    • Goodyear, M: Learning from the TGN1412 trial. BMJ 332, 677-678 (2006).
    • (2006) BMJ , vol.332 , pp. 677-678
    • Goodyear, M.1
  • 37
    • 85054111111 scopus 로고    scopus 로고
    • Anon.: Regulation no. 1907/2006 of the European parliament and the council of 18 December 2006 concerning the registration, evaluation, authorisation and restriction of chemicals (REACH), establishing a European chemicals agency, amending directive 1999/45/EC and repealing council regulation (EEC) no. 793/93 and commission regulation (EC) no. 1488/94 as well as council directive 76/769/EEC and commission directives 91/155/EEC, 93/67/EEC and 2000/21/EC. Official Journal of the European Union L396, 1-849 (2006).
    • Anon.: Regulation no. 1907/2006 of the European parliament and the council of 18 December 2006 concerning the registration, evaluation, authorisation and restriction of chemicals (REACH), establishing a European chemicals agency, amending directive 1999/45/EC and repealing council regulation (EEC) no. 793/93 and commission regulation (EC) no. 1488/94 as well as council directive 76/769/EEC and commission directives 91/155/EEC, 93/67/EEC and 2000/21/EC. Official Journal of the European Union L396, 1-849 (2006).
  • 38
    • 33749500436 scopus 로고    scopus 로고
    • A human lymph node in vitro - challenges and progress
    • Giese C, Demmler CD, Ammer R et al.: A human lymph node in vitro - challenges and progress. Artif. Organs 30, 803-808 (2006).
    • (2006) Artif. Organs , vol.30 , pp. 803-808
    • Giese, C.1    Demmler, C.D.2    Ammer, R.3
  • 39
    • 85054105597 scopus 로고    scopus 로고
    • Giese C, Marx U: Artificial human lymph node: a device for generation of human antibodies and testing for immune functions in vitro. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting. Harrogate, UK, June 5-8, 2005. Smith R (Ed.). Springer Netherlands, Dordrecht, The Netherlands (2007).
    • Giese C, Marx U: Artificial human lymph node: a device for generation of human antibodies and testing for immune functions in vitro. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting. Harrogate, UK, June 5-8, 2005. Smith R (Ed.). Springer Netherlands, Dordrecht, The Netherlands (2007).
  • 40
    • 0014377929 scopus 로고
    • Studies on insulin secretion in vitro from isolated islets of the rat pancreas
    • Lacy PE, Young DA, Fink CJ: Studies on insulin secretion in vitro from isolated islets of the rat pancreas. Endocrinology 83, 1155-1161 (1968).
    • (1968) Endocrinology , vol.83 , pp. 1155-1161
    • Lacy, P.E.1    Young, D.A.2    Fink, C.J.3
  • 41
    • 0017101002 scopus 로고
    • Standardization of a digestion-filtration method for isolation of pancreatic islets
    • Shibata A, Ludvigsen CW Jr, Naber SP, McDaniel ML, Lacy PE: Standardization of a digestion-filtration method for isolation of pancreatic islets. Diabetes 25, 667-672 (1976).
    • (1976) Diabetes , vol.25 , pp. 667-672
    • Shibata, A.1    Ludvigsen Jr, C.W.2    Naber, S.P.3    McDaniel, M.L.4    Lacy, P.E.5
  • 42
    • 17744372474 scopus 로고    scopus 로고
    • β-cell differentiation from a human pancreatic cell line in vitro and in vivo
    • de la Tour D, Halvorsen T, Demeterco C et al.: β-cell differentiation from a human pancreatic cell line in vitro and in vivo. Mol. Endocrinol. 15, 476-483 (2001).
    • (2001) Mol. Endocrinol , vol.15 , pp. 476-483
    • de la Tour, D.1    Halvorsen, T.2    Demeterco, C.3
  • 43
    • 27144551716 scopus 로고    scopus 로고
    • A human β-cell line for transplantation therapy to control Type 1 diabetes
    • Narushima M, Kobayashi N, Okitsu T et al.: A human β-cell line for transplantation therapy to control Type 1 diabetes. Nat. Biotechnol. 23, 1274-1282 (2005).
    • (2005) Nat. Biotechnol , vol.23 , pp. 1274-1282
    • Narushima, M.1    Kobayashi, N.2    Okitsu, T.3
  • 44
    • 0024430064 scopus 로고
    • Homologous but not heterologous contact increases the insulin secretion of individual pancreatic β-cells
    • Bosco D, Orci L, Meda P: Homologous but not heterologous contact increases the insulin secretion of individual pancreatic β-cells. Exp. Cell. Res. 184, 72-80 (1989).
    • (1989) Exp. Cell. Res , vol.184 , pp. 72-80
    • Bosco, D.1    Orci, L.2    Meda, P.3
  • 45
    • 0023242545 scopus 로고
    • Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets
    • Halban PA, Powers SL, George KL, Bonner-Weir S: Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets. Diabetes 36, 783-790 (1987).
    • (1987) Diabetes , vol.36 , pp. 783-790
    • Halban, P.A.1    Powers, S.L.2    George, K.L.3    Bonner-Weir, S.4
  • 46
    • 35848955929 scopus 로고    scopus 로고
    • E-cadherin and cell adhesion: A role in architecture and function in the pancreatic islet
    • Rogers GJ, Hodgkin MN, Squires PE: E-cadherin and cell adhesion: a role in architecture and function in the pancreatic islet. Cell. Physiol. Biochem. 20, 987-994 (2007).
    • (2007) Cell. Physiol. Biochem , vol.20 , pp. 987-994
    • Rogers, G.J.1    Hodgkin, M.N.2    Squires, P.E.3
  • 47
    • 0029588550 scopus 로고
    • Adequate connexin-mediated coupling is required for proper insulin production
    • Vozzi C, Ullrich S, Charollais A, Philippe J, Orci L, Meda P: Adequate connexin-mediated coupling is required for proper insulin production. Cell. J. Biol. 131, 1561-1572 (1995).
    • (1995) Cell. J. Biol , vol.131 , pp. 1561-1572
    • Vozzi, C.1    Ullrich, S.2    Charollais, A.3    Philippe, J.4    Orci, L.5    Meda, P.6
  • 48
    • 13844251790 scopus 로고    scopus 로고
    • Cell-to-cell contact influences proliferative marker expression and apoptosis in MIN6 cells grown in islet-like structures
    • Luther MJ, Davies E, Muller D et al.: Cell-to-cell contact influences proliferative marker expression and apoptosis in MIN6 cells grown in islet-like structures. Am. Physiol. J. Endocrinol. Metab. 288, E502-E509 (2005).
    • (2005) Am. Physiol. J. Endocrinol. Metab , vol.288
    • Luther, M.J.1    Davies, E.2    Muller, D.3
  • 50
    • 0027325513 scopus 로고
    • Mastoparan stimulates insulin secretion from pancreatic β-cells by effects at a late stage in the secretory pathway
    • Jones PM, Mann FM, Persaud SJ, Wheeler-Jones CP: Mastoparan stimulates insulin secretion from pancreatic β-cells by effects at a late stage in the secretory pathway. Mol. Cell. Endocrinol. 94, 97-103 (1993).
    • (1993) Mol. Cell. Endocrinol , vol.94 , pp. 97-103
    • Jones, P.M.1    Mann, F.M.2    Persaud, S.J.3    Wheeler-Jones, C.P.4
  • 51
    • 33748546919 scopus 로고    scopus 로고
    • Current animal models of bronchial asthma
    • Kurucz I, Szelenyi I: Current animal models of bronchial asthma. Curr. Pharm. Des. 12, 3175-3194 (2006).
    • (2006) Curr. Pharm. Des , vol.12 , pp. 3175-3194
    • Kurucz, I.1    Szelenyi, I.2
  • 52
    • 0033604599 scopus 로고    scopus 로고
    • Therapeutic strategies for allergic diseases
    • Barnes PJ: Therapeutic strategies for allergic diseases. Nature 402, B31-B38 (1999).
    • (1999) Nature , vol.402
    • Barnes, P.J.1
  • 54
    • 6644223789 scopus 로고    scopus 로고
    • Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Bryan SA, O'Connor BJ, Matti S et al.: Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356, 2149-2153 (2000).
    • (2000) Lancet , vol.356 , pp. 2149-2153
    • Bryan, S.A.1    O'Connor, B.J.2    Matti, S.3
  • 55
    • 0033841610 scopus 로고    scopus 로고
    • Effect of recombinant human platelet-activating factor-acetylhydrolase on allergen-induced asthmatic responses
    • Henig NR, Aitken ML, Liu MC, Yu AS, Henderson WR Jr: Effect of recombinant human platelet-activating factor-acetylhydrolase on allergen-induced asthmatic responses. Am. Respir. J. Crit. Care Med. 162, 523-527 (2000).
    • (2000) Am. Respir. J. Crit. Care Med , vol.162 , pp. 523-527
    • Henig, N.R.1    Aitken, M.L.2    Liu, M.C.3    Yu, A.S.4    Henderson Jr, W.R.5
  • 57
    • 33749321597 scopus 로고    scopus 로고
    • Management of asthma with anti-immunoglobulin E: A review of clinical trials of omalizumab
    • Nowak D: Management of asthma with anti-immunoglobulin E: a review of clinical trials of omalizumab. Respir. Med. 100, 1907-1917 (2006).
    • (2006) Respir. Med , vol.100 , pp. 1907-1917
    • Nowak, D.1
  • 58
    • 43749116168 scopus 로고    scopus 로고
    • Omalizumab: A review of its use in the treatment of allergic asthma
    • Plosker GL, Keam SJ: Omalizumab: a review of its use in the treatment of allergic asthma. BioDrugs 22, 189-204 (2008).
    • (2008) BioDrugs , vol.22 , pp. 189-204
    • Plosker, G.L.1    Keam, S.J.2
  • 59
    • 0034995872 scopus 로고    scopus 로고
    • Efficacy of soluble IL-4 receptor for the treatment of adults with asthma
    • Borish LC, Nelson HS, Corren J et al.: Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. Allergy J. Clin. Immunol. 107, 963-970 (2001).
    • (2001) Allergy J. Clin. Immunol , vol.107 , pp. 963-970
    • Borish, L.C.1    Nelson, H.S.2    Corren, J.3
  • 60
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie MJ, ten Brinke A, Khan J et al.: Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356, 2144-2148 (2000).
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    ten Brinke, A.2    Khan, J.3
  • 61
    • 35348909044 scopus 로고    scopus 로고
    • Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: Results of two Phase 2a studies
    • Wenzel S, Wilbraham D, Fuller R, Getz EB, Longphre M: Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two Phase 2a studies. Lancet 370, 1422-1431 (2007).
    • (2007) Lancet , vol.370 , pp. 1422-1431
    • Wenzel, S.1    Wilbraham, D.2    Fuller, R.3    Getz, E.B.4    Longphre, M.5
  • 62
    • 33845543076 scopus 로고    scopus 로고
    • The mouse trap: It still yields few answers in asthma
    • discussion 1176-1178
    • Wenzel S, Holgate ST: The mouse trap: it still yields few answers in asthma. Am. Respir. J. Crit. Care Med. 174, 1173-1176; discussion 1176-1178 (2006).
    • (2006) Am. Respir. J. Crit. Care Med , vol.174 , pp. 1173-1176
    • Wenzel, S.1    Holgate, S.T.2
  • 63
    • 50849140825 scopus 로고    scopus 로고
    • Animal models of COPD: Barriers, successes, and challenges
    • Wright JL, Churg A: Animal models of COPD: barriers, successes, and challenges. Pulm. Pharmacol. Ther. 21, 696-698 (2008).
    • (2008) Pulm. Pharmacol. Ther , vol.21 , pp. 696-698
    • Wright, J.L.1    Churg, A.2
  • 65
    • 0032768264 scopus 로고    scopus 로고
    • Current animal models are not predictive for clinical asthma
    • Coleman RA: Current animal models are not predictive for clinical asthma. Pulm. Pharmacol. Ther. 12, 87-89 (1999).
    • (1999) Pulm. Pharmacol. Ther , vol.12 , pp. 87-89
    • Coleman, R.A.1
  • 66
    • 0036644568 scopus 로고    scopus 로고
    • Persson CG: Con: mice are not a good model of human airway disease. Am. Respir. J. Crit. Care Med. 166, 6-7; discussion 8 (2002).
    • Persson CG: Con: mice are not a good model of human airway disease. Am. Respir. J. Crit. Care Med. 166, 6-7; discussion 8 (2002).
  • 68
    • 0036152688 scopus 로고    scopus 로고
    • Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects
    • Polosa R, Puddicombe SM, Krishna MT et al.: Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects. Allergy J. Clin. Immunol. 109, 75-81 (2002).
    • (2002) Allergy J. Clin. Immunol , vol.109 , pp. 75-81
    • Polosa, R.1    Puddicombe, S.M.2    Krishna, M.T.3
  • 69
    • 0033129273 scopus 로고    scopus 로고
    • Interleukin-5 production by human airway epithelial cells
    • Salvi S, Semper A, Blomberg A et al.: Interleukin-5 production by human airway epithelial cells. Am. Respir. J. Cell Mol. Biol. 20, 984-991 (1999).
    • (1999) Am. Respir. J. Cell Mol. Biol , vol.20 , pp. 984-991
    • Salvi, S.1    Semper, A.2    Blomberg, A.3
  • 70
    • 33645280327 scopus 로고    scopus 로고
    • Disintegrin A and metalloproteinase 33 protein in patients with asthma: Relevance to airflow limitation
    • Lee JY, Park SW, Chang HK et al.: Disintegrin A and metalloproteinase 33 protein in patients with asthma: relevance to airflow limitation. Am. Respir. J. Crit. Care Med. 173, 729-735 (2006).
    • (2006) Am. Respir. J. Crit. Care Med , vol.173 , pp. 729-735
    • Lee, J.Y.1    Park, S.W.2    Chang, H.K.3
  • 71
    • 44649133162 scopus 로고    scopus 로고
    • Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium
    • Pourazar J, Blomberg A, Kelly FJ et al.: Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium. Part. Fibre Toxicol. 5, 8 (2008).
    • (2008) Part. Fibre Toxicol , vol.5 , pp. 8
    • Pourazar, J.1    Blomberg, A.2    Kelly, F.J.3
  • 72
    • 4544231752 scopus 로고    scopus 로고
    • Safety of research bronchoscopy, biopsy and bronchoalveolar lavage in asthma
    • Elston WJ, Whittaker AJ, Khan LN et al.: Safety of research bronchoscopy, biopsy and bronchoalveolar lavage in asthma. Eur. Respir. J. 24, 375-377 (2004).
    • (2004) Eur. Respir. J , vol.24 , pp. 375-377
    • Elston, W.J.1    Whittaker, A.J.2    Khan, L.N.3
  • 73
    • 21244506485 scopus 로고    scopus 로고
    • Use of bronchoalveolar lavage to detect respiratory tract toxicity of inhaled material
    • Henderson RF: Use of bronchoalveolar lavage to detect respiratory tract toxicity of inhaled material. Exp. Toxicol. Pathol. 57(Suppl. 1), 155-159 (2005).
    • (2005) Exp. Toxicol. Pathol , vol.57 , Issue.SUPPL. 1 , pp. 155-159
    • Henderson, R.F.1
  • 74
    • 0035984581 scopus 로고    scopus 로고
    • Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis
    • Bucchieri F, Puddicombe SM, Lordan JL et al.: Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis. Am. Respir. J. Cell Mol. Biol. 27, 179-185 (2002).
    • (2002) Am. Respir. J. Cell Mol. Biol , vol.27 , pp. 179-185
    • Bucchieri, F.1    Puddicombe, S.M.2    Lordan, J.L.3
  • 75
    • 0036644701 scopus 로고    scopus 로고
    • Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells
    • Lordan JL, Bucchieri F, Richter A et al.: Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells. Immunol. J. 169, 407-414 (2002).
    • (2002) Immunol. J , vol.169 , pp. 407-414
    • Lordan, J.L.1    Bucchieri, F.2    Richter, A.3
  • 76
    • 17144403499 scopus 로고    scopus 로고
    • Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
    • Wark PA, Johnston SL, Bucchieri F et al.: Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. Exp. J. Med. 201, 937-947 (2005).
    • (2005) Exp. J. Med , vol.201 , pp. 937-947
    • Wark, P.A.1    Johnston, S.L.2    Bucchieri, F.3
  • 77
    • 49149107693 scopus 로고    scopus 로고
    • Cell types involved in allergic asthma and their use in in vitro models to assess respiratory sensitization
    • Verstraelen S, Bloemen K, Nelissen I, Witters H, Schoeters G, Heuvel RV: Cell types involved in allergic asthma and their use in in vitro models to assess respiratory sensitization. Toxicol. In Vitro 22, 1419-1431 (2008).
    • (2008) Toxicol. In Vitro , vol.22 , pp. 1419-1431
    • Verstraelen, S.1    Bloemen, K.2    Nelissen, I.3    Witters, H.4    Schoeters, G.5    Heuvel, R.V.6
  • 78
    • 0035144765 scopus 로고    scopus 로고
    • Bronchial mucosa produced by tissue engineering: A new tool to study cellular interactions in asthma
    • Chakir J, Page N, Hamid Q, Laviolette M, Boulet LP, Rouabhia M: Bronchial mucosa produced by tissue engineering: a new tool to study cellular interactions in asthma. Allergy J. Clin. Immunol. 107, 36-40 (2001).
    • (2001) Allergy J. Clin. Immunol , vol.107 , pp. 36-40
    • Chakir, J.1    Page, N.2    Hamid, Q.3    Laviolette, M.4    Boulet, L.P.5    Rouabhia, M.6
  • 80
    • 33748463005 scopus 로고    scopus 로고
    • Extracellular matrix remodeling by dynamic strain in a three-dimensional tissue-engineered human airway wall model
    • Choe MM, Sporn PH, Swartz MA: Extracellular matrix remodeling by dynamic strain in a three-dimensional tissue-engineered human airway wall model. Am. Respir. J. Cell Mol. Biol. 35, 306-313 (2006).
    • (2006) Am. Respir. J. Cell Mol. Biol , vol.35 , pp. 306-313
    • Choe, M.M.1    Sporn, P.H.2    Swartz, M.A.3
  • 81
    • 34250660588 scopus 로고    scopus 로고
    • Physiological 3D tissue model of the airway wall and mucosa
    • Choe MM, Tomei AA, Swartz MA: Physiological 3D tissue model of the airway wall and mucosa. Nat. Protoc. 1, 357-362 (2006).
    • (2006) Nat. Protoc , vol.1 , pp. 357-362
    • Choe, M.M.1    Tomei, A.A.2    Swartz, M.A.3
  • 82
    • 1542503093 scopus 로고    scopus 로고
    • Tissue-engineered human asthmatic bronchial equivalents
    • discussion 1-11
    • Paquette JS, Moulin V, Tremblay P et al.: Tissue-engineered human asthmatic bronchial equivalents. Eur. Cell. Mater. 7, 1-11; discussion 1-11 (2004).
    • (2004) Eur. Cell. Mater , vol.7 , pp. 1-11
    • Paquette, J.S.1    Moulin, V.2    Tremblay, P.3
  • 83
    • 16444371242 scopus 로고    scopus 로고
    • A three-dimensional cellular model of the human respiratory tract to study the interaction with particles
    • Rothen-Rutishauser BM, Kiama SG, Gehr P: A three-dimensional cellular model of the human respiratory tract to study the interaction with particles. Am. Respir. J. Cell Mol. Biol. 32, 281-289 (2005).
    • (2005) Am. Respir. J. Cell Mol. Biol , vol.32 , pp. 281-289
    • Rothen-Rutishauser, B.M.1    Kiama, S.G.2    Gehr, P.3
  • 84
    • 33751200647 scopus 로고    scopus 로고
    • Permeation of WIN 55,212-2, a potent cannabinoid receptor agonist, across human tracheobronchial tissue in vitro and rat nasal epithelium in vivo
    • Agu RU, Valiveti S, Paudel KS, Klausner M, Hayden PJ, Stinchcomb AL: Permeation of WIN 55,212-2, a potent cannabinoid receptor agonist, across human tracheobronchial tissue in vitro and rat nasal epithelium in vivo. Pharm. J. Pharmacol. 58, 1459-1465 (2006).
    • (2006) Pharm. J. Pharmacol , vol.58 , pp. 1459-1465
    • Agu, R.U.1    Valiveti, S.2    Paudel, K.S.3    Klausner, M.4    Hayden, P.J.5    Stinchcomb, A.L.6
  • 85
    • 33745037496 scopus 로고    scopus 로고
    • Therapeutic utility of a novel tight junction modulating peptide for enhancing intranasal drug delivery
    • Chen SC, Eiting K, Cui K et al.: Therapeutic utility of a novel tight junction modulating peptide for enhancing intranasal drug delivery. Pharm. J. Sci. 95, 1364-1371 (2006).
    • (2006) Pharm. J. Sci , vol.95 , pp. 1364-1371
    • Chen, S.C.1    Eiting, K.2    Cui, K.3
  • 86
    • 26944439522 scopus 로고    scopus 로고
    • The lungs as a portal of entry for systemic drug delivery
    • Patton JS, Fishburn CS, Weers JG: The lungs as a portal of entry for systemic drug delivery. Proc. Am. Thorac. Soc. 1, 338-344 (2004).
    • (2004) Proc. Am. Thorac. Soc , vol.1 , pp. 338-344
    • Patton, J.S.1    Fishburn, C.S.2    Weers, J.G.3
  • 87
    • 33750724104 scopus 로고    scopus 로고
    • Clinical perspectives on pulmonary systemic and macromolecular delivery
    • Scheuch G, Kohlhaeufl MJ, Brand P, Siekmeier R: Clinical perspectives on pulmonary systemic and macromolecular delivery. Adv. Drug Deliv. Rev. 58, 996-1008 (2006).
    • (2006) Adv. Drug Deliv. Rev , vol.58 , pp. 996-1008
    • Scheuch, G.1    Kohlhaeufl, M.J.2    Brand, P.3    Siekmeier, R.4
  • 88
    • 33750804217 scopus 로고    scopus 로고
    • Particle engineering techniques for inhaled biopharmaceuticals
    • Shoyele SA, Cawthorne S: Particle engineering techniques for inhaled biopharmaceuticals. Adv. Drug Deliv. Rev. 58, 1009-1029 (2006).
    • (2006) Adv. Drug Deliv. Rev , vol.58 , pp. 1009-1029
    • Shoyele, S.A.1    Cawthorne, S.2
  • 89
    • 2442547743 scopus 로고    scopus 로고
    • The pathophysiology of cigarette smoking and cardiovascular disease: An update
    • Ambrose JA, Barua RS: The pathophysiology of cigarette smoking and cardiovascular disease: an update. Am. J. Coll. Cardiol. 43, 1731-1737 (2004).
    • (2004) Am. J. Coll. Cardiol , vol.43 , pp. 1731-1737
    • Ambrose, J.A.1    Barua, R.S.2
  • 90
    • 31644443759 scopus 로고    scopus 로고
    • Respiratory health consequences of environmental tobacco smoke
    • Dhala A, Pinsker K, Prezant DJ: Respiratory health consequences of environmental tobacco smoke. Clin. Occup. Environ. Med. 5, 139-156 (2006).
    • (2006) Clin. Occup. Environ. Med , vol.5 , pp. 139-156
    • Dhala, A.1    Pinsker, K.2    Prezant, D.J.3
  • 91
    • 0036774647 scopus 로고    scopus 로고
    • A minireview of chronic animal inhalation studies with mainstream cigarette smoke
    • Coggins CR: A minireview of chronic animal inhalation studies with mainstream cigarette smoke. Inhal. Toxicol. 14, 991-1002 (2002).
    • (2002) Inhal. Toxicol , vol.14 , pp. 991-1002
    • Coggins, C.R.1
  • 92
    • 37549042349 scopus 로고    scopus 로고
    • An in vitro approach to assess the toxicity of inhaled tobacco smoke components: Nicotine, cadmium, formaldehyde and urethane
    • Balharry D, Sexton K, Berube KA: An in vitro approach to assess the toxicity of inhaled tobacco smoke components: nicotine, cadmium, formaldehyde and urethane. Toxicology 244, 66-76 (2008).
    • (2008) Toxicology , vol.244 , pp. 66-76
    • Balharry, D.1    Sexton, K.2    Berube, K.A.3
  • 93
    • 53549088577 scopus 로고    scopus 로고
    • Genomic biomarkers of pulmonary exposure to tobacco smoke components
    • Sexton K, Balharry D, BeruBe KA: Genomic biomarkers of pulmonary exposure to tobacco smoke components. Pharmacogenet. Genomics 18, 853-860 (2008).
    • (2008) Pharmacogenet. Genomics , vol.18 , pp. 853-860
    • Sexton, K.1    Balharry, D.2    BeruBe, K.A.3
  • 94
    • 0036972762 scopus 로고    scopus 로고
    • ECVAM's activities in validating alternative tests for skin corrosion and irritation
    • Fentem JH, Botham PA: ECVAM's activities in validating alternative tests for skin corrosion and irritation. Altern. Lab. Anim. 30(Suppl. 2), 61-67 (2002).
    • (2002) Altern. Lab. Anim , vol.30 , Issue.SUPPL. 2 , pp. 61-67
    • Fentem, J.H.1    Botham, P.A.2
  • 95
    • 20444426430 scopus 로고    scopus 로고
    • Validation of in vitro tests for skin corrosivity
    • Fentem JH: Validation of in vitro tests for skin corrosivity. ALTEX 16, 150-153 (1999).
    • (1999) ALTEX , vol.16 , pp. 150-153
    • Fentem, J.H.1
  • 96
    • 0036226331 scopus 로고    scopus 로고
    • Non-animal testing strategies for assessment of the skin corrosion and skin irritation potential of ingredients and finished products
    • Robinson MK, Cohen C, de Fraissinette Ade B, Ponec M, Whittle E, Fentem JH: Non-animal testing strategies for assessment of the skin corrosion and skin irritation potential of ingredients and finished products. Food Chem. Toxicol. 40, 573-592 (2002).
    • (2002) Food Chem. Toxicol , vol.40 , pp. 573-592
    • Robinson, M.K.1    Cohen, C.2    de Fraissinette Ade, B.3    Ponec, M.4    Whittle, E.5    Fentem, J.H.6
  • 97
    • 22844432717 scopus 로고    scopus 로고
    • Skin irritation and corrosion
    • Zuang V, Alonso MA, Botham PA et al.: Skin irritation and corrosion. Altern. Lab. Anim. 33(Suppl. 1), 35-46 (2005).
    • (2005) Altern. Lab. Anim , vol.33 , Issue.SUPPL. 1 , pp. 35-46
    • Zuang, V.1    Alonso, M.A.2    Botham, P.A.3
  • 98
    • 44749093939 scopus 로고    scopus 로고
    • Leiden reconstructed human epidermal model as a tool for the evaluation of the skin corrosion and irritation potential according to the ECVAM guidelines
    • El Ghalbzouri A, Siamari R, Willemze R, Ponec M: Leiden reconstructed human epidermal model as a tool for the evaluation of the skin corrosion and irritation potential according to the ECVAM guidelines. Toxicol. In Vitro 22, 1311-1320 (2008).
    • (2008) Toxicol. In Vitro , vol.22 , pp. 1311-1320
    • El Ghalbzouri, A.1    Siamari, R.2    Willemze, R.3    Ponec, M.4
  • 99
    • 47049123953 scopus 로고    scopus 로고
    • A feasibility study developing an integrated testing strategy assessing skin irritation potential of chemicals
    • Hoffmann S, Saliner AG, Patlewicz G, Eskes C, Zuang V, Worth AP: A feasibility study developing an integrated testing strategy assessing skin irritation potential of chemicals. Toxicol. Lett. 180, 9-20 (2008).
    • (2008) Toxicol. Lett , vol.180 , pp. 9-20
    • Hoffmann, S.1    Saliner, A.G.2    Patlewicz, G.3    Eskes, C.4    Zuang, V.5    Worth, A.P.6
  • 100
    • 33750212204 scopus 로고    scopus 로고
    • Infection of human cytomegalovirus in cultured human gingival tissue
    • Hai R, Chu A, Li H, Umamoto S, Rider P, Liu F: Infection of human cytomegalovirus in cultured human gingival tissue. Virol. J. 3, 84 (2006).
    • (2006) Virol. J , vol.3 , pp. 84
    • Hai, R.1    Chu, A.2    Li, H.3    Umamoto, S.4    Rider, P.5    Liu, F.6
  • 101
    • 44749091416 scopus 로고    scopus 로고
    • Successful prevalidation of the slug mucosal irritation test to assess the eye irritation potency of chemicals
    • Adriaens E, Bytheway H, De Wever B et al.: Successful prevalidation of the slug mucosal irritation test to assess the eye irritation potency of chemicals. Toxicol. In Vitro 22, 1285-1296 (2008).
    • (2008) Toxicol. In Vitro , vol.22 , pp. 1285-1296
    • Adriaens, E.1    Bytheway, H.2    De Wever, B.3
  • 102
    • 38349175746 scopus 로고    scopus 로고
    • Alternative methods for eye and skin irritation tests: An overview
    • Vinardell MP, Mitjans M: Alternative methods for eye and skin irritation tests: an overview. Pharm. J. Sci. 97, 46-59 (2008).
    • (2008) Pharm. J. Sci , vol.97 , pp. 46-59
    • Vinardell, M.P.1    Mitjans, M.2
  • 103
    • 29144468687 scopus 로고    scopus 로고
    • Prevalidation of a new in vitro reconstituted human cornea model to assess the eye irritating potential of chemicals
    • Van Goethem F, Adriaens E, Alepee N et al.: Prevalidation of a new in vitro reconstituted human cornea model to assess the eye irritating potential of chemicals. Toxicol. In Vitro 20, 1-17 (2006).
    • (2006) Toxicol. In Vitro , vol.20 , pp. 1-17
    • Van Goethem, F.1    Adriaens, E.2    Alepee, N.3
  • 104
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (2006).
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 105
    • 34249908901 scopus 로고    scopus 로고
    • In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
    • Wernig M, Meissner A, Foreman R et al.: In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448, 318-324 (2007).
    • (2007) Nature , vol.448 , pp. 318-324
    • Wernig, M.1    Meissner, A.2    Foreman, R.3
  • 106
    • 34648834682 scopus 로고    scopus 로고
    • The third dimension bridges the gap between cell culture and live tissue
    • Pampaloni F, Reynaud EG, Stelzer EH: The third dimension bridges the gap between cell culture and live tissue. Nat. Rev. Mol. Cell Biol. 8, 839-845 (2007).
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , pp. 839-845
    • Pampaloni, F.1    Reynaud, E.G.2    Stelzer, E.H.3
  • 107
    • 34247882949 scopus 로고    scopus 로고
    • High-resolution three-dimensional imaging of large specimens with light sheet-based microscopy
    • Verveer PJ, Swoger J, Pampaloni F, Greger K, Marcello M, Stelzer EH: High-resolution three-dimensional imaging of large specimens with light sheet-based microscopy. Nat. Methods 4, 311-313 (2007).
    • (2007) Nat. Methods , vol.4 , pp. 311-313
    • Verveer, P.J.1    Swoger, J.2    Pampaloni, F.3    Greger, K.4    Marcello, M.5    Stelzer, E.H.6


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