Design, synthesis and preliminary biological evaluation of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives as novel histone deacetylase inhibitors

European Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2009, Pages 4470-4476

  Jiao, Jie ^a   Fang, Hao ^a   Wang, Xuejian ^a   Guan, Peng ^a   Yuan, Yumei ^a   Xu, Wenfang ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Anticancer agents; Cell cycle arrest; Histone deacetylase inhibitors; HPPB; N Hydroxybenzamide

Indexed keywords

4 [3 (3,4 DIMETHOXYPHENYL)PROPANAMIDO]N HYDROXYBENZAMIDE; 4 [3 (4 BUTOXY 3 METHOXYPHENYL)PROPANAMIDO]N HYDROXYBENZAMIDE; 4 [3 (4 ETHOXY 3 METHOXYPHENYL)PROPANAMIDO]N HYDROXYBENZAMIDE; 4 [3 (4 SEC BUTOXY 3 METHOXYPHENYL)PROPANAMIDO]N HYDROXYBENZAMIDE; 4 [3 (BENZO[D][1,3]DIOXOL 5 YL)PROPANAMIDO)N HYDROXYBENZAMIDE; 4 [3 [4 (2 BROMOBENZYLOXY) 3 METHOXYPHENYL]PROPANAMIDO]N HYDROXYBENZAMIDE; 4 [3 [4 (2 CHLOROBENZYLOXY) 3 METHOXYPHENYL]PROPANAMIDO]N HYDROXYBENZAMIDE; 4 [3 [4 (2 METHYLBENZYLOXY) 3 METHOXYPHENYL]PROPANAMIDO]N HYDROXYBENZAMIDE; 4 [3 [4 (3 BROMOBENZYLOXY) 3 METHOXYPHENYL]PROPANAMIDO]N HYDROXYBENZAMIDE; 4 [3 [4 (3 CHLOROBENZYLOXY) 3 METHOXYPHENYL]PROPANAMIDO]N HYDROXYBENZAMIDE; 4 [3 [4 (3 METHYLBENZYLOXY) 3 METHOXYPHENYL]PROPANAMIDO]N HYDROXYBENZAMIDE; 4 [3 [4 (4 BROMOBENZYLOXY) 3 METHOXYPHENYL]PROPANAMIDO]N HYDROXYBENZAMIDE; 4 [3 [4 (4 CHLOROBENZYLOXY) 3 METHOXYPHENYL]PROPANAMIDO]N HYDROXYBENZAMIDE; 4 [3 [4 (4 METHYLBENZYLOXY) 3 METHOXYPHENYL]PROPANAMIDO]N HYDROXYBENZAMIDE; 4 [3 [4 (CYCLOPENTYLOXY) 3 METHOXYPHENYL]PROPANAMIDO]N HYDROXYBENZAMIDE; 4 [3[4 (BENZYLOXY) 3 METHOXYPHENYL]PROPANAMIDO]N HYDROXYBENZAMIDE; BENZAMIDE DERIVATIVE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; N HYDROXY 4 [3 (3 METHOXY 4 PROPOXYPHENYL)PROPANAMIDO]BENZAMIDE; N HYDROXY 4 [3 [3 METHOXY 4 (PYRIDIN 2 YLMETHOXY)PHENYL]PROPANAMIDO]BENZAMIDE; N HYDROXY 4 [3 [3 METHOXY 4 (THIOPHENE 2 YLMETHOXY)PHENYL]PROPANAMIDO]BENZAMIDE; N HYDROXY 4 [3 [4 (ISOPENTYLOXY) 3 METHOXYPHENYL]PROPANAMIDO]BENZAMIDE; UNCLASSIFIED DRUG; VORINOSTAT;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; COLON CARCINOMA; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; BENZAMIDES; CARCINOMA; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 70349761276     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.06.010     Document Type: Article

References (15)

1. Minucci S., and Pelicci P.G. Nat. Rev. Cancer 6 (2006) 38-51
2. Legube G., and Trouche D. EMBO Rep. 4 (2003) 944-947
3. Kim D.H., Kim M., and Kwon H.J. J. Biochem. Mol. Biol. 36 (2003) 110-119
4. Carew J.S., Giles F.J., and Nawrocki S.T. Cancer Lett. 269 (2008) 7-17
5. Marks P.A., Richon V.M., and Rifkind R.A. J. Natl. Cancer Inst. 92 (2000) 1210-1216
6. Acharya M.R., Sparreboom A., Venitz J., and Figg W.D. Mol. Pharmacol. 68 (2005) 917-932
7. Monneret C. Eur. J. Med. Chem. 40 (2005) 1-13
8. Paris M., Porcelloni M., Binaschi M., and Fattori D. J. Med. Chem. 51 (2008) 1505-1529
9. Madeleine D., and Jenny V. Expert Opin. Investig. Drugs 16 (2007) 1111-1120
10. Jung M., Brosch G., Kolle D., Scherf H., Gerhauser C., and Loidl P. J. Med. Chem. 42 (1999) 4669-4679
11. Woo S.H., Frechette S., Khalil E.A., Bouchain G., Vaisburg A., Bernstein N., Moradei O., Leit S., Allan M., Fournel M., Trachy-Bourget M., Li Z., Besterman J.M., and Delorme D. J. Med. Chem. 45 (2002) 2877-2885
12. Miller T.A., Witter D.J., and Belvedere S. J. Med. Chem. 46 (2003) 5097-5116
13. Lu Q., Wang D.S., Chen C.S., Hu Y.D., and Chen C.S. J. Med. Chem. 48 (2005) 5530-5535
14. Jiao J., Wang Q., Zhu H.W., Hao F., and Xu W.F. Chin. Chem. Lett. 19 (2008) 673-675
15. Pan L., Lu J., and Huang B. Cell. Mol. Immunol. 4 (2007) 337-343