Transplantation and repair: Combined cell implantation and chondroitinase delivery prevents deterioration of bladder function in rats with complete spinal cord injury

Spinal Cord

Volumn 47, Issue 10, 2009, Pages 727-732

  Fouad, K ^a   Pearse, D D ^b   Tetzlaff, W ^c   Vavrek, R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Bladder; Collagen; Combined treatment; Schwann cells; Spinal cord injury

Indexed keywords

ACTIN; AMPICILLIN; CHONDROITIN ABC LYASE; COLLAGEN TYPE 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER FUNCTION; BLADDER WALL; CANADA; CELL TRANSPLANTATION; CONTROLLED STUDY; FEMALE; NERVE FIBER REGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; SCHWANN CELL; SMOOTH MUSCLE FIBER; SPINAL CORD INJURY; THORACIC SPINAL CORD; URINE INCONTINENCE;

ANIMALS; CHONDROITIN ABC LYASE; CHONDROITINASES AND CHONDROITIN LYASES; CICATRIX; COLLAGEN; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; FEMALE; LAMININ; MUSCLE, SMOOTH; NERVE REGENERATION; NEUROGLIA; OLFACTORY BULB; PROTEOGLYCANS; RATS; RATS, INBRED F344; RECOVERY OF FUNCTION; SCHWANN CELLS; SPINAL CORD INJURIES; TISSUE TRANSPLANTATION; TREATMENT OUTCOME; URINARY BLADDER; URINARY BLADDER, NEUROGENIC;

EID: 70349748600     PISSN: 13624393     EISSN: 14765624     Source Type: Journal    
DOI: 10.1038/sc.2009.10     Document Type: Article

References (21)

1. Noto H, Roppolo JR, Steers WD, de Groat WC. Electrophysiological analysis of the ascending and descending components of the micturition reflex pathway in the rat. Brain Res 1991; 549: 95-105.
2. Marson L. Identification of central nervous system neurons that innervate the bladder body, bladder base, or external urethral sphincter of female rats: a transneuronal tracing study using pseudorabies virus. J Comp Neurol 1997; 389: 584-602. (Pubitemid 28355027)
3. de Groat WC, Kawatani M, Hisamitsu T, Cheng CL, Ma CP, Thor K et al. Mechanisms underlying the recovery of urinary bladder function following spinal cord injury. J Auton Nerv Syst 1990; 30: 71-77. (Pubitemid 20244728)
4. Pikov V, Wrathall JR. Coordination of the bladder detrusor and the external urethral sphincter in a rat model of spinal cord injury: effect of injury severity. J Neurosci 2001; 21: 559-569. (Pubitemid 32107445)
5. Nagatomi J, Gloeckner DC, Chancellor M, DeGroat RD, Sacks MS. Changes in the biaxial viscoelastic response of the urinary bladder following spinal cord injury. Ann Biomed Eng 2004; 32: 1409-1419.
6. Nagatomi J, Toosi KK, Grashow JS, Chancellor MB, Sacks MS. Quantification of bladder smooth muscle orientation in normal and spinal cord injured rats. Ann Biomed Eng 2005; 33: 1078-1089. (Pubitemid 41165011)
7. Yoshiyama M, Nez FM, Yokoyama O, de Groat WC, Chancellor MB. Changes in micturition after spinal cord injury in conscious rats. Urology 1999; 54: 929-933. (Pubitemid 29505602)
8. Fouad K, Schnell L, Bunge MB, Schwab ME, Liebscher T, Pearse DD. Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord. J Neurosci 2005; 25: 1169-1178. (Pubitemid 40268958)
9. Vavrek R, Pearse DD, Fouad K. Neuronal populations capable of regeneration following a combined treatment in rats with spinal cord transection. J Neurotrauma 2007; 24: 1667-1673. (Pubitemid 350035836)
10. Pearse DD, Sanchez AR, Pereira FC, Andrade CM, Puzis R, Pressman Y et al. Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: survival, migration, axon association, and functional recovery. Glia 2007; 55: 976-1000. (Pubitemid 46903998)
11. Newton BW, Hamill RW. The morphology and distribution of rat serotonergic intraspinal neurons: an immunohistochemical study. Brain Res Bull 1988; 20: 349-360. (Pubitemid 19271662)
12. Mitsui T, Kakizaki H, Tanaka H, Shibata T, Matsuoka I, Koyanagi T. Immortalized neural stem cells transplanted into the injured spinal cord promote recovery of voiding function in the rat. J Urol 2003; 170: 1421-1425. (Pubitemid 37108174)
13. Mitsui T, Fischer I, Shumsky JS, Murray M. Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder and hindlimb function following spinal contusion injury in rats. Exp Neurol 2005; 194: 410-431. (Pubitemid 40967000)
14. Caggiano AO, Zimber MP, Ganguly A, Blight AR, Gruskin EA. Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cord. J Neurotrauma 2005; 22: 226-239. (Pubitemid 40333517)
15. Mimata H, Satoh F, Tanigawa T, Nomura Y, Ogata J. Changes of rat urinary bladder during acute phase of spinal cord injury. Urol Int 1993; 51: 89-93. (Pubitemid 23230882)
16. Deveaud CM, Macarak EJ, Kucich U. Molecular analysis of collagens in bladder fibrosis. J Urol 1998; 160: 1518-1527. (Pubitemid 29480571)
17. Uvelius B, Mattiasson A. Collagen content in the rat urinary bladder subjected to intravesical outflow obstruction. J Urol 1984; 132: 587-590. (Pubitemid 14026180)
18. de Groat WC. Influence of central serotonergic mechanisms on lower urinary tract function. Urology 2002; 59: 30-36. (Pubitemid 34462256)
19. Lecci A, Giuliani S, Santicioli P, Maggi CA. Involvement of 5-hydroxytryptamine1A receptors in the modulation of micturition reflexes in the anesthetized rat. J Pharmacol Exp Ther 1992; 262: 181-189.
20. Leung PY, Johnson CS, Wrathall JR. Comparison of the effects of complete and incomplete spinal cord injury on lower urinary tract function as evaluated in anaesthetized rats. Exp Neurol 2007; 208: 80-91.
21. McMahon BB, Spillane K. Brainstem influences on the parasympathetic supply to the urinary bladder of the cat. Brain Res 1982; 234: 237-249. (Pubitemid 12175891)