Cytokines in the brain: From localization and function to clinical implications

NeuroImmune Biology

Volumn 1, Issue C, 2001, Pages 365-371

  Licinio, Julio ^a,b   Wong, Ma Li ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Gonda Genetics Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 70349742926     PISSN: 15677443     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1567-7443(01)80032-6     Document Type: Article

References (24)

1. Licinio J., and Wong M.L. Pathways and mechanisms for cytokine signaling of the central nervous system. J Clin Invest 100 (1997) 2941-2947
2. Sternberg E.M. Neural-immune interactions in health and disease. J Clin Invest 100 (1997) 2641-2647
3. Li P., Allen H., Banerjee S., Franklin S., Herzog L., Johnston C., et al. Mice deficient in IL-1β converting enzyme are defective in production of mature IL-1β and resistant to endototoxic shock. Cell 80 (1995) 401-411
4. Hannum C.H., Wilcox C.J., Arend W.P., Joslin F.G., Dripps D.J., Heimdal P.L., et al. Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature 343 (1990) 336-340
5. Eisenberg S.P., Evans R.J., Arend W.P., Verderber E., Brewer M.T., Hannum C.H., et al. Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature 343 (1990) 341-346
6. Ohlsson K., Bjork P., Bergenfeldt M., Hageman R., and Thompson R.C. Interleukin-1 receptor antagonist reduces mortality from endotoxin shock. Nature 348 (1990) 550-552
7. Licinio J., Wong M.L., and Gold P.W. Localization of interleukin-1 receptor antagonist mRNA in rat brain. Endocrinology 129 (1991) 562-564
8. Loddick S.A., Wong M.L., Bongiorno P.B., Gold P.W., Licinio J., and Rothwell N.J. Endogenous interleukin-1 receptor antagonist is neuroprotective. Biochem Biophys Res Commun 234 (1997) 211-215
9. Yang G.Y., Mao Y., Zhou L.F., Ye W., Liu X.H., Gong C., et al. Attenuation of temporary focal cerebral ischemic injury in the mouse following transfection with interleukin-1 receptor antagonist. Brain Res Mol Brain Res 72 (1999) 129-137
10. Wong M.L., Bongiorno P.B., Rettori V., McCann S.M., and Licinio J. Interleukin (IL) 1beta, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior-pituitary during systemic inflammation: pathophysiological implications. Proc Natl Acad Sci USA 94 (1997) 227-232
11. Laye S., Gheusi G., Cremona S., Combe C., Kelley K., Dantzer R., et al. Endogenous brain IL-1 mediates LPS-induced anorexia and hypothalamic cytokine expression. Am J Physiol 279 (2000) R93-R98
12. Eriksson C., Nobel S., Winblad B., and Schultzberg M. Expression of interleukin 1 alpha and beta, and interleukin 1 receptor antagonist mRNA in the rat central nervous system after peripheraladministration of lipopolysaccharides. Cytokine 12 (2000) 423-431
13. Eriksson C., Tehranian R., Iverfeldt K., Winblad B., and Schultzberg M. Increased expression of mRNA encoding interleukin-1 beta and caspase-1, and the secreted isoform of interleukin-1 receptor antagonist in the rat brain following systemic kainic acid administration. J Neurosci Res 60 (2000) 266-279
14. Herx L.M., Rivest S., and Yong V.W. Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor. J Immunol 165 (2000) 2232-2239
15. Stern E.L., Quan N., Proescholdt M.G., and Herkenham M. Spatiotemporal induction patterns of cytokine and related immune signal molecule mRNAs in response to intrastriatal injection of lipopolysaccharide. J Neuroimmunol 106 (2000) 114-129
16. Plata-Salaman C.R., Ilyin S.E., Turrin N.P., Gayle D., Flynn M.C., Romanovitch A.E., et al. Kindling modulates the IL-1 beta system, TNF-alpha, TGF-beta1, and neuropeptide mRNAs in specific brain regions. Brain Res Mol Brain Res 75 (2000) 248-258
17. Nguyen K.T., Deak T., Owens S.M., Kohno T., Fleshner M., Watkins L.R., et al. Exposure to acute stress induces brain interleukin-1 beta protein in the rat. J Neurosci 18 (1998) 2239-2246
18. Tanebe K., Nishijo H., Muraguchi A., and Ono T. Effects of chronic stress on hypothalamic interleukin-1 beta, interleukin-2, and gonadotrophin-releasing hormone gene expression in ovariectomized rats. J Neuroendocrinol 12 (2000) 13-21
19. Parker L.C., Rushforth D.A., Rothwell N.J., and Luheshi G.N. IL-1 beta induced changes in hypothalamic IL-1R1 and IL-1R2 mRNA expression in the rat. Brain Res Mol Brain Res 79 (2000) 156-158
20. Li X., and Wang X. application of real-time polymerase chain reaction for the quantitation of interleukin-1 beta mRNA upregulation in brain ischemic tolerance. Brain Res Brain Res Protoc. 5 (2000) 211-217
21. Hosoi T., Okuma Y., and Nomura Y. Electrical stimulation of afferent vagus nerve induces IL-1beta expression in the brain and activates HPA axis. Am J Physiol 279 (2000) R141-R147
22. Ilyin S.E., and Plata-Salaman C.R. An efficient, reliable and inexpensive device for the rapid homogenization of multiple tissue samples by centrifugation. J Neurosci Methods 95 (2000) 123-125
23. Brown H., Turner G., Rogerson S., Tembo M., Mwenechanya J., Molyneux M., et al. Cytokine expression in the brain in human cerebral malaria. J Infect Dis 180 (1999) 1742-1746
24. Knoblach S.M., and Faden A.I. Cortical interleukin-1 beta elevation after traumatic brain injury in the rat: no effect of two selective antagonists on motor recovery. Neurosci Lett 289 (2000) 5-8