High frequency of de novo mutations in Li-Fraumeni syndrome

Journal of Medical Genetics

Volumn 46, Issue 10, 2009, Pages 689-693

  Gonzalez, K D ^a,b   Buzin, C H ^a,b   Noltner, K A ^b   Gu, D ^b,c   Li, W ^b   Malkin, D ^d   Sommer, S S ^a,b  

^a MEDomics   (United States)

^b Department of Molecular Genetics City of Hope ^*  (United States)

^c Bioinformatics Group   (United States)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ADULT; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CANCER SUSCEPTIBILITY; EARLY CANCER; FAMILIAL CANCER; FAMILY HISTORY; FEMALE; GENE; GENE FREQUENCY; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TP53 GENE;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HUMANS; LI-FRAUMENI SYNDROME; MALE; MIDDLE AGED; MUTATION, MISSENSE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 70349705753     PISSN: 00222593     EISSN: 14686244     Source Type: Journal    
DOI: 10.1136/jmg.2008.058958     Document Type: Article

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