Effect of As2O3 on demethylation of SHP-1 gene in human lymphoma cell line T2

Chinese Journal of Cancer

Volumn 28, Issue 3, 2009, Pages 209-213

  Yang, Lin ^a,b   Luo, Jian Min ^a,b   Wen, Shu Peng ^a,b   Liu, Xiao Jun ^a,b   Du, Xing Yan ^a,b   Li, Yan ^a,b  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Key Laboratory of Hematology of Hebei Province   (China)

Author keywords

Apoptosis; As2O3; c kit; Lymphoma; Methylation; Proliferation; SHP 1; Signal transduction; T2 cell

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ARSENIC TRIOXIDE; MESSENGER RNA; PROTEIN TYROSINE PHOSPHATASE SHP 1; STEM CELL FACTOR RECEPTOR; TETRAZOLIUM;

APOPTOSIS; ARTICLE; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DEMETHYLATION; DOWN REGULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOMA; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 70349696066     PISSN: 1000467X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Kantarjian HM, O'Brein S, Cortes J, et al. Results of decitabine (5-aza-2′ deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia [J]. Cancer, 2003,98(3):522-528.
2. Yuan YF, Li JQ, Yang ZL, et al. The roles of DNA methylation in human neoplasms [J]. Ai Zheng, 2002,21(11):1267-1277.
3. Reddy J, Shivapurkar N, Takahashi T, et al. Differential methylation of genes that regulate cytokine signaling in lymphoid and hematopoietic tumors [J]. Oncogene, 2005,24(4):732-736.
4. Wu C, Sun M, Liu L, et al. The function of the protein tyrosine phosphatase SHP-1 in cancer[J]. Gene,2003,306(3):1-12.
5. Oka T, Yoshino T, Hayashi K, et al. Reduction of hematopoietic cell-specific tyrosine phosphatase SHP-1 gene expression in natural killer cell lymphoma and various types lymphomas/leukemia [J]. Am J Pathol, 2001,159(4):495-505.
6. Kozlowski M, Larose L, Lee F, et al. SHP-1 binds and negatively modulates the c-kit receptor by interaction with tyrosine 569 in the c-kit juxtamembrane domain [J]. Mol Cell Biol, 1998,18(4):2089-2099.
7. Koyma M, Oka T, Ouchida M, et al. Activated proliferation of B-cell lymphomas/leukemias with the SHP-1 gene silencing by aberrant CpG methyllation [J]. Lab Invest, 2003,83(12):1849-1858.
8. Witkiewicz A, Raghunath P, Wasik A, et al. Loss of SHP-1 tyrosine phosphatase expression correlates with the advanced stages of cutaneous T-cell lymphoma [J]. Hum Pathol, 2007,38(3):462-467.
9. Mare JM, Wang LJ. Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene P52 in human lung cell: a model for a mechanism of carcinogenesis [J]. Mutat Res, 1997,386(3):263-277.
10. Li JQ, Li Y, Shi YJ, et al. Re-expression of p16 gene in myeloma cell line U266 by arsenic trioxide [J]. Ai Zheng, 2004,23(6):626-630.
11. Jin ZJ. Addition in drug combination [J]. Zhongguo Yao Li Xue Bao, 1980,1(2):70-76.
12. Oka T, Ouchida M, Kovama M, et al. Gene silencing of the tyrosine phosphatase SHP-1 gene by aberrant methylation in leukemia/lymphomas [J]. Cancer Res, 2002,62(22):6390-6394.
13. Herbst R, Munemitsu S, Ullrich A. Oncogenic activation of v-kit involves deletion of a putative tyrosine-substrate interaction site [J]. Oncogene, 1995,10(2):369-379.
14. Heinrich MC, Blanke CD, Druker BJ, et al. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies [J]. J Clin Oncol, 2002,20(6):1692-1703.