Evidence for oesophageal visceral hypersensitivity and aberrant symptom referral in patients with globus

Neurogastroenterology and Motility

Volumn 21, Issue 11, 2009, Pages

  Chen, C L ^a,b   Szczesniak, M M ^b   Cook, I J ^a,b  

^a BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Globus; Oesophageal sensory function; Visceral hypersensitivity

Indexed keywords

ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; ELECTROSTIMULATION; ESOPHAGEAL VISCERAL HYPERSENSITIVITY; HUMAN; HYPERSENSITIVITY; HYPOTHESIS; INTESTINE DISTENSION; MANOMETRY; NOCICEPTION; PAIN THRESHOLD; PRIORITY JOURNAL; REFERRED PAIN; SENSORY STIMULATION; THROAT TIGHTNESS;

ADULT; BALLOON DILATION; ELECTRIC STIMULATION; ESOPHAGEAL DISEASES; ESOPHAGUS; FEMALE; HUMANS; HYPERALGESIA; MALE; MIDDLE AGED; PAIN; PAIN THRESHOLD; YOUNG ADULT;

EID: 70349686815     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2009.01316.x     Document Type: Article

References (46)

1. Moloy PJ, Charter R. The globus symptom. Incidence, therapeutic response, and age and sex relationships. Arch Otolaryngol 1982 108 : 740 744.
2. Thompson WG, Heaton KW. Heartburn and globus in apparently healthy people. Can Med Assoc J 1982 126 : 46 8.
3. Locke GR III, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ III. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology 1997 112 : 1448 1456.
4. Galmiche JP, Clouse RE, Balint A et al. Functional esophageal disorders. Gastroenterology 2006 130 : 1459 1465.
5. Watson WC, Sullivan SN. Hypertonicity of the cricopharyngeal sphincter: a cause of globus sensation. Lancet 1974 2 : 1417 1419.
6. Puhakka HJ, Kirveskari P. Globus hystericus: globus syndrome? J Laryngol Otol 1988 102 : 231 234.
7. Wilson JA, Pryde A, Piris J et al. Pharyngoesophageal dysmotility in globus sensation. Arch Otolaryngol Head Neck Surg 1989 115 : 1086 1090.
8. Batch AJ. Globus pharyngeus (Part I). J Laryngol Otol 1988 102 : 152 158.
9. Hill J, Stuart RC, Fung HK et al. Gastroesophageal reflux, motility disorders, and psychological profiles in the etiology of globus pharyngis. Laryngoscope 1997 107 : 1373 1377.
10. Batch AJ. Globus pharyngeus: (Part II), discussion. J Laryngol Otol 1988 102 : 227 230.
11. Wilson JA, Heading RC, Maran AG, Pryde A, Piris J, Allan PL. Globus sensation is not due to gastro-oesophageal reflux. Clin Otolaryngol Allied Sci 1987 12 : 271 275.
12. Harris MB, Deary IJ, Wilson JA. Life events and difficulties in relation to the onset of globus pharyngis. J Psychosom Res 1996 40 : 603 615.
13. Edwards DAW. Discriminatory value of symptoms in the differential diagnosis of dysphagia. Clin Gastroenterol 1976 5 : 49 57.
14. Jones B, Ravich WJ, Donner MW, Kramer SS, Hendrix TR. Pharyngoesophageal interrelationships: observations and working concepts. Gastrointest Radiol 1985 10 : 225 233.
15. Cook IJ. Role of mechanical and chemical stimulation of the esophagus in globus sensation. Gastroenterology 1989 96 : A99.
16. Mertz H. Review article: visceral hypersensitivity. Aliment Pharmacol Ther 2003 17 : 623 633.
17. Andreollo NA, Thompson DG, Kendall GP, Earlam RJ. Functional relationships between cricopharyngeal sphincter and oesophageal body in response to graded intraluminal distension. Gut 1988 29 : 161 166.
18. Mertz H, Naliboff B, Munakata J, Niazi N, Mayer EA. Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology 1995 109 : 40 52.
19. Drewes AM, Schipper KP, Dimcevski G et al. Gut pain and hyperalgesia induced by capsaicin: a human experimental model. Pain 2003 104 : 333 341.
20. Cook IJ, Dent J, Collins SM. Upper esophageal sphincter tone and reactivity to stress in patients with a history of globus sensation. Dig Dis Sci 1989 34 : 672 676.
21. Back GW, Leong P, Kumar R, Corbridge R. Value of barium swallow in investigation of globus pharyngeus. J Laryngol Otol 2000 114 : 951 954.
22. Caldarelli DD, Andrews AH Jr, Derbyshire AJ. Esophageal motility studies in globus sensation. Ann Otol Rhinol Laryngol 1970 79 : 1098 1100.
23. Moser G, Wenzel-Abatzi TA, Stelzeneder M et al. Globus sensation: pharyngoesophageal function, psychometric and psychiatric findings, and follow-up in 88 patients. Arch Intern Med 1998 158 : 1365 1373.
24. Chevalier JM, Brossard E, Monnier P. Globus sensation and gastroesophageal reflux. Eur Arch Otorhinolaryngol 2003 260 : 273 276.
25. Kibblewhite DJ, Morrison MD. A double-blind controlled study of the efficacy of cimetidine in the treatment of the cervical symptoms of gastroesophageal reflux. J Otolaryngol 1990 19 : 103 109.
26. Richter JE, Barish CF, Castell DO. Abnormal sensory perception in patients with esophageal chest pain. Gastroenterology 1986 91 : 845 852.
27. Mertz H, Fullerton S, Naliboff B, Mayer EA. Symptoms and visceral perception in severe functional and organic dyspepsia. Gut 1998 42 : 814 822.
28. Mearin F, Cucala M, Azpiroz F, Malagelada JR. The origin of symptoms on the brain-gut axis in functional dyspepsia. Gastroenterology 1991 101 : 999 1006.
29. Gebhart GF. Visceral pain-peripheral sensitisation. Gut 2000 47 (Suppl. 4 iv54 5 discussion iv8.
30. Blackshaw LA, Brookes SJ, Grundy D, Schemann M. Sensory transmission in the gastrointestinal tract. Neurogastroenterol Motil 2007 19 : 1 19.
31. Sengupta JN. Electrophysiological recording from neurons controlling sensory and motor functions of the esophagus. Am J Med 2001 111 (Suppl. 8A 169S 73S.
32. Zagorodnyuk VP, Brookes SJ. Transduction sites of vagal mechanoreceptors in the guinea pig esophagus. J Neurosci 2000 20 : 6249 6255.
33. Mayer EA, Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 1994 107 : 271 293.
34. Page AJ, Blackshaw LA. An in vitro study of the properties of vagal afferent fibres innervating the ferret oesophagus and stomach. J Physiol 1998 512 (Pt 3 907 916.
35. Sarkar S, Aziz Q, Woolf CJ, Hobson AR, Thompson DG. Contribution of central sensitisation to the development of non-cardiac chest pain. Lancet 2000 356 : 1154 1159.
36. Sarkar S, Hobson AR, Furlong PL, Woolf CJ, Thompson DG, Aziz Q. Central neural mechanisms mediating human visceral hypersensitivity. Am J Physiol Gastrointest Liver Physiol 2001 281 : G1196 202.
37. Frieling T, Enck P, Wienbeck M. Cerebral responses evoked by electrical stimulation of the esophagus in normal subjects. Gastroenterology 1989 97 : 475 478. (Pubitemid 19192187)
38. de Caestecker JS, Pryde A, Heading RC. Site and mechanism of pain perception with oesophageal balloon distension and intravenous edrophonium in patients with oesophageal chest pain. Gut 1992 33 : 580 586.
39. Sengupta JN, Saha JK, Goyal RK. Stimulus-response function studies of esophageal mechanosensitive nociceptors in sympathetic afferents of opossum. J Neurophysiol 1990 64 : 796 812.
40. Lang IM, Medda BK, Shaker R. Mechanisms of reflexes induced by esophageal distension. Am J Physiol Gastrointest Liver Physiol 2001 281 : G1246 63.
41. Frokjaer JB, Andersen SD, Gale J, Arendt-Nielsen L, Gregersen H, Drewes AM. An experimental study of viscero-visceral hyperalgesia using an ultrasound-based multimodal sensory testing approach. Pain 2005 119 : 191 200.
42. Yaksh TL, Hua XY, Kalcheva I, Nozaki-Taguchi N, Marsala M. The spinal biology in humans and animals of pain states generated by persistent small afferent input. Proc Natl Acad Sci USA 1999 96 : 7680 7686.
43. Qin C, Chandler MJ, Jou CJ, Foreman RD. Responses and afferent pathways of C1-C2 spinal neurons to cervical and thoracic esophageal stimulation in rats. J Neurophysiol 2004 91 : 2227 2235.
44. Munakata J, Naliboff B, Harraf F et al. Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome. Gastroenterology 1997 112 : 55 63.
45. Clouse RE, Lustman PJ. Psychiatric illness and contraction abnormalities of the esophagus. N Engl J Med 1983 309 : 1337 1342.
46. Richter JE, Obrecht WF, Bradley LA, Young LD, Anderson KO. Psychological comparison of patients with nutcracker esophagus and irritable bowel syndrome. Dig Dis Sci 1986 31 : 131 138.