Thymus transplantation

Thymus Gland Pathology: Clinical, Diagnostic, and Therapeutic Features

Volumn , Issue , 2008, Pages 255-267

  Markert, M Louise ^a   Devlin, Blythe H ^a   McCarthy, Elizabeth A ^a   Chinn, Ivan K ^a   Hale, Laura P ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 70349676133     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-88-470-0828-1_30     Document Type: Chapter

References (65)

1. Cleveland WW, Fogel BJ, Brown WT, Kay HE (1968) Foetal thymic transplant in a case of DiGeorge's syndrome. Lancet 2:1211-1214
2. August CS, Rosen FS, Filler RM et al (1968) Implantation of a foetal thymus, restoring immunological competence in a patient with thymic aplasia (DiGeorge's syndrome). Lancet 2:1210-1211
3. Wara DW, Golbus MS, Ammann AJ (1974) Fetal thymus glands obtained from prostaglandin-induced abortions. Cellular immune function in vitro and evidence of in vivo thymocyte activity following transplantation. Transplantation 18:387-390
4. Shearer WT, Wedner HJ, Strominger DB et al (1978) Successful transplantation of the thymus in Nezelof's syndrome. Pediatrics 61:619-624
5. Pahwa S, Pahwa R, Incefy G et al (1979) Failure of im-munologic reconstitution in a patient with the DiGeorge syndrome after fetal thymus transplantation. Clin Immunol Immunopathol 14:96-106
6. Hong R (1986) Reconstitution of T-cell deficiency by thymic hormone or thymus transplantation therapy. Clin Immunol Immunopathol 40:136-141
7. Hong R (1983) Thymus transplantation. Birth Defects Original Article Series 19:259-265
8. Hong R, Schulte-Wissermann H, Jarrett-Toth E et al (1979) Transplantation of cultured thymic fragments. II. Results in nude mice. J Exp Med 149:398-415
9. Barry TS, Jones DM, Richter CB, Haynes BF (1991) Successful engraftment of human postnatal thymus in severe combined immune deficient (SCID) mice: Differential engraftment of thymic components with irradiation versus anti-asialo GM-1 immunosuppressive regimens. J Exp Med 173:167-180
10. Lobach DF, Scearce RM, Haynes BF (1985) The human thymic microenvironment. Phenotypic characterization of Hassall's bodies with the use of monoclonal antibodies. J Immunol 134:250-257
11. McFarland EJ, Scearce RM, Haynes BF (1984) The human thymic microenvironment: Cortical thymic epithelium is an antigenically distinct region of the thymic microenvironment. J Immunol 133:1241-1249
12. Haynes BF, Scearce RM, Lobach DF, Hensley LL (1984) Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment. J Exp Med 159:1149-1168
13. Haynes BF, Denning SM, Singer KH, Kurtzberg J (1989) Ontogeny of T-cell precursors: A model for the initial stages of human T-cell development. Immunol Today 10:87-91
14. van Ewijk W (1991) T-cell differentiation is influenced by thymic microenvironments. Annu Rev Immunol 9:591-615
15. Markert ML, Watson TJ, Kaplan I et al (1997) The human thymic microenvironment during organ culture. Clin Immunol Immunopathol 82:26-36
16. Picker LJ, Treer JR, Ferguson-Darnell B et al (1993) Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition. J Immunol 150:1105-1121
17. Markert ML, Hummell DS, Rosenblatt HM et al (1998) Complete DiGeorge syndrome: Persistence of profound immunodeficiency. J Pediatr 132:15-21
18. Bastian J, Law S, Vogler L et al (1989) Prediction of persistent immunodeficiency in the DiGeorge anomaly. J Pediatr 115:391-396
19. Muller W, Peter HH, Wilken M et al (1988) The DiGe-orge syndrome. I. Clinical evaluation and course of partial and complete forms of the syndrome. Eur J Pediatr 147:496-502
20. Thomas RA, Landing BH, Wells TR (1987) Embry-ologic and other developmental considerations of thirty-eight possible variants of the DiGeorge anomaly. Am J Med Genet (Suppl) 3:43-66
21. Hong R (1991) The DiGeorge anomaly. Immunodefic Rev 3:1-14
22. Conley ME, Beckwith JB, Mancer JF, Tenckhoff L (1979) The spectrum of the DiGeorge syndrome. J Pe-diatr 94:883-890
23. Barrett DJ, Ammann AJ, Wara DW et al (1981) Clinical and immunologic spectrum of the DiGeorge syndrome. J Clin Lab Immunol 6:1-6
24. Ryan AK, Goodship JA, Wilson DI et al (1997) Spectrum of clinical features associated with interstitial chromosome 22q11 deletions: A European collaborative study. J Med Genet 34:798-804
25. Robin NH, Shprintzen RJ (2005) Defining the clinical spectrum of deletion 22q11.2. J Pediatr 147:90-96
26. Markert ML, Devlin BH, Alexieff MJ et al (2007) Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: Outcome of 44 consecutive transplants. Blood 109:4539-4547
27. Wilson DI, Goodship JA, Burn J et al (1992) Deletions within chromosome 22q11 in familial congenital heart disease. Lancet 340:573-575
28. Driscoll DA, Budarf ML, Emanuel BS (1992) A genetic etiology for DiGeorge syndrome: Consistent deletions and microdeletions of 22q11. Am J Hum Genet 50:924-933
29. Pagon RA, Graham JM Jr, Zonana J, Yong SL (1981) Coloboma, congenital heart disease, and choanal atresia with multiple anomalies: CHARGE association. J Pediatr 99:223-227
30. Blake KD, Davenport SL, Hall BD et al (1998) CHARGE association: An update and review for the primary pediatrician. Clin Pediatr (Phila) 37:159-173
31. Vissers LE, van Ravenswaaij CM, Admiraal R et al (2004) Mutations in a new member of the chromodomain gene family cause CHARGE syndrome. Nat Genet 36:955-957
32. Wang R, Martinez-Frias ML, Graham JM Jr (2002) Infants of diabetic mothers are at increased risk for the oculo-auriculo-vertebral sequence: A case-based and case-control approach. J Pediatr 141:611-617
33. Gosseye S, Golaire MC, Verellen G et al (1982) Association of bilateral renal agenesis and DiGeorge syndrome in an infant of a diabetic mother. Helv Paediatr Acta 37:471-474
34. Markert ML, Alexieff MJ, Li J et al (2004) Complete DiGeorge syndrome: Development of rash, lympha-denopathy, and oligoclonal T cells in 5 cases. J Allergy Clin Immunol 113:734-741
35. Archer E, Chuang TY, Hong R (1990) Severe eczema in a patient with DiGeorge's syndrome. Cutis 45:455-459
36. Pirovano S, Mazzolari E, Pasic S et al (2003) Impaired thymic output and restricted T-cell repertoire in two infants with immunodeficiency and early-onset generalized dermatitis. Immun Lett 86:93-97
37. Omenn GS (1965) Familial Reticuloendotheliosis with Eosinophilia. New Engl J Med 273:427-432
38. Villa A, Sobacchi C, Notarangelo LD et al (2001) V(D)J recombination defects in lymphocytes due to RAG mutations: Severe immunodeficiency with a spectrum of clinical presentations. Blood 97:81-88
39. Rieux-Laucat F, Bahadoran P, Brousse N et al (1998) Highly restricted human T cell repertoire in peripheral blood and tissue-infiltrating lymphocytes in Omenn's syndrome. J Clin Invest 102:312-321
40. Markert ML, Alexieff MJ, Li J et al (2004) Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome. Blood 104:2574-2581
41. Douek DC, McFarland RD, Keiser PH et al (1998) Changes in thymic function with age and during the treatment of HIV infection. Nature 396:690-695
42. Ocejo-Vinyals JG, Lozano MJ, Sanchez-Velasco P et al (2000) An unusual concurrence of graft versus host disease caused by engraftment of maternal lymphocytes with DiGeorge anomaly. Arch Dis Child 83:165-169
43. Gobbi A, Stoddart CA, Malnati MS et al (1999) Human herpesvirus 6 (HHV-6) causes severe thymocyte depletion in SCID-hu Thy/Liv mice. J Exp Med 189:1953-1960
44. Dictor M, Fasth A, Olling S (1984) Abnormal B-cell proliferation associated with combined immunodeficiency, cytomegalovirus, and cultured thymus grafts. Am J Clin Pathol 82:487-490
45. Borzy MS, Hong R, Horowitz SD et al (1979) Fatal lymphoma after transplantation of cultured thymus in children with combined immunodeficiency disease. New Engl J Med 301:565-568
46. Hanto DW, Frizzera G, Gajl-Peczalska KJ, Simmons RL (1985) Epstein-Barr virus, immunodeficiency, and B cell lymphoproliferation. Transplantation 39:461-472
47. Reece ER, Gartner JG, Seemayer TA et al (1981) Ep-stein-Barr virus in a malignant lymphoproliferative disorder of B-cells occurring after thymic epithelial transplantation for combined immunodeficiency. Cancer Res 41:4243-4247
48. 2006. Title 21-Food and Drugs; Chapter I-Food and Drug Administration, Department of Health and Human; Subchapter L-Regulations Under Certain Other Acts Administered by the Food and Drug Administration, Part 1270 Human Tissue intended for Transplantation. Code of Federal Regulations
49. Hong R, Moore AL (1996) Organ culture for thymus transplantation. Transplantation 61:444-448
50. 2006. Title 21-Food and Drugs; Chapter I-Food and Drug Administration, Department of Health and Human; Subchapter L-Regulations Under Certain Other Acts Administered by the Food and Drug Administration, Part 1271 Human Tissue Intended for Transplantation. Code of Federal Regulations
51. Rice HE, Skinner MA, Mahaffey SM et al (2004) Thymic transplantation for complete DiGeorge syndrome: Medical and surgical considerations. J Pediatr Surg 39:1607-1615
52. Ham Pong AJ, Cavallo A, Holman GH, Goldman AS (1985) DiGeorge syndrome: Long-term survival complicated by Graves disease. J Pediatr 106:619-620
53. Brown JJ, Datta V, Browning MJ, Swift PG (2004) Graves' disease in DiGeorge syndrome: Patient report with a review of endocrine autoimmunity associated with 22q11.2 deletion. J Pediatr Endocrinol Metab 17:1575-1579
54. Choi JH, Shin YL, Kim GH et al (2005) Endocrine manifestations of chromosome 22q11.2 microdeletion syndrome. Horm Res 63:294-299
55. Scuccimarri R, Rodd C (1998) Thyroid abnormalities as a feature of DiGeorge syndrome: A patient report and review of the literature. J Pediatr Endocrinol Metab 11:273-276
56. Mazzolari E, Forino C, Guerci S et al (2007) Long-term immune reconstitution and clinical outcome after stem cell transplantation for severe T-cell immunodeficiency. J Allergy Clin Immunol 120:892-899
57. Levy A, Michel G, Lemerrer M, Philip N (1997) Idio-pathic thrombocytopenic purpura in two mothers of children with DiGeorge sequence: A new component manifestation of deletion 22q11? Am J Med Genet 69:356-359
58. DePiero AD, Lourie EM, Berman BW et al (1997) Recurrent immune cytopenias in two patients with DiGe-orge/velocardiofacial syndrome. J Pediatr 131:484-486
59. Duke SG, McGuirt WF Jr, Jewett T, Fasano MB (2000) Velocardiofacial syndrome: Incidence of immune cy-topenias. Arch Otolaryngol Head Neck Surg 126:1141-1145
60. Welch P, Rose NR, Kite JH Jr (1973) Neonatal thymec-tomy increases spontaneous autoimmune thyroiditis. J Immunol 110:575-577
61. Markert ML, Sarzotti M, Ozaki DA et al (2003) Thymic transplantation in complete DiGeorge syndrome: Im-munologic safety evaluations in twelve patients. Blood 102:1121-1130
62. Chinn IK DB, Li YJ, Markert ML (2008) Long-term tolerance to allogeneic thymus transplants in complete Di-George anomaly. Clinical Immunol 126:277-281
63. Smith CA, Driscoll DA, Emanuel BS et al (1998) Increased prevalence of immunoglobulin A deficiency in patients with the chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome). Clin Diagn Lab 5:415-417
64. Kung SJ, Gripp KW, Stephan MJ et al (2007) Selective IgM deficiency and 22q11.2 deletion syndrome. Ann Allergy Asthma Immunol 99:87-92
65. Shearer W, Rosenblatt HM, Gelman RS et al (2003) Lymphocyte subsets in healthy children from birth through 18 years of age: The Pediatric AIDS Clinical Trials Group P1009 study. J Allergy Clin Immunol 112:973-980