Cellular magnetic resonance imaging for the differentiation of infectious and degenerative vertebral disorders: Preliminary results

Journal of Magnetic Resonance Imaging

Volumn 30, Issue 4, 2009, Pages 901-906

  Bierry, Guillaume ^a   Jehl, François ^a   Holl, Nathalie ^a   Sibilia, Jean ^a   Froelich, Sébastien ^a   Froehlig, Pierre ^a   Dietemann, Jean Louis ^a   Kremer, Stéphane ^a  

^a UNIVERSITY HOSPITAL OF STRASBOURG   (France)

Author keywords

Endplate; Infection; Inflammation; Macrophages; MRI

Indexed keywords

CLIAVIST; FERUCARBOTRAN; SUPERPARAMAGNETIC IRON OXIDE; UNCLASSIFIED DRUG;

ARTICLE; BONE INFECTION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; IMAGE ANALYSIS; IN VIVO STUDY; INTERVERTEBRAL DISK DEGENERATION; MACROPHAGE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SPONDYLITIS;

CONTRAST MEDIA; DISCITIS; FEMALE; FERROSOFERRIC OXIDE; GADOLINIUM; HUMANS; INTERVERTEBRAL DISK DISPLACEMENT; LUMBAR VERTEBRAE; MACROPHAGES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OSTEOMYELITIS; SPINAL DISEASES; STATISTICS, NONPARAMETRIC;

EID: 70349671445     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.21904     Document Type: Article

References (22)

1. Modic MT, Masaryk TJ, Ross JS, Carter JR. Imaging of degenerative disk disease. Radiology 1988;168:177-186.
2. Wilson AJ, Murphy WA, Hardy DC, Totty WG. Transient osteoporosis: transient bone marrow edema? Radiology 1988;167:757-760.
3. Resnick D. Degenerative disease of the spine. In: Resnick D, editor. Diagnosis in bone and joint disorders, 3rd ed. Philadelphia: Saunders; 1995. p 1372-1462.
4. Jevtic V. Vertebral infection. Eur Radiol 2004;14(Suppl 3):E43-52.
5. Modic MT, Steinberg PM, Ross JS, Masaryk TJ, Carter JR. Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology 1988;166:193-199.
6. Daley J, Shearer J, Mastrofrancesco B, Caldwell M. Glucose metabolism in injured tissue: a longitudinal study. Surgery 1990;107:187-192. (Pubitemid 20057283)
7. Kanerva A, Kommonen B, Gronblad M, et al. Inflammatory cells in experimental intervertebral disc injury. Spine 1997;22:2711-2715. (Pubitemid 28100360)
8. Hundt W, Petsch R, Helmberger T, Reiser M. Effect of superparamagnetic iron oxide on bone marrow. Eur Radiol 2000;10:1495-1500. (Pubitemid 30683076)
9. Lee SM, Lee SH, Kang HY, Baek SY, Kim SM, Shin MJ. Assessment of musculoskeletal infection in rats to determine usefulness of SPIO-enhanced MRI. AJR Am J Roentgenol 2007;189:542-548.
10. Fukuda Y, Ando K, Ishikura R, et al. Superparamagnetic iron oxide (SPIO) MRI contrast agent for bone marrow imaging: differentiating bone metastasis and osteomyelitis. Magn Reson Med Sci 2006;5:191-196.
11. Applegate K, Tello R, Ying J. Hypothesis testing III: counts and medians. Radiology 2003;228:603-608. (Pubitemid 37025463)
12. Tali ET. Spinal infections. Eur J Radiol 2004;50:120-133.
13. Burke JG, Watson RW, McCormack D, Dowling FE, Walsh MG, Fitzpatrick JM. Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. J Bone Joint Surg Br 2002;84:196-201. (Pubitemid 34257682)
14. Crock HV. Internal disc disruption. A challenge to disc prolapse fifty years on. Spine 1986;11:650-653.
15. Boos N, Dreier D, Hilfiker E, et al. Tissue characterization of symptomatic and asymptomatic disc herniations by quantitative magnetic resonance imaging. J Orthop Res 1997;15:141-149. (Pubitemid 27111213)
16. Weishaupt D, Zanetti M, Hodler J, et al. Painful lumbar disk derangement: relevance of endplate abnormalities at MR imaging. Radiology 2001;218:420-427. (Pubitemid 32121053)
17. Johnston RB Jr. Current concepts: immunology. Monocytes and macrophages. N Engl J Med 1988;318:747-752.
18. Appel H, Loddenkemper C, Grozdanovic Z, et al. Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis. Arthritis Res Ther 2006;8:R143.
19. Bollow M, Fischer T, Reisshauer H, et al. Quantitative analyses of sacroiliac biopsies in spondyloarthropathies: T cells and macrophages predominate in early and active sacroiliitis-cellularity correlates with the degree of enhancement detected by magnetic resonance imaging. Ann Rheum Dis 2000;59:135-140. (Pubitemid 30305612)
20. Daley JM, Shearer JD, Mastrofrancesco B, Caldwell MD. Glucose metabolism in injured tissue: a longitudinal study. Surgery 1990;107:187-192. (Pubitemid 20057283)
21. Tsuda N, Tsuji T, Kato N, et al. Potential of superparamagnetic iron oxide in the differential diagnosis of metastasis and inflammation in bone marrow: experimental study. Invest Radiol 2005;40:676-681. (Pubitemid 41384059)
22. Bierry G, Jehl F, Boehm N, et al. Macrophage activity in infected areas of an experimental vertebral osteomyelitis model: USPIO-enhanced MR imaging - feasibility study. Radiology 2008;248:114-123.