No correlation between clinical response to CTLA-4 blockade and presence of NY-ESO-1 antibody in patients with metastatic melanoma

Journal of Immunotherapy

Volumn 32, Issue 8, 2009, Pages 884-885

  Goff, Stephanie L ^a   Robbins, Paul F ^a   El Gamil, Mona ^a   Rosenberg, Steven A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLYCOPROTEIN GP 100; HLA A2 ANTIGEN; IPILIMUMAB; NY ESO 1 ANTIGEN;

CLINICAL TRIAL; DRUG TOLERANCE; HUMAN; IMMUNITY; LETTER; MELANOMA; METASTASIS; PRIORITY JOURNAL; SEROLOGY; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; VACCINATION;

ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; ANTIBODY FORMATION; ANTIGENS, CD; ANTIGENS, NEOPLASM; CLINICAL TRIALS AS TOPIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOGLOBULINS; MELANOMA; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; NEOPLASM METASTASIS; PEPTIDE FRAGMENTS;

EID: 70349669387     PISSN: 15249557     EISSN: None     Source Type: Journal    
DOI: 10.1097/CJI.0b013e3181affbf0     Document Type: Letter

References (7)

1. Yuan J, Gnjatic S, Li H, et al. CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical bene.t. Proc Natl Acad Sci USA. 2008;105:20410-20415.
2. Downey SG, Klapper JA, Smith FO, et al. Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. Clin Cancer Res. 2007;13:6681-6688.
3. Phan GQ, Yang JC, Sherry RM, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci USA. 2003;100:8372-8377.
4. Attia P, Phan GQ, Maker AV, et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol. 2005; 23:6043-6053.
5. Yang JC, Hughes M, Kammula U, et al. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother. 2007;30:825-830.
6. Blans.eld JA, Beck KE, Tran K, et al. Cytotoxic T-lymphocyte-associated antigen- 4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. J Immunother. 2005;28:593-598.
7. Beck KE, Blans.eld JA, Tran KQ, et al. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte- associated antigen 4. J Clin Oncol. 2006;24:2283-2289.