Preparation of uniformly sized chitosan nanospheres by a premix membrane emulsification technique

Industrial and Engineering Chemistry Research

Volumn 48, Issue 19, 2009, Pages 8819-8828

  Lv, Pi Ping ^a,b   Wei, Wei ^a   Gong, Fang Ling ^a   Zhang, Yue Ling ^a   Zhao, Hui Ying ^b   Lei, Jian Du ^a   Wang, Lian Yan ^a   Ma, Guang Hui ^a  

^a INSTITUTE OF PROCESS ENGINEERING   (China)

^b BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AQUEOUS SOLUTIONS; CHITOSAN NANOPARTICLES; CONCENTRATION OF; CONTINUOUS PHASE; DEGRADABILITY; DISPERSED PHASE; DRUG CONTROLLED RELEASE; HIGH PRESSURE; LIQUID PARAFFINS; MEMBRANE EMULSIFICATION; NANO-DROPLETS; NARROW SIZE DISTRIBUTIONS; NON-TOXICITY; OIL PHASE; OPTIMIZED CONDITIONS; PARTICLE SIZE CONTROL; PETROLEUM ETHER; POLYDISPERSITY INDICES; POTENTIAL TECHNIQUES; PREMIX MEMBRANE EMULSIFICATION; PREPARATION CONDITIONS; PREPARATION PROCESS; RELEASE BEHAVIORS; REPRODUCIBILITIES; SHIRASU POROUS GLASS; TRANSMEMBRANE PRESSURES;

BIOCHEMISTRY; BIOCOMPATIBILITY; CHITOSAN; DRUG PRODUCTS; EMULSIFICATION; ETHERS; MEMBRANES; NANOSPHERES; ORGANIC POLYMERS; PARAFFIN WAXES; PARAFFINS; POLYDISPERSITY; SIZE DISTRIBUTION;

CHITIN;

EID: 70349666689     PISSN: 08885885     EISSN: None     Source Type: Journal    
DOI: 10.1021/ie801758e     Document Type: Article

References (16)

1. Talmadge, J. E. The pharmaceutics and delivery of therapeutic polypeptides and proteins. Adv. Drug. Delivery Rev. 1993, 10, 247-299.
2. Wang, L. Y.; Ma, G. H.; Su, Z. G. Preparation of uniform sized chitosan microspheres by membrane emulsification technique and application as a carrier of protein drug. J. Controlled Release 2005, 106, 62-65.
3. Shi, X. Y.; Tan, T. W. Preparation of chitosan/ethylcellulose complex microcapsule and its application in controlled release of vitamin D2. Biomaterials 2002, 23, 4469-11472
4. Zhang, H.; Alsarra, I. A.; Neau, S. H. An in vitro evaluation of a chitosan-containing multiparticulate system for macromolecule delivery to the colon. Int. J. Pharm. 2002, 239, 197-205.
5. Talmadge, J. E. The pharmaceutics and delivery of therapeutic polypeptides and proteins. Adv. Drug Delivery Rev. 1993, 10, 247.
6. Couvreur, P.; Blanco-Prieto, M. J.; Puisieux, F.; Roques, B.; Fattal, E. Multiple emulsion technology for the design of microspheres containing peptides and oligopeptides. Adv. Drug Delivery Rev. 1997, 28, 85-87.
7. Perugini, P.; Genta, I.; Pavanetto, F.; Conti, B.; Scalia, S.; Baruffini, A. Study on glycolic acid delivery by liposomes and microspheres. Int. J. Pharm. 2000, 196, 51-61.
8. Pan, Y.; Li, Y. J.; Zhao, H. Y.; Zheng, J. M.; Xu, H.; Wei, G. Bioadhesive polysaccharide in protein delivery system: chitosan nanopar- ticles improve the intestinal absorption of insulin in vivo. Int. J. Pharm. 2002, 249, 139-147.
9. Liu, R.; Ma, G. H.; Wan, Y. H.; Su, Z. G. Influence of process parameters on the size distribution of PLA microcapsules prepared by combining membrane emulsification technique and double emulsion-solvent evaporation method. Colloids Surf. B 2005, 45, 144-149.
10. Carreno-Gomez, B.; Duncan, R. Evaluation of the biological properties of soluble chitosan and chitosan microspheres. Int. J. Pharm. 1997, 148, 231.
11. Illum, L.; Jabbal-Gill, I.; Hinchcliffe, M.; Fisher, A. N.; Davis, S. S. Chitosan as a novel nasal delivery system for vaccines. Adv. Drug Delivery Rev. 2001, 51, 81.
12. Wei, W.; Wang, L. Y.; Yuan, L.; Su, Z. G.; Ma, G. H. Bioprocess of uniformly sized crosslinked chitosan microspheres in rats following oral administration. Eur. J. Pharm. Biopharm. 2008, 69, 878-886.
13. Liu, R.; Ma, G. H.; Meng, F. T.; Su, Z. G. Preparation of uniformly sized PLA microcapsule by combining Shiraus porous glass membrane emulsification technique and multiple emulsion-solvent evaporation method. J. Controlled Release 2005, 103, 31.
14. Wang, L. Y.; Gu, Y. H.; Ma, G. H.; Su, Z. G. Preparation and improvement of release behavior of chitosan microspheres containing insulin. Int. J. Pharm. 2006, 311, 187-190.
15. Wei, Q.; Wei, Wei.; Wang, L. Y.; Ma, G. H.; Su, Z. G. Uniformsized PLA nanoparticles: Preparation by premix membrane emulsification. Int. J. Pharm. 2008, 323, 267.
16. Meng, F. T.; Ma, G. H.; Qiu, W.; Su, Z. G. W/O/W double emulsion techniqueusing ethyl acetate as organic solvent: effects of its diffusion rate on the characteristics of microparticles. J. Controlled Release 2003, 91, 407.