Baclofen suppresses binge eating of pure fat but not a sugar-rich or sweet-fat diet

Behavioural Pharmacology

Volumn 20, Issue 7, 2009, Pages 631-634

  Berner, Laura A ^a   Bocarsly, Miriam E ^a   Hoebel, Bartley G ^a   Avena, Nicole M ^a,b  

^a PRINCETON UNIVERSITY   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Animal model; Binge eating disorder; Bulimia; Gamma aminobutyric acid; Rat

Indexed keywords

BACLOFEN; CARBOHYDRATE; FAT; PROTEIN; SUCROSE; VEGETABLE OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINGE EATING DISORDER; CALORIC INTAKE; CONTROLLED STUDY; DRUG ABUSE; DRUG ACTIVITY; FAT INTAKE; FEEDING BEHAVIOR; FOOD INTAKE; LIPID DIET; MALE; NONHUMAN; RAT; SUGAR INTAKE;

ANIMALS; BACLOFEN; BULIMIA; DIETARY FATS; DIETARY SUCROSE; EATING; GABA AGONISTS; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 70349664757     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/FBP.0b013e328331ba47     Document Type: Article

References (29)

1. American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders, 4th edition, text revision. Washington, DC: American Psychiatric Association.
2. Avena NM, Rada P, Hoebel BG (2006). Unit 9.23C sugar bingeing in rats. In: Crawley J, Gerfen C, Rogawski M, Sibley D, Skolnick P, Wray S, editors. Current protocols in neuroscience. Indianapolis: John Wiley & Sons Inc. pp. 9.23C.1-9.23C.6.
3. Avena NM, Rada P, Hoebel BG (2009). Sugar and fat bingeing have notable differences in addictive-like behavior. J Nutr 139:623-628.
4. Brebner K, Froestl W, Andrews M, Phelan R, Roberts DC (1999). The GABA(B) agonist CGP 44 532 decreases cocaine self-administration in rats: demonstration using a progressive ratio and a discrete trials procedure. Neuropharmacology 38:1797-1804.
5. Brebner K, Phelan R, Roberts DC (2000). Effect of baclofen on cocaine self-administration in rats reinforced under fixed-ratio 1 and progressive-ratio schedules. Psychopharmacology (Berl) 148:314-321.
6. Brebner K, Ahn S, Phillips AG (2005). Attenuation of d-amphetamine selfadministration by baclofen in the rat: behavioral and neurochemical correlates. Psychopharmacology (Berl) 177:409-417.
7. Broft AI, Spanos A, Corwin RL, Mayer L, Steinglass J, Devlin MJ, et al. (2007). Baclofen for binge eating: an open-label trial. Int J Eat Disord 40:687-691.
8. Buda-Levin A,Wojnicki FH, Corwin RL (2005). Baclofen reduces fat intake under binge-type conditions. Physiol Behav 86:176-184.
9. Colantuoni C, Schwenker J, McCarthy J, Rada P, Ladenheim B, Cadet JL, et al. (2001). Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain. Neuroreport 12:3549-3552.
10. Colantuoni C, Rada P, McCarthy J, Patton C, Avena NM, Chadeayne A, et al. (2002). Evidence that intermittent, excessive sugar intake causes endogenous opioid dependence. Obes Res 10:478-488.
11. Di Ciano P, Everitt BJ (2003). The GABA(B) receptor agonist baclofen attenuates cocaine- and heroin-seeking behavior by rats. Neuropsychopharmacology 28:510-518.
12. Ebenezer IS (1995). Intraperitoneal administration of baclofen increases consumption of both solid and liquid diets in rats. Eur J Pharmacol 273:183-185.
13. Guertin TL, Conger AJ (1999). Mood and forbidden foods' influence on perceptions of binge eating. Addict Behav 24:175-193.
14. Hadigan CM, Kissileff HR, Walsh BT (1989). Patterns of food selection during meals in women with bulimia. Am J Clin Nutr 50:759-766.
15. Higgs S, Barber DJ (2004). Effects of baclofen on feeding behaviour examined in the runway. Prog Neuropsychopharmacol Biol Psychiatry 28:405-408.
16. Janak PH, Michael Gill T (2003). Comparison of the effects of allopregnanolone with direct GABAergic agonists on ethanol self-administration with and without concurrently available sucrose. Alcohol 30:1-7.
17. Leibowitz SF, Dourmashkin JT, Chang GQ, Hill JO, Gayles EC, Fried SK, et al. (2004). Acute high-fat diet paradigms link galanin to triglycerides and their transport and metabolism in muscle. Brain Res 1008:168-178.
18. Parrado C, Diaz-Cabiale Z, Garcia-Coronel M, Agnati LF, Covenas R, Fuxe K, et al. (2007). Region specific galanin receptor/neuropeptide Y Y1 receptor interactions in the tel- and diencephalon of the rat. Relevance for food consumption. Neuropharmacology 52:684-692.
19. Patel SM, Ebenezer IS (2008). The effects of chronic intraperitoneal administration of the GABA B receptor agonist baclofen on food intake in rats. Eur J Pharmacol 593:68-72.
20. Petry NM, Heyman GM (1997). Bidirectional modulation of sweet and bitter taste by chlordiazepoxide and Ro 15-4513: lack of effect with GABA drugs. Physiol Behav 61:119-126.
21. Ranaldi R, Poeggel K (2002). Baclofen decreases methamphetamine selfadministration in rats. Neuroreport 13:1107-1110.
22. Roberts DC (2005). Preclinical evidence for GABAB agonists as a pharmacotherapy for cocaine addiction. Physiol Behav 86:18-20.
23. Sato I, Arima H, Ozaki N, Ozaki N, Watanabe M, Goto M, et al. (2007). Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice. FEBS Lett 581:4857-4864.
24. Sclafani A (2004). Oral and postoral determinants of food reward. Physiol Behav 81:773-779.
25. Shoaib M, Swanner LS, Beyer CE, Goldberg SR, Schindler CW (1998). The GABA-B agonist baclofen modifies cocaine self-administration in rats. Behav Pharmacol 9:195-206.
26. Wang J, Akabayashi A, Dourmashkin J, Yu HJ, Alexander JT, Chae HJ, et al. (1998). Neuropeptide Y in relation to carbohydrate intake, corticosterone and dietary obesity. Brain Res 802:75-88.
27. Wojnicki FH, Roberts DC, Corwin RL (2006). Effects of baclofen on operant performance for food pellets and vegetable shortening after a history of binge-type behavior in non-food deprived rats. Pharmacol Biochem Behav 84:197-206.
28. Wong KJ, Wojnicki FHW, Corwin RLW (2009). Baclofen, raclopride, and naltrexone differentially affect intake of fat/sucrose mixtures under limited access conditions. Pharmacol Biochem Behav 92:528-536.
29. Xi ZX, Stein EA (1999). Baclofen inhibits heroin self-administration behavior and mesolimbic dopamine release. J Pharmacol Exp Ther 290:1369-1374.