Blockade of connexin 43 hemichannels reduces neointima formation after vascular injury by inhibiting proliferation and phenotypic modulation of smooth muscle cells

Experimental Biology and Medicine

Volumn 234, Issue 10, 2009, Pages 1192-1200

  Song, MingBao ^a   Yu, XueJun ^a   Cui, Xin ^b   Zhu, GuangXu ^a,c   Zhao, Gang ^a   Chen, JianFei ^a   Huang, Lan ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c KUNMING GENERAL HOSPITAL   (China)

Author keywords

Connexin; Gap junction; Neointimal formation; Smooth muscle cell

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALPHA ACTIN; CALPONIN; CARBENOXOLONE; CONNEXIN 43; MESSENGER RNA; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTERY INTIMA PROLIFERATION; ARTICLE; BLOOD VESSEL INJURY; CAROTID ARTERY INJURY; CELL COMMUNICATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; MARKER GENE; NONHUMAN; PHENOTYPE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; CARBENOXOLONE; CAROTID ARTERY INJURIES; CELL PROLIFERATION; COLORING AGENTS; CONNEXIN 43; ENDOTHELIUM, VASCULAR; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; TETRAZOLIUM SALTS; THIAZOLES; TRANSFECTION; TUNICA INTIMA;

RATTUS;

EID: 70349660081     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/0902-RM-80     Document Type: Article

References (40)

1. Zampetaki A, Kirton JP, Xu Q. Vascular repair by endothelial progenitor cells. Cardiovasc Res 78:413-421, 2008. (Pubitemid 351769775)
2. Owens GK. Molecular control of vascular smooth muscle cell differentiation and phenotypic plasticity. Novartis Found Symp 283:174-191; discussion 191-173, 238-1141, 2007.
3. Rzucidlo EM, Martin KA, Powell RJ. Regulation of vascular smooth muscle cell differentiation. J Vasc Surg 45 Suppl A:A25-A32, 2007.
4. Bennett MV, Zheng X, Sogin ML. The connexins and their family tree. Soc Gen Physiol Ser 49:223-233, 1994.
5. O'Brien J, Bruzzone R, White TW, Al-Ubaidi MR, Ripps H. Cloning and expression of two related connexins from the perch retina define a distinct subgroup of the connexin family. J Neurosci 18:7625-7637, 1998. (Pubitemid 28441005)
6. Burnier L, Fontana P, Angelillo-Scherrer A, Kwak BR. Intercellular communication in atherosclerosis. Physiology (Bethesda) 24:36-44, 2009.
7. Haefliger JA, Nicod P, Meda P. Contribution of connexins to the function of the vascular wall. Cardiovasc Res 62:345-356, 2004. (Pubitemid 38496547)
8. Jiang JX, Gu S. Gap junction- and hemichannel-independent actions of connexins. Biochim Biophys Acta 1711:208-214, 2005. (Pubitemid 40799295)
9. Hix LM, Lockwood SF, Bertram JS. Upregulation of connexin 43 protein expression and increased gap junctional communication by water soluble disodium disuccinate astaxanthin derivatives. Cancer Lett 211:25-37, 2004.
10. Inai T, Mancuso MR, McDonald DM, Kobayashi J, Nakamura K, Shibata Y. Shear stress-induced upregulation of connexin 43 expression in endothelial cells on upstream surfaces of rat cardiac valves. Histochem Cell Biol 122:477-483, 2004. (Pubitemid 40379017)
11. Vine AL, Bertram JS. Upregulation of connexin 43 by retinoids but not by non-provitamin A carotenoids requires RARs. Nutr Cancer 52:105-113, 2005.
12. Martin PE, Wall C, Griffith TM. Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells. Br J Pharmacol 144:617-627, 2005. (Pubitemid 40445609)
13. Evans WH, Boitano S. Connexin mimetic peptides: specific inhibitors of gap-junctional intercellular communication. Biochem Soc Trans 29:606-612, 2001. (Pubitemid 32783666)
14. Braet K, Vandamme W, Martin PE, Evans WH, Leybaert L. Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium 33:37-48, 2003. (Pubitemid 36230881)
15. Pandey NR, Benkirane K, Amiri F, Schiffrin EL. Effects of PPARgamma knock-down and hyperglycemia on insulin signaling in vascular smooth muscle cells from hypertensive rats. J Cardiovasc Pharmacol 49:346-354, 2007. (Pubitemid 47000308)
16. Gomes P, Srinivas SP, Vereecke J, Himpens B. Gap junctional intercellular communication in bovine corneal endothelial cells. Exp Eye Res 83:1225-1237, 2006. (Pubitemid 44404134)
17. Suzuki T, Matsunami T, Hisa Y, Takata K, Takamatsu T, Oyamada M. Roles of gap junctions in glucose transport from glucose transporter 1-positive to -negative cells in the lateral wall of the rat cochlea. Histochem Cell Biol 131:89-102, 2009.
18. Ye ZC, Oberheim N, Kettenmann H, Ransom BR. Pharmacological "cross-inhibition" of connexin hemichannels and swelling activated anion channels. Glia 57:258-269, 2009.
19. Werner N, Junk S, Laufs U, Link A, Walenta K, Bohm M, Nickenig G. Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury. Circ Res 93:e17-e24, 2003.
20. Chadjichristos CE, Matter CM, Roth I, Sutter E, Pelli G, Luscher TF, Chanson M, Kwak BR. Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice. Circulation 113:2835-2843, 2006. (Pubitemid 44305296)
21. Perez-Alcazar M, Nicolas MJ, Valencia M, Alegre M, Iriarte J, Artieda J. Chirp-evoked potentials in the awake and anesthetized rat. A procedure to assess changes in cortical oscillatory activity. Exp Neurol 210:144-153, 2008.
22. Carruba G, Cocciadiferro L, Bellavia V, Rizzo S, Tsatsanis C, Spandidos D, Muti P, Smith C, Mehta P, Castagnetta L. Intercellular communication and human hepatocellular carcinoma. Ann N Y Acad Sci 1028:202-212, 2004. (Pubitemid 40361823)
23. Essalihi R, Ouellette V, Dao HH, McKee MD, Moreau P. Phenotypic modulation of vascular smooth muscle cells during medial arterial calcification: a role for endothelin? J Cardiovasc Pharmacol 44 Suppl 1:S147-S150, 2004.
24. Hao H, Gabbiani G, Camenzind E, Bacchetta M, Virmani R, Bochaton-Piallat ML. Phenotypic modulation of intima and media smooth musclecells in fatal cases of coronary artery lesion. Arterioscler Thromb Vasc Biol 26:326-332, 2006. (Pubitemid 43732195)
25. Zargham R. Preventing restenosis after angioplasty: a multistage approach. Clin Sci (Lond) 114:257-264, 2008. (Pubitemid 351294001)
26. Muto A, Fitzgerald TN, Pimiento JM, Maloney SP, Teso D, Paszkowiak JJ, Westvik TS, Kudo FA, Nishibe T, Dardik A. Smooth muscle cell signal transduction: implications of vascular biology for vascular surgeons. J Vasc Surg 45 Suppl A:A15-A24, 2007. (Pubitemid 46818876)
27. Chan-Park MB, Shen JY, Cao Y, Xiong Y, Liu Y, Rayatpisheh S, Kang GC, Greisler HP. Biomimetic control of vascular smooth muscle cell morphology and phenotype for functional tissue-engineered small-diameter blood vessels. J Biomed Mater Res A 88:1104-1121, 2009.
28. Orr AW, Lee MY, Lemmon JA, Yurdagul A Jr, Gomez MF, Bortz PD, Wamhoff BR. Molecular mechanisms of collagen isotype-specific modulation of smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol 29:225-231, 2009.
29. Peeters W, Hellings WE, de Kleijn DP, de Vries JP, Moll FL, Vink A, Pasterkamp G. Carotid atherosclerotic plaques stabilize after stroke: insights into the natural process of atherosclerotic plaque stabilization. Arterioscler Thromb Vasc Biol 29:128-133, 2009.
30. Lien SC, Usami S, Chien S, Chiu JJ. Phosphatidylinositol 3-kinase/Akt pathway is involved in transforming growth factor-beta1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells. Cell Signal 18:1270-1278, 2006. (Pubitemid 43674039)
31. Hayashi K, Takahashi M, Nishida W, Yoshida K, Ohkawa Y, Kitabatake A, Aoki J, Arai H, Sobue K. Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids. Circ Res 89:251-258, 2001. (Pubitemid 34132683)
32. Liu ZP, Wang Z, Yanagisawa H, Olson EN. Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. Dev Cell 9:261-270, 2005. (Pubitemid 41051744)
33. Chadjichristos CE, Derouette JP, Kwak BR. Connexins in atherosclerosis. Adv Cardiol 42:255-267, 2006.
34. Yeh HI, Lupu F, Dupont E, Severs NJ. Upregulation of connexin43 gap junctions between smooth muscle cells after balloon catheter injury in the rat carotid artery. Arterioscler Thromb Vasc Biol 17:3174-3184, 1997. (Pubitemid 28016074)
35. Kwak BR, Mulhaupt F, Veillard N, Gros DB, Mach F. Altered pattern of vascular connexin expression in atherosclerotic plaques. Arterioscler Thromb Vasc Biol 22:225-230, 2002. (Pubitemid 34127031)
36. Matsushita T, Rama A, Charolidi N, Dupont E, Severs NJ. Relationship of connexin43 expression to phenotypic modulation in cultured human aortic smooth muscle cells. Eur J Cell Biol 86:617-628, 2007. (Pubitemid 47408711)
37. Geraghty JG, Stoltenberg RL, Sollinger HW, Hullett DA. Vascular smooth muscle cells and neointimal hyperplasia in chronic transplant rejection. Transplantation 62:502-509, 1996.
38. Richardson M, Hatton MW, Buchanan MR, Moore S. Wound healing in the media of the normolipemic rabbit carotid artery injured by air drying or by balloon catheter de-endothelialization. Am J Pathol 137:1453-1465, 1990.
39. Fujimoto H, Tao S, Dohi T, Ito S, Masuda J, Haruo M, Fujimoto Y, Maehara A, Yamaguchi T, Ishiwata S, Ohno M. Primary and mid-term outcome of sirolimus-eluting stent implantation with angiographic guidance alone. J Cardiol 51:18-24, 2008. (Pubitemid 351699924)
40. Sheiban I, Chiribiri A, Galli S, Biondi-Zoccai G, Montorsi P, Beninati S, Fabbiocchi F, Moretti C, Omede P, Trabattoni D, Lotrionte M, Trevi GP, Bartorelli AL. Sirolimus-eluting stent implantation for bare-metal in-stent restenosis: is there any evidence for a late catch-up phenomenon? J Cardiovasc Med (Hagerstown) 9:783-788, 2008.