General anesthesia and ascending arousal pathways

Anesthesiology

Volumn 111, Issue 4, 2009, Pages 695-696

  Zecharia, Anna Y ^a   Franks, Nicholas P ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEXMEDETOMIDINE; HISTAMINE; ISOFLURANE; PENTOBARBITAL; PROPOFOL; TRIPROLIDINE;

AROUSAL; BRAIN CORTEX; BREATHING RATE; CENTRAL NERVOUS SYSTEM; CONSCIOUSNESS; EDITORIAL; ELECTROENCEPHALOGRAPHY; GENERAL ANESTHESIA; HIPPOCAMPUS; HISTAMINE BLOOD LEVEL; HISTAMINE RELEASE; PRIORITY JOURNAL; RIGHTING REFLEX; SEDATION; SLEEP WAKING CYCLE; THALAMUS; WAKEFULNESS;

EID: 70349658877     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e3181b061bc     Document Type: Editorial

References (13)

1. Franks NP: General anaesthesia: From molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci 2008; 9:370-386
2. Velly LJ, Rey MF, Bruder NJ, Gouvitsos FA, Witjas T, Regis JM, Peragut JC, Gouin FM: Differential dynamic of action on cortical and subcortical structures of anesthetic agents during induction of anesthesia. ANESTHESIOLOGY 2007; 107:202-212
3. Jia F, Pignataro L, Schofield CM, Yue M, Harrison NL, Goldstein PA: An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons. J Neurophysiol 2005; 94:4491-4501
4. Meuth SG, Budde T, Kanyshkova T, Broicher T, Munsch T, Pape HC: Contribution of TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 channels to the control of activity modes in thalamocortical neurons. J Neurosci 2003; 23:6460-6469
5. Nelson LE, Guo TZ, Lu J, Saper CB, Franks NP, Maze M: The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway. Nat Neurosci 2002; 5:979-984
6. Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M: The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. ANESTHESIOLOGY 2003; 98:428-436
7. Zecharia AY, Nelson LE, Gent TC, Schumacher M, Jurd R, Rudolph U, Brickley SG, Maze M, Franks NP: The involvement of hypothalamic sleep pathways in general anesthesia: Testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse. J Neurosci 2009; 29:2177-2187
8. Luo T, Leung LS: Basal forebrain histaminergic transmission modulates electroencephalographic activity and emergence from isoflurane anesthesia. ANESTHESIOLOGY 2009; 111:725-733
9. Kelz MB, Sun Y, Chen J, Cheng Meng Q, Moore JT, Veasey SC, Dixon S, Thornton M, Funato H, Yanagisawa M: An essential role for orexins in emergence from general anesthesia. Proc Natl Acad Sci USA 2008; 105:1309-1314
10. Alkire MT, McReynolds JR, Hahn EL, Trivedi AN: Thalamic microinjection of nicotine reverses sevoflurane-induced loss of righting reflex in the rat. ANESTHESIOLOGY 2007; 107:264-272
11. Meuret P, Backman SB, Bonhomme V, Plourde G, Fiset P: Physostigmine reverses propofol-induced unconsciousness and attenuation of the auditory steady state response and bispectral index in human volunteers. ANESTHESIOLOGY 2000; 93:708-717
12. Kushikata T, Hirota K, Yoshida H, Kudo M, Lambert DG, Smart D, Jerman JC, Matsuki A: Orexinergic neurons and barbiturate anesthesia. Neuroscience 2003; 121:855-863
13. Rabin BC, Guo TZ, Gregg K, Maze M: Role of serotonergic neurotransmission in the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. Eur J Pharmacol 1996; 306:51-59