Cellular characterization of the peritumoral edema zone in malignant brain tumors

Cancer Science

Volumn 100, Issue 10, 2009, Pages 1856-1862

  Engelhorn, Tobias ^a   Savaskan, Nic E ^b,c   Schwarz, Marc A ^a   Kreutzer, Jürgen ^a,f   Meyer, Eric P ^d   Hahnen, Eric ^e   Ganslandt, Oliver ^a   Dörfler, Arnd ^a   Nimsky, Christopher ^a,g   Buchfelder, Michael ^a   Eyüpoglu, Ilker Y ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b ETH ZURICH   (Switzerland)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e UNIVERSITY OF COLOGNE   (Germany)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^g PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 4; CD11B ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; MACROPHAGE MIGRATION INHIBITION FACTOR; RED FLUORESCENT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN TISSUE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INVASION; CANCER TRANSPLANTATION; CELL ACTIVATION; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; GLIOMA; GLIOMA CELL; HISTOPATHOLOGY; IMMUNOCYTOCHEMISTRY; IN VIVO STUDY; MACROGLIA; MICROGLIA; MICROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RODENT;

ANIMALS; AQUAPORIN 4; BRAIN EDEMA; BRAIN NEOPLASMS; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOMA; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTRAMOLECULAR OXIDOREDUCTASES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MAGNETIC RESONANCE IMAGING; MICROGLIA; MICROSCOPY, FLUORESCENCE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; RATS;

EID: 70349603638     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2009.01259.x     Document Type: Article

References (30)

1. DeAngelis LM. Brain tumors. N Engl J Med 2001, 344:114-23.
2. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000, 100:57-70.
3. Maher EA, Furnari FB, Bachoo RM. Malignant glioma: genetics and biology of a grave matter. Genes Dev 2001, 15:1311-33.
4. Papadopoulos MC, Saadoun S, Binder DK, Manley GT, Krishna S, Verkman AS. Molecular mechanisms of brain tumor edema. Neuroscience 2004, 129:1011-20.
5. Stewart LA. Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 2002, 359:1011-8.
6. Badie B, Schartner JM, Paul J, Bartley BA, Vorpahl J, Preston JK. Dexamethasone-induced abolition of the inflammatory response in an experimental glioma model: a flow cytometry study. J Neurosurg 2000, 93:634-9.
7. Badie B, Schartner J. Role of microglia in glioma biology. Microsc Res Tech 2001, 54:106-13.
8. Wick W, Kuker W. Brain edema in neurooncology: radiological assessment and management. Onkologie 2004, 27:261-6.
9. Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT. Angiogenesis in brain tumours. Nat Rev Neurosci 2007, 8:610-22.
10. Lin TN, He YY, Wu G, Khan M, Hsu CY. Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke 1993, 24:117-21.
11. Takano T, Lin JH, Arcuino G, Gao Q, Yang J, Nedergaard M. Glutamate release promotes growth of malignant gliomas. Nat Med 2001, 7:1010-5.
12. Ye ZC, Sontheimer H. Glioma cells release excitotoxic concentrations of glutamate. Cancer Res 1999, 59:4383-91.
13. Savaskan NE, Heckel A, Hahnen E. Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema. Nat Med 2008, 14:629-32.
14. Ko L, Koestner A, Wechsler W. Morphological characterization of nitrosourea-induced glioma cell lines and clones. Acta Neuropathol (Berl) 1980, 51:23-31.
15. Reifenberger G, Bilzer T, Seitz RJ, Wechsler W. Expression of vimentin and glial fibrillary acidic protein in ethylnitrosourea-induced rat gliomas and glioma cell lines. Acta Neuropathol (Berl) 1989, 78:270-82.
16. Eyupoglu IY, Hahnen E, Heckel A. Malignant glioma-induced neuronal cell death in an organotypic glioma invasion model. Technical note. J Neurosurg 2005, 102:738-44.
17. Kim B, Chenevert TL, Ross BD. Growth kinetics and treatment response of the intracerebral rat 9L brain tumor model: a quantitative in vivo study using magnetic resonance imaging. Clin Cancer Res 1995, 1:643-50.
18. Eyupoglu IY, Bechmann I, Nitsch R. Modification of microglia function protects from lesion-induced neuronal alterations and promotes sprouting in the hippocampus. Faseb J 2003, 17:1110-1.
19. Berens ME, Giese A. '... those left behind.' Biology and oncology of invasive glioma cells. Neoplasia 1999, 1:208-19.
20. von Deimling A, Louis DN, Wiestler OD. Molecular pathways in the formation of gliomas. Glia 1995, 15:328-38.
21. Pilkington GJ, Bjerkvig R, De Ridder L, Kaaijk P. In vitro and in vivo models for the study of brain tumour invasion. Anticancer Res 1997, 17:4107-9.
22. Neeman M, Gilad AA, Dafni H, Cohen B. Molecular imaging of angiogenesis. J Magn Reson Imaging 2007, 25:1-12.
23. Farber K, Synowitz M, Zahn G. An alpha5beta1 integrin inhibitor attenuates glioma growth. Mol Cell Neurosci 2008, 39(4):579-85.
24. Nishie A, Ono M, Shono T. Macrophage infiltration and heme oxygenase-1 expression correlate with angiogenesis in human gliomas. Clin Cancer Res 1999, 5:1107-13.
25. Roggendorf W, Strupp S, Paulus W. Distribution and characterization of microglia/macrophages in human brain tumors. Acta Neuropathol (Berl) 1996, 92:288-93.
26. Leung SY, Wong MP, Chung LP, Chan AS, Yuen ST. Monocyte chemoattractant protein-1 expression and macrophage infiltration in gliomas. Acta Neuropathol 1997, 93:518-27.
27. Bingle L, Brown NJ, Lewis CE. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J Pathol 2002, 196:254-65.
28. Platten M, Kretz A, Naumann U. Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas. Ann Neurol 2003, 54:388-92.
29. Yao Y, Kubota T, Sato K, Kitai R. Macrophage infiltration-associated thymidine phosphorylase expression correlates with increased microvessel density and poor prognosis in astrocytic tumors. Clin Cancer Res 2001, 7:4021-6.
30. Badie B, Schartner JM, Hagar AR. Microglia cyclooxygenase-2 activity in experimental gliomas: possible role in cerebral edema formation. Clin Cancer Res 2003, 9:872-7.