Environmental and biological monitoring of persistent fluorinated compounds in Japan and their toxicities

Environmental Health and Preventive Medicine

Volumn 14, Issue 1, 2009, Pages 7-19

  Harada, Kouji H ^a   Koizumi, Akio ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Distribution in Japan; Perfluorooctane sulfonate; Perfluorooctanoic acid; Toxicokinetics

Indexed keywords

PERFLUOROOCTANESULFONIC ACID; PERFLUOROOCTANOIC ACID;

ANIMAL EXPERIMENT; BILIARY EXCRETION; BIOLOGICAL MONITORING; BLOOD LEVEL; CARCINOGENICITY; ENVIRONMENTAL EXPOSURE; FEMALE; HALF LIFE TIME; HUMAN; JAPAN; LIVER TOXICITY; MACACA; MALE; MENSTRUATION; NEUROTOXICITY; NONHUMAN; OCCUPATIONAL EXPOSURE; RAT; REPRODUCTIVE TOXICITY; REVIEW; RISK ASSESSMENT; SEX DIFFERENCE; SPECIES DIFFERENCE; TOXICITY; TOXICOKINETICS; URINARY EXCRETION;

MACACA; RATTUS; RATTUS NORVEGICUS;

EID: 70349598449     PISSN: 1342078X     EISSN: 13474715     Source Type: Journal    
DOI: 10.1007/s12199-008-0058-5     Document Type: Review

References (101)

1. Kissa E. Fluorinated surfactants and repellents. 2nd edn. New York: Marcel Dekker; 2001.
2. C Hogue 2004 Government & policy - Perfluorinated pollutant puzzle Chem Engl News 82 17 19,59
3. K Prevedouros IT Cousins RC Buck SH Korzeniowski 2006 Sources, fate and transport of perfluorocarboxylates Environ Sci Technol 40 32 44 16433330 10.1021/es0512475 1:CAS:528:DC%2BD2MXht1Gru7zK (Pubitemid 43069883)
4. UNEP, 2007. POPRC3: development of risk management evaluation. UNEP/POPS/POPRC.3/20. http://chm.pops.int/Portals/0/Repository/poprc3/UNEP-POPS- POPRC.3-POPRC-3-5.English.PDF.
5. A Wood W Clarin 2000 3M to phase out PFOS Chem Week 162 9 9
6. K Kannan J Koistinen K Beckmen T Evans JF Gorzelany KJ Hansen, et al. 2001 Accumulation of perfluorooctane sulfonate in marine mammals Environ Sci Technol 35 1593 8 11329707 10.1021/es001873w 1:CAS:528:DC%2BD3MXhvVSgsbk%3D
7. KJ Hansen LA Clemen ME Ellefson HO Johnson 2001 Compound-specific, quantitative characterization of organic fluorochemicals in biological matrices Environ Sci Technol 35 766 70 11349290 10.1021/es001489z 1:CAS:528: DC%2BD3MXivValtA%3D%3D (Pubitemid 32173716)
8. CY Fei JK McLaughlin RE Tarone J Olsen 2007 Perfluorinated chemicals and fetal growth: a study within the Danish National Birth Cohort Environ Health Perspect 115 1677 82 18008003 1:CAS:528:DC%2BD2sXhtl2ns7zJ
9. BH Alexander GW Olsen JM Burris JH Mandel JS Mandel 2003 Mortality of employees of a perfluorooctanesulphonyl fluoride manufacturing facility Occup Environ Med 60 722 9 14504359 10.1136/oem.60.10.722 1:CAS:528:DC%2BD2cXitlel (Pubitemid 37203427)
10. BJ Apelberg FR Witter JB Herbstman AM Calafat RU Halden LL Needham, et al. 2007 Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth Environ Health Perspect 115 1670 6 18008002 1:CAS:528:DC%2BD2sXhtl2ns7zI
11. FD Gilliland JS Mandel 1993 Mortality among employees of a perfluorooctanoic acid production plant J Occup Med 35 950 4 8229349 10.1097/00043764-199309000-00020 1:STN:280:ByuD2cngs10%3D
12. USEPA. Perfluoroalkyl sulfonates, proposed significant new use rule. Federal Register. 2006;71:12311-24.
13. Canada. Order Adding Toxic Substances to Schedule 1 to the Canadian Environmental Protection Act, 1999. Canada Gazette Part II. 2006;140:2147-53.
14. European Commission. Directive 2006/122/EC amending for Directive 76/769/EEC. Off J Eur Commun 2006;L 372/32, 27 December 2006.
15. USEPA, Risk profile on perfluorooctane sulfonate. UNEP/POPS/POPRC.2/17/ Add.5 http://www.pops.int/documents/meetings/poprc-2/meeting-docs/report/ default.htm.
16. K Harada N Saito K Sasaki K Inoue A Koizumi 2003 Perfluorooctane sulfonate contamination of drinking water in the Tama River, Japan: estimated effects on resident serum levels Bull Environ Contam Toxicol 71 31 6 12945838 10.1007/s00128-003-0126-x 1:CAS:528:DC%2BD3sXmtV2isL4%3D (Pubitemid 36792349)
17. N Saito K Harada K Inoue K Sasaki T Yoshinaga A Koizumi 2004 Perfluorooctanoate and perfluorooctane sulfonate concentrations in surface water in Japan J Occup Health 46 49 59 14960830 10.1539/joh.46.49 1:CAS:528:DC%2BD2cXitVGjsLs%3D (Pubitemid 38298099)
18. K Harada N Saito K Inoue T Yoshinaga T Watanabe S Sasaki, et al. 2004 The influence of time, sex and geographic factors on levels of perfluorooctane sulfonate and perfluorooctanoate in human serum over the last 25 years J Occup Health 46 141 7 15090689 10.1539/joh.46.141 1:CAS:528:DC%2BD2cXjslersbg%3D (Pubitemid 38506782)
19. GW Olsen TR Church JP Miller JM Burris KJ Hansen JK Lundberg, et al. 2003 Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors Environ Health Perspect 111 1892 901 14644663 1:CAS:528:DC%2BD2cXit1Oquw%3D%3D
20. S Taniyasu K Kannan Y Horii N Hanari N Yamashita 2003 A survey of perfluorooctane sulfonate and related perfluorinated organic compounds in water, fish, birds, and humans from Japan Environ Sci Technol 37 2634 9 12854699 10.1021/es0303440 1:CAS:528:DC%2BD3sXjs1GgtLo%3D (Pubitemid 36706002)
21. PHL Nguyen S Fujii S Tanaka M Nozoe H Tanaka 2008 Contamination of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in surface water of the Yodo River basin (Japan) Desalination 226 338 47 10.1016/j.desal.2007.01. 247
22. Y Zushi T Takeda S Masunaga 2008 Existence of nonpoint source of perfluorinated compounds and their loads in the Tsurumi River basin, Japan Chemosphere 71 1566 73 18191440 10.1016/j.chemosphere.2007.11.055 1:CAS:528:DC%2BD1cXktFCmtbg%3D
23. N Yamashita K Kannan S Taniyasu Y Horii T Okazawa G Petrick, et al. 2004 Analysis of perfluorinated acids at parts-per-quadrillion levels in seawater using liquid chromatography-tandem mass spectrometry Environ Sci Technol 38 5522 8 15575267 10.1021/es0492541 1:CAS:528:DC%2BD2cXnvVKltLg%3D (Pubitemid 39447177)
24. KJ Hansen HO Johnson JS Eldridge JL Butenhoff LA Dick 2002 Quantitative characterization of trace levels of PFOS and PFOA in the Tennessee River Environ Sci Technol 36 1681 5 11993863 10.1021/es010780r 1:CAS:528:DC%2BD38XhslGlt78%3D (Pubitemid 34310933)
25. CA Moody JW Martin WC Kwan DC Muir SA Mabury 2002 Monitoring perfluorinated surfactants in biota and surface water samples following an accidental release of fire-fighting foam into Etobicoke Creek Environ Sci Technol 36 545 51 11883418 10.1021/es011001+ 1:CAS:528:DC%2BD3MXptV2nu78%3D (Pubitemid 34157491)
26. S Nakayama MJ Strynar L Helfant P Egeghy X Ye AB Lindstrom 2007 Perfluorinated compounds in the Cape Fear Drainage Basin in North Carolina Environ Sci Technol 41 5271 6 17822090 10.1021/es070792y 1:CAS:528: DC%2BD2sXnt1Sns7c%3D (Pubitemid 47221743)
27. D Skutlarek M Exner H Farber 2006 Perfluorinated surfactants in surface and drinking water Environ Sci Pollut R 13 299 307 10.1065/espr2006.07.326 1:CAS:528:DC%2BD28XhtFCrtb%2FN (Pubitemid 44544831)
28. Osaka Prefecture, Monitoring of perfluorooctanoic acid and perfluorooctane sulfonate in river. 2007. http://www.epcc.pref.osaka.jp/press/ h19/0831-2/.
29. Mitsuya R, Sometani A, Hosoda N, Matsuzaki T, Ohara K. A survey of PFOS and PFOA and its removal during water treatment. Abstracts of 58th annual meeting of Japan Water Works Association. 2007; 554-5.
30. K Harada S Nakanishi N Saito T Tsutsui A Koizumi 2005 Airborne perfluorooctanoate may be a substantial source contamination in Kyoto area, Japan Bull Environ Contam Toxicol 74 64 9 15768499 10.1007/s00128-004-0548-0 1:CAS:528:DC%2BD2MXmtlCrtg%3D%3D (Pubitemid 41794599)
31. K Harada S Nakanishi K Sasaki K Furuyama S Nakayama N Saito, et al. 2006 Particle size distribution and respiratory deposition estimates of airborne perfluorooctanoate and perfluorooctanesulfonate in Kyoto area, Japan Bull Environ Contam Toxicol 76 306 10 16468011 10.1007/s00128-006-0922-1 1:CAS:528:DC%2BD28Xht1Cltbw%3D (Pubitemid 43221131)
32. K Sasaki K Harada N Saito T Tsutsui S Nakanishi H Tsuzuki, et al. 2003 Impact of airborne perfluorooctane sulfonate on the human body burden and the ecological system Bull Environ Contam Toxicol 71 408 13 14560396 10.1007/s00128-003-0179-x 1:CAS:528:DC%2BD3sXmsFGmtLk%3D (Pubitemid 36909720)
33. Ministry of Environment, Chemicals in the Environment FY2004, 2006. http://www.env.go.jp/chemi/kurohon/2005/http2005d/d-section02-01.html.
34. B Boulanger AM Peck JL Schnoor KC Hornbuckle 2005 Mass budget of perfluorooctane surfactants in Lake Ontario Environ Sci Technol 39 74 9 15667077 10.1021/es049044o 1:CAS:528:DC%2BD2cXhtVCmsLvE
35. JL Barber U Berger C Chaemfa S Huber A Jahnke C Temme, et al. 2007 Analysis of per- and polyfluorinated alkyl substances in air samples from Northwest Europe J Environ Monit 9 530 41 17554424 10.1039/b701417a 1:CAS:528:DC%2BD2sXmtFemsrw%3D (Pubitemid 46889462)
36. T Katsumata A Nakata Y Iwasaki R Ito K Saito H Nakazawa 2006 Determination of perfluorochemicals in house-dust by LC/MS/MS after supercritical fluid extraction Bunseki Kagaku 55 955 61 10.2116/bunsekikagaku. 55.955 1:CAS:528:DC%2BD2sXotVCisg%3D%3D
37. H Moriwaki Y Takatah R Arakawa 2003 Concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in vacuum cleaner dust collected in Japanese homes J Environ Monit 5 753 7 14587845 10.1039/b307147m 1:CAS:528:DC%2BD3sXnsFagtb4%3D (Pubitemid 37297027)
38. MJ Strynar AB Lindstrom 2008 Perfluorinated compounds in house dust from Ohio and North Carolina, USA Environ Sci Technol 42 3751 6 18546718 10.1021/es7032058 1:CAS:528:DC%2BD1cXkvVyhtLw%3D (Pubitemid 351694088)
39. MJ Dinglasan-Panlilio SA Mabury 2006 Significant residual fluorinated alcohols present in various fluorinated materials Environ Sci Technol 40 1447 53 16568755 10.1021/es051619+ 1:CAS:528:DC%2BD28XntFGhtA%3D%3D (Pubitemid 43376382)
40. DA Ellis JW Martin SA Mabury MD Hurley MPS Andersen TJ Wallington 2003 Atmospheric lifetime of fluorotelomer alcohols Environ Sci Technol 37 3816 20 12967100 10.1021/es034136j 1:CAS:528:DC%2BD3sXltlaqt7o%3D (Pubitemid 37071591)
41. S Oono KH Harada M Mahmoud K Inoue A Koizumi 2008 Survey of airborne polyfluorinated telomers in Japan Chemosphere 73 932 7 18701130 10.1016/j.chemosphere.2008.06.069 1:CAS:528:DC%2BD1cXhtFCkt7%2FL
42. S Oono E Matsubara KH Harada S Takagi S Hamada A Asakawa, et al. 2008 Survey of airborne polyfluorinated telomers in Keihan area, Japan Bull Environ Contam Toxicol 80 102 6 18058041 10.1007/s00128-007-9324-2 1:CAS:528: DC%2BD1cXivFWgtbc%3D
43. H Fromme M Schlummer A Moller L Gruber G Wolz J Ungewiss, et al. 2007 Exposure of an adult population to perfluorinated substances using duplicate diet portions and biomonitoring data Environ Sci Technol 41 7928 33 18075110 10.1021/es071244n 1:CAS:528:DC%2BD2sXhtFOitLrK (Pubitemid 350133340)
44. SA Tittlemier K Pepper C Seymour J Moisey R Bronson XL Cao, et al. 2007 Dietary exposure of Canadians to perfluorinated carboxylates and perfluorooctane sulfonate via consumption of meat, fish, fast foods, and food items prepared in their packaging J Agric Food Chem 55 3203 10 17381114 10.1021/jf0634045 1:CAS:528:DC%2BD2sXjtlCmurs%3D (Pubitemid 46668336)
45. Karrman A, Harada KH, Inoue K, Takasuga T, Ohi E, Koizumi A. Analysis of perfluorochemicals (PFCs) in diet duplicates and serum from Japan. DIOXIN 2007, Tokyo, Japan.
46. J Falandysz S Taniyasu A Gulkowska N Yamashita U Schulte-Oehlmann 2006 Is fish a major source of fluorinated surfactants and repellents in humans living on the Baltic Coast? Environ Sci Technol 40 748 51 16509313 10.1021/es051799n 1:CAS:528:DC%2BD28XlsFei (Pubitemid 43222156)
47. TH Begley K White P Honigfort ML Twaroski R Neches RA Walker 2005 Perfluorochemicals: potential sources of and migration from food packaging Food Addit Contam 22 1023 31 16227186 10.1080/02652030500183474 1:CAS:528: DC%2BD2MXhtFSmtLbL (Pubitemid 41700836)
48. NN Aung J Yoshinaga J-I Takahashi 2004 Exposure Assessment of Lead among Japanese Children Environ Health Prev Med 9 257 61 10.1007/BF02898139 1:CAS:528:DC%2BD2MXhsVeitrY%3D
49. K Harada K Inoue A Morikawa T Yoshinaga N Saito A Koizumi 2005 Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion Environ Res 99 253 61 16194675 10.1016/j.envres.2004.12.003 1:CAS:528:DC%2BD2MXhtVGrsbvP
50. K Harada A Koizumi N Saito K Inoue T Yoshinaga C Date, et al. 2007 Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan Chemosphere 66 293 301 16793116 10.1016/j.chemosphere.2006.05.010 1:CAS:528:DC%2BD28Xht1Cqt7rF (Pubitemid 44791402)
51. H Fromme O Midasch D Twardella J Angerer S Boehmer B Liebl 2007 Occurrence of perfluorinated substances in an adult German population in southern Bavaria Int Arch Occup Environ Health 80 313 9 16915390 10.1007/s00420-006-0136-1 1:CAS:528:DC%2BD2sXnvVShsA%3D%3D (Pubitemid 46165364)
52. A Kärrman JF Mueller B van Bavel F Harden LM Toms G Lindstrom 2006 Levels of 12 perfluorinated chemicals in pooled australian serum, collected 2002-2003, in relation to age, gender, and region Environ Sci Technol 40 3742 8 16830536 10.1021/es060301u (Pubitemid 43902369)
53. AM Calafat Z Kuklenyik SP Caudill JA Reidy LL Needham 2006 Perfluorochemicals in pooled serum samples from USA residents in 2001 and 2002 Environ Sci Technol 40 2128 34 16646443 10.1021/es0517973 1:CAS:528: DC%2BD28Xhs1SqsLg%3D
54. GW Olsen HY Huang KJ Helzlsouer KJ Hansen JL Butenhoff JH Mandel 2005 Historical comparison of perfluorooctanesulfonate, perfluorooctanoate, and other fluorochemicals in human blood Environ Health Perspect 113 539 45 15866760 1:CAS:528:DC%2BD2MXkvFCjtL8%3D
55. Y Jin N Saito KH Harada K Inoue A Koizumi 2007 Historical trends in human serum levels of perfluorooctanoate and perfluorooctane sulfonate in Shenyang, China Tohoku J Exp Med 212 63 70 17464105 10.1620/tjem.212.63 1:CAS:528:DC%2BD2sXmtVyktr4%3D (Pubitemid 46711727)
56. GW Olsen DC Mair WK Reagen ME Ellefson DJ Ehresman JL Butenhoff, et al. 2007 Preliminary evidence of a decline in perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations in American Red Cross Blood Donors Chemosphere 68 105 11 17267015 10.1016/j.chemosphere.2006.12.031 1:CAS:528:DC%2BD2sXjs1OjtLc%3D (Pubitemid 46483613)
57. GW Olsen JM Burris DJ Ehresman JW Froehlich AM Seacat JL Butenhoff, et al. 2007 Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers Environ Health Perspect 115 1298 305 17805419 1:CAS:528:DC%2BD2sXhtFamsr7J
58. N Kudo M Katakura Y Sato Y Kawashima 2002 Sex hormone-regulated renal transport of perfluorooctanoic acid Chem Biol Interact 139 301 16 11879818 10.1016/S0009-2797(02)00006-6 1:CAS:528:DC%2BD38XhslSqtrk%3D (Pubitemid 34195580)
59. Kudo N, Kawashima Y, The study of excretion pathway and long-term persistency of fluorinated fatty acids in primates. In: Annual reports of the Primate Research Institute, Kyoto University, Aichi, Vol. 31;2001
60. JL Butenhoff GL Kennedy Jr PM Hinderliter PH Lieder R Jung KJ Hansen, et al. 2004 Pharmacokinetics of perfluorooctanoate in cynomolgus monkeys Toxicol Sci 82 394 406 15470233 10.1093/toxsci/kfh302 1:CAS:528:DC%2BD2cXhtVSqsr%2FI (Pubitemid 39600066)
61. 14C in rats after a single oral dose. Riker Laboratories, Inc., Subsidiary of 3 M, St. Paul, MN, USEPA Public Docket AR-226-0007.1979.
62. Noker PE, Gorman GS. A pharmacokinetic study of potassium perfluorooctanesulfonate in the Cynomolgus monkey. USEPA public docket, administrative record AR-226-1356. 2003.
63. 14C] perfluorooctanesulfonate Fundam Appl Toxicol 4 972 6 6519377 10.1016/0272-0590(84)90235-5 1:CAS:528:DyaL2MXlslCiug%3D%3D (Pubitemid 15182587)
64. JP Vanden Heuvel BI Kuslikis MJ Van Rafelghem RE Peterson 1991 Tissue distribution, metabolism, and elimination of perfluorooctanoic acid in male and female rats J Biochem Toxicol 6 83 92 10.1002/jbt.2570060202
65. ME Andersen HJ Clewell 3rd YM Tan JL Butenhoff GW Olsen 2006 Pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys-probing the determinants of long plasma half-lives Toxicology 227 156 64 16978759 10.1016/j.tox.2006.08.004 1:CAS:528:DC%2BD28XpvV2rtL4%3D (Pubitemid 44404227)
66. H Nakagawa T Hirata T Terada P Jutabha D Miura KH Harada, et al. 2008 Roles of organic anion transporters in the renal excretion of perfluorooctanoic acid Basic Clin Pharmacol Toxicol 103 1 8 18373647 10.1111/j.1742-7843.2007. 00155.x 1:CAS:528:DC%2BD1cXotlKisL8%3D (Pubitemid 351874526)
67. M Katakura N Kudo T Tsuda Y Hibino A Mitsumoto Y Kawashima 2007 Rat organic anion transporter 3 and organic anion transporting polypeptide 1 mediate perfluorooctanoic acid transport J Health Sci 53 77 83 10.1248/jhs.53.77 1:CAS:528:DC%2BD2sXisVGntLY%3D (Pubitemid 46219371)
68. KH Harada S Hashida T Kaneko K Takenaka M Minata K Inoue, et al. 2007 Biliary excretion and cerebrospinal fluid partition of perfluorooctanoate and perfluorooctane sulfonate in humans Environ Toxicol Pharmacol 24 134 9 10.1016/j.etap.2007.04.003 1:CAS:528:DC%2BD2sXot1yjsbw%3D (Pubitemid 47088325)
69. L Maestri S Negri M Ferrari S Ghittori F Fabris P Danesino, et al. 2006 Determination of perfluorooctanoic acid and perfluorooctanesulfonate in human tissues by liquid chromatography/single quadrupole mass spectrometry Rapid Commun Mass Spectrom 20 2728 34 16915561 10.1002/rcm.2661 1:CAS:528: DC%2BD28XhtVCgurnE (Pubitemid 44497402)
70. SC Buist NJ Cherrington S Choudhuri DP Hartley CD Klaassen 2002 Gender-specific and developmental influences on the expression of rat organic anion transporters J Pharmacol Exp Ther 301 145 51 11907168 10.1124/jpet.301.1. 145 1:CAS:528:DC%2BD38Xis1Kru7g%3D (Pubitemid 34250290)
71. A Karrman I Ericson B van Bavel PO Darnerud M Aune A Glynn, et al. 2007 Exposure of perfluorinated chemicals through lactation: levels of matched human milk and serum and a temporal trend, 1996-2004, in Sweden Environ Health Perspect 115 226 30 17384769
72. K Inoue F Okada R Ito S Kato S Sasaki S Nakajima, et al. 2004 Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancy Environ Health Perspect 112 1204 7 15289168 1:CAS:528:DC%2BD2cXot1alsL8%3D
73. X Han TA Snow RA Kemper GW Jepson 2003 Binding of perfluorooctanoic acid to rat and human plasma proteins Chem Res Toxicol 16 775 81 12807361 10.1021/tx034005w 1:CAS:528:DC%2BD3sXjslOhtrY%3D
74. PD Jones W Hu W De Coen JL Newsted JP Giesy 2003 Binding of perfluorinated fatty acids to serum proteins Environ Toxicol Chem 22 2639 49 14587903 10.1897/02-553 1:CAS:528:DC%2BD3sXotFOgs7w%3D (Pubitemid 37214748)
75. GW Olsen JM Burris MM Burlew JH Mandel 2003 Epidemiologic assessment of worker serum perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations and medical surveillance examinations J Occup Environ Med 45 260 70 12661183 10.1097/01.jom.0000052958.59271.10 1:CAS:528:DC%2BD3sXhs1elt7g%3D (Pubitemid 36343227)
76. GW Olsen JM Burris JH Mandel LR Zobel 1999 Serum perfluorooctane sulfonate and hepatic and lipid clinical chemistry tests in fluorochemical production employees J Occup Environ Med 41 799 806 10491796 10.1097/00043764-199909000-00012 1:CAS:528:DyaK1MXmsVOlt7g%3D (Pubitemid 29426786)
77. CJ Sakr KH Kreckmann JW Green PJ Gillies JL Reynolds RC Leonard 2007 Cross-sectional study of lipids and liver enzymes related to a serum biomarker of exposure (ammonium perfluorooctanoate or APFO) as part of a general health survey in a cohort of occupationally exposed workers J Occup Environ Med 49 1086 96 18000414 1:CAS:528:DC%2BD2sXhtFWltr%2FI
78. P Anderson-Mahoney J Kotlerman H Takhar D Gray J Dahlgren 2008 Self-reported health effects among community residents exposed to perfluorooctanoate New Solut 18 129 43 18511391
79. AG Abdellatif V Preat HS Taper M Roberfroid 1991 The modulation of rat liver carcinogenesis by perfluorooctanoic acid, a peroxisome proliferator Toxicol Appl Pharmacol 111 530 7 1684073 10.1016/0041-008X(91)90257-F 1:CAS:528:DyaK38XnvVaksQ%3D%3D
80. AM Seacat PJ Thomford JL Butenhoff 2002 Terminal observations in Sprague Dawley rats after lifetime dietary exposure to potassium perfluorooclanesulfonate Toxicologist 66 185
81. Y Oda S Nakayama KH Harada A Koizumi 2007 Negative results of umu mutagenecity test of fluorotelomer alcohols and perfluorinated alkyl acids Environ Health Prev Med 12 217 9 10.1265/ehpm.12.217 1:CAS:528: DC%2BD2sXhtlertbvI (Pubitemid 350106362)
82. JP Vanden Heuvel JT Thompson SR Frame PJ Gillies 2006 Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha Toxicol Sci 92 476 89 10.1093/toxsci/kfl014 (Pubitemid 44018964)
83. DC Wolf T Moore BD Abbott MB Rosen KP Das RD Zehr, et al. 2008 Comparative hepatic effects of perfluorooctanoic acid and WY 14, 643 in PPAR-alpha knockout and wild-type mice Toxicol Pathol 36 632 9 18467680 10.1177/0192623308318216 1:CAS:528:DC%2BD1cXnslKhsLk%3D
84. MB Rosen JS Lee H Ren B Vallanat J Liu MP Waalkes, et al. 2008 Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR Toxicol Sci 103 46 56 18281256 10.1093/toxsci/kfn025 1:CAS:528: DC%2BD1cXksF2ls78%3D
85. J Butenhoff G Costa C Elcombe D Farrar K Hansen H Iwai, et al. 2002 Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months Toxicol Sci 69 244 57 12215680 10.1093/toxsci/69.1.244 1:CAS:528:DC%2BD38XmvVGjs7g%3D
86. AM Seacat PJ Thomford KJ Hansen GW Olsen MT Case JL Butenhoff 2002 Subchronic toxicity studies on perfluorooctanesulfonate potassium salt in cynomolgus monkeys Toxicol Sci 68 249 64 12075127 10.1093/toxsci/68.1.249 1:CAS:528:DC%2BD38XlsVSmsro%3D (Pubitemid 34785246)
87. C Lau JL Butenhoff JM Rogers 2004 The developmental toxicity of perfluoroalkyl acids and their derivatives Toxicol Appl Pharmacol 198 231 41 15236955 10.1016/j.taap.2003.11.031 1:CAS:528:DC%2BD2cXlsVSnsb8%3D (Pubitemid 38952836)
88. C Lau JR Thibodeaux RG Hanson JM Rogers BE Grey ME Stanton, et al. 2003 Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation Toxicol Sci 74 382 92 12773772 10.1093/toxsci/kfg122 1:CAS:528:DC%2BD3sXlsl2kurc%3D (Pubitemid 36958307)
89. J Thibodeaux RG Hanson BE Grey BD Barbee JH Richards JL Butenhoff, et al. 2003 Maternal and developmental toxicity of perfluorooctane sulfonate (PFOS) in the mouse Toxicol Sci 72 342
90. DE Keil T Mehlmann L Butterworth MM Peden-Adams 2008 Gestational exposure to perfluorooctane sulfonate suppresses immune function in B6C3F1 mice Toxicol Sci 103 77 85 18252804 10.1093/toxsci/kfn015 1:CAS:528:DC%2BD1cXksF2lsro%3D
91. BD Abbott CJ Wolf JE Schmid KP Das RD Zehr L Helfant, et al. 2007 Perfluorooctanoic acid-induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator-activated receptor-alpha Toxicol Sci 98 571 81 17488742 10.1093/toxsci/kfm110 1:CAS:528:DC%2BD2sXosFGjur0%3D (Pubitemid 47244825)
92. Abbott BD, Wolf CJ, Das KP, Zehr RD, Schmid JE, Lindstrom AB, et al. Developmental toxicity of perfluorooctane sulfonate (PFOS) is not dependent on expression of peroxisome proliferator activated receptor-alpha (PPARα) in the mouse. Reprod Toxicol. 2008.
93. ME Austin BS Kasturi M Barber K Kannan PS MohanKumar SM MohanKumar 2003 Neuroendocrine effects of perfluorooctane sulfonate in rats Environ Health Perspect 111 1485 9 12948888 1:CAS:528:DC%2BD3sXnvFOhtrc%3D
94. A Asakawa M Toyoshima M Fujimiya K Harada K Ataka K Inoue, et al. 2007 Perfluorooctane sulfonate influences feeding behavior and gut motility via the hypothalamus Int J Mol Med 19 733 9 17390077 1:CAS:528:DC%2BD2sXlsFCntLk%3D
95. A Asakawa M Toyoshima KH Harada M Fujimiya K Inoue A Koizumi 2008 The ubiquitous environmental pollutant perfluorooctanoic acid inhibits feeding behavior via peroxisome proliferator-activated receptor-alpha Int J Mol Med 21 439 45 18360689 1:CAS:528:DC%2BD1cXkslKqsbk%3D
96. S Fuentes P Vicens MT Colomina JL Domingo 2007 Behavioral effects in adult mice exposed to perfluorooctane sulfonate (PFOS) Toxicology 242 123 9 17950980 10.1016/j.tox.2007.09.012 1:CAS:528:DC%2BD2sXhtlaht7nF (Pubitemid 350087436)
97. 2+ currents in guinea-pig ventricular myocytes Biochem Biophys Res Commun 329 487 94 15737613 10.1016/j.bbrc.2005.01.163 1:CAS:528:DC%2BD2MXhslCgtLk%3D (Pubitemid 40311771)
98. KH Harada TM Ishii K Takatsuka A Koizumi H Ohmori 2006 Effects of perfluorooctane sulfonate on action potentials and currents in cultured rat cerebellar Purkinje cells Biochem Biophys Res Commun 351 240 5 17056011 10.1016/j.bbrc.2006.10.038 1:CAS:528:DC%2BD28XhtFequ7%2FP (Pubitemid 44635432)
99. E Matsubara K Harada K Inoue A Koizumi 2006 Effects of perfluorinated amphiphiles on backward swimming in Paramecium caudatum Biochem Biophys Res Commun 339 554 61 16300727 10.1016/j.bbrc.2005.11.048 1:CAS:528: DC%2BD2MXhtlSiur7J (Pubitemid 41739703)
100. E Matsubara T Nakahari H Yoshida T Kuroiwa KH Harada K Inoue, et al. 2007 Effects of perfluorooctane sulfonate on tracheal ciliary beating frequency in mice Toxicology 236 190 8 17544559 10.1016/j.tox.2007.04.016 1:CAS:528:DC%2BD2sXntFKntLg%3D (Pubitemid 46977110)
101. CY Liao XY Li B Wu S Duan GB Jiang 2008 Acute enhancement of synaptic transmission and chronic inhibition of synaptogenesis induced by perluorooctane sulfonate through mediation of voltage-dependent calcium channel Environ Sci Technol 42 5335 41 18754390 10.1021/es800018k 1:CAS:528:DC%2BD1cXntlKqsbY%3D