Increase in apoptosis and of the stress protein HSP70 in the mouse epididymis produced by the antiandrogen Flutamide;El antiandrógeno Flutamida produce un aumento de la apoptosisy de la proteína de stress HSP70 en el epidídimo del ratón

International Journal of Morphology

Volumn 27, Issue 2, 2009, Pages 463-468

  Bustos Obregón, Eduardo ^a   Esponda, Pedro ^b  

^a UNIVERSITY OF CHILE   (Chile)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

Antiandrogen; Apoptosis; Epididymis; Flutamide; Stress proteins

Indexed keywords

EID: 70349588707     PISSN: 07179367     EISSN: 07179502     Source Type: Journal    
DOI: 10.4067/S0717-95022009000200025     Document Type: Article

References (22)

1. Beere, H. M. & Green, D. R. Stress management of heat shock protein-70 and the regulation of apoptosis. Trends Cell. Biol., 11(1):6-10, 2001.
2. Brinkmann, A. O.; Block, L. J.; De Ruiter, P. E.; Doesburg, P.; Steketee, K.; Berrevoets, C. A. & Trapman, J. Mechanisms of androgen receptor activation and function. J. Steroid. Biochem. Mol. Biol., 69(1-6):307-13, 1999.
3. Brogden, R. N. & Clissold, S. P. Flutamide. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in advanced prostate cancer. Drugs, 38(2):185-203, 1989.
4. Bustos-Obregón, E. & Esponda, P. Ageing induces apoptosis and increases HSP70 Stress Protein in the epididymis of Octodon degus. Int. J. Morphol., 22(3):29-34, 2004.
5. Carballada, C.; Jara, M. & Esponda, P. Photoperiod-induced apoptosis in the male genital tract epithelia of the golden hamster. Int. J. Androl., 30(2):73-9, 2007.
6. Cooper, T. G. The Epididymis, Sperm Maturation and Fertilisation. Berlin, Springer Verlag, 1986.
7. Esponda, P. & Bedford, J. M. The influence of body temperature and castration on the protein composition of the fluid in the rat cauda epididymis. J. Reprod. Fertil., 78(2):505-14, 1986.
8. Ezer, N. & Robaire, B. Gene expression is differentially regulated in the epididymis after orchidectomy. Endocrinology, 144(3):975-88, 2003.
9. Fan, X. & Robaire, B. Orchidectomy induces a wave of apoptotic cell death in the epididymis. Endocrinology, 139(4): 2128-36, 1998.
10. Georgopoulos, C. & Welch, W. J. Role of the major heat shock proteins as molecular chaperones. Ann. Rev. Cell Biol., 9:601-34, 1993.
11. Gooren, L. Endocrine aspects of ageing in the male. Molec. Cell. Endocrinol., 145(1-2):153-9, 1998.
12. Guo C. X;Ma, J.; Zhou, X. C. Liu, Y. X. Expression of HSP70-2 gene during germ cell apoptosis in rat unilateral cryptorchid testes.Arch. Androl., 46(2):109-15, 2001.
13. Hermo, L.; Xiaohong, S. & Morales, C. Circulating and luminal testicular factors affected LPR-2 and Apo J expression in the epididymis following efferent duct legation. J. Androl., 21(1):122- 44, 2000.
14. Hinton, B. T.; Lan, Z. J.; Rudolp, D. B.; Labus, J. C. & Lye, R. J. Testicular regulation of epididymal gene expression. J. Reprod. Fertil., 53:47-57, 1998.
15. Jara, M.; Esponda, P. & Carballada, R. Abdominal temperature induces region specific p-53-Independent apoptosis in the cauda epididimis of the mouse. Biol. Reprod., 67(4):1189-96, 2002.
16. Jara, M.; Carballada, R. & Esponda, P. Age-induced apoptosis in the male genital tract of the mouse. Reproduction, 127(3):359-66, 2004.
17. Lan, Z. J.; Labus, J. C. & Hinton, B. T. Regulation of gamma-glutamyl transpeptidase catalytic activity and protein level in the initial segment of the rat epididymis by testicular factors: role of basic fibroblast growth factor. Biol. Reprod., 58(1):197-206, 1998.
18. Legare, C.; Thabet, M. & Sullivan, R. Expression of heat shock protein in normal and cryptorchid human excurrent duct. Mol. Hum. Reprod., 10(3):197-202, 2004.
19. Samali, A. & Cotter, T. G. Heath shock proteins increase resistance to apoptosis. Exp. Cell. Res., 223(1):163-70, 2006.
20. Serre, V. & Robaire, B. Segment specific morphological changes in aging Brown Norway rat epididymis. Biol. Reprod., 58(2):497-513, 1998.
21. Viguier-Martinez, M. C.; Hochereau de Reviers, M. T.; Barenton, B. & Perreau, C. Endocrinological and histological changes induced by flutamide treatment on the hypothalamo-hypophysisl testicular axis of the adult male on fertiliy. Acta Endocrinol., 104(2):246-52, 1983.
22. Wyllie, A. H.; Kerr, F. & Currie, A. R. Cell death: the significance of apoptosis. Int. Rev. Cytol., 68:251-306, 1980.