Involvement of Akt1/protein kinase Bα in tumor conditioned medium-induced endothelial cell migration and survival in vitro

Journal of Cancer Research and Clinical Oncology

Volumn 135, Issue 11, 2009, Pages 1543-1550

  Tu, Ming Li ^a   Wang, Han Qin ^a   Chen, Long Ju ^a   Lu, Jin Chang ^a   Jiang, Fei ^a   Liang, Jiang Hong ^a   Xu, Da Guo ^a   Li, Dong Sheng ^a  

^a HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

A549; Akt; Conditioned medium; Endothelial cell; Migration

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE B ALPHA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WORTMANNIN; AKT1 PROTEIN, HUMAN;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL ASSAY; CELL DEATH; CELL MIGRATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CARCINOMA; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; WOUND HEALING; CELL CULTURE; CELL MOTION; CULTURE MEDIUM; GENETICS; LUNG TUMOR; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHYSIOLOGY; VASCULARIZATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; ENDOTHELIAL CELLS; HUMANS; LUNG NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING;

EID: 70349582142     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-009-0601-9     Document Type: Article

References (23)

1. P Carmeliet 2003 Angiogenesis in health and disease Nat Med 9 653 660 10.1038/nm0603-653 12778163 10.1038/nm0603-653 1:CAS:528:DC%2BD3sXktFOntbY%3D (Pubitemid 36749213)
2. WS Chen PZ Xu K Gottlob ML Chen K Sokol T Shiyanova I Roninson W Weng R Suzuki K Tobe, et al. 2001 Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene Genes Dev 15 2203 2208 10.1101/gad.913901 11544177 10.1101/gad.913901 1:CAS:528:DC%2BD3MXmvFSrurg%3D (Pubitemid 32843832)
3. J Chen PR Somanath O Razorenova WS Chen N Hay P Bornstein TV Byzova 2005 Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo Nat Med 11 1188 1196 10.1038/nm1307 16227992 10.1038/nm1307 1:CAS:528:DC%2BD2MXhtFOhsLrL (Pubitemid 43093666)
4. H Cho JL Thorvaldsen Q Chu F Feng MJ Birnbaum 2001 Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice J Biol Chem 276 38349 38352 10.1074/jbc.C100462200 11533044 10.1074/jbc.C100462200 1:CAS:528:DC%2BD3MXnvVens70%3D
5. B Dummler BA Hemmings 2007 Physiological roles of PKB/Akt isoforms in development and disease Biochem Soc Trans 35 231 235 10.1042/BST0350231 17371246 10.1042/BST0350231 1:CAS:528:DC%2BD2sXjt1WrsLg%3D (Pubitemid 46596476)
6. J Folkman 1995 Angiogenesis in cancer, vascular, rheumatoid and other disease Nat Med 1 27 31 10.1038/nm0195-27 7584949 10.1038/nm0195-27 1:CAS:528:DyaK2MXjs1KnsLk%3D
7. HP Gerber A McMurtrey J Kowalski M Yan BA Keyt V Dixit N Ferrara 1998 Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation J Biol Chem 273 30336 30343 10.1074/jbc.273.46.30336 9804796 10.1074/jbc.273.46.30336 1:CAS:528:DyaK1cXnsVyrtb0%3D (Pubitemid 28545503)
8. Y Huang HJ Yang Y Jin HM Li SB Fu 2005 13q14 aberration is related to the metastatic potential of human NSCLC Yi Chuan 27 531 534 16120571
9. YD Jung SA Ahmad W Liu N Reinmuth A Parikh O Stoeltzing F Fan LM Ellis 2002 The role of the microenvironment and intercellular cross-talk in tumor angiogenesis Semin Cancer Biol 12 105 112 10.1006/scbi.2001.0418 12027582 10.1006/scbi.2001.0418 1:CAS:528:DC%2BD38XjvVers74%3D (Pubitemid 34680739)
10. O Kargiotis C Chetty CS Gondi AJ Tsung DH Dinh M Gujrati SS Lakka AP Kyritsis JS Rao 2008 Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma Oncogene 27 4830 4840 10.1038/onc.2008.122 18438431 10.1038/onc.2008.122 1:CAS:528: DC%2BD1cXpvVSqtbw%3D
11. NM Mazure EY Chen KR Laderoute AJ Giaccia 1997 Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element Blood 90 3322 3331 9345014 1:CAS:528:DyaK2sXntVSjtrw%3D
12. M Oberringer C Meins M Bubel T Pohlemann 2008 In vitro wounding: effects of hypoxia and transforming growth factor beta1 on proliferation, migration and myofibroblastic differentiation in an endothelial cell-fibroblast co-culture model J Mol Histol 39 37 47 10.1007/s10735-007-9124-3 17786573 10.1007/s10735-007-9124-3 1:CAS:528:DC%2BD1cXosFWisg%3D%3D
13. W Risau 1997 Mechanisms of angiogenesis Nature 386 671 674 10.1038/386671a0 9109485 10.1038/386671a0 1:STN:280:DyaK2s3mtlGksg%3D%3D
14. E Shaulian M Karin 2002 AP-1 as a regulator of cell life and death Nat Cell Biol 4 E131 E136 10.1038/ncb0502-e131 11988758 10.1038/ncb0502-e131 1:CAS:528:DC%2BD38Xjt1Kgsbg%3D (Pubitemid 34521026)
15. T Shimada Y Nishimura T Nishiuma Y Rikitake T Hirase M Yokoyama 2007 Adenoviral transfer of rho family proteins to lung cancer cells ameliorates cell proliferation and motility and increases apoptotic change Kobe J Med Sci 53 125 134 17684444 1:CAS:528:DC%2BD2sXptlKru70%3D
16. I Shiojima K Sato Y Izumiya S Schiekofer M Ito R Liao WS Colucci K Walsh 2005 Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure J Clin Invest 115 2108 2118 10.1172/JCI24682 16075055 10.1172/JCI24682 1:CAS:528:DC%2BD2MXntFCmtLs%3D (Pubitemid 41134152)
17. PR Somanath OV Razorenova J Chen TV Byzova 2006 Akt1 in endothelial cell and angiogenesis Cell Cycle 5 512 518 16552185 1:CAS:528:DC%2BD28Xkslejsr8%3D
18. GP van Nieuw Amerongen P Koolwijk A Versteilen VW van Hinsbergh 2003 Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro Arterioscler Thromb Vasc Biol 23 211 217 10.1161/01.ATV.0000054198.68894.88 12588761 10.1161/01.ATV.0000054198.68894.88 (Pubitemid 36231930)
19. HQ Wang LX Huang MJ Qu ZQ Yan B Liu BR Shen ZL Jiang 2006 Shear stress protects against endothelial regulation of vascular smooth muscle cell migration in a coculture system Endothelium 13 171 180 10.1080/10623320600760282 16840173 10.1080/10623320600760282 (Pubitemid 44110583)
20. HQ Wang L Bai BR Shen ZQ Yan ZL Jiang 2007 Coculture with endothelial cells enhances vascular smooth muscle cell adhesion and spreading via activation of beta1-integrin and phosphatidylinositol 3-kinase/Akt Eur J Cell Biol 86 51 62 10.1016/j.ejcb.2006.09.001 17141917 10.1016/j.ejcb.2006.09.001 1:CAS:528:DC%2BD2sXhsVWgtrw%3D (Pubitemid 44910103)
21. KA Warner M Miyazawa MM Cordeiro WJ Love MS Pinsky KG Neiva AC Spalding JE Nor 2008 Endothelial cells enhance tumor cell invasion through a crosstalk mediated by CXC chemokine signaling Neoplasia 10 131 139 10.1593/neo.07815 18283335 10.1593/neo.07815 1:CAS:528:DC%2BD1cXltleisbg%3D (Pubitemid 351240879)
22. J Ye L Yuan 2007 Inhibition of p38 MAPK reduces tumor conditioned medium-induced angiogenesis in co-cultured human umbilical vein endothelial cells and fibroblasts Biosci Biotechnol Biochem 71 1162 1169 10.1271/bbb.60617 17485858 10.1271/bbb.60617 1:CAS:528:DC%2BD2sXmsFShu7s%3D (Pubitemid 47164232)
23. Q Zeng S Li DB Chepeha TJ Giordano J Li H Zhang PJ Polverini J Nor J Kitajewski CY Wang 2005 Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling Cancer Cell 8 13 23 10.1016/j.ccr.2005.06.004 16023595 10.1016/j.ccr.2005.06.004 1:CAS:528:DC%2BD2MXntVejs7w%3D (Pubitemid 40991811)