Rabbit study of an in situ forming hydrogel vitreous substitute

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 10, 2009, Pages 4840-4846

  Swindle Reilly, Katelyn E ^a,b   Shah, Milan ^c   Hamilton, Paul D ^a   Eskin, Thomas A ^c   Kaushal, Shalesh ^c   Ravi, Nathan ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLAMIDE; ACRYLAMIDE COPOLYMER; POLYMER; UNCLASSIFIED DRUG; BIOMATERIAL; DISULFIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CHEMICAL STRUCTURE; CILIARY DISK; CONTROLLED STUDY; CROSS LINKING; ELECTRORETINOGRAM; ENDOPHTHALMITIS; EXPERIMENTAL RABBIT; FLOW MEASUREMENT; GELATION; HISTOPATHOLOGY; HYDROGEL; HYDROGEL VITREOUS SUBSTITUTE; MATERIAL STATE; NONHUMAN; PRIORITY JOURNAL; REFRACTOMETRY; RETINA; SLIT LAMP; SYNTHESIS; UVEITIS; VISCOELASTICITY; VITRECTOMY; VITREOUS BODY; ANIMAL; CHEMISTRY; ELASTICITY; ELECTRORETINOGRAPHY; IMPLANT; PROSTHESES AND ORTHOSES; RABBIT; SWINE; VISCOSITY;

ANIMALS; BIOCOMPATIBLE MATERIALS; DISULFIDES; ELASTICITY; ELECTRORETINOGRAPHY; HYDROGELS; IMPLANTS, EXPERIMENTAL; POLYMERS; PROSTHESES AND IMPLANTS; RABBITS; REFRACTOMETRY; SWINE; VISCOSITY; VITRECTOMY; VITREOUS BODY;

EID: 70349578971     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2891     Document Type: Article

References (25)

1. Sebag J. Age-related changes in human vitreous structure. Graefes Arch Clin Exp Ophthalmol. 1987;225(2):89-93.
2. Bishop PN. Structural macromolecules and supramolecular organisation of the vitreous gel. Prog Retin Eye Res. 2000;19(3):323-344.
3. Sebag J, Balazs EA. Morphology and ultrastructure of human vitreous fibers. Invest Ophthalmol Vis Sci. 1989;30:1867-1871.
4. Matteucci A, Formisano G, Paridisi S, et al. Biocompatibility assessment of liquid artificial vitreous replacements: relevance of in vitro studies. Surv Ophthalmol. 2007;52(3):289-299.
5. Chirila TV, Hong Y, Dalton PD, Constable IJ, Refojo MF. The use of hydrophilic polymers as artificial vitreous. Prog Polym Sci. 1998; 23(3):475-508.
6. Swindle KE, Ravi N. Recent advances in polymeric vitreous substitutes. Expert Rev Ophthalmol. 2007;2(2):255-265.
7. Maruoka S, Matsuura T, Kawasaki K, et al. Biocompatibility of polyvinylalcohol gel as a vitreous substitute. Curr Eye Res. 2006; 31:599-606.
8. Soman N, Banerjee R. Artificial vitreous replacements. Biomed Mater Eng. 2003;13:59-74.
9. Chirila TV, Hong Y. Poly(1-vinyl-2-pyrrolidinone) hydrogels as vitreous substitutes: a rheological study. Polym Int. 1998;46:183-195.
10. Daniele S, Refojo MF, Schepens CL, Freeman HM. Glyceryl methacrylate hydrogel as a vitreous implant: an experimental study. Arch Ophthalmol. 1968;80(1):120-127.
11. Muller-Jensen K, Kohler H. An attempt to replace the vitreous body by poly(acrylamide) [in German]. Ber Zusammenkunft Dtsch Ophthalmol Ges. 1968;68:181-184.
12. Muller-Jensen K. Alloplastic vitreous replacement with acrylamide. Mod Probl Ophthalmol. 1974;12:385-389.
13. Gao Q, Mou S, Ge J, et al. A new strategy to replace the natural vitreous by a novel capsular artificial vitreous body with pressurecontrol valve. Eye. 2008;22:461-468.
14. Aliyar HA, Hamilton PD, Ravi N. Refilling of ocular lens capsule with copolymeric hydrogel containing reversible disulfide. Biomacromolecules. 2005;6:204-211.
15. Foster WJ, Aliyar HA, Hamilton PD, Ravi N. Internal osmotic pressure as a mechanism of retinal attachment in a vitreous substitute. J Bioact Compat Pol. 2006;21(3):221-235.
16. Swindle KE, Hamilton PD, Ravi N. In situ formation of hydrogels as vitreous substitutes: viscoelastic comparison to porcine vitreous. J Biomed Mater Res. 2008;87(3):656-665.
17. Nickerson CS, Karageozian HL, Park J, Kornfield JA. Internal tension: a novel hypothesis concerning the mechanical properties of the vitreous humor. Macromol Symp. 2005;227:183-189.
18. Tokita M, Fujiya Y, Hikichi K. Dynamic viscoelasticity of bovine vitreous body. Biorheology. 1984;21:751-756.
19. Fernandez-Vigo J, Refojo MF, Verstraeten T. Evaluation of a viscoelastic solution of hydroxypropyl methylcellulose as a potential vitreous substitute. Retina. 1990;10:148-152.
20. Vijayasekaran S, Chirila TV, Hong Y, et al. Poly(1-vinyl-2-pyrrolidinone) hydrogels as vitreous substitutes: histopathological evaluation in the animal eye. J Biomat Sci Polym E. 1996;7(8):695-696.
21. Hong Y, Chirila TV, Vijayasekaran S, Shen W, Lou X, Dalton PD. Biodegradation in vitro and retention in the rabbit eye of crosslinked poly(1-vinyl-2-pyrrolidinone) hydrogel as a vitreous substitute. J Biomed Mater Res. 1998;39:650-659.
22. Kanski JJ, Daniel R. Intravitreal silicone injection in retinal detachment. Br J Ophthalmol. 1973;57(8):542-545.
23. Nakamura K, Refojo MF, Crabtree DV, Pastor J, Leong FL. Ocular toxicity of low-molecular weight components of silicone and fluorosilicone oils. Invest Ophthalmol Vis Sci. 1991;32:3007-3020.
24. Kirchhof B, Wong D, Van Meurs J, et al. Use of perfluorohexyloctane as a long-term internal tamponade agent in complicated retinal detachment surgery. Am J Ophthalmol. 2002;133(1):95-101.
25. Flores-Aguilar M, Munguia D, Loeb E, et al. Intraocular tolerance of perfluorooctylbromide (perflubron). Retina. 1995;15(1):1-13.