Yttrium-90 radioembolization using TheraSphere® in the management of primary and secondary liver tumors

Quarterly Journal of Nuclear Medicine and Molecular Imaging

Volumn 53, Issue 3, 2009, Pages 311-316

  Riaz, A ^a   Lewandowski, R J ^a   Kulik, L ^a   Salem, R ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Carcinoma, hepatocellular; Liver neoplasms; Operative; Surgical procedures

Indexed keywords

MACROSALB TC 99M; MICROSPHERE; SORAFENIB; THERASPHERE; UNCLASSIFIED DRUG; YTTRIUM 90; RADIOISOTOPE; RADIOPHARMACEUTICAL AGENT; YTTRIUM;

ADVERSE OUTCOME; ARTIFICIAL EMBOLISM; BILE DUCT CARCINOMA; BLOOD FLOW; BLOOD VESSEL INJURY; CANCER RADIOTHERAPY; CHEMOEMBOLIZATION; CHOLANGITIS; CLINICAL ASSESSMENT; CLINICAL TRIAL; COLORECTAL CARCINOMA; DOSE CALCULATION; DRUG DOSE ESCALATION; GASTROINTESTINAL TOXICITY; HUMAN; LIVER CANCER; LIVER CELL CARCINOMA; LIVER METASTASIS; LIVER TOXICITY; LIVER TUMOR; MEDICAL HISTORY; MIXED TUMOR; NEUROENDOCRINE TUMOR; NONHUMAN; PORTAL VEIN THROMBOSIS; POSTRADIOEMBOLIZATION SYNDROME; PREMEDICATION; RADIATION DOSE; RADIATION PNEUMONIA; REVIEW; METASTASIS;

CARCINOMA, HEPATOCELLULAR; HUMANS; LIVER NEOPLASMS; RADIOISOTOPES; RADIOPHARMACEUTICALS; RADIOTHERAPY DOSAGE; YTTRIUM RADIOISOTOPES;

EID: 70349576355     PISSN: 18244785     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (45)

1. El-Serag HB. Hepatocellular carcinoma and hepatitis C in the United States. Hepatology 2002;36:S74-83.
2. Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996;334:693-9. (Pubitemid 26079803)
3. Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359:378-90.
4. Welsh JS, Kennedy AS, Thomadsen B. Selective Internal Radiation Therapy (SIRT) for liver metastases secondary to colorectal adenocarcinoma. Int J Radiat Oncol Biol Phys 2006;66:S62-73.
5. Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 2001;35:421-30.
6. Covey AM, Brody LA, Maluccio MA, Getrajdman GI, Brown KT. Variant hepatic arterial anatomy revisited: digital subtraction angiography performed in 600 patients. Radiology 2002;224:542-7.
7. Liu DM, Salem R, Bui JT, Courtney A, Barakat O, Sergie Z et al. Angiographic considerations in patients undergoing liver-directed therapy. J Vasc Interv Radiol 2005;16:911-35.
8. Murthy R, Nunez R, Szklaruk J, Erwin W, Madoff DC, Gupta S et al. Yttrium-90 microsphere therapy for hepatic malignancy: devices, indications, technical considerations, and potential complications. Radiographics 2005;25 Suppl 1:S41-55.
9. Cosin O, Bilbao JI, Alvarez S, de Luis E, Alonso A, Martinez-Cuesta A. Right gastric artery embolization prior to treatment with yttrium-90 microspheres. Cardiovasc Intervent Radiol 2007;30:98-103. (Pubitemid 44900497)
10. Salem R, Thurston KG, Carr BI, Goin JE, Geschwind JF. Yttrium-90 microspheres: radiation therapy for unresectable liver cancer. J Vasc Interv Radiol 2002;13;S223-229.
11. Ibrahim SM, Nikolaidis P, Miller FH, Lewandowski RJ, Ryu RK, Sato KT et al. Radiologic findings following Y90 radioembolization for primary liver malignancies. Abdom Imaging 2008. [Epub ahead of print]
12. Riaz A, Kulik L, Lewandowski RJ, Ryu RK, Giakoumis Spear G, Mulcahy MF et al. Radiologie-pathologie correlation of hepatocellular carcinoma treated with internal radiation using yttrium-90 microspheres. Hepatology 2008 Nov 19;49:1185-93.
13. Rhee TK, Naik NK, Deng J, Atassi B, Mulcahy MF, Kulik LM et al. Tumor response after yttrium-90 radioembolization for hepatocellular carcinoma: comparison of diffusion-weighted functional MR imaging with anatomic MR imaging. J Vasc Interv Radiol 2008;19:1180-6.
14. Ingold JA, Reed GB, Kaplan HS, Bagshaw MA. Radiation hepatitis. Am J Roentgenol Radium Ther Nucl Med 1965;93:200-8.
15. Geschwind JF, Salem R, Carr BI, Soulen MC, Thurston KG, Goin KA et al. Yttrium-90 microspheres for the treatment of hepatocellular carcinoma. Gastroenterology 2004;127:S194-205.
16. Dawson LA, McGinn NJ, Ensminger WD. Preliminary results of escalated focal liver radiation and hepatic artery floxuridine for unresectable liver malignancies. American Society of Clincial Oncology 1999;18:86.
17. Nolan TR, Grady ED. Intravascular particulate radioisotope therapy: clinical observations of 76 patients with advanced cancer treated with 90-yttrium particles. Am Surg 1969;35:181-8.
18. Mantravadi RV, Spigos DG, Tan WS, Felix EL. Intraarterial yttrium 90 in the treatment of hepatic malignancy. Radiology 1982;142: 783-6.
19. Wollner I, Knutsen C, Smith P et al. Effects of hepatic arterial yttrium 90 glass microspheres in dogs. Cancer 1988;61:1336-44. (Pubitemid 18076406)
20. Wollner IS, Knutsen CA, Ullrich KA, Chrisp CE, Juni JE, Andrews JC et al. Effects of hepatic arterial yttrium-90 microsphere administration alone and combined with regional bromodeoxyuridine infusion in dogs. Cancer Res 1987;47:3285-90.
21. Shepherd FA, Rotstein LE, Houle S, Yip TC, Paul K, Sniderman KW. A phase I dose escalation trial of yttrium-90 microspheres in the treatment of primary hepatocellular carcinoma. Cancer 1992;70: 2250-4.
22. Yan ZP, Lin G, Zhao HY, Dong YH. An experimental study and clinical pilot trials on yttrium-90 glass microspheres through the hepatic artery for treatment of primary liver cancer. Cancer 1993;72:3210-5. (Pubitemid 23356762)
23. Andrews JC, Walker SC, Ackermann RJ, Cotton LA, Ensminger WD, Shapiro B. Hepatic radioembolization with yttrium-90 containing glass microspheres: preliminary results and clinical follow-up. J Nucl Med 1994;35:1637-44.
24. Lau WY, Leung WT, Ho S, Cotton LA, Ensminger WD, Shapiro B. Treatment of inoperable hepatocellular carcinoma with intrahepatic arterial yttrium-90 microspheres: a phase I and II study. Br J Cancer 1994;70:994-9. (Pubitemid 24331102)
25. Kulik LM, Atassi B, van Holsbeeck L, Souman T, Lewandowski RJ, Mulcahy MF et al. Yttrium-90 microspheres (TheraSphere(R)) treatment of unresectable hepatocellular carcinoma: Downstaging to resection, RFA and bridge to transplantation. J Surg Oncol 2006; 94:572-86. (Pubitemid 44851918)
26. Kulik LM, Carr BI, Mulcahy MF, Lewandowski RJ, Atassi B, Ryu RK et al. Safety and efficacy of (90)Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosis. Hepatology 2007;47:71-81.
27. Ibrahim SM, Mulcahy MF, Lewandowski RJ, Sato KT, Ryu RK, Masterson EJ et al. Treatment of unresectable cholangiocarcinoma using yttrium-90 microspheres: results from a pilot study. Cancer 2008;113:2119-28..
28. Gray B, Van Hazel G, Hope M, Burton M, Moroz P, Anderson J et al. Randomised trial of SIR-Spheres plus chemotherapy vs. chemotherapy alone for treating patients with liver metastases from primary large bowel cancer. Ann Oncol 2001;12:1711-20.
29. Goin JE, Dancey JE, Hermann GA, Sickles CJ, Roberts CA, MacDonald JS. Treatment of unresectable metastatic colorectal carcinoma to the liver with intrahepatic Y-90 microspheres: a dose-ranging study. World J of Nuc Med 2003;2:216-25.
30. Hong K, McBride JD, Georgiades CS, Reyes DK, Herman JM, Kamel IR et al. Salvage therapy for liver-dominant colorectal metastatic adenocarcinoma: comparison between transcatheter arterial chemoembolization versus yttrium-90 radioembolization. J Vasc Interv Radiol 2009;20:360-7
31. Rhee TK, Lewandowski RJ, Liu DM, Mulcahy MF, Takahashi G, Hansen PD et al. 90Y Radioembolization for metastatic neuroendocrine liver tumors: preliminary results from a multi-institutional experience. Ann Surg 2008;247:1029-35. (Pubitemid 351770424)
32. Kennedy AS, Dezarn WA, McNeillie P, Coldwell D, Nutting C, Carter D et al. Radioembolization for unresectable neuroendocrine hepatic metastases using resin 90Y-microspheres: early results in 148 patients. Am J Clin Oncol 2008;31:271-9.
33. Coldwell D, Nutting C, Kennedy AK. Treatment of hepatic metastases from breast cancer with Yttrium-90 SIR-Spheres radioembolization. Society of Interventional Radiology Annual Meeting. New Orleans, LA; 2005.
34. Jakobs TF, Hoffmann RT, Fischer T, Stemmler HJ, Tatsch K, La Fougere C et al. Radioembolization in patients with hepatic metastases from breast cancer. J Vasc Interv Radiol 2008;19:683-90.
35. Kennedy AS, Nutting C, Jakobs T, Cianni R, Notarianni E, Ofer A et al. A first report of radioembolization for hepatic metastases from ocular melanoma. Cancer Invest 2009;14:1.
36. Sato KT, Lewandowski RJ, Mulcahy MF, Atassi B, Ryu RK, Gates VL et al. Unresectable chemorefractory liver metastases: radioembolization with 90Y microspheres-safety, efficacy, and survival. Radiology 2008;247:507-15.
37. Kennedy AS, Coldwell D, Nutting C, Murthy R, Wertman DE Jr, Loehr SP et al. Resin 90Y-microsphere brachytherapy for unresectable colorectal liver metastases: modern USA experience. Int J Radiat Oncol Biol Phys 2006;65:412-25.
38. Salem R, Lewandowski RJ, Atassi B, Gordon SC, Gates VL, Barakat O et al. Treatment of unresectable hepatocellular carcinoma with use of 90y microspheres (TheraSphere): safety, tumor response, and survival. J Vasc Interv Radiol 2005;16:1627-39. (Pubitemid 44431160)
39. Young JY, Rhee TK, Atassi B, Gates VL, Kulik L, Mulcahy MF et al. Radiation dose limits and liver toxicities resulting from multiple yttrium-90 radioembolization treatments for hepatocellular carcinoma. J Vasc Interv Radiol 2007;18:1375-82.
40. Sangro B, Gil-Alzugaray B, Rodriguez J, Sola I, Martinez-Cuesta A, Viudez A et al. Liver disease induced by radioembolization of liver tumors: description and possible risk factors. Cancer 2008;112: 1538-46. (Pubitemid 351441166)
41. Jakobs TF, Saleem S, Atassi B, Reda E, Lewandowski RJ, Yaghmai V et al. Fibrosis, portal hypertension, and hepatic volume changes induced by intra-arterial radiotherapy with (90)yttrium microspheres. Dig Dis Sci 2008;53:2556-63.
42. Carretero C, Munoz-Navas M, Betes M, Angos R, Subtil JC, Fernandez-Urien I et al. Gastroduodenal injury after radioembolization of hepatic tumors. Am J Gastroenterol 2007;102: 1216-20. (Pubitemid 46802020)
43. Leung TW, Lau WY, Ho SK, Ward SC, Chow JH, Chan MS et al. Radiation pneumonitis after selective internal radiation treatment with intraarterial 90yttrium-microspheres for inoperable hepatic tumors. Int J Radiat Oncol Biol Phys 1995;33:919-24.
44. TheraSphere Yttrium-90 microspheres package insert, MDS Nordion, Kanata, Canada; 2004.
45. Murthy R, Eng C, Krishnan S, Madoff DC, Habbu A, Canet S et al. Hepatic yttrium-90 radioembolotherapy in metastatic colorectal cancer treated with cetuximab or bevacizumab. J Vasc Interv Radiol 2007;18:1588-91.