Gonadotropin administration after gonadotropin-releasing-hormone agonist: a therapeutic option in severe testiculopathies

Fertility and Sterility

Volumn 92, Issue 4, 2009, Pages 1326-1332

  Foresta, Carlo ^a   Selice, Riccardo ^a   Moretti, Afra ^a   Pati, Mauro Antonio ^a   Carraro, Marina ^a   Engl, Bruno ^b   Garolla, Andrea ^a  

^a Centre for Male Gamete Cryopreservation   (Italy)

^b Obstetrics and Gynaecology Unit   (Italy)

Author keywords

FSH treatment; GNRH agonist; Male infertility; pregnancy rate; severe testiculopathy; sperm aneuploidies

Indexed keywords

CHORIONIC GONADOTROPIN; FOLLITROPIN; INHIBIN B; LEUPRORELIN; LUTEINIZING HORMONE; RECOMBINANT FOLLITROPIN; TESTOSTERONE;

ADULT; ANEUPLOIDY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EMBRYO TRANSFER; FERTILIZATION IN VITRO; FOLLITROPIN BLOOD LEVEL; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; PREGNANCY RATE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEMEN ANALYSIS; TESTIS DISEASE; TESTOSTERONE BLOOD LEVEL;

ADULT; ANEUPLOIDY; CHORIONIC GONADOTROPIN; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; FEMALE; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; GONADOTROPINS; HUMANS; INFERTILITY, MALE; MALE; PREGNANCY; RECOMBINANT PROTEINS; SEMEN ANALYSIS; SEVERITY OF ILLNESS INDEX; SEX CHROMOSOME ABERRATIONS; TESTICULAR DISEASES; TIME FACTORS; UNIPARENTAL DISOMY;

EID: 70349575090     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2008.07.1766     Document Type: Article

References (31)

1. McLachlan R.I., Wreford N.G., de Kretser D.M., and Robertson D.M. The effects of recombinant follicle-stimulating hormone on restoration of spermatogenesis in gonadotropin-releasing hormone-immunized adult rat. Endocrinology 136 (1995) 4035-4043
2. Tapanainen J.S., Aittomaki K., Min J., Vaskivuo T., and Huhtaniemi I.T. Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility. Nat Genet 15 (1997) 205-206
3. Bockers T.M., Nieschlag E., Kreutz M.R., and Bergmann M. Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men. Cell Tissue Res 278 (1994) 595-600
4. Rannikki A.S., Zhang F.P., and Huhtaniemi I.T. Ontogeny of follicle stimulating hormone receptor gene expression in the rat testis and ovary. Mol Cell Endocrinol 107 (1995) 199-208
5. Hayes F.J., Pitteloud N., DeCruz S., Crowley Jr. W.F., and Boepple P.A. Importance of inhibin B in the regulation of FSH secretion in the human male. J Clin Endocrinol Metab 86 (2001) 5541-5546
6. Foresta C., Bettella A., Rossato M., La Sala G., De Paoli M., and Plebani M. Inhibin B plasma concentrations in oligozoospermic subjects before and after therapy with follicle stimulating hormone. Hum Reprod 14 (1999) 101-107
7. de Kretser D.M., Meinhardt A., Meehan T., Phillips D.J., O'Bryan M.K., and Loveland K.A. The roles of inhibin and related peptides in gonadal function. Mol Cell Endocrinol 161 (2000) 43-46
8. Bartoov B., Eltes F., and Lunenfeld E. Sperm quality of subfertile males before and after treatment with human follicle-stimulating hormone. Fertil Steril 61 (1994) 727-734
9. Foresta C., Bettella A., Merico M., Garolla A., Plebani M., Ferlin A., et al. FSH in the treatment of oligozoospermia. Mol Cell Endocrinol 161 (2000) 89-97
10. Attia A.M., Al-Inany H.G., Farquhar C., and Proctor M. Gonadotrophins for idiopathic male factor subfertility. Cochrane Database Syst Rev 17 (2007) CD005071
11. Foresta C., Bettella A., Merico M., Garolla A., Ferlin A., and Rossato M. Use of recombinant human follicle-stimulating hormone in the treatment of male factor infertility. Fertil Steril 77 (2002) 238-244
12. Foresta C., Bettella A., Garolla A., Ambrosini G., and Ferlin A. Treatment of male idiopathic infertility with recombinant human follicle-stimulating hormone: a prospective, controlled, randomized clinical study. Fertil Steril 84 (2005) 654-661
13. Foresta C., Bettella A., Spolaore D., Merico M., Rossato M., and Ferlin A. Suppression of the high endogenous levels of plasma FSH in infertile men are associated with improved Sertoli cell function as reflected by elevated levels of plasma inhibin B. Hum Reprod 19 (2004) 1431-1437
14. Groome N.P., Illingworth P.J., O'Brien M., Pai R., Rodger F.E., Mather J.P., et al. Measurement of dimeric inhibin B throughout the human mestrua cycle. J Clin Endocrinol Metab 81 (1996) 1401-1405
15. World Health Organization. Towards more objectivity in diagnosis and management of male infertility. Results of a World Health Organization multicenter study. Int J Androl 10 Suppl 7 (1987) 1-53
16. Foresta C., Galeazzi C., Bettella A., Stella M., and Scandellari C. High incidence of sperm sex chromosomes aneuploidies in two patients with Klinefelter's syndrome. J Clin Endocrinol Metab 83 (1998) 203-205
17. Robbins W.A., Baulch J.E., Moore II D., Weier H.U., Blakey D., and Wyrobek A.J. Three-probe fluorescence in situ hybridization to assess chromosome X, Y, and 8 aneuploidy in sperm of 14 men from two healthy groups: evidence for a paternal age effect on sperm aneuploidy. Reprod Fertil Dev 7 (1995) 799-809
18. Foresta C., Varotto A., and Scandellari C. Assessment of testicular cytology by fine needle aspiration as a diagnostic parameter in the evaluation of the azoospermic subject. Fertil Steril 57 (1992) 858-865
19. Bhasin S. Approach to the infertile man. J Clin Endocrinol Metab 92 (2007) 1995-2004
20. Foresta C., Selice R., Ferlin A., Arslan P., and Garolla A. Hormonal treatment of male infertility: FSH. Reprod Biomed Online 15 (2007) 666-672
21. Isidori A.M., Pozza C., Gianfrilli D., and Isidori A. Medical treatment to improve sperm quality. Reprod Biomed Online 12 (2006) 704-714
22. Anawalt B.D., Bebb R.A., Matsumoto A.M., Groome N.P., Illingworth P.J., McNeilly A.S., et al. Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction. J Clin Endocrinol Metab 81 (1996) 3341-3345
23. Gnanaprakasam M.S., Chen C.J., Sutherland J.G., and Bhalla V.K. Receptor depletion and replenishment processes: in vivo regulation of gonadotropin receptors by luteinizing hormone, follicle stimulating hormone and ethanol in rat testis. Biol Reprod 20 (1979) 991-1000
24. Themmen A.P., Blok L.J., Post M., Baarends W.M., Hoogerbrugge J.W., Parmentier M., et al. Follitropin receptor downregulation involves a cAMP-dependent post-transcriptional decrease of receptor mRNA expression. Mol Cell Endocrinol 78 (1991) R7-13
25. Matsumiya K., Kitamura M., Kishikawa H., Kondoh N., Fujiwara Y., Namiki M., et al. A prospective comparative trial of a gonadotropin-releasing hormone analogue with clomiphene citrate for the treatment of oligoasthenozoospermia. Int J Urol 5 (1998) 361-363
26. Kawakami E., Masaoka Y., Hirano T., Hori T., and Tsutsui T. Changes in plasma testosterone levels and semen quality after 3 injections of a GnRH analogue in 3 dogs with spermatogenic dysfunction. J Vet Med Sci 67 (2005) 1249-1252
27. Foresta C., Garolla A., Bartoloni L., Bettella A., and Ferlin A. Genetic abnormalities among severely oligospermic men who are candidates for intracytoplasmic sperm injection. J Clin Endocrinol Metab 90 (2005) 152-156
28. Ma S., Arsovska S., Moens P., Nigro M., and Chow V. Analysis of early meiotic events and aneuploidy in nonobstructive azoospermic men: a preliminary report. Fertil Steril 85 (2006) 646-652
29. Martin R.H. Meiotic chromosome abnormalities in human spermatogenesis. Reprod Toxicol 22 (2006) 142-147
30. Ferlin A., Arredi B., Speltra E., Cazzadore C., Selice R., Garolla A., et al. Molecular and clinical characterization of Y chromosome microdeletions in infertile men: a 10-year experience in Italy. J Clin Endocrinol Metab 92 (2007) 762-770
31. Nicopoullos J.D., Gilling-Smith C., Almeida P.A., Homa S., Nice L., Tempest H., et al. The role of sperm aneuploidy as a predictor of the success of intracytoplasmic sperm injection?. Hum Reprod 23 (2008) 240-250