Non-functional parathyroid carcinoma: A review of the literature and report of a case requiring extensive surgery

Head and Neck Pathology

Volumn 3, Issue 2, 2009, Pages 140-149

  Wilkins, Benjamin J ^a   Lewis Jr , James S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Carcinoma; Non functional; Parafibromin; Parathyroid

Indexed keywords

AMLODIPINE; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; METFORMIN;

ARTICLE; CASE REPORT; DYSPHAGIA; ESOPHAGUS RESECTION; HUMAN; HYPERTENSION; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; PARATHYROID TUMOR; PARATHYROIDECTOMY; PATHOLOGY; COMPLICATION; DEGLUTITION DISORDERS; DIABETES MELLITUS, TYPE 2; PARATHYROID NEOPLASMS;

AMLODIPINE; ANTIHYPERTENSIVE AGENTS; DEGLUTITION DISORDERS; DIABETES MELLITUS, TYPE 2; ESOPHAGECTOMY; HUMANS; HYPERTENSION; HYPOGLYCEMIC AGENTS; MAGNETIC RESONANCE IMAGING; MALE; METFORMIN; MIDDLE AGED; PARATHYROID NEOPLASMS; PARATHYROIDECTOMY;

EID: 70349572009     PISSN: 1936055X     EISSN: 19360568     Source Type: Journal    
DOI: 10.1007/s12105-009-0115-4     Document Type: Article

References (41)

1. Hundahl SA, Fleming ID, Fremgen AM, et al. Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985-1995: a National Cancer Data Base Report. Cancer. 1999;86:538-44. doi:10.1002/(SICI)1097-0142(19990801)86:3<538::AID-CNCR25>3.0.CO;2-K.
2. Rawat N, Khetan N, Williams DW, et al. Parathyroid carcinoma. Br J Surg. 2005;92:1345-53. doi:10.1002/bjs.5182.
3. Munson ND, Foote RL, Northcutt RC, et al. Parathyroid carcinoma: is there a role for adjuvant radiation therapy? Cancer. 2003;98:2378-84. doi:10.1002/cncr.11819.
4. Chow E, Tsang RW, Brierley JD, et al. Parathyroid carcinoma-the Princess Margaret Hospital experience. Int J Radiat Oncol Biol Phys. 1998;41:569-72. doi:10.1016/S0360-3016(98)00098-4.
5. Busaidy NL, Jimenez C, Habra MA, et al. Parathyroid carcinoma: a 22-year experience. Head Neck. 2004;26:716-26. doi:10.1002/hed.20049.
6. Iacobone M, Ruffolo C, Lumachi F, et al. Results of iterative surgery for persistent and recurrent parathyroid carcinoma. Langenbecks Arch Surg. 2005;390:385-90. doi:10.1007/s00423-005-0555-6.
7. Peacock M, Bilezikian JP, Klassen PS, et al. Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism. J Clin Endocrinol Metab. 2005;90:135-41. doi:10.1210/jc.2004-0842.
8. Fernandez-Ranvier GG, Jensen K, Khanafshar E, et al. Nonfunctioning parathyroid carcinoma: case report and review of the literature. Endocr Pract. 2007;13:750-7.
9. Kirkby-Bott J, Lewis P, Harmer CL, et al. One stage treatment of parathyroid carcinoma. Eur J Surg Oncol. 2005;31:78-83. doi:10.1016/j.ejso.2004.06.014.
10. Yamashita H, Noguchi S, Murakami N, et al. Immunohistological study of nonfunctional parathyroid carcinoma: review of a case. Acta Pathol Jpn. 1992;42:279-85.
11. Klink BK, Karulf RE, Maimon WN, et al. Nonfunctioning parathyroid carcinoma. Am Surg. 1991;7:463-7.
12. Collins FD, Warren MC, Palmer FJ, et al. Nonfunctioning parathyroid carcinoma: a case history. J Surg Oncol. 1986;31:60-1. doi:10.1002/jso.2930310114.
13. Murphy MN, Glennon PG, Diocee MS, et al. Nonsecretory parathyroid carcinoma of the mediastinum: light microscopic, immunocytochemical, and ultrastructural features of a case, and review of the literature. Cancer. 1986;58:2468-76. doi:10.1002/1097-0142(19861201)58:11<2468::AID-CNCR2820581120>3.0.CO;2-M.
14. Merlano M, Conte P, Scarsi P, et al. Non-functioning parathyroid carcinoma: a case report. Tumori. 1985;71:193-6.
15. Yamashita H, Noguchi S, Nakayama I, et al. Light and electron microscopic study of nonfunctioning parathyroid carcinoma: report of a case with a review of the literature. Acta Pathol Jpn. 1984;34:123-32.
16. Anderson BJ, Samaan NA, Vassilopoulou-Sellin R, et al. Parathyroid carcinoma: features and difficulties in diagnosis and management. Surgery. 1983;94:906-15.
17. Ordoñez NG, Ibanez ML, Samaan NA, et al. Immunoperoxidase study of uncommon parathyroid tumors. Am J Surg Pathol. 1983;7:535-42.
18. Aldinger KA, Hickey RC, Ibanez ML, et al. Parathyroid carcinoma: a clinical study of seven cases of functioning and two cases of nonfunctioning parathyroid cancer. Cancer. 1982;49:388-97. doi:10.1002/1097-0142(19820115)49:2<388::AID-CNCR2820490230>3.0.CO;2-F.
19. Chahinian AP, Holland JF, Nieburgs HE, et al. Metastatic nonfunctioning parathyroid carcinoma: ultrastructural evidence of secretory granules and response to chemotherapy. Am J Med Sci. 1981;282:80-4. doi:10.1097/00000441-198109000-00005.
20. Dhom G, Hohbach C. Case 12. Ultrastruct Pathol. 1980;1:141-50. doi:10.3109/01913128009141410.
21. Altenähr E, Saeger W. Light and electron microscopy of parathyroid carcinoma: report of three cases. Virchows Arch A Pathol Anat. 1973;360:107-22.
22. Pachter MR, Lattes R. Uncommon mediastinal tumors: report of two parathyroid adenomas, one nonfunctional parathyroid carcinoma and one "bronchial-type-adenoma". Chest. 1963;43:519-28. doi:10.1378/chest.43.5.519.
23. Sieracki JC, Horn RC. Nonfunctional carcinoma of the parathyroid. Cancer. 1960;13:502-6. doi:10.1002/1097-0142(196005/06)13:3<502::AID-CNCR2820130312>3.0.CO;2-R.
24. McQuillan AS. Parathyroid tumor: report of two cases. Ann Surg. 1938;108:464-8. doi:10.1097/00000658-193809000-00008.
25. Armstrong HG. Primary carcinoma of the parathyroid gland with report of a case. Bull Acad Med Tor. 1938;11:105-10.
26. Guy CC. Tumors of the parathyroid glands. Surg Gynecol Obstet. 1929;149:522-7.
27. Baba H, Kishihara M, Tohmon M, et al. Identification of parathyroid hormone messenger ribonucleic acid in an apparently nonfunctioning parathyroid carcinoma transformed from a parathyroid carcinoma with hyperparathyroidism. J Clin Endocrinol Metab. 1986;62:247-52.
28. Rodgers SE, Perrier ND. Parathyroid carcinoma. Curr Opin Oncol. 2006;18:16-22. doi:10.1097/01.cco.0000198019.53606.2b.
29. Schantz A, Castleman B. Parathyroid carcinoma: a study of 70 cases. Cancer. 1973;31:600-5. doi:10.1002/1097-0142(197303)31:3<600::AID-CNCR2820310316>3.0.CO;2-0.
30. Ippolito G, Palazzo FF, Sebag F, et al. Intraoperative diagnosis and treatment of parathyroid cancer and atypical parathyroid adenoma. Br J Surg. 2007;94:566-70. doi:10.1002/bjs.5570.
31. Carpten JD, Robbins CD, Villablanca A, et al. HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome. Nat Genet. 2002;32:676-80. doi:10.1038/ng1048.
32. Shattuck TM, Välimäki S, Obara T, et al. Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinomas. N Engl J Med. 2003;349:1722-9. doi:10.1056/NEJMoa031237.
33. Howell VM, Haven CJ, Kahnoski K, et al. HRPT2 mutations are associated with malignancy in sporadic parathyroid tumors. J Med Genet. 2003;40:657-63. doi:10.1136/jmg.40.9.657.
34. Tan MH, Morrison C, Wang P, et al. Loss of parafibromin immunoreactivity is a distinguishing feature of parathyroid carcinoma. Clin Cancer Res. 2004;10:6629-37. doi:10.1158/1078-0432.CCR-04-0493.
35. Gill AJ, Clarkson A, Gimm O, et al. Loss of nuclear expression of parafibromin distinguishes parathyroid carcinomas and hyperparathyroidism-jaw tumor (HPT-JT) syndrome-related adenomas from sporadic parathyroid adenomas and hyperplasias. Am J Surg Pathol. 2006;30:1140-9. doi:10.1097/01.pas.0000209827.39477.4f.
36. Rozenblatt-Rosen O, Hughes CM, Nannepaga SJ, et al. The parafibromin tumor suppressor protein is part of a human Paf1 complex. Mol Cell Biol. 2005;25:612-20. doi:10.1128/MCB.25.2.612-620.2005.
37. Woodard GE, Lin L, Zhang JH, et al. Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression. Oncogene. 2005;24:1272-6. doi:10.1038/sj.onc.1208274.
38. Yart A, Gstaiger M, Wirbelauer C, et al. The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II. Mol Cell Biol. 2005;25:5052-60. doi:10.1128/MCB.25.12.5052-5060.2005.
39. Mosimann C, Hausmann G, Basler K. Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo. Cell. 2006;125:327-41. doi:10.1016/j.cell.2006.01.053.
40. Wang P, Bowl MR, Bender S, et al. Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol Cell Biol. 2008;28:2930-40. doi:10.1128/MCB.00654-07.
41. Hunt JL, Carty SE, Yim JH, et al. Allelic loss in parathyroid neoplasia can help characterize malignancy. Am J Surg Pathol. 2005;29:1049-55.