Effects of different dilutions of botulinum toxin type A treatment for children with cerebral palsy with spastic ankle plantarflexor: A randomized controlled trial

Journal of Rehabilitation Medicine

Volumn 41, Issue 9, 2009, Pages 740-745

  Jung, Hwan Lee ^a   In, Young Sung ^b   Jong, Yoon Yoo ^b   Eun, Ha Park ^a   Song, Rae Park ^b  

^a Gimpo Airport Wooridul Spine Hospital   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

Author keywords

Botulinum toxin; Cerebral palsy; Gait; Gastrocnemius muscle; Muscle spasticity

Indexed keywords

BOTULINUM TOXIN A; SODIUM CHLORIDE;

ANKLE; ANKLE PLANTARFLEXOR SPASTICITY; CEREBRAL PALSY; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DILUTION; DRUG EFFICACY; FEMALE; FUNCTIONAL ASSESSMENT; GAIT; GASTROCNEMIUS MUSCLE; HUMAN; INJECTION SITE PAIN; MALE; PHYSICAL EXAMINATION; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; RANGE OF MOTION; SCHOOL CHILD; SPASTICITY; UNSPECIFIED SIDE EFFECT; ARTICLE; DOSE RESPONSE; PATHOPHYSIOLOGY; PHYSIOLOGY; TREATMENT OUTCOME;

BOTULINUM TOXIN TYPE A; CEREBRAL PALSY; CHILD; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GAIT; HUMANS; MALE; MUSCLE SPASTICITY; SODIUM CHLORIDE; TREATMENT OUTCOME;

EID: 70349571137     PISSN: 16501977     EISSN: None     Source Type: Journal    
DOI: 10.2340/16501977-0418     Document Type: Conference Paper

References (25)

1. Ubhi T, Bhakta BB, Ives HL, Allgar V, Roussounis SH. Randomised double blind placebo controlled trial of the effect of botulinum toxin on walking in cerebral palsy. Arch Dis Child 2000; 83: 481-487.
2. Eames NW, Baker R, Hill N, Graham K, Taylor T, Cosgrove A. The effect of botulinum toxin A on gastrocnemius length: magnitude and duration of response. Dev Med Child Neurol 1999; 41: 226-232. (Pubitemid 29209924)
3. Wong AMK, Chen CL, Chen CPC, Chou SW, Chung CY, Chen MJL. Clinical effects of botulinum toxin A and phenol block on gait in children with cerebral palsy. Am J Phys Med Rehabil 2004; 83: 284-291.
4. Preiss RA, Condie DN, Rowley DI, Graham HK. Aspects of current management: the effects of botulinum toxin (BoNT-A) on spasticity of the lower limb and on gait in cerebral palsy. J Bone Joint Surg Br 2003; 85-B: 943-948.
5. Martial M, Nanni A. Roles of exercise testing in the functional assessment of cerebral palsy children after botulinum A toxin injection. J Pediatr Orthop 1999; 19: 362-365. (Pubitemid 29214982)
6. Sutherland DH, Kaufman KR, Wyatt MP, Chamber HG, Mubarak SJ. Double-blind study of botulinum A toxin injections into the gastrocnemius muscle in patients with cerebral palsy. Gait Posture 1999; 10: 1-9. (Pubitemid 29406176)
7. Sutherland DH, Kaufman KR, Wyatt MP, Chamber HG. Injection of botulinum A toxin into the gastrocnemius muscle of patients with cerebral palsy: a 3-dimensional motion analysis study. Gait Posture 1996; 4: 269-279.
8. Bang MS, Chung SG, Kim SB, Kim SJ. Change of dynamic gastrocnemius and solues muscle length after block of spastic calf muscle in cerebral palsy. Am J Phys Med Rehabil 2002; 81: 760-764.
9. Metaxiotis D, Siebel A, Doederlein L. Repeated botulinum toxin A injections in the treatment of spastic equines foot. Clin Orthop 2002; 394:177-185. (Pubitemid 34062723)
10. Lee LR, Chuang YC, Yang BJ, Hsu MJ, Liu YH. Botulinum toxin for lower limb spasticity in children with cerebral palsy. Am J Phys Med Rehabil 2004; 83: 766-773.
11. Gooch JL, Patton CP. Combining botulinum toxin and phenol to manage spasticity in children. Arch Phys Med Rehabil 2004; 85: 1121-1124.
12. Shaari C, Sanders I. Quantifying how location and dose of botulinum toxin injections affect muscle paralysis. Muscle Nerve 1993; 16: 964-969. (Pubitemid 23246323)
13. Kim HS, Hwang JH, Jeong ST, Lee YT, Lee PK, Suh YL, Shim JS. Effects of muscle activity and botulinum toxin dilution volume on muscle paralysis. Dev Med Child Neurol 2003; 45: 200-206. (Pubitemid 36221398)
14. Francisco GE, Boake C, Vaughn A. Botulinum toxin in upper limb spasticity after acquired brain injury: a randomized trial comparing dilution techniques. Am J Phys Med Rehabil 2002; 81: 355-363. (Pubitemid 34412072)
15. Gracies JM, Weisz DJ, Yang BY, Franagan S, Simpson DM. Impact of botulinum toxin type A (BoNT-A) dilution and endplate targeting technique in upper limb spasticity. Ann Neurol 2002; 52 Suppl 1: S87.
16. Papadonikolakis AS, Vekris MD, Korompilias AV, Kostas JP, Ristanis SE, Soucacos PN. Botulinum A toxin for treatment of lower limb spasticity in cerebral palsy: gait analysis in 49 patients. Acta Orthop Scand 2003; 74: 749-755. (Pubitemid 38067880)
17. Sätilä H, Iisalo T, Pietikäinen T, Seppänen RL, Salo M, Koivikko M, et al. Botulinum toxin treatment of spastic equines in cerebral palsy. A randomized trial comparing two injection sites. Am J Phys Med Rehabil 2005; 84: 355-365. (Pubitemid 40563118)
18. El-Etribi MA, Salem ME, El-Shakankiry HM, El-kahky AM, El-Mahboub SM. The effect of botulinum toxin type-A injection on spasticity, range of motion and gait patterns in children with spastic diplegic cerebral palsy: an Egyptian study. Int J Rehabil Res 2004; 27: 275-281.
19. Ma J, Elsaidi GA, Smith TL, Walker FO, Tan KH, Martin E, et al. Time course of recovery of juvenile skeletal muscle after botulinum toxin A injection: an animal model study. Am J Phys Med Rehabil 2004; 83: 774-780. (Pubitemid 40006668)
20. Ibrahim AI, Hawamdeh ZM, Al-Qudah AA. Functional outcome of botulinum toxin injection of gastrocnemius and adductors in spastic hemiplegic cerebral palsied children. Eura Medicophys 2006; 42: 1-8.
21. Corry IS, Cosgrove AP, Duffy CM, McNeill S, Taylor TC, Graham HK. Botulinum toxin A compared with stretching casts in the treatment of spastic equines: a randomised prospective trial. J Pediatr Orthop 1998; 18: 304-311. (Pubitemid 28212938)
22. Stawek J, Kilmont L. Functional improvement in cerebral palsy patients treated with botulinum toxin A injections-preliminary results. Eur J Neurol 2003; 10: 313-317.
23. Boyd RN, Graham HK. Botulinum toxin A in the management of children with cerebral palsy: indications and outcome. Eur J Neurol 1997; 4: 15-22.
24. Love SC, Valentine JP, Blair EM, Price CJ, Cole JH, Chauvel PJ. The effects of botulinum toxin type A on the functional ability of the child with spastic hemiplegia: a randomized controlled trial. Eur J Neurol 2001; 8: 50-58.
25. Hu GC, Chuang YC, Liu JP, Chien KL, Chen YM, Chen YF. Botulinum toxin (Dysport) treatment of the spastic gastrocnemius muscle in children with cerebral palsy: a randomized trial comparing two injection volumes. Clin Rehabil 2009; 23: 64-71.