Multinucleated giant cells' Incidence, immune markers, and Significance: A study of 172 cases of papillary thyroid Carcinoma

Head and Neck Pathology

Volumn 3, Issue 2, 2009, Pages 95-99

  Brooks, Erin ^a   Simmons Arnold, Linda ^b   Naud, Shelly ^b   Evans, Mark F ^b   Elhosseiny, Abdel ^a  

^a FLETCHER ALLEN HEALTH CARE   (United States)

^b UNIVERSITY OF VERMONT   (United States)

Author keywords

Colloid; Multinucleated giant cells; Papillary thyroid carcinoma; Thyroglobulin

Indexed keywords

BIOLOGICAL MARKER; TUMOR MARKER; COLLOID;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; COLLOID; FEMALE; GIANT CELL; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MALE; METABOLISM; MIDDLE AGED; PAPILLARY CARCINOMA; PATHOLOGY; THYROID TUMOR; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CARCINOMA, PAPILLARY; CHILD; COLLOIDS; FEMALE; GIANT CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MALE; MIDDLE AGED; THYROID NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 70349561788     PISSN: 1936055X     EISSN: 19360568     Source Type: Journal    
DOI: 10.1007/s12105-009-0110-9     Document Type: Article

References (10)

1. Guiter G, DeLellis R. Multinucleate giant cells in papillary thyroid carcinoma. A morphologic and immunohistochemical study. Am J Clin Pathol. 1996;106:765-8.
2. Tabbara S, Acoury N, Sidawy M. Multinucleated giant cells in thyroid neoplasms. A cytologic, histologic and immunohistochemical study. Acta Cytol. 1996;40:1184-8.
3. Padberg B, Schroder S. Diagnostic relevance of multinucleated giant cells in papillary thyroid cancer. Pathologe. 2003;24:382-6. doi:10.1007/s00292-003-0619-8. Article in German.
4. Stanta G, Carcangiu M, Rosai J. The biochemical and immunohistochemical profile of thyroid neoplasia. Pathol Annu. 1988;23:129-57.
5. Sinadinovic J, Cvejic D, et al. Altered terminal glycosylation of thyroglobulin in papillary thyroid carcinoma. Exp Clin Endocrinol. 1992;100:124-8.
6. Shabb NS, Tawil A, Gergeos F, Saleh M, Azar S. Multinucleated giant cells in fine-needle aspirations of thyroid nodules: their diagnostic significance. Diagn Cytopathol. 1999;21:307-12. doi:10.1002/(SICI)1097-0339(199911)21:5<307::AID-DC2>3.0.CO;2-1.
7. LiVolsi VA. Surgical pathology of the thyroid. Philadelphia: WB Saunders Co; 1990.
8. Al-Brahim N, Asa S. Overview of papillary thyroid carcinoma. Arch Pathol Lab Med. 2006;130:1057-62.
9. LiVolsi V, Albores-Saavedra J, Asa S, et al. Papillary carcinoma. In: DeLellis R, Lloyd R, Heitz P, Eng C, editors. World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of the Endocrine Organs. Lyon, France: IARC Press; 2004. p. 57-66.
10. Tsou PL, Hsiao YL, Chang TC. Multinnucleated giant cells in fine needle aspirations. Can they help differentiate papillary thyroid cancer from benign nodular goiter? Acta Cytol. 2002;46:823-7.