Pathogen reduction technology (Mirasol®) treated single-donor platelets resuspended in a mixture of autologous plasma and PAS

Vox Sanguinis

Volumn 97, Issue 3, 2009, Pages 234-239

  Janetzko, K ^a   Hinz, K ^a   Marschner, S ^b   Goodrich, R ^b   Kluter H ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b CaridianBCT Biotechnologies   (United States)

Author keywords

Mirasol; Pathogen inactivation; Pathogen reduction; Platelet concentrates; Riboflavin

Indexed keywords

LACTIC ACID; PADGEM PROTEIN;

ARTICLE; BLOOD AUTOTRANSFUSION; BLOOD DONOR; BLOOD GAS ANALYSIS; CELL METABOLISM; CONTROLLED STUDY; GLUCOSE INTAKE; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE; THROMBOCYTE ACTIVATION;

BICARBONATES; BLOOD PLATELETS; BLOOD PRESERVATION; BLOOD-BORNE PATHOGENS; GLUCOSE; GLYCOLYSIS; HUMANS; HYDROGEN-ION CONCENTRATION; LACTATES; P-SELECTIN; PHARMACEUTICAL SOLUTIONS; PLASMA; PLATELET ACTIVATION; RIBOFLAVIN; SUSPENSIONS; ULTRAVIOLET RAYS;

EID: 70349536147     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/j.1423-0410.2009.01193.x     Document Type: Article

References (26)

1. Janetzko K, Cazenave JP, Klüter H, Kientz D, Michel M, Beris P, Lioure B, Hastka J, Marblie S, Mayaudon V, Lin L, Lin JS, Conlan MG, Flament. J : Therapeutic efficacy and safety of photchemically treated single donor platelets processed with an optimized integrated set. Transfusion 2005 45 : 1443 1452
2. Kumar V, Lockerbie O, Keil SD, Ruane PH, Platz MS, Marin CB, Ravanat JL, Cadet J, Goodrich RP : Riboflavin and UV-light based pathogen reduction: extent and consequence of DNA damage at the molecular level. Photochem Photobiol, 2004 80 : 15 21
3. 2, production by riboflavin, lumichrome and lumiflavin. Indian J Biochem Biophys 1989 26 : 186 189
4. 2) and superoxide radicala. Mech Toxicol Lett 1985 26 : 211 217
5. Speck WT, Rosenkranz HS, Rosenkranz S. Further observation on the photooxidation of DNA in the presence of riboflavin. Biochem Biophys Acta 1976 435 : 39 44
6. Klinger MH : The storage lesion of platelets: ultra structural and function aspects. Ann Hematol 1996 73 : 103 112
7. Li J, Goodrich L, Hansen E, Edrich R, Gampp D, Goodrich RP : Platelet glycolytic flux increases stimulated by ultraviolet-induced stress is not the direct cause of platelet morphology and activation changes. Possible implications for the role of glucose in platelet storage. Transfusion 2005 45 : 1750 1758
8. ®) treated platelets collected by plateletpheresis. Transfus Med Hemotherapy (in press)
9. Li J, de Korte D, Woolum MD, Ruane PH, Keil SD, Lockerbie O, McLean R, Goodrich RP : Pathogen reduction of buffy coat platelet concentrates using riboflavin and light: comparison with pathogen- reduction technology-treated apheresis platelet concentrates. Vox Sang 2004 87 : 82 90
10. Ruane PH, Edrich R, Gampp D, Keil SD, Leonard RL, Goodrich RP : Photochemical inactivation of selected viruses and bacteria in platelet concentres using riboflavin and light. Transfusion 2004 44 : 877 885
11. AuBuchon JP, Herschel L, Roger J, Taylor H, Whitley P, Li J, Edrich R, Goodrich RP : Efficacy of single donor platelets treated with riboflavin and ultraviolet light for pathogen reduction. Transfusion 2005 45 : 1335 1341
12. Murphy S : The efficacy of synthetic media in the storage of human platelets for transfusion. Transfus Med Rev 1999 13 : 153 163
13. Li J, Xia Y, Bertino AM, Coburn JP, Kuter DJ : The mechanism of apoptosis in human platelets during storage. Transfusion 2000 40 : 1320 1329
14. Kilkson H, Holme S, Murphy S : Platelet metabolism during storage of platelet concentrates at 22°C. Blood 1984 64 : 406 414
15. Shimizu T, Murphy S : Role of acetate and phosphate in the successful storage of platelet concentrates prepared with an acetate-containing additive solution. Transfusion 1993 33 : 304 310
16. Picker SM, Steisel A, Gathof BS : Cell integrity and mitochondrial function after Miraso-PRT treatment for pathogen reduction of apheresis-derived platelets: results of a 3-arm in vitro study. Transf Apheres Sci 2009 40 : 79 85
17. Murphy S : The efficacy of synthetic media in the storage of human platelets for transfusion. Transfus Med Rev 1999 13 : 153 163
18. Jansen GA, van Vliet HH, Vermeij H, Beckers EA, Leebeek FM, Sonneveld P, van Rhenen DJ : Functional characteristics of photochemically treated platelets. Transfusion 2004 44 : 313 319
19. Dijkstra-Tiekstra MJ, Pietersz RNI, Huijgens PC : Correlation between the extent of platelet activation in platelet concentrates and in vitro and in vivo parameters. Vox Sang 2004 87 : 257 263
20. Berger G, Harwell DW, Wagner DD : P-selectin and platelet clearance. Blood 1998 92 : 4446 4452
21. Maurer-Spurej E, Chipperfield K. Past and future approaches to assess the quality of platelets for transfusion. Transfus Med Rev 2007 21 : 295 306
22. Goodrich RP, Li J, Pietes H, Crookes R, Roodt J, Heyns AdP : Correlation of in vitro platelet quality measurements with in vivo platelet viability in human subjects. Vox Sang 2006 90 : 279 285
23. van Marwijk Kooy M, Akkermann JWN, van Asbeck S, Borghuis L, van Prooijen HC : UVB radiation exposes fibrinogen binding sites on platelets by activating protein kinase C via reactive oxygen species. Br J Haematol 1993 83 : 253 258
24. Perez-Pujol S, Tonda R, Lozano M, Fuste B, Lopesz-Vilchez I, Galan AM, Li J, Goodrich RP, Escolar G : Effects of a new pathogen-reduction technology (Mirasol PRT) on functional aspects of platelet concentrates. Transfusion 2005 45 : 911 919
25. Curvers J, van Pampus EC, Feijge MA, Rombout-Sestrienkova E, Giesen PL, Heemskerk JW : Decreased responsiveness and development of activation markers of PLTs stored in plasma. Transfusion 2004 44 : 49 58
26. Goodrich RP, Folleá G, Robert T : Clinical evaluation of Mirasol PRT treated single-donor platelets in thrombocytopenic patients. Transfusion 2008 48s : 20A