Proteomic study via a non-gel based approach of meningococcal outer membrane vesicle vaccine obtained from strain CU385: A road map for discovering new antigens

Human Vaccines

Volumn 5, Issue 5, 2009, Pages 347-356

  Gil, Jeovanis ^a   Betancourt, Lázaro H ^a   Sardiñas, Gretel ^a   Yero, Daniel ^a,b   Niebla, Olivia ^a   Delgado, Maité ^a   García, Darien ^a   Pajón, Rolando ^a   Sánchez, Aniel ^a   González, Luis J ^a   Padrón, Gabriel ^a   Campa, Concepción ^b   Sotolongo, Franklin ^b   Barberá, Ramón ^b   Guillén, Gerardo ^a   Herrera, Luis ^a   Besada, Vladimir ^a  

^a CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

^b FINLAY INSTITUTE   (Cuba)

Author keywords

Neisseria meningitidis; OMV vaccine; Proteomics; SCAPE

Indexed keywords

ARGININE; CONSERVED HYPOTHETICAL PROTEIN; HEMAGGLUTININ; HEMOLYSIN; HISTIDINE; MENINGOCOCCUS VACCINE; OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN P1; TONB DEPENDENT RECEPTOR; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL OUTER MEMBRANE; BIOINFORMATICS; CLONING; CONTROLLED STUDY; DRUG DETERMINATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEMBRANE VESICLE; MOUSE; NEISSERIA MENINGITIDIS; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SELECTIVE CAPTURE OF PEPTIDE; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CHROMATOGRAPHY, LIQUID; CUBA; HUMANS; MENINGOCOCCAL VACCINES; NEISSERIA MENINGITIDIS, SEROGROUP B; PROTEOME; SECRETORY VESICLES; TANDEM MASS SPECTROMETRY;

EID: 70349527823     PISSN: 15548600     EISSN: 15548619     Source Type: Journal    
DOI: 10.4161/hv.5.5.7367     Document Type: Article

References (46)

1. Girard MP, Preziosi MP, Aguado MT, Kieny MP. A review of vaccine research and development: Meningococcal disease. Vaccine 2006; 24:4692-700.
2. Wyle FA, Artenstein MS, Brandt BL, Tramont EC, Kasper DL, Altieri PL, et al. Immunologic response of man to group B meningococcal polysaccharide vaccines. J Infect Dis 1972; 126:514-21.
3. Fredriksen JH, Rosenqvist E, Wedege E, Bryn K, Bjune G, Froholm LO, et al. Production, characterization and control of MenB-vaccine "Folkehelsa": An outer membrane vesicle vaccine against group B meningococcal disease. NIPH Ann 1991; 14:67-79.
4. Sierra GV, Campa HC, Varcacel NM, Garcia IL, Izquierdo PL, Sotolongo PF, et al. Vaccine against group B Neisseria meningitidis: Protection trial and mass vaccination results in Cuba. NIPH Ann 1991; 14:195-207.
5. Holst J, Feiring B, Naess LM, Norheim G, Kristiansen P, Hoiby EA, et al. The concept of "tailor-made", protein-based, outer membrane vesicle vaccines against meningococcal disease. Vaccine 2005; 23:2202-5.
6. Giuliani MM, Adu-Bobie J, Comanducci M, Arico B, Savino S, Santini L, et al. A universal vaccine for serogroup B meningococcus. Proc Natl Acad Sci USA 2006; 103:10834-9.
7. Sotolongo F, Campa C, Casanueva GV, Fajardo EM, Cuevas I, Gonzalez N. Cuban meningococcal BC vaccine: Experiences & contributions from 20 years of application. MEDICC Review 2007; 9:16-22.
8. Dominguez F, Menendez J, Ochoa R. An effective serogroup B meningococcal vaccine. Vaccine 2006; 24:7025-6.
9. Noronha CP, Struchiner CJ, Halloran ME. Assessment of the direct effectiveness of BC meningococcal vaccine in Rio de Janeiro, Brazil: A case-control study. Int J Epidemiol 1995; 24:1050-7.
10. de Moraes JC, Perkins BA, Camargo MC, Hidalgo NT, Barbosa HA, Sacchi CT, et al. Protective efficacy of a serogroup B meningococcal vaccine in Sao Paulo, Brazil. Lancet 1992; 340:1074-8.
11. Uli L, Castellanos-Serra L, Betancourt L, Dominguez F, Barbera R, Sotolongo F, et al. Outer membrane vesicles of the VA-MENGOC-BC(R) vaccine against serogroup B of Neisseria meningitidis: Analysis of protein components by two-dimensional gel electrophoresis and mass spectrometry. Proteomics 2006; 6:3389-99.
12. Delgado M, Yero D, Niebla O, Gonzalez S, Climent Y, Perez Y, et al. Lipoprotein NMB0928 from Neisseria meningitidis serogroup B as a novel vaccine candidate. Vaccine 2007; 25:8420-31.
13. Betancourt L, Gil J, Besada V, Gonzalez LJ, Fernandez-de-Cossio J, Garcia L, et al. SCAPE: A new tool for the Selective CApture of PEptides in protein identification. J Proteome Res 2005; 4:491-6.
14. Yi EC, Marelli M, Lee H, Purvine SO, Aebersold R, Aitchison JD, et al. Approaching complete peroxisome characterization by gas-phase fractionation. Electrophoresis 2002; 23:3205-16.
15. Gardy JL, Laird MR, Chen F, Rey S, Walsh CJ, Ester M, et al. PSORTb v.2.0: Expanded prediction of bacterial protein subcellular localization and insights gained from comparative proteome analysis. Bioinformatics 2005; 21:617-23.
16. Williams JN, Skipp PJ, Humphries HE, Christodoulides M, O'Connor CD, Heckels JE. Proteomic analysis of outer membranes and vesicles from wild-type serogroup B Neisseria meningitidis and a lipopolysaccharide-deficient mutant. Infect Immun 2007; 75:1364-72.
17. Schmitt C, Turner D, Boesl M, Abele M, Frosch M, Kurzai O. A functional two-partner secretion system contributes to adhesion of Neisseria meningitidis to epithelial cells. J Bacteriol 2007; 189:7968-76.
18. Tettelin H, Saunders NJ, Heidelberg J, Jeffries AC, Nelson KE, Eisen JA, et al. Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science 2000; 287:1809-15.
19. van den BB, Black PN, Clemons WM Jr, Rapoport TA. Crystal structure of the long-chain fatty acid transporter FadL. Science 2004; 304:1506-9.
20. Vipond C, Suker J, Jones C, Tang C, Feavers IM, Wheeler JX. Proteomic analysis of a meningococcal outer membrane vesicle vaccine prepared from the group B strain NZ98/254. Proteomics 2006; 6:3400-13.
21. Vaughan TE, Skipp PJ, O'Connor CD, Hudson MJ, Vipond R, Elmore MJ, et al. Proteomic analysis of Neisseria lactamica and Neisseria meningitidis outer membrane vesicle vaccine antigens. Vaccine 2006; 24:5277-93.
22. Nesvizhskii AI, Vitek O, Aebersold R. Analysis and validation of proteomic data generated by tandem mass spectrometry. Nat Methods 2007; 4:787-97.
23. Campa C, Sierra GV, Gutierrez MM, Biset G, Garcia LG, Puentes G. Method of producing Neisseria meningitidis B vaccine, and vaccine produced by method. US Patent Office 1997; US005597572.
24. Ferrari G, Garaguso I, Adu-Bobie J, Doro F, Taddei AR, Biolchi A, et al. Outer membrane vesicles from group B Neisseria meningitidis delta gna33 mutant: Proteomic and immunological comparison with detergent-derived outer membrane vesicles. Proteomics 2006; 6:1856-66.
25. Ishihama Y, Oda Y, Tabata T, Sato T, Nagasu T, Rappsilber J, et al. Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein. Mol Cell Proteomics 2005; 4:1265-72.
26. Vipond C, Wheeler JX, Jones C, Feavers IM, Suker J. Characterization of the protein content of a meningococcal outer membrane vesicle vaccine by polyacrylamide gel electrophoresis and mass spectrometry. Hum Vaccin 2005; 1:80-4.
27. Grifantini R, Bartolini E, Muzzi A, Draghi M, Frigimelica E, Berger J, et al. Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays. Nat Biotechnol 2002; 20:914-21.
28. Sun Y, Li Y, Exley RM, Winterbotham M, Ison C, Smith H, et al. Identification of novel antigens that protect against systemic meningococcal infection. Vaccine 2005; 23:4136-41.
29. Grifantini R, Bartolini E, Muzzi A, Draghi M, Frigimelica E, Berger J, et al. Gene expression profile in Neisseria meningitidis and Neisseria lactamica upon host-cell contact: From basic research to vaccine development. Ann N Y Acad Sci 2002; 975:202-16.
30. Pizza M, Scarlato V, Masignani V, Giuliani MM, Arico B, Comanducci M, et al. Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. Science 2000; 287:1816-20.
31. Masignani V, Comanducci M, Giuliani MM, Bambini S, Adu-Bobie J, Arico B, et al. Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870. J Exp Med 2003; 197:789-99.
32. Comanducci M, Bambini S, Brunelli B, Adu-Bobie J, Arico B, Capecchi B, et al. NadA, a novel vaccine candidate of Neisseria meningitidis. J Exp Med 2002; 195:1445-54.
33. Martin D, Cadieux N, Hamel J, Brodeur BR. Highly conserved Neisseria meningitidis surface protein confers protection against experimental infection. J Exp Med 1997; 185:1173-83.
34. Judd RC. Identification of surface epitopes of neisserial outer membrane protein 85. In: M A Apicella and H S Seifert (ed), Proceedings of the 14th International Pathogenic Neisseria Conference, Milwaukee, WI 2004; 166.
35. Chong P, Yang YP, Persaud D, Haer M, Tripet B, Tam E, et al. Immunogenicity of synthetic peptides of Haemophilus influenzae type b outer membrane protein P1. Infect Immun 1995; 63:3751-8.
36. Hetherington SV, Patrick CC, Hansen EJ. Outer membrane protein binding sites of complement component 3 during opsonization of Haemophilus influenzae. Infect Immun 1993; 61:5157-63.
37. Finney M, Vaughan T, Taylor S, Hudson MJ, Pratt C, Wheeler JX, et al. Characterization of the key antigenic components and pre-clinical immune responses to a meningococcal disease vaccine based on Neisseria lactamica outer membrane vesicles. Hum Vaccin 2008; 4:23-30.
38. Basler M, Linhartova I, Halada P, Novotna J, Bezouskova S, Osicka R, et al. The iron-regulated transcriptome and proteome of Neisseria meningitidis serogroup C. Proteomics 2006; 6:6194-206.
39. Delany I, Grifantini R, Bartolini E, Rappuoli R, Scarlato V. Effect of Neisseria meningitidis fur mutations on global control of gene transcription. J Bacteriol 2006; 188:2483-92.
40. Sun YH, Bakshi S, Chalmers R, Tang CM. Functional genomics of Neisseria meningitidis pathogenesis. Nat Med 2000; 6:1269-73.
41. Hsu CA, Lin WR, Li JC, Liu YL, Tseng YT, Chang CM, et al. Immunoproteomic identification of the hypothetical protein NMB1468 as a novel lipoprotein ubiquitous in Neisseria meningitidis with vaccine potential. Proteomics 2008; 8:2115-25.
42. Morley SL, Cole MJ, Ison CA, Camaraza MA, Sotolongo F, Anwar N, et al. Immunogenicity of a serogroup B meningococcal vaccine against multiple Neisseria meningitidis strains in infants. Pediatr Infect Dis J 2001; 20:1054-61.
43. Milagres LG, Gorla MC, Sacchi CT, Rodrigues MM. Specificity of bactericidal antibody response to serogroup B meningococcal strains in Brazilian children after immunization with an outer membrane vaccine. Infect Immun 1998; 66:4755-61.
44. Lewis LA, Gipson M, Hartman K, Ownbey T, Vaughn J, Dyer DW. Phase variation of HpuAB and HmbR, two distinct haemoglobin receptors of Neisseria meningitidis DNM2. Mol Microbiol 1999; 32:977-89.
45. Yero D, Pajon R, Niebla O, Sardinas G, Vivar I, Perera Y, et al. Bicistronic expression plasmid for the rapid production of recombinant fused proteins in Escherichia coli. Biotechnol Appl Biochem 2006; 44:27-34.
46. Rosenqvist E, Wedege E, Hoiby EA, Froholm LO. Serogroup determination of Neisseria meningitidis by whole-cell ELISA, dot-blotting and agglutination. APMIS 1990; 98:501-6.