Neurological manifestations in chagas disease without cardiac dysfunction: Correlation between dysfunction of the parasympathetic nervous system and white matter lesions in the brain

Journal of Neuroimaging

Volumn 19, Issue 4, 2009, Pages 332-336

  Py, Marco ^a,c   Pedrosa, Roberto ^a   Silveira, Juliana ^b   Medeiros, Aline ^a   Andre, Charles ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^c Rua Marechal Mascarenhas de Moraes   (Brazil)

Author keywords

Autonomic nervous system; Chagas disease; Magnetic resonance imaging; Neurological manifestations

Indexed keywords

ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BRAIN DAMAGE; CEREBROVASCULAR DISEASE; CHAGAS DISEASE; CHOLINERGIC SYSTEM; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; MALE; NEUROLOGIC DISEASE; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; RISK FACTOR; SINUS ARRHYTHMIA; WHITE MATTER;

AUTONOMIC NERVOUS SYSTEM DISEASES; BRAIN; CHAGAS DISEASE; CHRONIC DISEASE; COHORT STUDIES; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NERVE FIBERS, MYELINATED; NEUROLOGIC EXAMINATION; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 70349515969     PISSN: 10512284     EISSN: 15526569     Source Type: Journal    
DOI: 10.1111/j.1552-6569.2008.00305.x     Document Type: Article

References (38)

1. Chagas C. Nova tripanossomíase humana. Estudos sobre a morfologia e o evolutivo da Schizotrypanum cruzi n. gen., n. sp., agente etiológico de nova entidade mórbida no homem. Mem Inst Oswaldo Cruz 1909 1 : 1 62.
2. Dias E. Estudos sobre o Schizotrypanum cruzi. Mem Inst Oswaldo Cruz 1934 28 : 1 59.
3. Scaravilli F. Parasitic and fungal infections. In Adams JH, Duchen LW, eds. Greenfield's Neuropathology. 5th ed. London : Edward Arnold 1992 : 400 446.
4. Pittella JEH. Central nervous system involvement in Chagas' disease. An updating. Rev Inst Med Trop São Paulo 1993 : 35 : 111 116.
5. Leon-Sarmiento FE, Prada DG, Bayona-Prieto J, et al. Neurotripanosomiasis Americana: aspectos clinicos de un problema basico. Biomedica 2003 23 : 462 475.
6. Chimelli L, Scaravilli F. Trypanosomiasis. Brain Pathology 1997 7 : 599 611.
7. Lopes ER, Chapadeiro E, Tafuri WK, et al Doença de Chagas. In Brasileiro-Filho G, ed. Bogliolo Patologia. 5th. ed. Rio de Janeiro : Guanabara-Koogan 1994 : 1103 1124.
8. Schmunis GA. American trypanosomiasis as a public health problem. In Pan American Health Organization, ed. Chagas' disease and the nervous system. Washington, DC : Paho 1994 : 3 29.
9. da Silva GR. Reversible catalytic model applied to the study of epidemiologic kynetics of chagasic infection. Rev Saude Publica 1969 3 : 23 29.
10. Coura JR. Transmission of chagasic infection by oral route in the natural history of Chagas disease. Rev Soc Bras Med Trop 2006 39 (Suppl 3 113 117.
11. WHO Expert Committee. Control of Chagas disease. WHO Tech Rep Ser 2002 905 : 1 109.
12. Cardoso AV, Lescano SA, Amato Neto V, et al Survival of Trypanosoma cruzi in sugar cane used to prepare juice. Rev Inst Med Trop Sao Paulo 2006 48 : 287 289.
13. Shikanai-Yasuda MA, Marcondes CB, Guedes LA, et al Possible oral transmission of acute Chagas' disease in Brazil. Rev Inst Med Trop Sao Paulo 1991 33 : 351 357.
14. Pedrosa RC, Campos MC. Teste ergométrico e o Holter de 24 horas da detecção de arritmias ventriculares complexas em diferentes estágios da cardiopatia chagásica crônica. Rev Soc Bras Med Trop 2004 37 : 376 383.
15. Cunha AB. A doença de Chagas e o envolvimento do sistema nervoso autônomo. Rev Port Cardiol 2003 22 : 813 824.
16. Mahler-Araújo MB, Chimelli L. Autonomic dysfunction in Chagas disease: lack of participation of the vagus nerve. Trans R Soc Trop Med Hyg 2000 94 : 405 408.
17. Alencar A. Atrofia cortical na cardiopatia crônica chagásica. O Hospital 1964 66 : 807 815.
18. Alencar A. Alterações cerebelares em pacientes com cardiopatia crônica chagásica. Arq Neuropsiquiatr 1967 25 : 191 198.
19. Alencar A. Encefalopatia crônica chagásica. J Bras Neurol 1982 18 : 7 12.
20. Nussenzweig I, Wajchember BL, Macruz R, et al Acidentes vasculares cerebrais embólicos na cardiopatia chagásica crônica. Arq Neuropsiquiatr 1953 11 : 386 402.
21. Queiroz AC. Estudo anatomopatológico do encéfalo na forma crônica da doença de Chagas. Rev Pathol Trop 1978 7 : 135 145.
22. Pittella JEH. Ischemic cerebral changes in the chronic chagasic cardiopathy. Arq Neuropsiquiatr 1984 42 : 105 115.
23. Carod-Artal FJ, Vargas AP, Melo M, et al. American trypanosomiasis (Chagas' disease): an unrecognized cause of stroke. J Neurol Neurosurg Psychiatry 2003 74 : 516 518.
24. Leon-Sarmiento FE, Mendoza E, Torres-Hillera M, et al Trypanosoma cruzi-associated cerebrovascular disease: a case-control study in Eastern Colombia. J Neurol Sci 2004 217 : 61 64.
25. Oliveira-Filho J, Viana LC, Vieira-de-Melo RM, et al Chagas disease is an independent risk factor for stroke: baseline characteristics of a Chagas Disease cohort. Stroke 2005 36 : 2015 2017.
26. Caplan LR, Hennerici M. Impaired clearance of emboli (washout) is an important link between hypoperfusion, embolism and ischemic stroke. Arch Neurol 1998 55 : 1475 1482.
27. Derdeyn CP, Grubb RL Jr., Powers WJ. Cerebral hemodynamic impairment: methods of measurement and association with stroke risk. Neurology 1999 53 : 251 259.
28. Carrasco HA. Diagnóstico Dedano Miocárdico en la Enfermedad de Chagas. Mérida : Consejo de Publicaciones de la Universidad de Los Andes 1983.
29. Baldwa VS, Ewing DJ. Heart rate response to Valsalva manoeuver: reproductibility in normals and relation to variation in resting heart rate in diabetics. Br Heart J 1977 39 : 641 644.
30. Task Force of the European Society of Cardiology and the North American Society of Pacing Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 1996 93 : 1043 1065.
31. Barbosa PRB, Barbosa Filho J, Cardovil I, et al Phase response of the spectral coherence between heart rate variability and ventricular repolarization duration in normal subjects. Comp Cardiol 2000 27 : 159 162.
32. Bigger JT, Fleiss JL, Steinman RC. Correlations among time and frequency domain measures of heart period variability two weeks after myocardial infarction. Am J Cardiol 1992 69 : 891 898.
33. Fazekas F, Niederkorn K, Schmidt R, et al White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors. Stroke 1988 19 : 1285 1258.
34. Schmidt R, Fazekas F, Kleinert G, et al. H. Magnetic resonance imaging signal hyperintensities in the deep and subcortical white matter. A comparative study between stroke patients and normal volunteers. Arch Neurol 1992 49 : 825 827.
35. Vermeer SE, Hollander M, van Dijk EJ, et al. Rotterdam Scan Study. Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study. Stroke 2003 34 : 1126 1129.
36. Luiz RR. Análise estatística com múltiplas variáveis. In : Luiz RR, Costa AJL, Nadanovsky P, eds. Epidemiologia e Bioestatística na Pesquisa Odontológica. São Paulo : Editora Atheneu 2005 : 341 372.
37. Marin-Neto JA, Cunha-Neto E, Maciel BC, et al Pathogenesis of chronic Chagas heart disease. Circulation 2007 115 : 1109 1123.
38. Culebras A, Kase CS, Masdeu JC, et al Practice guidelines for the use of imaging in transient ischemic attacks and acute stroke. Stroke 1997 28 : 1480 1497.