Randomized open comparative trial of dexamethasone-cyclophosphamide pulse and daily oral cyclophosphamide versus cyclophosphamide pulse and daily oral prednisolone in pemphigus vulgaris

Indian Journal of Dermatology, Venereology and Leprology

Volumn 75, Issue 5, 2009, Pages 476-482

  Sethy, Pradeep ^a   Khandpur, Sujay ^a   Sharma, Vinod ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Cyclophosphamide; Dexamethasone; Pemphigus vulgaris; Pulse therapy

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CALCIUM CARBONATE; CREATININE; CYCLOPHOSPHAMIDE; DESMOGLEIN ANTIBODY; DEXAMETHASONE; ONDANSETRON; PANTOPRAZOLE; PREDNISOLONE; UREA; VITAMIN D;

ADULT; ANEMIA; ANTIBODY BLOOD LEVEL; ANXIETY; ARTHRALGIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BACTERIURIA; BONE PAIN; CATARACT; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE CONTROL; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG PULSE THERAPY; DYSGEUSEA; DYSGEUSIA; DYSPEPSIA; DYSPNEA; EPIGASTRIC PAIN; FEMALE; FLUSHING; FOLLOW UP; HAIR LOSS; HEADACHE; HEART PALPITATION; HEMATURIA; HICCUP; HUMAN; HYPERGLYCEMIA; HYPERTENSION; HYPOGLYCEMIA; LEUKOCYTOSIS; LEUKOPENIA; MALE; MENSTRUAL IRREGULARITY; MOON FACE; NAIL DISCOLORATION; NAIL DISEASE; NAUSEA; OPEN STUDY; PEMPHIGUS VULGARIS; PROSPECTIVE STUDY; PYODERMA; PYURIA; RANDOMIZED CONTROLLED TRIAL; RECURRENCE RISK; RELAPSE; REMISSION; SECONDARY AMENORRHEA; SIDE EFFECT; TASTE DISORDER; TREATMENT DURATION; TREATMENT RESPONSE; URINARY TRACT INFECTION; VISUAL ACUITY; VOMITING; WEAKNESS; WEIGHT; WITHDRAWAL SYNDROME;

ADMINISTRATION, ORAL; ADULT; AGED; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DRUG COMBINATIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; PEMPHIGUS; PREDNISOLONE; PROSPECTIVE STUDIES; PULSE THERAPY, DRUG;

EID: 70349429842     PISSN: 03786323     EISSN: None     Source Type: Journal    
DOI: 10.4103/0378-6323.55390     Document Type: Article

References (18)

1. Seidenbaum M, David M, Sandbank M. The course and prognosis of pemphigus: A review of 115 patients. Int J Dermatol 1988;27:580-584
2. Chryssomallis F, Dimitriades A, Chaidemenos GC, Panagiotides D, Karakatsanis G. Steroid-pulse therapy in pemphigus vulgaris: long term follow-up. Int J Dermatol 1995;34:438-442
3. Pasricha JS, Khaitan BK, Raman RS, Chandra M. Dexamethasone cyclophosphamide pulse therapy for pemphigus. Int J Dermatol 1995;34:875-882
4. Pandya AG, Sontheimer RD. Treatment of pemphigus vulgaris with pulse intravenous cyclophosphamide. Arch Dermatol 1992;128:1626-1630
5. Werth VP. Pulse intravenous cyclophosphamide for treatment of autoimmune blistering diseases: Is there an advantage over the oral route? Arch Dermatol 1997;133:229-230
6. Haubitz M, Ehlerding C, Kamino K, Koch KM, Brunkhorst R. Reduced gonadal toxicity after i.v. cyclophosphamide administration in patients with nonmalignant diseases. Clin Nephrol 1998;49:19-23.
7. Fox LP, Pandya AG. Pulse intravenous cyclophosphamide therapy for dermatologic disorders. Dermatol Clin 2000;18:459-473
8. Pasricha JS, Thanzama J, Khan UK. Intermittent high-dose dexamethasone-cyclophosphamide therapy for pemphigus. Br J Dermatol 1988;119:73-77
9. Pasricha JS, Das SS. Curative effect of dexamethasonecyclophosphamide pulse therapy for the treatment of pemphigus vulgaris. Int J Dermatol 1992;31:875-877
10. Kaur S, Kanwar AJ. Dexamethasone-cyclophosphamide pulse therapy in pemphigus. Int J Dermatol 1990;29:371-374
11. Masood Q, Hassan I, Majid I, Khan D, Manzooi S, Qayoom S, et al. Dexamethasone cyclophosphamide pulse therapy in pemphigus: experience in Kashmir valley. Indian J Dermatol Venereol Leprol 2003;69:97-9.12.
12. Kanwar AJ, Kaur S, Thami GP. Long-term efficacy of dexamethasone- cyclophosphamide pulse therapy in pemphigus. Dermatology 2002;204:228-231
13. Thappa DM, Karthikeyan K, Jeevankumar B. Dexamethasone- Cyclophosphamide Pulse therapy in pemphigus: An appraisal of its out come in a tertiary health Care Center in South India. Indian J Dermatol 2004;49:9-13.
14. Akhtar SJ, Hasan MU. Treatment of pemphigus: A local experience. J Pak Med Assoc 1998;48:300-304 (Abstr).
15. Shahidi-Dadras M, Karami A, Toosy P, Shafiyan A. Pulse versus oral methylprednisolone therapy in pemphigus vulgaris. Arch Iran Med 2007;10:1-6.
16. Fleischli ME, Valek RH, Pandya AG. Pulse intravenous cyclophosphamide therapy in pemphigus. Arch Dermatol 1999;135:57-61.
17. Gokhale NR, Mahajan PM, Sule RR, Belgaumkar VA, Jain SM. Treatment of pemphigus with intravenous pulse cyclophosphamide. Indian J Dermatol Venereol Leprol 2003;69: 334-337
18. Bhat R, Sharma VK, Ramam M, Kumar A. Cyclophosphamide pulses with oral prednisolone in the treatment of pemphigus: a pilot study. Dermatol Online J 2005;11:4.