Synthesis, antitubercular and antimicrobial activity of some new N-aryl-1,4-dihydropyridines containing furan nucleus

Journal of the Indian Chemical Society

Volumn 86, Issue 2, 2009, Pages 186-191

  Rokad, S V ^a   Tala, S D ^a   Akbari, J D ^a   Dhaduk, M F ^a   Joshi, H S ^a  

^a SAURASHTRA UNIVERSITY   (India)

Author keywords

Antimicrobial activity; Antitubercular activity; N Aryl 1,4 dihydropyridines

Indexed keywords

FURAN DERIVATIVE; N 2 CHLOROPHENYL 2,6 DIMETHYL 3,5 DICARBETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 2 CHLOROPHENYL 2,6 DIMETHYL 3,5 DICARBMETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 2 NITROPHENYL 2,6 DIMETHYL 3,5 DICARBETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 2 NITROPHENYL 2,6 DIMETHYL 3,5 DICARBMETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 4 ANISYL 2,6 DIMETHYL 3,5 DICARBETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHDYDROPYRIDINE; N 4 ANISYL 2,6 DIMETHYL 3,5 DICARBMETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 4 BROMOPHENYL 2,6 DIMETHYL 3,5 DICARBETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 4 BROMOPHENYL 2,6 DIMETHYL 3,5 DICARBMETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 4 CHLOROPHENYL 2,6 DIMETHYL 3,5 DICARBETHOXY 4 [5' (6 CHLORO 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 4 CHLOROPHENYL 2,6 DIMETHYL 3,5 DICARBMETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 4 FLUOROPHENYL 2,6 DIMETHYL 3,5 DICARBETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 4 FLUOROPHENYL 2,6 DIMETHYL 3,5 DICARBMETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 4 NITROPHENYL 2,6 DIMETHYL 3,5 DICARBETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 4 NITROPHENYL 2,6 DIMETHYL 3,5 DICARBMETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 4 TOLYL 2,6 DIMETHYL 3,5 DICARBETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 4 TOLYL 2,6 DIMETHYL 3,5 DICARBMETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 6 CHLOROPHENYL 2,6 DIMETHYL 3,5 DICARBETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N 6 CHLOROPHENYL 2,6 DIMETHYL 3,5 DICARBMETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N ARYL 1,4 DIHYDROPYRIDINE; N PHENYL 2,6 DIMETHYL 3,5 DICARBETHOXY 4 [5' (6 CHLORO 4 FLUOROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; N PHENYL 2,6 DIMETHYL 3,5 DICARBMETHOXY 4 [5' (6 CHLORO 4 FLOUROPHENYL) 2' FURYL] 1,4 DIHYDROPYRIDINE; PYRIDINE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 70349377694     PISSN: 00194522     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. R. Kulbhasuan, K. Balbir and B. Kumar, Indian J. Chem., Sect. B, 2004, 41, 1553.
2. B. Desai, D. Sureja, Y. Naliapara, A. Saha and A. K. Shaxena, Bioorg. Med. Chem., 2001, 9, 1993.
3. A. K. Chhillar, A. K. Prasad and G. L. Sharma, Bioorg. Med. Chem., 2005, 14, 937.
4. G. Gunics, S. Farkas, N. Motohashi, A. Shah, G. Harsukh and J. Molnar, Antimicrob. Agents, 2002, 20, 227.
5. F. Hodixadeh, Z. Hassanaba, M. Bamshad and M. Fetehi-Hassanabad, Indian J. Chem., Sect. B, 2005, 44, 2343.
6. K. Rana, B. Kaur and B. Kumar, Indian J. Chem., Sect. B, 2003, 43, 1553.
7. R. A. Jains and D. J. Triggle, J. Med. Chem., 1983, 26, 775.
8. R. H. Bocker and E. P. Guengerich, J. Med. Chem., 1986, 29, 1596.
9. M. F. Gordeev, D. V. Patel and E. M. Gordon, J. Org. Chem., 1996, 61, 924.
10. R. A. Janis, P. J. Silver and D. J. Triggle, Adv. Drug Res., 1987, 16, 309.
11. F. Bossert and M. Water, Med. Res. Rev., 1989, 9, 291.
12. C. E. Sunkel, M. F. Fau de Casa-Juana, L. Santos, A. G. Garcia, C. R. Artalijero, M. A. Villarroya, M. A. Gonzalez-Morales, M. G. Lopez, J. Cillero, S. Alonso and J. G. Priego, J. Med. Chem., 1992, 35, 2407.
13. D. Vo, W. C. Matowe, M. Ramesh, N. Iabal, M. W. Wolowyk, S. E. Howlett and E. E. Knaus, J. Med. Chem., 1995, 38, 2851.
14. C. Velazquez and E. E. Knaus, Bioorg. Med. Chem., 2004, 12, 3831.
15. V. Klusa, Drugs Fut., 1995, 20, 135.
16. T. Godfraind, R. Miller and M. Wibo, Pharmacol. Rev., 1986, 38, 321.
17. A. Sausin and G. Duburs, Heterocycles, 1988, 27, 269.
18. A. C. Gaudio, A. Korolkovas and Y. J. Takahata, Pharm. Sci., 1994, 83, 1110.
19. K. Cooper, M. J. Fray, M. J. Parry, K. Richardson and J. Steele, J. Med. Chem., 1992, 35, 3115.
20. J. S. Yadav, V. S. Reddy and P. T. Reddy, Synth. Commun., 2001, 31, 425.
21. A. D. Patil, N. V. Kumar, W. C. Kokke, M. F. Bean, A. J. Freyer, C. Debrosse, S. Mai, A. Trunch, D. J. Faulkner, B. Carte, A. L. Breen, R. P. Hertzberg, R. K. Johnson, J. W. Westley and B. C. Potts, J. Org. Chem., 1995, 60, 1182.
22. B. B. Sinder and Z. Shi, J. Org. Chem., 1938, 58, 3828.
23. A. Hantzsch, Justus Leibigs Ann. Chem., 1882, 215, 1.
24. N. R. Natale, Chem. Inno., 2000, 30, 22.
25. J. D. Akbari, S. D. Tala, M. F. Dhaduk and H. S. Joshi, ARKIVOC, 2008, xii, 126.
26. A. L. Barry, "The Antimicrobial Susceptibility Test: Principle and Practices", eds. Illuslea and Febiger, Philadelphia, USA, 180;
27. Biol. Abstr., 1977, 64, 25183.