Esmolol Reduces Perioperative Ischemia in Cardiac Surgery: A Meta-analysis of Randomized Controlled Studies

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 23, Issue 5, 2009, Pages 625-632

  Zangrillo, Alberto ^a   Turi, Stefano ^a   Crescenzi, Giuseppe ^a   Oriani, Alessandro ^a   Distaso, Francesco ^a   Monaco, Fabrizio ^a   Bignami, Elena ^a   Landoni, Giovanni ^a  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

blocker; anesthesia; cardiac anesthesia; cardiac protection; cardiac surgery; esmolol

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; ESMOLOL; INOTROPIC AGENT; PLACEBO;

ARTICLE; BRADYCARDIA; CARDIOPULMONARY BYPASS; CARDIOVASCULAR RISK; CLINICAL TRIAL; DRUG EFFECT; HEART ARRHYTHMIA; HEART MUSCLE ISCHEMIA; HEART SURGERY; HUMAN; HYPOTENSION; META ANALYSIS; PRIORITY JOURNAL; SYSTEMATIC REVIEW;

CARDIAC SURGICAL PROCEDURES; HUMANS; MYOCARDIAL ISCHEMIA; PERIOPERATIVE CARE; PROPANOLAMINES; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 70349337620     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jvca.2009.01.003     Document Type: Article

References (51)

1. ACC/AHA. 2007 guidelines on perioperative cardiovascular evaluation and care for non cardiac surgery: A report of American College of Cardiology/American Heart Association Task Force on practice guidelines. Anesth Analg 1063 (2008) 685-712
2. McGory M.L., Maggard M.A., and Ko C.Y. A meta-analysis of perioperative beta-blockade: What is the actual risk reduction?. Surgery 138 (2005) 171-179
3. Weisbauer F., Schagler O., Domanovits H., et al. Perioperative beta-blockers for preventing surgery related mortality and morbidity: A systematic review and meta-analysis. Anesth Analg 104 (2007) 27-41
4. Crystal E., Garfinkle M.S., Connolly S.S., et al. Interventions for preventing postoperative atrial fibrillation in patients undergoing heart surgery. Cochrane Database Syst Rev 18 (2004) CD 003611
5. Ferguson Jr. T.B., Coombs L.P., and Peterson E.D. Preoperative beta-blocker use and mortality and morbidity following CABG surgery in North America. JAMA 287 (2002) 2221-2227
6. Fita G., Gomar C., and Rovira I. Esmolol in anaesthesiology: Pharmacology and indications. Rev Esp Anestesiol Reanim 46 (1999) 401-414
7. Ravussin P. Characteristics and clinical use of esmolol. Minerva Anestesiol 58 suppl 1 (1992) 77-79
8. Cork R., Kramer T.H., Dreischmeier B., et al. The effect of esmolol given during cardiopulmonary bypass. Anesth Analg 80 (1995) 28-40
9. Boldt J., Brosch C., Lehmann A., et al. The prophylactic use of the beta-blocker esmolol in combination with phosphodiesterase III inhibitor enoximone in elderly cardiac surgery patients. Anesth Analg 99 (2004) 1009-1017
10. Scorsin M., Mebazaa A., Al Attar N., et al. Efficacy of esmolol as a myocardial protective agent during continuous retrograde blood cardioplegia. J Cardiothorac Vasc Surg 125 (2003) 1022-1029
11. Deng Y.K., Wei F., Li Z.L., et al. Esmolol protects the myocardium and facilitates intracardiac operation with a beating heart. Circulation 66 (2002) 715-717
12. Kurian S.M., Evans R., Fernandes N.O., et al. The effect of an infusion of esmolol on the incidence of myocardial ischaemia during tracheal extubation following coronary artery surgery. Anaesthesia 56 (2001) 1163-1168
13. Mehlhorn U., Fattah M., Kuhn-Regnier F., et al. Impact of myocardial protection during coronary bypass surgery on patient outcome. Cardiovasc Surg 9 (2001) 482-486
14. Mooss A.N., Wurdeman R.L., Mohiuddin S.Y., et al. Esmolol versus diltiazem in the treatment of postoperative atrial fibrillation/atrial flutter after open heart surgery. Am Heart J 140 (2000) 176-180
15. Mehlhorn U., Blochb W., Krahwinkelb A., et al. Activation of myocardial constitutive nitric oxide synthase during coronary artery surgery. Eur J Cardiothorac Surg 17 (2007) 305-311
16. Mehlhorn U., Sauer H., Kuhn-Regnier F., et al. Myocardial β-blockade as an alternative to cardioplegic arrest during coronary artery surgery. Cardiovasc Surg 7 (1999) 549-557
17. Kuhn-Regnier F., Natour E., Dheind S., et al. Beta-blockade versus Buckberg blood-cardioplegia in coronary bypass operation. Eur J Cardiothorac Surg 15 (1999) 67-74
18. Newsome L.R., Roth J.V., Hug Jr. C.C., et al. Esmolol attenuates hernodynamic responses during fentanyl-pancuronium anesthesia for aortocoronary bypass surgery. Anesth Analg 65 (1986) 451-456
19. Arar C., Colak A., Alagol A., et al. The use of esmolol and magnesium to prevent haemodynamic responses to extubation after coronary artery grafting. Eur J Anesthesiol 24 (2007) 826-831
20. Balcetyte-Harris N., Tamis J.E., Homel P., et al. Randomized study of early intravenous esmolol versus oral beta-blockers in preventing post-CABG atrial fibrillation in high risk patients identified by signal-averaged ECG: Results of a pilot study. Ann Noninvasive Electrocardiol 7 (2002) 86-91
21. Maniar P.B., Balcetyte-Harris N., Tamis J.E., et al. Intravenous versus oral beta-blockers for prevention of post-CABG atrial fibrillation in high-risk patients identified by signal-averaged ECG: lessons of a pilot study. Cardiac Electrophysiol Rev 7 (2003) 158-161
22. Hilleman D.E., Reyes A.P., Mooss A.N., et al. Esmolol versus diltiazem in atrial fibrillation following coronary bypass graft surgery. Curr Med Res Opin 19 (2003) 376-382
23. Rinne T., Hairmonen A., and Kaukinen S. Esmolol cardioplegia in unstable coronary revascularisation patients. Acta Anesthesiol Scand 44 (2000) 727-732
24. Chahuan S., Saxena N., Rao B.H., et al. A comparison of esmolol and diltiazem for heart rate control during coronary revascularisation on beating heart. Indian J Med Res 110 (1999) 174-177
25. Hekamt K., Clemens R.M., Mehlhorn U., et al. Emergency coronary artery surgery after failed PTCA: Myocardial protection with continuous coronary perfusion of beta-blocker enriched blood. Thorac Cardiovasc Surg 46 (1998) 333-338
26. Cork R.C., Azari D.M., McQueen K.A.K., et al. Effect of esmolol given during cardiopulmonary bypass on fractional area of contraction from transesophageal echocardiography. Anesth Analg 81 (1995) 219-224
27. Neustein S.M., Bronheim D.S., Lasker S., et al. Esmolol and intraoperative myocardial ischemia: A double-blind study. J Cardiothorac Vasc Anesth 8 (1994) 273-277
28. Boylan J.F., O'Leary J., Weisel R.D., et al. A comparison of esmolol, diltiazem, nifedipine and nitroprusside therapy of post-CABG hypertension. Can J Anesth 37 (1990) s156
29. Kling D., Boldt J., Zickmann B., et al. The hemodynamic effect of treatment with beta-receptor blockers during coronary surgery. A comparison between acebutolol and esmolol. Anaesthesist 39 (1990) 264-268
30. Harrison L., Ralley F.E., Wynands E., et al. The role of an ultra-short adrenergic blocker (esmolol) in patients undergoing coronary artery bypass surgery. Anesthesiology 66 (1987) 413-418
31. Girard D., Shulman B.J., Thys D.M., et al. The safety and efficacy of esmolol during myocardial revascularisation. Anesthesiology 65 (1986) 157-164
32. De Brujin N.P., Croughwell N., and Reves J.G. Hemodynamic effects of esmolol in chronically beta-blocked patients undergoing aortocoronary bypass surgery. Anesth Analg 66 (1987) 137-141
33. Tempe D.K., Mulchandani P., Tandon S.M., et al. Control of tachycardia and hypertension following coronary artery bypass graft surgery: Efficacy and haemodynamic effects of esmolol. Indian Heart J 51 (1999) 294-300
34. O'Dwyer J.P., Yorukoglu D., and Harris M.N.E. The use of esmolol to attenuate the haemodynamic response when extubating patients following cardiac surgery-A double blind controlled study. Eur Heart J 14 (1993) 701-704
35. Gray R.J., Bateman T.M., Czer L.S.C., et al. Use of esmolol in hypertension after cardiac surgery. Am J Cardiol 56 (1985) 49F-56F
36. Reves J.G., Croughwell N.D., Hawkins E., et al. Esmolol for treatment of intraoperative tachycardia and/or hypertension in patients having cardiac operations. J Cardiovasc Surg 100 (1990) 221-227
37. Gray R.J., Bateman T.M., Czer L.S.C., et al. Comparison of esmolol and nitroprusside for acute post-cardiac surgery hypertension. Am J Cardiol 59 (1987) 887-891
38. Higgins J.P.T., and Green S. The Cochrane Handbook for Systematic Reviews of Interventions 4.2.5. http://www.cochrane.org/resources/handbook/hbook.htm Accessed October 10, 2005
39. Moher D., Cook D.J., Eastwood S., et al. Improving the quality of reports of meta-analyses of randomised controlled trials: The QUOROM statement. Quality of reporting of meta-analyses. Lancet 354 (1999) 1896-1900
40. Biondi-Zoccai G.G., Lotrionte M., Abbate A., et al. Compliance with QUOROM and quality of reporting of overlapping metaanalysis on the role of acetylcysteine in the prevention of contrast associated nephropathy: Case study. BMJ 332 (2006) 202-209
41. Killingsworth C.R., Wei C.C., Dell'Italia L.J., et al. Shorting-acting beta-adrenergic antagonist esmolol given at reperfusion improves survival after prolonged ventricular fibrillation. Circulation 109 (2004) 2469-2474
42. Rosenfeld D.M., Trentman T.L., Hentz J.G., et al. Patients understanding of the importance of the beta-blocker use in the perioperative period. J Cardiothorac Vasc Anesth 21 (2007) 325-329
43. A report of the American College of Cardiology/American Heart Association ACC/AHA guidelines and indications for coronary artery bypass graft surgery. Task Force on Assessment of Diagnostic and Therapeutic Cardiovascular Procedures (Subcommittee on Coronary Artery Bypass Graft Surgery). Circulation 83 (1991) 1125-1173
44. Landoni G., Pappalardo F., Calabrò M.G., et al. Myocardial necrosis biomarkers after different cardiac surgical operations. Minerva Anestesiol 73 (2007) 49-56
45. Beattie W.S., Wijeysundera D.N., Karkouti K., et al. Does tight heart rate control improve beta-blocker efficacy?. An update analysis of the noncardiac surgical randomized trials. Anesth Analg 106 (2008) 1025-1030
46. Opie L.H. Myocardial infarct size. Part 1. Basic considerations. Am Heart J 100 (1980) 355-372
47. Becker L.C., Fortuin N.J., and Pitt B. Effect of ischemia and antianginal drugs on the distribution of radioactive microspheres in the canine left ventricle. Circ Res 28 (1971) 263-269
48. Frishman W.H., and Chang C.M. Beta-adrenergic blockade in the prevention of myocardial infarction: A new theory. J Hypertens Suppl 9 (1991) 531-534
49. Heringlake M., Bahlmann L., Misfeld M., et al. High myocardial concentration is associated with poor myocardial function prior to cardiopulmonary bypass. Minerva Anestesiol 71 (2005) 775-783
50. Feringa H.H., Bax J.J., Boersma E., et al. High dose beta-blockers and tight heart rate control reduce myocardial ischemia and troponin T release in vascular surgery patients. Circulation 114 suppl (2006) 1344-1349
51. POISE Study Group. Effects of extended-release metoprolol succinate in patients undergoing noncardiac surgery (POISE trial): A randomised controlled trial. Lancet 371 (2008) 1839-1847