Neonatal maternal separation alters the development of glucocorticoid receptor expression in the interpositus nucleus of the cerebellum

International Journal of Developmental Neuroscience

Volumn 27, Issue 7, 2009, Pages 649-654

  Wilber, A A ^a   Wellman, C L ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

Glucocorticoid receptor; Immunohistochemistry; Interpositus nucleus; Maternal separation; Sex differences

Indexed keywords

GLUCOCORTICOID RECEPTOR;

ADULTHOOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; FEMALE; INTERPOSITUS NUCLEUS; LEARNING DISORDER; MALE; MATERNAL DEPRIVATION; MEMORY DISORDER; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REARING; SEX DIFFERENCE;

ANIMALS; BLINKING; CEREBELLAR NUCLEI; CONDITIONING, CLASSICAL; FEMALE; GLUCOCORTICOIDS; LEARNING; MALE; MATERNAL DEPRIVATION; MEMORY; RANDOM ALLOCATION; RATS; RATS, LONG-EVANS; RECEPTORS, GLUCOCORTICOID;

RATTUS;

EID: 70349336680     PISSN: 07365748     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijdevneu.2009.08.001     Document Type: Article

References (39)

1. Aisa, B., Gil-Bea, F.J., Marcos, B., Tordera, R., Lasheras, B., Del Río, J., Ramírez, M.J., in press. Neonatal stress affects vulnerability of cholinergic neurons and cognition in the rat: involvement of the HPA axis. Psychoneuroendocrinology.
2. Aisa B., Tordera R., Lasheras B., Del Rio J., and Ramirez M.J. Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats. Psychoneuroendocrinology 32 (2007) 256-266
3. Avishai-Eliner S., Hatalski C.G., Tabachnik E., Eghbal-Ahmadi M., and Baram T.Z. Differential regulation of glucocorticoid receptor messenger RNA (GR-mRNA) by maternal deprivation in immature rat hypothalamus and limbic regions. Brain Res. Dev. 114 (1999) 265-268
4. Chebotaev D.V., Yemelyanov A.Y., Lavker R.M., Budunova I.V., Chebotaev D.V., Yemelyanov A.Y., Lavker R.M., and Budunova I.V. Epithelial cells in the hair follicle bulge do not contribute to epidermal regeneration after glucocorticoid-induced cutaneous atrophy (see comment). J. Invest. Dermatol. 127 (2007) 2749-2758
5. Christian K.M., and Thompson R.F. Neural substrates of eyeblink conditioning acquisition and retention. Learn. Mem. 11 (2003) 427-455
6. Delgado-Garcia J.M., and Gruart A. The role of interpositus nucleus in eyelid conditioned responses. Cerebellum 1 (2002) 289-308
7. Delgado-Garcia J.M., and Gruart A. Firing activities of identified posterior interpositus nucleus neurons during associative learning in behaving cats. Brain Res. Rev. 49 (2005) 367-376
8. Delgado-Garcia J.M., and Gruart A. Building new motor responses: eyelid conditioning revisited. Trends Neurosci. 29 (2006) 330-338
9. Erdeljan P., Andrews M.H., MacDonald J.F., and Matthews S.G. Glucocorticoids and serotonin alter glucocorticoid receptor mRNA levels in fetal guinea-pig hippocampal neurons, in vitro. Reprod. Fertil. Dev. 17 (2005) 743-749
10. Erdeljan P., MacDonald J.F., and Matthews S.G. Glucocorticoids and serotonin alter glucocorticoid receptor (GR) but not mineralocorticoid receptor (MR) mRNA levels in fetal mouse hippocampal neurons, in vitro. Brain Res. 896 (2001) 130-136
11. Garrett J.E., Kim I., Wilson R.E., and Wellman C.L. Effect of N-methyl-d-aspartate receptor blockade on plasticity of frontal cortex after cholinergic deafferentation in rat. Neuroscience 140 (2006) 57-66
12. Gibb R., and Kolb B. Neonatal handling alters brain organization but does not influence recovery from perinatal cortical injury. Behav. Neurosci. 119 (2005) 1375-1383
13. Huot R.L., Plotsky P.M., Lenox R.H., and McNamara R.K. Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats. Brain Res. 950 (2002) 52-63
14. Jimenez-Diaz L., de Dios Navarro-Lopez J., Gruart A., and Delgado-Garcia J.M. Role of cerebellar interpositus nucleus in the genesis and control of reflex and conditioned eyelid responses. J. Neurosci. 24 (2004) 9138-9145
15. Kosten T.A., Lee H.J., and Kim J.J. Neonatal handling alters learning in adult male and female rats in a task-specific manner. Brain Res. 1154 (2007) 144-153
16. Kozhevnikova L.M., Avdonin P.P., Sukhanova I.F., and Avdonin P.V. The role of desensitization of glucocorticoid receptors in the development of vascular resistance to endogenous vasoconstrictors in traumatic shock. Vestn. Ross. Akad. Med. Nauk. (2007) 3-8
17. Krupa D.J., Thompson J.K., and Thompson R.F. Localization of a memory trace in the mammalian brain. Science 260 (1993) 989-991
18. Ladd C.O., Huot R.L., Thrivikraman K.V., Nemeroff C.B., Meaney M.J., and Plotsky P.M. Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation. Biol. Psychiatry 55 (2004) 367-375
19. McCormick D.A., and Thompson R.F. Cerebellum: essential involvement in the clasically conditioned eyeblink response. Science 223 (1984) 296-299
20. McCormick D.A., and Thompson R.F. Neuronal responses of the rabbit cerebellum during acquisition and performance of a classically conditioned nictitating membrane-eyelid response. J. Neurosci. 4 (1984) 2811-2822
21. Meaney M.J., Aitken D.H., Bodnoff S.R., Iny L.J., Tatarewicz J.E., and Sapolsky R.M. Early postnatal handling alters glucorticoid receptor concentrations in selected brain regions. Behav. Neurosci. 99 (1985) 765-770
22. Meaney M.J., Diorio J., Francis D., Weaver S., Yau J., Chapman K., and Seckl J.R. Postnatal Handling Increases the expression of cAMP-inducible transcription factors in the rat hippocampus: the effects of thyroid hormones and serotonin. J. Neurosci. 20 (2000) 3926-3935
23. Meaney M.J., Diorio J., Francis D., Widdowson J., LaPlante P., Caldji C., Sharma S., Seckl J.R., and Plotsky P.M. Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress. Dev. Neurosci. 18 (1996) 49-72
24. Meerlo P., Horvath K.M., Nagy G.M., Bohus B., and Koolhaas J.M. The influence of postnatal handling on adult neuroendocrine and behavioural stress reactivity. J. Neuroendocrinol. 11 (1999) 925-933
25. Mitchell J.B., Iny L.J., and Meaney M.J. The role of serotonin in the development and environmental regulation of type II corticosteroid receptor binding in rat hippocampus. Dev. Brain Res. 55 (1990) 231-235
26. Mitchell J.B., Rowe W., Boksa P., and Meaney M.J. Serotonin regulates type II corticosteroid receptor binding in hippocampal cell cultures. J. Neurosci. 10 (1990) 1745-1752
27. Osborne M.C., Verhovshek T., and Sengelaub D.R. Androgen regulates trkB immunolabeling in spinal motoneurons. J. Neurosci. Res. 85 (2007) 303-309
28. Pryce C.R., Bettschend D., Nanz-Bahr N.I., and Feldon J. Comparison of the effects of early handling and early deprivation on conditioned stimulus, context, and spatial learning and memory in adult rats. Behav. Neurosci. 117 (2003) 883-893
29. Reid K., Hayashi Y., Guo T.-S., Correa-Sales C., Nacif-Coelho C., and Maze M. Chronic administration of an [alpha]2 adrenergic agonist desensitizes rats to the anesthetic effects of dexmedetomidine. Pharmacol. Biochem. Behav. 47 (1994) 171-175
30. Solt K., Ruesch D., Forman S.A., Davies P.A., and Raines D.E. Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model. J. Neurosci. 27 (2007) 13151-13160
31. Steinmetz J.E. Brain substrates of classical eyeblink conditioning: a highly localized but also distributed system. Behav. Brain Res. 110 (2000) 13-24
32. Steinmetz J.E., Lavond D.G., Ivkovich D., Logan C.G., and Thompson R.F. Disruption of classical eyelid conditioning after cerebellar lesions: damage to a memory trace system or a simple performance deficit?. J. Neurosci. 12 (1992) 4403-4426
33. Steinmetz J.E., Logue S.F., and Steinmetz S.S. Rabbit classically conditioned eyelid responses do not reappear after interpositus nucleus lesion and extensive post-lesion training. Behav. Brain Res. 51 (1992) 103-114
34. Uysal N., Ozdemir D., Dayi A., Yalaz G., Baltaci A.K., and Bediz C.S. Effects of maternal deprivation on melatonin production and cognition in adolescent male and female rats. Neuroendocrinol. Lett. 26 (2005) 555-560
35. van Oers H.J.J., de Kloet E.R., Whelan T., and Levine S. Maternal deprivation effect on the infant's neural stress markers is reversed by tactile stimulation and feeding but not by suppressing corticosterone. J. Neurosci 18 (1998) 10171-10179
36. Wilber A.A., Southwood C., Sokoloff G., Steinmetz J.E., and Wellman C.L. Neonatal maternal separation alters adult eyeblink conditioning and glucocorticoid receptor expression in the interpositus nucleus of the cerebellum. Dev. Neurobiol. 67 (2007) 1751-1764
37. Wilber A.A., Southwood C.J., and Wellman C.L. Brief neonatal maternal separation alters extinction of conditioned fear and corticolimbic glucocorticoid and NMDA receptor expression in adult rats. Dev. Neurobiol. 69 (2009) 73-87
38. Wilber A.A., and Wellman C.L. Neonatal maternal separation-induced changes in glucocorticoid receptor expression in posterior interpositus interneurons but not projection neurons predict deficits in adult eyeblink conditioning. Neurosci. Lett. 460 (2009) 214-218
39. Wood D.A., Buse J.E., Wellman C.L., and Rebec G.V. Differential environmental exposure alters NMDA but not AMPA receptor subunit expression in nucleus accumbens core and shell. Brain Res. 1042 (2005) 176-183