New variant of CTX-M-type extended-spectrum β-lactamases, CTX-M-71, with a Gly238Cys substitution in a klebsiella pneumoniae isolate from Bulgaria

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 10, 2009, Pages 4518-4521

  Schneider, Ines ^a   Queenan, Anne Marie ^b   Markovska, Rumyana ^c   Markova, Boyka ^d   Keuleyan, Emma ^e   Bauernfeind, Adolf ^a  

^a MICOER Institute   (Germany)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

^d UNIVERSITY HOSPITAL ALEXANDROVSKA   (Bulgaria)

^e MINISTRY OF THE INTERIOR   (Bulgaria)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; AZTREONAM; CEFEPIME; CEFOTAXIME; CEFOXITIN; CEFTAZIDIME; CEFUROXIME; CLAVULANIC ACID; CTX M 15; CTX M 71; CYSTEINE; ERTAPENEM; EXTENDED SPECTRUM BETA LACTAMASE; FROPENEM; GLYCINE; IMIPENEM; MEROPENEM; METRONIDAZOLE; PENICILLIN G; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; UNCLASSIFIED DRUG; VANCOMYCIN;

ADULT; AGAR DILUTION; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; ASPIRATION PNEUMONIA; BACTERIAL STRAIN; BACTERIUM ISOLATE; BULGARIA; CASE REPORT; GENE SEQUENCE; HUMAN; HYDROLYSIS; KLEBSIELLA PNEUMONIAE; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; RESPIRATORY FAILURE; TRAUMATIC BRAIN INJURY; URINE CULTURE;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; BULGARIA; CEFOTAXIME; CEFTAZIDIME; CEPHALOSPORINS; KINETICS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA;

EID: 70349334603     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00461-09     Document Type: Article

References (20)

1. Ambler, R. P., A. F. Coulson, J. M. Frère, J. M. Ghuysen, B. Joris, M. Forsman, R. C. Levesque, G. Tiraby, and S. G. Waley. 1991. A standard numbering scheme for the class A β-lactamases. Biochem. J. 276:269-270.
2. Bauernfeind, A., H. Grimm, and S. Schweighart. 1990. A new plasmidic cefotaximase in a clinical isolate of Escherichia coli. Infection 18:294-298.
3. Bauernfeind, A., I. Schneider, R. Jungwirth, H. Sahly, and U. Ullmann. 1999. A novel type of AmpC β-lactamase, ACC-1, produced by a Klebsiella pneumoniae strain causing nosocomial pneumonia. Antimicrob. Agents Chemother. 43:1924-1931.
4. Bernard, H., C. Tancrède, V. Livrelli, A. Morand, M. Barthélémy, and R. Labia. 1992. A novel plasmid-mediated extended-spectrum β-lactamase not derived from TEM- or SHV-type enzymes. J. Antimicrob. Chemother. 29: 590-592.
5. Bonnet, R. 2004. Growing group of extended-spectrum β-lactamases: the CTX-M enzymes. Antimicrob. Agents Chemother. 48:1-14.
6. Cantón, R., and T. M. Coque. 2006. The CTX-M β-lactamase pandemic. Curr. Opin. Microbiol. 9:466-475.
7. Elliott, E., A. J. Brink, J. van Greune, Z. Els, N. Woodford, J. Turton, M. Warner, and D. M. Livermore. 2006. In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum β-lactamase. Clin. Infect. Dis. 42:e95-e98.
8. Girlich, D., L. Poirel, and P. Nordmann. 2008. Do CTX-M β-lactamases hydrolyse ertapenem? J. Antimicrob. Chemother. 62:1155-1156.
9. Jacoby, G. A., D. M. Mills, and N. Chow. 2004. Role of β-lactamases and porins in resistance to ertapenem and other β-lactams in Klebsiella pneumoniae. Antimicrob. Agents Chemother. 48:3203-3206.
10. Reference deleted.
11. Markovska, R., I. Schneider, E. Keuleyan, and A. Bauernfeind. 2004. Extended spectrum β-lactamase (ESBL) CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae in Sofia, Bulgaria. Clin. Microbiol. Infect. 10:752-755.
12. Markovska, R., I. Schneider, E. Keuleyan, M. Sredkova, D. Ivanova, B. Markova, G. Lazarova, E. Dragijeva, E. Savov, I. Haydouchka, N. Hadjieva, L. Setchanova, I. Mitov, and A. Bauernfeind. 2008. Extended-spectrum β-lactamase-producing Enterobacteriaceae in Bulgarian hospitals. Microb. Drug Resist. 14:119-128.
13. Matsumoto, Y., F. Ikeda, T. Kamimura, Y. Yokota, and Y. Mine. 1988. Novel plasmid-mediated β-lactamase from Escherichia coli that inactivates oxyiminocephalosporins. Antimicrob. Agents Chemother. 32:1243-1246.
14. Matthew, M., A. M. Harris, M. J. Marshall, and G. W. Ross. 1975. The use of analytical isoelectric focusing for detection and identification of β-lactamases. J. Gen. Microbiol. 88:169-178.
15. Miró, E., B. Mirelis, F. Navarro, A. Rivera, R. J. Mesa, M. C. Roig, L. Gómez, and P. Coll. 2005. Surveillance of extended-spectrum β-lactamases from clinical samples and faecal carriers in Barcelona, Spain. J. Antimicrob. Chemother. 56:1152-1155.
16. National Committee for Clinical Laboratory Standards. 2002. Performance standards for antimicrobial susceptibility testing; 12th informational supplement. M100-S12. National Committee for Clinical Laboratory Standards, Wayne, PA.
17. Pérez-Llarena, F. J., M. Cartelle, S. Mallo, A. Beceiro, A. Pérez, R. Villanueva, A. Romero, R. Bonnet, and G. Bou. 2008. Structure-function studies of arginine at position 276 in CTX-M β-lactamases. J. Antimicrob. Chemother. 61:792-797.
18. Queenan, A. M., W. Shang, M. Kania, M. G. P. Page, and K. Bush. 2007. Interactions of ceftobiprole with β-lactamases from molecular classes A to D. Antimicrob. Agents Chemother. 51:3089-3095.
19. Shimizu-Ibuka, A., H. Matsuzawa, and H. Sakai. 2004. An engineered disulfide bond between residues 69 and 238 in extended-spectrum beta-lactamase Toho-1 reduces its activity toward third-generation cephalosporins. Biochemistry 43:15737-15745. (Pubitemid 39665073)
20. Shimizu-Ibuka, A., H. Matsuzawa, and H. Sakai. 2006. Effect of disulfidebond introduction on the activity and stability of the extended-spectrum class A beta-lactamase Toho-1. Biochim. Biophys. Acta 1764:1349-1355.