Simultaneous enantioseparation of a basic active pharmaceutical ingredient compound and its neutral intermediate using reversed phase and normal phase liquid chromatography with a new type of polysaccharide stationary phase

Journal of Pharmaceutical and Biomedical Analysis

Volumn 51, Issue 1, 2010, Pages 153-157

  Zhou, Lili ^a   Antonucci, Vincent ^a   Biba, Mirlinda ^a   Gong, Xiaoyi ^a   Ge, Zhihong ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Active pharmaceutical ingredient; Chiral liquid chromatographic method; Polysaccharide stationary phase; Simultaneous enantioseparations

Indexed keywords

2 AMINO N [2 [1,2 DIHYDRO 1 (METHYLSULFONYL)SPIRO(3H INDOLE 3,4' PIPERIDIN) 1' YL] 2 OXO 1 (PHENYLMETHYLOXY)ETHYL] 2 METHYLPROPANAMIDE MONOMETHANESULFONATE; 2 TERT BUTOXYCARBONYL AMINO N [2 [1,2 DIHYDRO 1 (METHYLSULFONYL)SPIRO(3H INDOLE 3,4' PIPERIDIN) 1' YL] 2 OXO 1 (PHENYLMETHYLOXY)ETHYL] 2 METHYLPROPANAMIDE MONOMETHANESULFONATE; ALCOHOL; POLYSACCHARIDE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; ELUTION; ENANTIOMER; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PARTICLE SIZE; PRIORITY JOURNAL; PROCESS DEVELOPMENT; QUANTITATIVE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; VALIDATION PROCESS;

AMINOISOBUTYRIC ACIDS; CARBAMATES; CHROMATOGRAPHY, LIQUID; MASS SPECTROMETRY; STEREOISOMERISM; SULFONAMIDES;

EID: 70349330468     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.08.027     Document Type: Article

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