Noninvasive functional imaging of the retina reveals outer retinal and hemodynamic intrinsic optical signal origins

Japanese Journal of Ophthalmology

Volumn 53, Issue 4, 2009, Pages 334-344

  Ts'o, Daniel ^a   Schallek, Jesse ^a   Kwon, Young ^b   Kardon, Randy ^b,c   Abramoff, Michael ^b,c   Soliz, Peter ^d  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c Veterans Administration   (United States)

^d VisionQuest Biomedical   (United States)

Author keywords

Functional retinal imaging; Hemodynamics; Intrinsic signals; Optical imaging

Indexed keywords

DIAGNOSTIC IMAGING; ELECTRORETINOGRAM; EXPERIMENTAL CAT; HEMODYNAMICS; INTRINSIC OPTICAL SIGNAL; NON INVASIVE PROCEDURE; NONHUMAN; OPEN ANGLE GLAUCOMA; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; RETINA; REVIEW; VISUAL STIMULATION;

ANIMALS; CATS; DIAGNOSTIC IMAGING; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; GLAUCOMA, OPEN-ANGLE; HEMODYNAMICS; MACACA FASCICULARIS; PATTERN RECOGNITION, VISUAL; PHOTIC STIMULATION; RETINA; RETINAL VESSELS; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 70349319274     PISSN: 00215155     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10384-009-0687-2     Document Type: Review

References (27)

1. A. Grinvald E. Lieke R.D. Frostig C.D. Gilbert T.N. Wiesel 1986 Functional architecture of cortex revealed by optical imaging of intrinsic signals Nature 324 361 364
2. R.D. Frostig E.E. Lieke D.Y. Ts'o A. Grinvald 1990 Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high-resolution optical imaging of intrinsic signals Proc Natl Acad Sci U S A 87 6082 6086
3. D.Y. Ts'o R.D. Frostig E.E. Lieke A. Grinvald 1990 Functional organization of primate visual cortex revealed by high resolution optical imaging Science 249 417 420
4. M.M. Haglund G.A. Ojemann D.W. Hochman 1992 Optical imaging of epileptiform and functional activity in human cerebral cortex Nature 358 668 671
5. A.W. Toga A.F. Cannestra K.L. Black 1995 The temporal/spatial evolution of optical signals in human cortex Cereb Cortex 5 561 565
6. A.F. Cannestra A.J. Blood K.L. Black A.W. Toga 1996 The evolution of optical signals in human and rodent cortex Neuroimage 3 202 208
7. C.E. Riva S. Harino R.D. Shonat B.L. Petrig 1991 Flicker evoked increase in optic nerve head blood flow in anesthetized cats Neurosci Lett 128 291 296
8. R.A. Linsenmeier 1986 Effects of light and darkness on oxygen distribution and consumption in the cat retina J Gen Physiol 88 521 542
9. I.M. Hogeboom van Buggenum G.L. van der Heijde G.J. Tangelder J.W. Reichert-Thoen 1996 Ocular oxygen measurement Brit J Ophthalmol 80 567 573
10. M. Schmidt A. Giessl T. Laufs T. Hankeln U. Wolfrum T. Burmester 2003 How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina J Biol Chem 278 1932 1935
11. D.C. Hood L.J. Frishman S. Viswanathan J.G. Robson J. Ahmed 1999 Evidence for a ganglion cell contribution to the primate electroretinogram (ERG): effects of TTX on the multifocal ERG in macaque Vis Neurosci 16 411 416
12. W.A. Hare H. Ton 2002 Effects of APB, PDA, and TTX on ERG responses recorded using both multifocal and conventional methods in monkey Doc Ophthalmol 105 189 222
13. M.M. Slaughter R.F. Miller 1981 2-Amino-4-phosphonobutyric acid: a new pharmacological tool for retina research Science 211 182 185
14. M. Slaughter R. Miller 1983 An excitatory amino acid antagonist blocks cone input to sign-conserving second-order retinal neurons Science 219 1230 1232
15. A. Shmuel M. Augath A. Oeltermann N.K. Logothetis 2006 Negative functional MRI response correlates with decreases in neuronal activity in monkey visual area V1 Nat Neurosci 9 569 577
16. A. Shmuel E. Yacoub J. Pfeuffer P.F. Van de Moortele G. Adriany X. Hu K. Ugurbil 2002 Sustained negative BOLD, blood flow and oxygen consumption response and its coupling to the positive response in the human brain Neuron 36 1195 1210
17. M.D. Abramoff Y.H. Kwon D. Ts'o 2006 Visual stimulus-induced changes in human near-infrared fundus reflectance Invest Ophthalmol Vis Sci 47 715 721
18. K. Tsunoda Y. Oguchi G. Hanazono M. Tanifuji 2004 Mapping coneand rod-induced retinal responsiveness in macaque retina by optical imaging Invest Ophthalmol Vis Sci 45 3820 3826
19. D.A. Nelson S. Krupsky A. Pollack 2005 Noninvasive multiparameter functional optical imaging of the eye Ophthalmic Surg Lasers Imaging 36 57 66
20. G. Hanazono K. Tsunoda K. Shinoda K. Tsubota Y. Miyake M. Tanifuji 2007 Intrinsic signal imaging in macaque retina reveals different types of flash-induced light reflectance changes of different origins Invest Ophthalmol Vis Sci 48 2903 2912
21. Y. Okawa T. Fujikado T. Miyoshi Y. Hirohara T. Mihashi Y. Tano 2007 Contribution of retinal ganglion cell activity to intrinsic signals Invest Ophthalmol Vis Sci 48 3845
22. T.Q. Duong S.-C. Ngan K. Ugurbil S.-G. Kim 2002 Functional magnetic resonance imaging of the retina Invest Ophthalmol Vis Sci 43 1176 1181
23. G. Birol S. Wang E. Budzynski N.D. Wangsa-Wirawan R.A. Linsenmeier 2007 Oxygen distribution and consumption in the macaque retina Am J Physiol Heart Circ Physiol 293 H1696 H1704
24. X.C. Yao J.S. George 2006 Dynamic neuroimaging of retinal light responses using fast intrinsic optical signals Neuroimage 33 898 906
25. L.B. Cohen 1973 Changes in neuron structure during action potential propagation and synaptic transmission Physiol Rev 53 373 418
26. Schallek JB, Li H, Kardon RH, et al. Stimulus-evoked intrinsic optical signals in the retina: spatial and temporal characteristics. Invest Ophthalmol Vis Sci 2009 (in press).
27. Schallek JB, Kardon RH, Kwon YH, Abramoff MD, Soliz P, Ts'o D. Stimulus-evoked intrinsic optical signals in the retina: pharmacological dissection reveals outer retinal origins. Invest Ophthalmol Vis Sci 2009 (in press).