A validated stability-indicating RP-HPLC method for levofloxacin in the presence of degradation products, its process related impurities and identification of oxidative degradant

Journal of Pharmaceutical and Biomedical Analysis

Volumn 50, Issue 5, 2009, Pages 710-717

  Lalitha Devi, M ^a   Chandrasekhar, K B ^b  

^a UNITED STATES PHARMACOPEIA   (United States)

^b JNTUA COLLEGE OF ENGINEERING   (India)

Author keywords

Forced degradation stress studies; Levofloxacin; Liquid chromatography mass spectrometer (LCMS); Reversed phase liquid chromatography; RSD and validation

Indexed keywords

LEVOFLOXACIN; METHANOL; SODIUM DIHYDROGEN PHOSPHATE; TRIETHYLAMINE; WATER;

ACIDITY; ARTICLE; BATCH PROCESS; CONTROLLED STUDY; DRUG DEGRADATION; DRUG HYDROLYSIS; DRUG IMPURITY; DRUG QUALITY; DRUG STABILITY; DRUG STRUCTURE; HEAT STRESS; LIQUID CHROMATOGRAPHY; OXIDATION; OXIDATIVE STRESS; PH; PHOTOLYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY;

BUFFERS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HYDROLYSIS; MASS SPECTROMETRY; MODELS, CHEMICAL; OFLOXACIN; OXIDATIVE STRESS; OXYGEN; REPRODUCIBILITY OF RESULTS; TECHNOLOGY, PHARMACEUTICAL;

EID: 70349316561     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.05.038     Document Type: Article

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