A genotype-dependent intermediate ECG phenotype in patients with persistent lone atrial fibrillation genotype ECG-phenotype correlation in atrial fibrillation

Circulation: Arrhythmia and Electrophysiology

Volumn 2, Issue 1, 2009, Pages 24-28

  Husser, Daniela ^a,b   Stridh, Martin ^c   Sörnmo, Leif ^c   Roden, Dan M ^b   Darbar, Dawood ^b   Bollmann, Andreas ^a,b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b VANDERBILT UNIVERSITY   (United States)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Atrial fibrillation; Electrocardiography; Electrophysiology; Genetics

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; ECG ABNORMALITY; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; FEMALE; GENE; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; HEART ATRIUM FIBRILLATION; HEART RHYTHM; HUMAN; KCNE1 GENE; MALE; PHENOTYPE; PRIORITY JOURNAL; SCN5A GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; ATRIAL FIBRILLATION; ELECTROCARDIOGRAPHY; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HEART CONDUCTION SYSTEM; HUMANS; MALE; MIDDLE AGED; MUSCLE PROTEINS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; POTASSIUM CHANNELS, VOLTAGE-GATED; PROSPECTIVE STUDIES; REGISTRIES; REGRESSION ANALYSIS; RISK ASSESSMENT; RISK FACTORS; SODIUM CHANNELS;

EID: 70349308417     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.108.799098     Document Type: Article

References (20)

1. Lai LP, Su MJ, Yeh HM, Lin JL, Chiang FT, Hwang JJ, Hsu KL, Tseng CD, Lien WP, Tseng YZ, Huang SK. Association of the human minK gene 38G allele with atrial fibrillation: evidence of possible genetic control on the pathogenesis of atrial fibrillation. Am Heart J. 2002; 144: 485-490.
2. Fatini C, Sticchi E, Genuardi M, Sofi F, Gensini F, Gori AM, Lenti M, Michelucci A, Abbate R, Gensini GF. Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation. Eur Heart J. 2006; 27:1712-1718.
3. Chen LY, Ballew JD, Herron KJ, Rodeheffer RJ, Olson TM. A common polymorphism in SCN5A is associated with lone atrial fibrillation. Clin Pharmacol Ther. 2007; 81:35-41.
4. Ehrlich JR, Zicha S, Coutu P, Hebert TE, Nattel S. Atrial fibrillationassociated minK38G/S polymorphism modulates delayed rectifier current and membrane localization. Cardiovasc Res. 2005; 67:520-528.
5. Makielski JC, Ye B, Valdivia CR, Pagel MD, Pu J, Tester DJ, Ackerman MJ. A ubiquitous splice variant and a common polymorphism affect heterologous expression of recombinant human SCN5A heart sodium channels. Circ Res. 2003; 93:821-828.
6. Husser D, Stridh M, Cannom DS, Bhandari AK, Girsky MJ, Kang S, Sörnmo L, Olsson SB, Bollmann A. Validation and clinical application of time-frequency analysis of atrial fibrillation electrocardiograms. J Cardiovasc Electrophysiol. 2007; 18:41-46.
7. Xi Q, Sahakian AV, Frohlich TG, Ng J, Swiryn S. Relationship between pattern of occurrence of atrial fibrillation and surface electrocardiographic fibrillatory wave characteristics. Heart Rhythm. 2004; 1:656-663.
8. Husser D, Cannom DS, Bhandari AK, Stridh M, Sornmo L, Olsson SB, Bollmann A. Electrocardiographic characteristics of fibrillatory waves in new-onset atrial fibrillation. Europace. 2007; 9:638-642.
9. Bollmann A, Husser D, Mainardi L, Lombardi F, Langley P, Murray A, Rieta JJ, Millet J, Olsson SB, Stridh M, Sörnmo L. Analysis of surface electrocardiograms in atrial fibrillation: techniques, research, and clinical applications. Europace. 2006; 8:911-926.
10. Firouzi M, Ramanna H, Kok B, Jongsma HJ, Koeleman BP, Doevendans PA, Groenewegen WA, Hauer RN. Association of human connexin40 gene polymorphisms with atrial vulnerability as a risk factor for idiopathic atrial fibrillation. Circ Res. 2004; 95:e29-e33.
11. Capucci A, Biffi M, Boriani G, Ravelli F, Nollo G, Sabbatani P, Orsi C, Magnani B. Dynamic electrophysiological behavior of human atria during paroxysmal atrial fibrillation. Circulation. 1995; 92:1193-1202.
12. Holm M, Johansson R, Brandt J, Luhrs C, Olsson SB. Epicardial right atrial free wall mapping in chronic atrial fibrillation. Documentation of repetitive activation with a focal spread-a hitherto unrecognised phenomenon in man. Eur Heart J. 1997; 18:290-310.
13. Juang JM, Chern YR, Tsai CT, Chiang FT, Lin JL, Hwang JJ, Hsu KL, Tseng CD, Tseng YZ, Lai LP. The association of human connexin 40 genetic polymorphisms with atrial fibrillation. Int J Cardiol. 2007; 116: 107-112.
14. Bollmann A, Binias KH, Toepffer I, Molling J, Geller C, Klein HU. Importance of left atrial diameter and atrial fibrillatory frequency for conversion of persistent atrial fibrillation with oral flecainide. Am J Cardiol. 2002; 90:1011-1014.
15. Bollmann A, Husser D, Steinert R, Stridh M, Sörnmo L, Olsson SB, Polywka D, Molling J, Geller C, Klein HU. Echo- and electrocardiographic predictors for atrial fibrillation recurrence following cardioversion. J Cardiovasc Electrophysiol. 2003; 14:S162-S165.
16. Holmqvist F, Stridh M, Waktare JE, Sornmo L, Olsson SB, Meurling CJ. Atrial fibrillatory rate and sinus rhythm maintenance in patients undergoing cardioversion of persistent atrial fibrillation. Eur Heart J. 2006; 27:2201-2207. (Pubitemid 44412835)
17. Darbar D, Motsinger AA, Ritchie MD, Gainer JV, Roden DM. Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation. Heart Rhythm. 2007; 4: 743-749.
18. Li D, Shinagawa K, Pang L, Leung TK, Cardin S, Wang Z, Nattel S. Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacinginduced congestive heart failure. Circulation. 2001; 104:2608 -2614.
19. Lazar S, Dixit S, Marchlinski FE, Callans DJ, Gerstenfeld EP. Presence of left-to-right atrial frequency gradient in paroxysmal but not persistent atrial fibrillation in humans. Circulation. 2004; 110:3181-3186.
20. Xi Q, Sahakian AV, Ng J, Swiryn S. Atrial fibrillatory wave characteristics on surface electrogram: ECG to ECG repeatability over twenty-four hours in clinically stable patients. J Cardiovasc Electrophysiol. 2004; 15: 911-917.