Cocaine and opiates use in pregnancy: Detection of drugs in neonatal meconium and urine

Journal of Analytical Toxicology

Volumn 33, Issue 7, 2009, Pages 351-355

  Lopez P ^a   Bermejo, A M ^a   Tabernero, M J ^a   Cabarcos, P ^a   Alvarez I ^a   Fernandez P ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOYLECGONINE; COCAINE; CODEINE; MORPHINE; MORPHINE 6 ACETATE; OPIATE;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG URINE LEVEL; DRUG USE; ENZYME MULTIPLIED IMMUNOASSAY TECHNIQUE; EXCITABILITY; HUMAN; MASS FRAGMENTOGRAPHY; MECONIUM; NEWBORN; PREGNANCY; URINALYSIS;

EID: 70349301431     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/33.7.351     Document Type: Article

References (32)

1. C. Christensen. Management of chemical dependence in pregnancy. Obstet. Gynecol. 51(2): 445-455 (2008).
2. Y. Oyelese and C.V. Ananth. Placental abruption. Obstet. Gynecol. 108(4): 1005-1016 (2006).
3. U. Von Mandach. Drug use in pregnancy. Therapeutische Umschau 62(1): 29-35 (2005).
4. O. Fajemirokun-Odudeyia and S.W. Lindow. Obstetric implications of cocaine use in pregnancy: a literature review. Eur. J.Obst. Gynecol. Reprod. Biol. 112: 2-8 (2004).
5. E. Sheiner, I. Shoham-Vardi, M. Hallak, A. Hadar, L. Gortzak- Uzan, M. Katz, and M. Mazor. Placental abruption in term pregnancies: clinical significance and obstetric risk factors. J.Matern. Fetal Neonatal Med. 13(1): 45-49 (2003).
6. C.V. Ananth and A.J. Wilcox. Placental abruption and perinatal mortality in the United States. Am. J. Epidemiol. 153(4): 332-337 (2001).
7. B. Rizt, J.L. Atterbury and L.J. Groome. Reproductive risks of cocaine. Hum. Reprod. Updat. 2(1): 43-55 (1996).
8. G. Hussein Rassool and M. Villar-Luís. Reproductive risks of alcohol and illicit drugs: an overview. J. Addict. Nurs. 17(4): 211-213 (2006).
9. M.A. Al-Mobagani and A.S. Mohamed. Congenital malformations in mice induced by addiction to alcohol and cocaine. East Afr. Med. J. 82(8): 433-438 (2005).
10. M.A. Huestis and R.E. Choo. Drug abuse's smallest victims: in utero drug exposure. Forensic Sci. Int. 128(1-2): 20-30 (2002).
11. N. Hendrix and V. Berghella. Non-placental causes of intrauterine growth restriction. Semin. Perinatol. 32(3): 161-165 (2008).
12. N.M. Vélez, I.E. García, L. García, and M. Valcárcel. The use of illicit drugs during pregnancy among mothers of premature infants. P. R. Health Sci. J. 27(3): 209-212 (2008).
13. C. Johanson and C.R. Schster. Cocaine. In Psyhopharmacology: The Fourth Generation of Progress, F.E. Bloom and D.J. Kupfer, Eds. Raven Press, New York, NY, 1995.
14. J. Gareri, J. Klein, and G. Koren. Drugs of abuse testing in meconium. Clin. Chim. Acta 366(1-2): 101-111 (2006).
15. G.D. Clark, I.B. Rosenzweig, V.A. Raisys, C.M. Callahan, T.M. Grant, and A.P. Steissguth. The analysis of cocaine and benzoylecgonine inmeconium. J.Anal. Toxicol. 16(4): 261-263 (1992).
16. E.M. Ostrea, Jr., M.J. Brady, P.M. Parks, D.C. Asensio, and A. Naluz. Drug screening of meconium in infants of drug-dependent mothers: an alternative to urine testing. J. Pediatr. 115(3): 474-477 (1989).
17. M.A. ElSohly, S. Feng, and T.P. Murphy. Analysis of methadone and its metabolites in meconium by enzyme immunoassay (EMIT®) and GC-MS. J. Anal. Toxicol. 25(1): 40-44 (2001).
18. Y. Xia, P.Wang, M.G. Bartlett, H.M. Solomon, and K.L. Busch. An LC-MS-MS method for the comprehensive analysis of cocaine and cocaine metabolites in meconium. Anal. Chem. 72: 764-771 (2000).
19. H.C. Mofenson and T.R. Caraccio. Cocaine and its metabolites are not distributed uniformly in meconium. Pediatr. Ann. 16(11): 864-874 (1987).
20. M.A. ElSohly, D.F. Stanford, T.P. Murphy, B.M. Lester, L.L.Wright, V.L. Smeriglio, J. Verter, C.R. Baurer, S. Shankaran, H.S. Bada, and H.C. Walls. Immunoassay and GC-MS procedures for the analysis of drugs of abuse in meconium. J. Anal. Toxicol. 23(6): 436-445 (1999).
21. E.M. Ostrea, Jr., A. Romero, D.K. Knapp, A.R. Ostrea, J.E. Lucena, and R.B. Utarnachitt. Postmortem drug analysis of meconium in early-gestation human fetuses exposed to cocaine: clinical implications. J. Pediatr. 124(3): 477-479 (1994).
22. E.J.F. Franssen, L.M.L. Stolk, W. Van den Brand, and B.J. Smit. Analysis of morphine and amphetamine in meconium with immunoassay and HPLC-diode-array detection. J. Anal. Toxicol. 18(5): 294-295 (1994).
23. T. Howe, J.H. Tsushima, and K.K. Batra. Neonatal screening of meconium for drug abuse by Abbot TDx with GC and GC/MS confirmation: comparison with urine EMIT results. (Abstract). Clin. Chem. 38: 1005 (1992).
24. F. Moriya, K.M. Chan, T.T. Noguchi, and P.Y.K. Wu. Testing for drugs of abuse in meconium of newborn infants. J. Anal. Toxicol. 18(1): 41-45 (1994).
25. L.J. Murphey, G.D. Olsen, and R.J. Konkol. Quantitation of benzoylnorecgonine and other cocaine metabolites in meconium by high-performance liquid chromatography. J. Chromatogr. B 613(2): 330-335 (1993).
26. M.Y. Salem, S.A. Ross, T.P. Murphy, and M.A. ElSohly. GC-MS determination of heroin metabolites in meconium: evaluation of four solid-phase cartridges. J. Anal. Toxicol. 25(2): 93-98 (2001).
27. I. Álvarez, F. Palos, A.M. Bermejo, P. Fernández, and M.J. Tabernero. Simultaneous determination of methadone, heroin, cocaine and their metabolites in urine using GC-MS. Anal. Lett. 39(7): 1393-1399 (2006).
28. P. López, A.M. Bermejo, M.J. Tabernero, P. Fernández, and I. Álvarez. Determination of cocaine and heroin with their respective metabolites in meconium by gas chromatography-mass spectrometry. J. Appl. Toxicol. 27(5): 464-471 (2007).
29. Food and Drug Administration: U.S. Department of Health and Human Services. Guidance for Industry, Bioanalytical Method Validation. http://www.fda.gov/cder/guidance/4252fnl.pdf.
30. J. Oyler, W.D. Darwin, K.L. Preston, P. Suess, and E.J. Cone. Cocaine disposition in meconium from newborns of cocaine-abusing mothers and urine of adult drug users. J. Anal. Toxicol. 20(6): 453-462 (1996).
31. M.A. ElSohly, W. Kopycky, S. Feng, and T.P. Murphy. Identification and analysis of the major metabolites of cocaine in meconium. J. Anal. Toxicol. 23(6): 446-451 (1999).
32. C. Moore, A. Negrusz, and D. Lewis. Determination of drugs of abuse in meconium. J. Chromatogr. B 713: 137-146 (1998).