Subconjunctivally implantable hydrogels with degradable and thermoresponsive properties for sustained release of insulin to the retina

Biomaterials

Volumn 30, Issue 33, 2009, Pages 6541-6547

  Misra, Gauri P ^a,b   Singh, Ravi S J ^b   Aleman, Tomas S ^c   Jacobson, Samuel G ^c   Gardner, Thomas W ^b   Lowe, Tao L ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Diabetic retinopathy; Hydrogels; Retina; Retinal diseases; Subconjunctival implantation; Sustained release

Indexed keywords

DIABETIC RETINOPATHY; RETINA; RETINAL DISEASES; SUBCONJUNCTIVAL IMPLANTATION; SUSTAINED RELEASE;

ACRYLIC MONOMERS; AMIDES; BIOMATERIALS; CELL CULTURE; CELL MEMBRANES; ETHANOL; EYE PROTECTION; GLUCOSE; INSULIN; OPHTHALMOLOGY; ORGANIC SOLVENTS; PHOTOPOLYMERIZATION; SUGAR (SUCROSE); SYNTHESIS (CHEMICAL);

HYDROGELS;

2 HYDROXYETHYL METHACRYLATE; ALCOHOL; DEXTRAN; EOSIN; HEMATOXYLIN; INSULIN; POLY(N ISOPROPYLACRYLAMIDE); WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIODEGRADABILITY; CELL ACTIVATION; CELL VIABILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DEGRADATION KINETICS; DIABETES MELLITUS; DIABETIC RETINOPATHY; DRUG DELIVERY SYSTEM; DRUG IMPLANT; DRUG RELEASE; ELECTRORETINOGRAPHY; HYDROGEL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MALE; MICROGLIA; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; RAT; RETINA NERVE CELL; SAFETY; SUSTAINED DRUG RELEASE; ULTRAVIOLET RADIATION;

ANIMALS; BIOCOMPATIBLE MATERIALS; CATTLE; CELL DEATH; CONJUNCTIVA; DELAYED-ACTION PREPARATIONS; ELECTRORETINOGRAPHY; FLUORESCEIN-5-ISOTHIOCYANATE; HYDROGELS; IMPLANTS, EXPERIMENTAL; INSULIN; KINETICS; MALE; MATERIALS TESTING; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; RETINA; TEMPERATURE;

EID: 70349290518     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.08.025     Document Type: Article

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