Identification and profiling of circulating metabolites of atazanavir, a HIV protease inhibitor

Drug Metabolism and Disposition

Volumn 37, Issue 9, 2009, Pages 1826-1840

  Ter Heine, R ^a   Hillebrand, M J X ^a   Rosing, H ^a   Van Gorp, E C M ^a   Mulder, J W ^a   Beijnen, J H ^a   Huitema, A D R ^a  

^a SLOTERVAART HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ATAZANAVIR; CARBAMIC ACID; DRUG METABOLITE; OXOACID;

ARTICLE; CONTROLLED STUDY; DEACYLATION; DRUG GLUCURONIDATION; DRUG HYDROLYSIS; DRUG HYDROXYLATION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG SCREENING; HUMAN; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; OXYGENATION; PLASMA; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; QUANTITATIVE ANALYSIS;

BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEALKYLATION; HIV PROTEASE INHIBITORS; HUMANS; HYDROLYSIS; HYDROXYLATION; INDICATORS AND REAGENTS; OLIGOPEPTIDES; PYRIDINES; SPECIMEN HANDLING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 70349268228     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.028258     Document Type: Article

References (3)

1. Rezk NL, Crutchley RD, Yeh RF, and Kashuba AD (2006) Full validation of an analytical method for the HIV-protease inhibitor atazanavir in combination with 8 other antiretroviral agents and its applicability to therapeutic drug monitoring. Ther Drug Monit 28:517-525.
2. Swainston Harrison T and Scott LJ (2005) Atazanavir: a review of its use in the management of HIV infection. Drugs 65:2309-2336. (Pubitemid 41573606)
3. ter Heine R, Alderden-Los CG, Rosing H, Hillebrand MJ, van Gorp EC, Huitema AD, and Beijnen JH (2007) Fast and simultaneous determination of darunavir and eleven other antiretroviral drugs for therapeutic drug monitoring: method development and validation for the determination of all currently approved HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 21:2505-2514. (Pubitemid 47203278)